3,927 Works

Intertidal temperatures 12-Jun-2016

Sonja M. Ehlers & Julius A. Ellrich
Intertidal temperatures measured by temperature loggers 1 & 2 on 12-Jun-2016 every 30 minutes

Raw data for Figure 1.

Lakshmi Ganapathi, Alana Arnold, Sarah Jones, Al Patterson, Dionne Graham, Marvin Harper & Ofer Levy
Adenovirus blood viral load is represented in each column at each particular time in days (before or after onset of cidofovir treatment) for each patient.

Development of new EEG monitoring head set for neurological emergency

Hiroshi Okudera, Sakamoto Mie, Masahiro Wakasugi & Megumi Takahashi

In Japan, the first step of neurocritical care in hospital is mainly provided by resuscitation team consisting of emergency physicians, neurologists and neurosurgeons. Japan Resuscitation Council (JRC) described an independent chapter termed "neuroressuscitation"(NR) in the first and original ressuscitation guideline 2010. NR referes to cerebrovascular diseases, acute encephalopathies, Infection of the central nervous system, acute neuromuscular diseases, neuroleptic malignant syndrome, heat emergencies, persistent consciousness disturbance and brain death. Among of them, non convulsive status epilepticus(NCSE)...

Anti-viral drug design: an integrative approach to targeting the M2-1 protein of human respiratory syncytial virus (hRSV)

Rachel Dods, Kavestri Yegambaram, Andrew Buckley, Roger Taylor, Rachel Trowbridge, Jean-Francois Eleouet, Richard Foster & John Barr
Human respiratory syncytial virus (HRSV) is the leading cause of lower respiratory tract illness in young children and the immunocompromised, with over 250,000 annual fatalities worldwide. HRSV-mediated diseases are especially prevalent in developing countries, where no financially viable treatment exists. The M2-1 protein of HRSV represents a potential anti-viral target for the treatment of HRSV-mediated diseases. M2-1 is a transcription anti-terminator with a critical role in viral gene expression. M2-1 binds both viral RNA and...

The clinical utility of a self-reported swallowing outcome measure

Laurie Sterling, Julia McCaffrey, Heather Thompson & Peggy Allred
Nearly all ALS patients develop dysphagia at some point in the disease process. The Eating Assessment Tool-10 (EAT-10) is being used in clinics to screen for swallowing disorders and monitor change. This poster examined the clinical utility of the EAT-10 in ALS patients.

BioSharing: Mapping the landscape of standard and database resources in the life sciences

Peter McQuilton, Alejandra Gonzalez-Beltran, Massimiliano Izzo, Allyson Lister, Eamonn Maguire, Philippe Rocca-Serra, Milo Thurston & Susanna-Assunta Sansone
We introduce BioSharing (http://www.biosharing.org), a curated, web-based, searchable portal of content standards, databases, and data policies in the life sciences, broadly encompassing the biological, environmental and biomedical sciences. As of today, BioSharing has >1500 records of which >650 are community-developed standards (terminologies, formats and models, and reporting guidelines), >750 are databases and >80 are data policies.

BioSharing maps the dynamic landscape of data standards, monitoring their: development, evolution and integration; implementation and use in databases; and...

CD30 cell graphs of Hodgkin lymphoma are not scale-free—an image analysis approach

Hendrik Schäfer, Tim Schäfer, Jörg Ackermann, Norbert Dichter, Claudia Döring, Sylvia Hartmann, Martin-Leo Hansmann & Ina Koch
Slides for my highlight talk at ISMB 2016. The topic is an analysis of the spatial distributions of CD30 positive cells in Hodgkin lymphoma (HL). We used high resolution whole slide images of HL and detected cells in them using a custom imaging pipeline. We analyzed typical cell and image properties, e.g., cell size, cell density, etc. Then, we modeled the cell distribution as a graph and compared graph properties like the vertex degree distribution...

Ecology and epidemiology of brucellosis and tuberculosis: One Health Perspective

Gloria Kang, Rachel Culp, L Gunaseelan, A Srividya, Soumya Swaminathan & Kaja Abbas
The study objectives are:
(i) To develop a mathematical model of brucellosis transmission dynamics, and predict the impact of different prevention interventions.
(ii) To conduct a cohort study from household surveys and estimate the protective effects of the Bacillus Calmette–Guérin (BCG) vaccine for household contacts of tuberculosis cases.

Genetic variability and chemotoxicity of 5-FU and cisplatin in head and neck cancer patients

Dipali Dhawan, Harsha Panchal, Shilin Shukla & Harish Padh
This study evaluates a genotype-phenotype association between genetic variants in genes coding for drug metabolizing enzymes and drug targets and the chemotherapeutics prescribed to head and neck cancer. This study provides an insight into the effect of genetic variants on toxicity due to cancer chemotherapeutics in Indian cancer patients and the importance of genetic testing before medication is prescribed, to enable more efficacious cancer treatment and better patient management.

The International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) response to the Zika virus outbreak

Olaa Mohamed-Ahmed, Bethan McDonald, Raul Pardinaz-Solis, Louise Sigfrid, Chelsea McMullen, Sarah Moore, Kajsa-Stina Longuere, Maria Del Pilar Ramon-Pardo, Nikki Shindo & Gail Carson
The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) is a consortium of organisations and individuals, launched in 2011, and spanning more than 100 countries.

ISARIC’s vision is to change the approach to global collaborative patient oriented research between and during epidemics of rapidly emerging public health threats in order to generate new knowledge, maximise the availability of clinical information, and thereby save lives.

Immunohistochemical expression of AIM1 in normal prostate and in primary and metastatic prostate carcinoma

Michael C. Haffner, Srinivasan Yegnasubramanian, George J. Netto & Alcides Chaux
INTRODUCTION: Absent in melanoma 1 (AIM1) is a novel actin-interacting protein that shows tumor suppressor function in prostate cancer. We have recently shown that loss of AIM1 increases actin remodeling and promotes cell invasion and cell motility in prostate epithelial cells. Herein we evaluated the expression pattern of AIM1 in normal prostate epithelium, primary prostate cancer, and lymph node metastases.

MATERIAL & METHODS: To evaluate the expression pattern of AIM1in human tissues we developed a...

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