18,530 Works

Recommendations for filling identified gaps in standards for land and nutrition data

Deborah Yates, Leigh Dodds, Jeni Tennison, Valeria Pesce & Panagiotis Zervas
This report provides a number of recommendations to improve practices around the creation and use of standards that support the collection and use of land and nutrition data.

We have drawn on the analyses of gaps in land and nutrition standards reported in our survey of data standards for land and nutrition data (Pesce, Mey, L’Hénaff and Tejo-Alonso, 2018). Land data, like geology, soil and irrigation, and nutrition data, like food consumption and health statistics, are...

Study molecular of interaction between N,N-dimethyltryptamine analogs (DMT) with 5-HT1A and 5-HT1B receptors, associated in neuronal alterations

Hilder Mercado-La Peira, José Dussan-Ordoñez, Antistio Alvíz-Amador, Neyder Contreras-Puentes, Veronica Castro-Bocanegra, Francisco Liñan-Tobías & Karick Jotty-Arroyo
Study molecular of interaction between N,N-dimethyltryptamine analogs (DMT) with 5-HT1A and 5-HT1B receptors. Likewise, complexes mechanisms that related the interaction with these receptors involved in alterations such as depression, post-traumatic stress disorders and anxiety. Therefore, have been evaluated the activity of DMT analogs by docking molecular studies in the determination of the ligand-receptor interaction. We identified new DMT analogs with activity in serotonergic receptors with high structural and energy affinity. The complexes of receptors-ligands were...

Discriminant balance analysis: a new approach to balance selection

Thomas Quinn
Since the turn of the century, technological advances have made it possible to obtain a molecular profile of any tissue in a cost-effective manner. Among these advances include sophisticated high-throughput assays that measure the relative abundance of microorganisms, RNA molecules, and metabolites. While these data are most often collected to gain new insights into biological systems, they can also be used as biomarkers to create clinically useful diagnostic classifiers. How best to classify high-dimensional “-omics”...

OncoMX: a cancer biomarker resource leveraging published literature and genomics data

Evan Holmes
These slides were presented at Biocuration 2019 during the Curation for human health and nutrition session by Evan Holmes, a member of the OncoMX team and graduate research assistant in the Mazumder lab at the George Washington University. This presentation detailed the leveraging of published literature and genomics data by the OncoMX team to provide the scientific community with the integrated cancer biomarker database, OncoMX. This work is a collaborative project between the George Washington...

MEMNAR: finding mutually exclusive mutation sets through negative association rule mining

Iman Deznabi, Ahmet Alparslan Celik & Oznur Tastan
It has been reported in multiple cancers that certain set of gene mutations tend not to occur concurrently in the same patient. This mutual exclusivity pattern hints at a functional relation and can help uncover cancer-driver alterations. We address the problem of discovering mutually exclusive mutation gene sets through mining negative association rules. Our proposed algorithm, MEMNAR, efficiently mines for negative association rules in patient mutation data and constructs mutually exclusive gene sets based on...

Loss of PTEN expression is associated with increased risk of recurrence after prostatectomy for clinically-localized prostate cancer

Alcides Chaux, Sarah B. Peskoe, Nilda González-Roibón, Jessica Hicks, Luciana Schultz, Roula Albadine, Angelo M. De Marzo, Elizabeth A. Platz & George J. Netto
BACKGROUND: PTEN is one of the most frequently lost tumor suppressor genes in human cancers and it has been described in more than two-thirds of patients with advanced/aggressive prostate cancer. Previous studies suggest that, in prostate cancer, genomic PTEN loss is associated with tumor progression and poor prognosis.

DESIGN: We evaluated whether immunohistochemical PTEN expression in prostate cancer glands was associated with higher risk of recurrence using a nested case-control study that included 451 men...

Nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA) among hospitalized patients: a cross-sectional study

Adrian Yong, Gan Kim Kun, Myron Anthony Godinho, Arjan Dhillon & Shobana Raj
Methicillin resistant Staphylococcus aureus (MRSA) infection is an important cause of increased morbidity and mortality among hospitalized patients. Major issues with multidrug resistant hospital associated (HA) strains are the treatment failures. The community associated MRSA (CA-MRSA) are discerned for the production of Panton valentine leucocidine (PVL) which makes them more virulent and capable of causing necrotizing pneumonia and necrotizing fasciitis. Nasal carriers of MRSA are thought to be the prime sources of infection in health...

Identification of strengths and weaknesses of cooperative efforts within the wider Caribbean using a collaboration network approach

Ruben D. Ramírez-Ramírez, Luis M. Montilla, Francoise Cavada-Blanco & Aldo Croquer
Strategic planning for conservation of coral reefs is focused on building resilience by an integrated management approach based on cooperative efforts. Here, we built a connectivity network of Caribbean researchers using the papers presented at AMLC scientific meetings as a proxy of collaboration among organizations for five decades. We aimed to evaluate the usefulness of this analysis as a tool for identifying regional research gaps, key organizations that functions as hubs and prioritizing research efforts...

Feedback on revised pharmacology record for medical undergraduates

Dhanya Palappallil & Reneega Gangadhar
Medical Council of India has made it mandatory to maintain records as a part of curriculum. This study sought the feedback on new revised record adopted in the institution as we the clinical pharmacology exercises.The new improved pharmacology record is an effective teaching-learning method. Student need to be senistised on the importance of critical appraisal of medical literature and essential medicine list

In silico analysis of cross-reactivity between lipocalins of domestic animals

María Nordmann, Yuliana Emiliani, Andrés Sánchez, Dilia Aparicio, Jorge Sánchez & Marlon Gustavo Múnera Gomez
Lipocalins are one of the groups of allergens derived from animals with greater clinical importance for the development of respiratory allergies in humans. To identify possible antigenic regions involved in cross-reactivity, it is explored through bioinformatics tools through the MEGA, Swiss Modeller and PYMOL bioinformatic tools. Five clades resulted from the alignment and allergens Fel d 4, Rat n 1 and Equ c 1 presented the highest identity (58%). This explains the cross-reactivity between allergens...

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