7,780 Works

Review of food and agricultural policies in Malawi

Federica Angelucci, Alethia Cameron, Hélène Gourichon & Valentina Pernechele
Review of food and agricultural policies in Malawi

A surprising finding related to cybersex and high risk sexual behaviors

Jesús Castro Calvo, Rafael Ballester-Arnal, Maria Dolores Gil-Llario, Beatriz Gil-Julià & Cristina Juárez-Tamargo
Background: Some studies have documented higher rates of risky sexual behaviors among young people who are exposed to online pornography. However, results are inconsistent and the link between cybersex and high risk sexual behavior remains unclear. The aim of this study was to extend current knowledge by analyzing the association between cybersex consumption and several high risk sexual indicators (number of sexual partners, condom use during vaginal intercourse, anal intercourse, etc.) in young people.

Methods: Data...

Supporting evidence-informed priority-setting

John Lavis
This report highlights some of the key insights about how best to support evidence-informed priority setting. It is divided into two parts, the first focuses on the importance of knowing your context as different types of policy decisions will likely warrant different approaches when making and influencing policy decisions to support evidence-informed priority setting. Second, the report provides guidance on how to approach intervening within the defined context. Intervening involves assessing ‘evidence-supply side’ versus ‘evidence-demand...

Distribution patterns and genetic diversity of Cedrela montana Moritz ex Turcz. in Ecuador.

Carlos Manchego, Augusta Cueva-Agila, Cristian Bastidas, Patrick Hildebrant, Bernd Stimm, Sven Gunter, Manuel Curto & Harald Meimberg
Deforestation and climate change are two of the main threats to tropical forests. The first is largely caused by an unsustainable approach linked to resource acquisition and the second by uncertainty associated with future climate scenarios and their impact on forest dynamics. The problem increases if we take into account that Ecuador reached in 2014 one of the highest deforestation rates in all of South America and temperature increases > 1oC have already been detected...

dnaasm – new tool to assemble repetitive DNA regions

Wiktor Kuśmirek & Robert Nowak
Some parts of the genome are composed of repetitive DNA sequences. Existing genome assemblers reconstruct these repetitive regions using information about the insert size length of paired-end tags.

We propose a modification of the algorithm for DNA de-novo assembly, which uses the relative frequency of reads to properly reconstruct repetitive sequences (tandem repeats). The main advantage of our approach is that tandem repeats, which are longer than the insert size of paired-end tags, can also be...

Data stewardship wizard

Robert Pergl, Marek Suchánek, Jan Slifka, Vojtěch Knaisl, Rob Hooft & Mateusz Kuzak
The development of the Data Stewardship Wizard is a project that is ongoing since 2016.The Wizard gets more and more attention in life sciences as well as other domains where scientists need to efficiently work with data as a key element of their projects. In the last year, we released a new generation of the Wizard with brand new features and increased usability. This development has largely been done as part of the ELIXIR Implementation...

EXTRACTION OF CURCUMIN

Naresh Dilip Joshi & Kulkarni Aditya Arvindrao
Economic part of turmeric is rhizomes. Rhizomes are horizontal underground stems. Since ancient time we used turmeric as a medicine. Mostly in India people use turmeric as medicine in Ayurveda as Anti-bacterial, Anti-oxidant, Anti-inflamentary, etc. Curcumin is a colour pigment present in turmeric which gives yellow colour to the turmeric as well as medicinal properties. Curcumin has anti-cancerous medicinal property it has ability to cure the cancer. Hence curcumin can be replaced against expensive medicinal...

Access to non-communicable disease health care among non-camp Syrian refugees in northern Jordan

Manuela Rehr, Muhammad Shoaib, Idriss Ait-Bouziad, Cono Ariti, Paul Van Den Bosch, Sara Ellithy, Suhib Okour, Anais Deprade, Mohammad Altarawneh, Abdel Alshafee, Sadeq Gabashneh & Annick Lenglet
This abstract corresponds with the following slides: https://f1000research.com/slides/6-716, presented at Médecins Sans Frontières UK Scientific Days: Medical Research 2017. To watch the presentation click here: https://f1000research.com/videos/6-841.

This abstract is part of an F1000Research gateway that includes posters, slides and videos from the MSF Scientific Day: Medical Research 2017. To see more please visit: https://f1000research.com/gateways/MSF/scidays

Anti-viral drug design: an integrative approach to targeting the M2-1 protein of human respiratory syncytial virus (hRSV)

Rachel Dods, Kavestri Yegambaram, Andrew Buckley, Roger Taylor, Rachel Trowbridge, Jean-Francois Eleouet, Richard Foster & John Barr
Human respiratory syncytial virus (HRSV) is the leading cause of lower respiratory tract illness in young children and the immunocompromised, with over 250,000 annual fatalities worldwide. HRSV-mediated diseases are especially prevalent in developing countries, where no financially viable treatment exists. The M2-1 protein of HRSV represents a potential anti-viral target for the treatment of HRSV-mediated diseases. M2-1 is a transcription anti-terminator with a critical role in viral gene expression. M2-1 binds both viral RNA and...

Using clustering trees to visualise single-cell RNA-sequencing data

Luke Zappia & Alicia Oshlack
Single-cell RNA-sequencing is commonly used to interrogate complex tissues in order to identify and compare the cell types present. This type of experiment is particularly prevalent in the developmental setting. A key step in this approach is assigning cells to different clusters that are assumed to be distinct cell types. Although this can be done by comparison with reference datasets, cells are more routinely grouped using unsupervised clustering and we have catalogued more than 60...

Isolation and characterization of novel bacteriophages Phalcolm and Helpful

Shawn Barman, Preston Carroll, Naiomi Desai, Erin Natale, Malcolm Phung, Ryan Ngo, Krisanavane Reddi & Amanda Freise
Bacteriophages are efficient and specific in killing bacteria, and therefore are increasingly being studied to better understand phage-bacteria interactions. However, phages can also spread antibiotic resistance and toxic genes to beneficial bacteria through Horizontal Gene Transfer. Therefore, if prevention of phage adsorption to host bacteria is studied, then these negative consequences could be prevented. Phage Phalcolm, a Bacillus subtilis-infecting phage and phage Helpful, a Mycobacterium smegmatis-infecting phage, were both purified through enriched isolation. B. subtilis...

Propranolol treatment for children with hemangioma

Juliana Albuquerque, Rosane Magalhães, Jamille Felix, Maria Vilani Bastos, Francisco H C Felix & Juvenia Fontenele
Introduction: Hemangioma are tumors formed by the proliferation of blood vessels, most common in childhood. Recently, propranolol has been shown to have an effect on these lesions. Objectives: To evaluate the response of children with hemangiomas to treatment with propranolol. Methodology: Retrospective analysis of medical records. Patients aged 0-19 years with hemangioma with or without previous treatment were included. The response was assessed by comparing the onset of treatment and the status at the last...

Rethinking Mozambique’s cotton price fixing system to align producers’ prices with international prices

Bill
Rethinking Mozambique’s cotton price fixing system to align producers’ prices with international prices

Establish a 5-day growth curve starting with 16,000 cells/ well

Christopher Dardis, Eric C Woolf & Adrienne C Scheck
Example 2; using R to generate LaTeX output. Intermediary .Rnw file, typeset with knitr.

Optimal rates for phylogenetic inference and experimental design in the era of genome-scale data sets

Alex Dornburg, Zhou Su & Jeffrey P. Townsend
Time and rate of character evolution can be used to predict the probability of convergence in states. Theory predicts the existence of an optimal rate that maximizes phylogenetic information and minimizes homoplasious characters. The question of how to select data appropriate for a given phylogenetic problem has become a major topic of interest. This question has been driving development of theory of phylogenetic experimental design for over two decades. Some research has failed to find...

Networks and Low Adoption of Hybrid Technology: The Case of Pearl Millet in Rajasthan, India

Abdul Munasib, Devesh Roy & Ekin Birol
Networks and Low Adoption of Hybrid Technology: The Case of Pearl Millet in Rajasthan, India

Nanopore detection of Influenza virus direct from respiratory samples.

Kuiama Lewandowski, Yifei Xu, Sheila Lumley, Ali Vaughan, Richard Vipond, Miles Carroll, Sarah Walker, Peter Simmonds, Dona Foster, Tim Peto, Derrick Crook, Philippa Matthews & Steven Pullan
A poster describing the development of a Nanopore sequencing solution to detect and provide complete sequences of Influenza virus from patient throat swabs.

The wheat data interoperability guidelines: feedback, news and next steps

Esther Dzale Yeumo
The wheat data interoperability guidelines (http://ist.blogs.inra.fr/wdi/) result from a joint effort of the wheat research community and data experts, who wish to make their research data more accessible, interoperable and reusable. During more than 18 months, the Wheat Data Interoperability working group questioned the wheat research community about their usage of data standards, discussed and selected a set of recommendations based on some consensual criterias.

This presentation will give you some feedback about the work of...

SeeGEM: Lightweight interactive visualization of DNA sequence variation prioritization

David McGaughey
Identification of genetic variation causing human disease in a proband is a complex process; raw DNA sequence must be aligned to a reference genome, genotypes called from the aligned reads, annotations (e.g. gnomAD, CADD) appended, and family structure (proband, mother, father) delineated.

The most powerful and popular tool for doing the filtering and inheritance pattern testing is the GEMINI tool. However even running GEMINI to filter for DNA variants passing quality control metrics, match proper...

The clinical utility of a self-reported swallowing outcome measure

Laurie Sterling, Julia McCaffrey, Heather Thompson & Peggy Allred
Nearly all ALS patients develop dysphagia at some point in the disease process. The Eating Assessment Tool-10 (EAT-10) is being used in clinics to screen for swallowing disorders and monitor change. This poster examined the clinical utility of the EAT-10 in ALS patients.

BioSharing: Mapping the landscape of standard and database resources in the life sciences

Peter McQuilton, Alejandra Gonzalez-Beltran, Massimiliano Izzo, Allyson Lister, Eamonn Maguire, Philippe Rocca-Serra, Milo Thurston & Susanna-Assunta Sansone
We introduce BioSharing (http://www.biosharing.org), a curated, web-based, searchable portal of content standards, databases, and data policies in the life sciences, broadly encompassing the biological, environmental and biomedical sciences. As of today, BioSharing has >1500 records of which >650 are community-developed standards (terminologies, formats and models, and reporting guidelines), >750 are databases and >80 are data policies.

BioSharing maps the dynamic landscape of data standards, monitoring their: development, evolution and integration; implementation and use in databases; and...

ELIXIR Galaxy Working Group

Frederik Coppens & ELIXIR Galaxy Working Group
Galaxy is widely used in the ELIXIR community. ELIXIR Galaxy Working Group assessed what the needs of its members are and how this can be incorporated in ELIXIR’s technical strategy. Galaxy is mainly used through local instances to enable biologists to perform data intensive massive parallel sequencing analyses. Resources for setup and maintenance of the Galaxy instance are often limited.

Several ELIXIR nodes are active in the Galaxy community, hereby a non-­exhaustive list highlighting some services...

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