19,290 Works

COPO: Aiding the journey from data to publication in the plant sciences

Robert Davey, Anthony Etuk, Felix Shaw, Alejandra Gonzalez-Beltran, Philippe Rocca-Serra & Susanna Sansone
The development of new experimental technologies has opened the way to new, data-generative approaches to plant research, particularly within the genomics field but also high-throughput transcriptomics, proteomics and metabolomics. Furthermore, publication models are moving away from the traditional "data late” approach, and are shifting towards the "data early", with particular pressure being made by funding agencies to see data publicised quickly. Alongside the wealth of these large plant science datasets held in public and private...

Population receptive field analysis using Bayesian model selection

Joram Soch & John-Dylan Haynes
The analysis of population receptive fields (pRF) or voxel receptive fields (vRF) using data from functional magnetic resonance imaging (fMRI) has seen several methodological developments in the last 15 years, demonstrated by application to controlled stimuli as well as natural images. In this work, we propose a new framework for vRF analysis based on Bayesian model selection (BMS) and averaging (BMA) that identifies voxel tuning via encoding model family comparison and performs visual reconstruction via...

Network based modelling for Neuroblastoma drug discovery

Samuel C. Lee, Nathan P. Williams, Belamy Cheung, Glenn Marshall & Jessica K. Holien
Neuroblastoma is the most common solid tumour in infants. However, due to its heterogeneous presentation successful treatment is rare even with intensive multi-modal therapy. Treatment of Neuroblastoma is further affected by the high rates of refractory and relapsed metastasis that occur in patients. There currently is an unmet need for treatments specific to this relapsed form of the disease.

While a number of proteins have been associated with Neuroblastoma (e.g., N-MYC) no druggable targets...

Nitrogen mitigation potential of short rotation woody crops in riparian areas of Lower Mississippi Alluvial Valley

Thu Ya Kyaw, Heidi Renninger, Courtney Siegert & Randy Rousseau
The Lower Mississippi Alluvial Valley (LMAV) has marginal lands that are less opted for traditional agriculture due to alternation of seasonal flooding and high water tables. On such waterlogged sites, short rotation woody crops (SRWCs) can potentially generate landowner income in conjunction with excess nutrient removal. Therefore, this study compared the year-one survival and growth performance of species- and genotype-level willows (Salix nigra) and eastern cottonwoods (Populus deltoides) (with a total of 600 plants, 300...

Nonconsumptive predator effects on eastern oysters Crassostrea virginica across environmental and ecological gradients

Avery E. Scherer, Delbert L. Smee, David L. Kimbro, Jonathan H. Grabowski, James Byers, Randall Hughes & Michael F. Piehler
Nonconsumptive predator effects (NCEs) have the potential to exert great influence on ecosystem structure and function, but the strength of NCEs is strongly influenced by abiotic and biotic factors. Studies which investigate biogeographic patterns in the emergence of NCEs across natural environmental and ecological gradients will improve predictions of role of predators in community regulation. We investigated the effects of a biotic factor (trophic structure) on NCE emergence in basal prey species (oysters Crassostrea virginica)...

Tracking the world's largest land crab: coconut crabs and habitat Habitat associations on Palmyra Atoll

Michael W. Burnett, Timothy D. White, Giulio A. De Leo & Fiorenza Micheli
The coconut crab (Birgus latro (L.)) is the world’s largest terrestrial crab. Limited to tropical areas of the Indian and Pacific oceans, the crab can weigh up to 4 kilograms and exceed a one-meter legspan over its 50+ year lifetime. But Birgus populations have faced significant pressures over the last century: many small island communities have replaced large native forest trees (e.g. Pisonia and Pandanus sp.) with coconut palm monocultures, disrupting the coconut crab’s natural...

Pollen production across a city: Scaling from anthers to neighborhoods with allometric equations and remote sensing

Daniel Katz & Stuart Batterman
Pollen allergies afflict tens of millions of Americans, triggering both allergic rhinitis (hay fever) and asthma attacks. Despite the considerable public health consequences of allergenic pollen exposure, little is known about how pollen concentrations vary within cities. This is in part because there are few municipal-scale estimates of pollen production. This information could serve as the basis for pollen dispersion models, which are required for individual level estimates of allergenic pollen exposures.
In this study, we...

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