39 Works

Synthesis of new (-)-Bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase.

Geetha Velmourougane, Michael Harbut, Seema Dalal, Sheena McGowan, Christine Oellig, James Whisstock, Michael Klemba & Doron Greenbaum

The structural basis for membrane binding and pore formation by lymphocyte perforin

Ruby Law, Natalya Lukoyanova, Ilia Voskoboinik, Tom Caradoc-Davies, Katherine Baran, Michelle Dunstone, Michael D?Angelo, Fasseli Coulibaly, Sandra Verschoor, Kylie Browne, Annette Ciccone, Michael Kuiper, Phillip Bird, Joseph Trapani, Helen Saibil & James Whisstock

Synthesis of new (-)-Bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase.

Geetha Velmourougane, Michael Harbut, Seema Dalal, Sheena McGowan, Christine Oellig, James Whisstock, Michael Klemba & Doron Greenbaum

A common fold mediates vertebrate defense and bacterial attack

Ashley Buckle, Michelle Dunstone, Ruby Law & James Whisstock

The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition

SP Bottomley, AM Buckle, RE Butcher, LD Cabrita, KF Fulton, JA Irving, AM Lesk, SL Reeve, J Rossjohn, I Smith & JC Whisstock

X-ray crystal structure of the streptococcal specific phage lysin PlyC

Sheena McGowan, Ashley Buckley & James Whisstock

Structure-Informed Design of an Enzymatically Inactive Vaccine Component for Group A Streptococcus

Anna Henningham, Daniel Ericsson, Karla Langer, Lachlan Casey, Blagojce Jovcevski, G. Singh Chhatwal, J. Andrew Aquilina, Michael Batzloff, Bostjan Kobe & Mark Walker

Virulence-associated subtilisin-like proteases that use a novel disulphide-tethered exosite to mediate substrate specificity

RM Kennan, W Wong, O Dhungyel, X Han, D Wong, D Parker, CJ Rosado, RHP Law, S McGowan, SB Reeve, V Levina, GA Powers, RN Pike, SP Bottomley, AI Smith, I Marsh, RJ Whittington, JC Whisstock, CJ Porter & JI Rood

Registration Year

  • 2015
    32
  • 2016
    7