19,246 Works

Immunoexpression status and prognostic significance of mTOR pathway members in upper tract urothelial carcinoma

Kazutoshi Fujita, Sheila Faraj, Enrico Munari, Alcides Chaux, Nilda González-Roibón, Jessica Hicks, Alan Meeker, Norio Nonomura & George Netto
Upper tract urothelial carcinoma accounts for 5-10% of all urothelial carcinomas. Due to its lower prevalence, relatively less attention has been given to the study of its pathogenesis. Key clinical and molecular differences with bladder are becoming apparent. We have previously demonstrated dysregulation of the mTOR pathway in bladder carcinoma. In these slides, we present the results of a study aimed to assess the expression of mTOR markers in upper tract urothelial carcinomas. We also...

A unified protein docking procedure with a shape complementarity screening using 3D Zernike descriptors

Daisuke Kihara, Vishwesh Venkatraman, David La, Yifeng David Yang, Lee Sael, Esquivel-Rodriguez Juan & Bin Li
Effective methods of capturing geometrical information of proteins are very useful for comparing structure similarity of proteins and shape complementarity between protein-protein docking interfaces. We use the 3D Zernike descriptors (3DZD), a spherical harmonics-based series expansion in representing protein surface shape and physicochemical properties. Advantages of 3DZD include compactness, rotation invariance, and controlable resolution of the representation. Here we present two applications of 3DZD: Surface-shape based protein docking method (LZerD: Local 3DZD-based Docking algorithm) and...

Figure 1 data

Gavin E. Jarvis
See README.docx for a description of the file.

Closing in on the reservoir: pro-active case detection as a strategy to contribute to Plasmodium falciparum elimination in an area of multidrug resistance in Cambodia

Gabriele Rossi, Mark Debackere, Chea Nguon, Nimol Khim, Dider Menard, Martin De Smet & Jean-Marie Kindermans
This presentation looks at using pro-active case detection as a strategy to help eliminate Plasmodium falciparum in an area of multidrug resistance in Cambodia.

New insights into cytotoxicity induced by microcystin-LR, estradiol, and ractopamine with mathematical models: Individual and combined effects

Min Ma, Fuwei Pi, Jiasheng Wang, Jian Ji & Xiulan Sun
Humans are most likely to be exposed to microcystins (MCs) combined with other water pollutants rather than to individual compounds through the consumption of contaminated drinking water or through recreational activities, such as swimming. However, the combined effects of MC-LR, estradiol (EST), and ractopamine (RAC) have not been extensively researched. The goal of this study was to investigate the combined effects of these compounds. For this purpose, cytotoxicity was evaluated in HepG2 cells treated with...

Agricultural data sharing: putting the users in the front

Sander Janssen, Rob Knapen, Yke Van Randen & Hendrik Boogaard
Enabling use of crop experiment trials and agricultural open data through open and community based platforms

Apple school: the Alberta project promoting active living and healthy eating in school

Andi Rifai Nursin & Atiq Harkati
School-based health promotion, such as APPLE Schools is a cost-effective intervention for obesity prevention and reduction of chronic disease risk over the lifetime.

Expanding the coverage and allocating resources towards school-based programs like the APPLE Schools program, is likely to reduce the public health burden of obesity and chronic diseases.

London time series: mortality and ozone

S. Stanley Young & Cheng You
London Time Series: Mortality and Ozone
S. Stanley Young, genetree@bellsouth.net; Cheng You, cheng1you@gmail.com

C1
In November of 1952 there was an inversion over London trapping smoke that created a dense smog. Analysis of death data showed that there were thousands of excess deaths over a short period of time. The great London smog has inspired considerable research.

C2
One of the air components with claimed health effects is ozone. The left figure gives some of the health effects...

Hypersensitivity to low intensity fearful faces in people with autism focusing on the eye region

Amandine Lassalle, Jakob Åsberg Johnels, Nicole R. Zürcher, Loyse Hippolyte, Eva Billstedt, Noreen Ward, Eric Lemonnier, Christopher Gillberg & Nouchine Hadjikhani
Previous studies that showed decreased social brain activation in people with Autism Spectrum Disorder (ASD) viewing expressive faces did not control that participants looked in the eye region. This is problematic because ASD is characterized by abnormal attention to the eyes. This study investigates social brain activation to expressive faces when fixation is maintained in the eyes.

We collected functional magnetic resonance imaging (fMRI) data from 48 male participants (27 with ASD) viewing pictures of neutral...

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