40,972 Works

Life on the edge: A perspective on precarious home ownership in Australia and the UK

GA Wood, Susan Smith, M Cigdem & R Ong
This paper focuses on two countries with debt-funded ownership-centred housing systems, Australia and the UK. Financially, there are similarities between these two societies, which have relatively ‘complete’, reasonably well-regulated mortgage markets, had limited exposure to the extremes of subprime, and have been pre-occupied with (and reasonably successful in) restoring ‘business as usual’ in housing and mortgage markets. Institutionally, however, the countries differ from each other, notably with respect to the size and function of the...

Ivan Vankaev, About a Temple in Ulan Hol

Baasanjav Terbish
Ivan talks about a temple in Ulan Hol which was destroyed after the Bolshevik Revolution, and reminisces about how people went to see that place in the Soviet period.

Living alone and cognitive function in later life.

Isobel EM Evans, David J Llewellyn, Fiona E Matthews, Robert T Woods, Carol Brayne, Linda Clare & CFAS-Wales Research Team
Background: Living alone may be associated with greater risk for social isolation and loneliness. Living alone, social isolation, loneliness, and limited engagement in social activity have all been associated with poorer cognitive function in later life. Hence, if individuals who live alone are also at greater risk of isolation and loneliness, this may exacerbate poor cognitive function. Objective: To determine whether people living alone are more at risk of social isolation, feelings of loneliness, and...

An Approach to Evaluate Alternative Process and Supply Chain Opportunities Enabled by Sustainable Chemical Feedstocks

Ettore Settanni, Naoum Tsolakis & Jagjit Srai
This paper outlines a mixed-methods approach to evaluate reconfiguration opportunities for pharmaceutical supply chains (PSCs) arising from a terpene-based renewable chemical feedstock platform technology delivering intermediate products. The proposed approach provides guidance on how to navigate alternative PSC configuration options based on insights into the economic, environmental and social repercussions of each option obtained from both qualitative and quantitative data analyses. A simplified case on manufacturing ‘green’ paracetamol underpinned by real experimental and industry data...

Placental mitochondria adapt developmentally and in response to hypoxia to support fetal growth.

Amanda Sferruzzi-Perri, Josephine S Higgins, Owen R Vaughan, Andrew Murray & Abigail Fowden
Mitochondria respond to a range of stimuli and function in energy production and redox homeostasis. However, little is known about the developmental and environmental control of mitochondria in the placenta, an organ vital for fetal growth and pregnancy maintenance in eutherian mammals. Using respirometry and molecular analyses, the present study examined mitochondrial function in the distinct transport and endocrine zones of the mouse placenta during normal pregnancy and maternal inhalation hypoxia. The data show that...

Valuing forest ecosystem services and disservices – Case study of a protected area in India

KN Ninan & Andreas Kontoleon
This study estimates the value of forest ecosystem services provided by a protected area in a biodiversity hotspot in India. It also addresses some of the shortcomings identified in existing literature by estimating the value of several intangible benefits, and disservices of forests ignored in most valuation studies, as well as the added value from intact forests as compared to from alternative landscapes. Using primary and secondary data, and economic valuation techniques the study shows...

A Novel Human Pluripotent Stem Cell-Derived Neural Crest Model of Treacher Collins Syndrome Shows Defects in Cell Death and Migration.

Felipe Serrano, William Bernard, Alessandra Granata, Dharini Iyer, Benjamin Steventon, Matthew Kim, Ludovic Vallier, Laure Gambardella & Sanjay Sinha
The neural crest (NC) is a transient, multipotent cell population present during embryonic development. The NC can give rise to multiple cell types and is involved in a number of different diseases. Therefore, the development of new strategies to model NC in vitro enables investigations into the mechanisms involved in NC development and disease. Here we report a simple and efficient protocol to differentiate human pluripotent stem cells (HPSC) into NC using a chemically defined...

A Poetics of Dissociability: Poetry and Punk in Los Angeles, 1976–83

Diarmuid Hester
In this article I consider the impact of New York School poetry and New York punk rock on the Los Angeles literary scene of the 1970s and 1980s. I explore the emergence of a distinct grouping of poets that grew up around a Venice Beach literary arts center but was profoundly East Coast in orientation: the so-called “punk poets” of L.A. that are the subject of this article revered the New York School poetry of...

Research data supporting "Solar-driven reforming of lignocellulose to H2 with a CdS/CdOx photocatalyst"

Erwin Reisner, David Wakerley, Moritz Kuehnel, Timothy Rosser, K Ly & K Orchard
Raw data supporting Nature Energy publication: Solar-driven reforming of lignocellulose to H2 with a CdS/CdOx photocatalyst

Genetic modification of primary human B cells to model high-grade lymphoma

Rebecca Caeser, Miriam Di Re, Joanna Krupka, Jie Gao, Maria Lara Chica, Joao Dias, Rachel Fenner, Zelvera Usheva, Hendrick Runge, Hesham Eldaly, George Vassiliou, Brian Huntly, Annalisa Mupo & Daniel Hodson
Sequencing studies of Diffuse Large B Cell Lymphoma (DLBCL) have identified hundreds of recurrently altered genes. However, it remains largely unknown whether and how these mutations may contribute to lymphomagenesis, either individually or in combination. Existing strategies to address this problem predominantly utilize cell lines, which are limited by their initial characteristics and subsequent adaptions to prolonged in vitro culture. Here, we describe a co-culture system that enables the ex vivo expansion and viral transduction...

Structural effects of cap, crack and intrinsic curvature on the microtubule catastrophe kinetics

Eugene Terentjev & Cheng-Tai Lee
Microtubule (MT) experience an effect called `catastrophe', which is the transition from the MT growth to a sudden dramatic shrinkage in length. The straight GTP-tubulin cap at the lament tip, and the intrinsic curvature of GDP-tubulins are known to be the key thermodynamic factors that determine MT catastrophe, while the hydrolysis of this GTP-cap acts as the kinetic control of the process. Although several theoretical models have been developed, assuming the catastrophe occurs when the...

HCMV upregulates expression of HCLS1 resulting in increased cell motility and transendothelial migration during latency

Emma Poole, John Sinclair, Paul Lehner, Mark Wills, B Krishna, V Romashova, James Williamson & Y Aslam
Human cytomegalovirus establishes a lifelong, latent infection in the human host and can cause significant morbidity and mortality, particularly, in immune compromised individuals. One established site of HCMV latency and reactivation is in cells of the myeloid lineage. In undifferentiated myeloid cells, such as CD34+ progenitors and their CD14+ monocyte derivatives, virus is maintained latently but differentiation of these cells to tissue macrophages and dendritic cells results in virus reactivation. We have recently reported an...

A deep learning approach to automatic characterisation of rhythm in non-native English speech

Konstantinos Kyriakopoulos, Mark Gales & Katherine Knill
A speaker's rhythm contributes to the intelligibility of their speech and can be characteristic of their language and accent. For non-native learners of a language, the extent to which they match its natural rhythm is an important predictor of their proficiency. As a learner improves, their rhythm is expected to become less similar to their L1 and more to the L2. Metrics based on the variability of the durations of vocalic and consonantal intervals have...

DICE: Dichoptic contrast enhancement for binocular displays

F Zhong, MS Banks, GA Koulieris, M Chambe, G Drettakis, F Durand & Rafal Mantiuk
© 2019 Copyright held by the owner/author(s). In stereoscopic displays, such as those used in VR/AR headsets, our two eyes are presented with diferent views. The disparity between the views is typically used to convey depth cues, but it could be used for other purposes. We devise a novel technique that takes advantage of binocular fusion to boost perceived local contrast and visual quality of images. Since the technique is based on ixed tone-curves, it...

Diagnostic and prognostic significance of cardiovascular magnetic resonance native myocardial T1 mapping in patients with pulmonary hypertension.

Laura C Saunders, Chris S Johns, Neil J Stewart, Charlotte JE Oram, David A Capener, Valentina O Puntmann, Charlie A Elliot, Robin C Condliffe, David G Kiely, Martin Graves, Jim M Wild & Andy J Swift
BACKGROUND: Native T1 may be a sensitive, contrast-free, non-invasive cardiovascular magnetic resonance (CMR) marker of myocardial tissue changes in patients with pulmonary artery hypertension. However, the diagnostic and prognostic value of native T1 mapping in this patient group has not been fully explored. The aim of this work was to determine whether elevation of native T1 in myocardial tissue in pulmonary hypertension: (a) varies according to pulmonary hypertension subtype; (b) has prognostic value and (c)...

Internal Universes in Models of Homotopy Type Theory

Andrew Pitts, Daniel Licata, Ian Orton & Bas Spitters
We begin by recalling the essentially global character of universes in various models of homotopy type theory, which prevents a straightforward axiomatization of their properties using the internal language of the presheaf toposes from which these model are constructed. We get around this problem by extending the internal language with a modal operator for expressing properties of global elements. In this setting we show how to construct a universe that classifies the Cohen-Coquand-Huber-Mörtberg (CCHM) notion...

Maria Erdnieva, About Bad and Good Signs

Darina Gedeeva & Andrei Babaev
Refrain from leaning against the door of someone’s house, for doing so is no different to sitting on the neck of the head of that household. Both acts are disrespectful. It is forbidden to fold your arms, for you may lose your mother. Also, if you hold your arms behind your back or lean your jaw on your hand, you may lose your father. If a magpie sits at your door it is a bad...

Dynamical differential expression (DyDE) reveals the period control mechanisms of the Arabidopsis circadian oscillator.

Laurent Mombaerts, Alberto Carignano, Fiona C Robertson, Timothy Hearn, Jin Junyang, David Hayden, Zoe Rutterford, Carlos T Hotta, Katherine E Hubbard, Marti Ruiz C Maria, Ye Yuan, Matthew A Hannah, Jorge Goncalves & Alexander Webb
The circadian oscillator, an internal time-keeping device found in most organisms, enables timely regulation of daily biological activities by maintaining synchrony with the external environment. The mechanistic basis underlying the adjustment of circadian rhythms to changing external conditions, however, has yet to be clearly elucidated. We explored the mechanism of action of nicotinamide in Arabidopsis thaliana, a metabolite that lengthens the period of circadian rhythms, to understand the regulation of circadian period. To identify the...

Doubling the Power of DP4 for Computational Structure Elucidation

Jonathan Goodman, Kristaps Ermanis, KEB Parkes & T Agback
A large-scale optimisation of density functional theory (DFT) conditions for computational NMR structure elucidation has been conducted by systematically screening the DFT functionals and statistical models. The extended PyDP4 workflow was tested on a diverse and challenging set of 42 biologically-active and stereochemically rich compounds, including highly flexible molecules. MMFF/mPW1PW91/M06-2X in combination with 2 Gaussian, 1 region statistical model was capable of identifying the correct diastereomer among up to 32 potential diastereomer upper limit. Overall...

Scalar flux modeling in turbulent flames using iterative deconvolution

ZM Nikolaou, Robert Cant & L Vervisch
In the context of Large Eddy Simulations, deconvolution is an attractive alternative for modelling the un-closed terms appearing in the filtered governing equations. Such methods have been used in a number of studies for non-reacting and incompressible flows, however their application in reacting flows is limited in comparison. Deconvolution methods originate from clearly defined operations, and in theory can be used in order to model any un-closed term in the filtered equations including the scalar...

Nina Koksunova, Parental Advice

Baasanjav Terbish & Elvira Churyumova
Nina is a teacher of the Kalmyk language at a secondary school in Khar-Buluk. In this video she talks about what parents teach their children: Children should be taught from a very young age. Parents should serve as an example to their children. I believe that the mother's milk nourishes children in the same way as the father’s advice helps the children grow into proper human beings. My father Badma Ulanov was a very educated...

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential.

Cindy JM Loomans, Nerys Williams Giuliani, Jeetindra Balak, Femke Ringnalda, Léon Van Gurp, Meritxell Huch, Sylvia F Boj, Toshiro Sato, Lennart Kester, Susana M Chuva De Sousa Lopes, Matthias S Roost, Susan Bonner-Weir, Marten A Engelse, Ton J Rabelink, Harry Heimberg, Robert GJ Vries, Alexander Van Oudenaarden, Françoise Carlotti, Hans Clevers & Eelco JP De Koning

Gradient-enhanced statistical analysis of cleavage fracture

Emilio Martínez-Pañeda, S Fuentes-Alonso & C Betegón
We present a probabilistic framework for brittle fracture that builds upon Weibull statistics and strain gradient plasticity. The constitutive response is given by the mechanism-based strain gradient plasticity theory, aiming to accurately characterize crack tip stresses by accounting for the role of plastic strain gradients in elevating local strengthening ahead of cracks. It is shown that gradients of plastic strain elevate the Weibull stress and the probability of failure for a given choice of the...

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