19,852 Works

Sustainable livelihoods & adaptation to climate change

Dhruv Puri & Kunal Prasad
Globally, agriculture is one of the most climate-sensitive of all economic sectors. Among the developing nations, India is one of the biggest agro-based economies in the world, where nearly 70% rural households rely on it for their sustenance.

Climate change will not only make it more difficult to feed the projected 10 billion people by 2050 but its impact is already being felt in the form of reduced yields and more frequent extreme weather events...

Quantitative analysis of blood cells from microscopic images using Convolutional Neural Network

Abel Worku, Timothy Chung Kwa, Mohammed Aliy Mohammed, Gelan Ayana Zewdie & Gizeaddis Lamesgin Simegn
Blood cell count provides relevant clinical information about different kinds of disorders. Any deviation in the number of blood cells implies the presence of infection, inflammation, edema, bleeding, and other blood-related issues. Current microscopic methods used for blood cell counting are very tedious and are highly prone to different sources of errors. In addition, these techniques do not provide full information related to blood cells like shape and size, which play important roles in the...

Strategic collaboration between Medicines for Malaria Venture (MMV) and Antimicrobial and Biocontrol Agents Unit (AmBcAU) at the University of Yaoundé 1 identifies potent inhibitors of the causative agents of Amoebiasis, Buruli ulcer and Toxoplasmosis

Fabrice Boyom, Darline Dize, Rufin Marie Kouipou Toghueo, Patrick Valere Tsouh Fokou, Benoit Laleu & Thomas Spangenberg
The Antimicrobial and Biocontrol Agents Unit (AmBcAU) at the University of Yaoundé 1 has been collaborating with Medicines for Malaria Venture (MMV) over the past seven years to repurpose libraries of compounds including Malaria Box, Pathogen Box and Stasis Box using standard laboratory methods to identify potential inhibitors of Mycobacterium ulcerans, Entamoeba histolytica and Toxoplasma gondi that cause two NTDs (Buruli ulcer, amoebiasis) and toxoplasmosis respectively. Overall, phenotypic screening of compounds libraries and subsequent structure-activity-relationship...

UWE – Scion collaboration: 1st generation MFCs

Ioannis Ieropoulos & Christopher Francois
Slide deck capturing the collaboration between UWE and SCION

Introducing capacity building and mentorship program for routine immunization by local medical colleges

Ashenafi Amare, Alemayehu Teklu Toni, Biniyam Tilahun & Zeleke Abebaw Mekonen
In this project, we have developed a program to supplement the government led supervision through a capacity building and mentorship approach by medical college staffs with better knowledge, skills, and preparation to give supportive supervision and onsite training on specific immunization programs.
The primary implementation hypothesis is that Introducing Capacity building and Mentorship Program (CBMP)by medical and health science colleges is feasible, acceptable and effective. We plan to develop an appropriate implementation strategy that results in...

Hardwood Genomics Database (HGD): a web portal and database resource for hardwood tree genomic and genetic research

Ming Chen, Nathan Henry, John Carlson & Margaret Staton
The Hardwood Genomics Database (HGD, www.hardwoodgenomics.org) serves forest tree scientists by providing online access to hardwood tree genomic and genetic data. HGD currently houses data for economically and phylogenetically important hardwood species including assembled reference genomes, transcriptomes, and genetic mapping information. The results of bioinformatic analysis including functional annotation of genes, ontology assignment, analysis of gene expression patterns across RNASeq libraries and simple sequence repeat (SSR) identification are available to enhance the utility of the...

Lab specimen tracking with Galaxy

Martin Čech, Pavel Švéda & Ondřej Fabián
No experiment begins with sequencing. Instead it commences with a collection of samples followed by DNA isolation (generation of cDNA, immunoprecipitation etc.), preparation of sequencing libraries, sequencing itself, and, finally, data analysis. In other words, during an NGS experiment a biological specimen undergoes transformation into a dataset to be analyzed. When an experiment involves a handful of samples, tracking the specimen-to-dataset metamorphosis is straightforward. However, low cost of sequencing enables individual single-PI laboratories to perform...

Simple actions influence eye movements

Jihyun Suh, Blaire Weidler & Richard Abrams
Recent research has revealed that action can have an influence on visual perception. For example, participants find targets more quickly in a visual search task when the target is associated with a feature they previously acted towards. However, all evidence for this phenomenon comes from manual response time data. Thus, it is theoretically possible that action’s effect is not on perception but instead on post-perceptual response processes. Here for the first time we investigated if...

Effect of blur in colour dicrimination

Leticia Álvaro, João M.M. Linhares, Talia Ali, Monika A. Formankiewicz & Sarah J Waugh
Blur impairs colour discrimination but this impairment has not been systematically investigated across hue. In this work we obtained colour discrimination thresholds for a number of hue angles, stimulus sizes and blur levels. A colour discrimination task (Linhares et al., 2016 JOSA A 33(3): A178-A83) was performed on a calibrated CRT monitor controlled by a ViSaGe-MKII. A square chromatic target was presented on an achromatic static luminance noise background. Observers indicated the location of the...

A comparison by parametric and non-parametric approach: Brazilian homicide rates before and after statute of disarmament.

Ana Carolina Raimondi & Antonio Marcos Raimondi
One and a half million people were murdered between 1979 and 2017 in Brazil. In December, 2003, Brazilian federal government enacted the National Statute of Disarmament. Its regulation occurred in July, 2004. This law limited the ownership and use of firearms by citizens. It has been expected that this measure would reduce firearm murders.
The aim of this study is describing parametric and non-parametric test results on homicide rates in Brazil. Two periods were compared: BEFORE...

Agricultural R&D Indicators Factsheet — Sierra Leone

Nienke Beintema, John Momoh & Kathleen Flaherty
Agricultural R&D indicators factsheet--Sierra Leone

Automated filtering of multiple sequence alignment worsens phylogenetic inference

Ge Tan, Matthieu Muffato, Christian Ledergerber, Javier Herrero, Nick Goldman, Manuel Gil & Christophe Dessimoz
In the context of phylogenetic analysis, a multiple sequence alignment (MSA) is the general way of comparing simultaneously several sequences. However, computing a MSA appears to be difficult because of errors in the initial sequences (due to sequencing, the assembly or the annotation) and the divergence of the sequences. As this could seriously impact the tree estimation, some automated algorithms are thus used to filter out the less-supported columns to increase the signal vs noise...

Measuring layer-dependent CBV fMRI in the visual system

Laurentius Huber, Elisha Merriam, Insub Kim, Yuhui Chai, Sriranga Kashyap, Jonathan Polimeni, Won Mok Shim, Seong-Gi Kim, Dimo Ivanov, Benedikt Poser & Peter Bandettini
With recent developments of ultra-high field MRI and high-resolution CBV-sensitive VASO sequences, it became possible to measure activity
changes across cortical depths in brain areas of large cortical thicknesses (4mm in M1). Applications of layer-dependent CBV-fMRI in the visual cortex, however, have been complicated by long arterial-arrival-times, coverage requirements, and lower cortical thickness (1.9mm). Here, we developed new sequence setups for layer-dependent acquisition of CBV changes during tasks and resting-state. We find that the proposed large-...

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