136 Works

Lack of FAS receptor expression in colorectal cancer patients correlates with high TNM staging

Bas Laan
Cancer cells often inhibit the expression of FAS to evade T-cell mediated apoptosis upon HLA-mediated recognition. In this study, we aim to find the prognostic value of FAS expression, next to HLA expression, in colorectal cancer (CRC) patients. Colorectal tissue was immunohistochemically stained for the FAS and HLA receptors. Results show that there are significantly more patients with no FAS and HLA expressions in higher stages corresponding with tumor node metastasis (TNM) than in lower...

Does pupil dilation indicate cognitive dissonance and strength of attitude change? Replicating the spreading of alternatives effect in a blind-choice task.

Alexander Fries & Sebastiaan Mathôt
The aim of the present research was twofold. First, we aimed to replicate a recent study by Sharot et al. (2010), which found evidence for the spreading of alternatives (SOA) effect. Second, we investigated the hypothesis that cognitive dissonance, which may explain an existing SOA effect, is accompanied by significant changes in pupil diameter. Our results provide neither support for this hypothesis nor do they replicate the SOA effect. We conclude that more research is...

Optimalisatie van een kraakbeen- en botkleuring in de zebravislarve

Jente Hoyberghs
Zebravisembryo’s worden door verschillende farmaceutische bedrijven gebruikt als een alternatief model om teratogene stoffen te detecteren. In vergelijking met dierproeven in zoogdieren komen echter nog steeds vals-negatieve resultaten voor, waardoor teratogene stoffen gemist worden tijdens de geneesmiddelenontwikkeling. In het zebravismodel worden nog geen skeletale eindpunten bekeken in tegenstelling tot studies in zoogdieren. Het doel van deze studie was om een dubbelkleuring op punt te stellen waarbij kraakbeen en bot in zebravislarven kan worden geëvalueerd. Uit...

Remigius Schrijver

Joost Verheggen
In dit onderzoek wordt ingegaan op Remigius Schrijver, organist en componist, geboren in de 17e eeuw in Zeeland. Schrijver blijkt een bijzondere rol te hebben gespeeld in de Nederlandse muziekgeschiedenis, die systematisch onderschat wordt. Hij blijkt een van de vroegste voorbeelden van een Nederlandse barokcomponist te zijn, en ook in religieuze kringen was hij samen met Joachim Oudaan een innoverende factor. Daarnaast werd in eerder onderzoek er altijd van uitgegaan dat Schrijver in Middelburg geboren...

The seven-factor hybrid model of PTSD and its relation to MDD and GAD

Fleur Helmink
The relation between posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and generalized anxiety disorder (GAD) has been extensively examined. However, few studies have examined this relation in the context of the seven-factor hybrid model of PTSD. We examined whether specific factors of the hybrid model relate to affective depression, somatic depression, and GAD in a nonclinical student sample. Results show that the hybrid model was superior to the DSM-5 model. Also, affective depression related...

How to Connect Artisanal & Small-Scale Gold Miners in Uganda to the International Market for Ethically Produced ASM Gold?

David Sturmes
Four artisanal and small-scale mining organisations (ASMOs) producing gold in Uganda have been subjected to a value chain analysis, showing that they currently lack access to any legal market channels. Despite receiving high per gram prices for their gold on the illegal market, these organisations do not trust current trade partners regarding the measurements of weight and purity and end up making meagre profits due to high maintenance and production costs. Opportunities for an alternative...

Diagnostics Based on Acoustic Distributed Sensor Data and Machine Learning

Dennis Struver & Wouter Weekers
Accurate real-time diagnostics of high-tech systems are becoming more and more important. Therefore, the potential of distributed acoustic sensors in combination with machine learning for contactless diagnostics of machine performance has been investigated. Hereto, frequency response data of a brass plate has been gathered through experiments and a finite element model. In order to investigate the possibility of identifying the locations and weight of the masses, Support Vector Machines and Random Forest algorithms have been...

Het Buddy-project voor eetstoornispatiënten: een exploratief kwalitatief onderzoek naar de inzet van herstelde ervaringsdeskundigen als Buddy

Marloes Biegel
Het Buddy-project is een initiatief om eetstoornis- patiënten te ondersteunen, waarbij de patiënt één op één wordt gekoppeld aan een herstelde ervaringsdeskundige. In dit onderzoek is middels interviews, vragenlijsten en een focusgroep het perspectief van ervaringsdeskundigen en eetstoornispatiënten ten aanzien van het Buddy-project in kaart gebracht. Uit dit onderzoek blijkt dat patiënten een Buddy zien als een begripvolle, gelijkwaardige en laagdrempelige gesprekspartner, die zou kunnen ondersteunen bij het oefenen van lastige situaties, zoals samen eten,...

Proximal Esophageal Cancer

Maximilian Kloft, Sandra Geurts, Margreet Van Putten & Judith De Vos-Geelen
Proximal esophageal cancer (PEC) is a highly mortal cancer with a five-year survival rate of 30%. Because second primary tumors could decrease survival in PEC patients, this research is aiming at finding out about tumors associated with PEC and their infuence on survival. With the use of a database with PEC patients, diagnosed between 1989 and 2014, it was found that head and neck cancers (H&N) are the most prevalent previous tumor in PEC patients....

Whistles as Loud as their Recipients? A Framework for Analyzing Complaint Recipients

Selina Rathke
Tax avoidance, fraud, endangerment of public safety - whistleblowers are crucial for making organizational misconduct transparent. Unsurprisingly, whistleblowing is a commonly researched subject (e.g. Brown, 2008). Yet, only few studies systematically focus on the recipients of whistleblowers’ reports. This lack of attention is striking in light of the decisive role which complaint recipients play in the whistleblowing process (e.g. Lewis, Brown, & Moberly, 2014; Read & Rama, 2003). Drawing on existing literature, this study develops...

Historical consciousness and Hanseatic identity in Deventer 1578-1672

Kerrewin Van Blanken
This article considers the Deventer identification with the Hanse as an interregional identity that for the most part existed outside the borders of the Dutch Republic, in order to nuance and extend the discussion on the formation of a proto-national Dutch identity in the seventeenth century. There will be a particular focus on the role of history writing and conceptions of time in relation to seventeenth century identity formation.

The destruction of cultural property by the Islamic State in Mosul and Palmyra

Alessandra Silva
Among countless atrocities, the Islamic State (IS) is responsible for wreaking cultural artifacts in Mosul and Palmyra. This paper enquire what actions Iraq and Syria could undertake under International Law to protect cultural property and to hold IS’s fighters accountable for their crimes. After analyzing International Humanitarian law instruments, the rules on the use of force, the UNESCO Declaration on the Intentional Destruction of Cultural Heritage and the Statute of the International Criminal Court, it...

Empowerment though Indignation

Hannah Nonnenberg
This research investigates activists of the Indignados movement in Spain. It identifies and explores what empowerment mechanisms said activists use in order to overcome alienation. Alienation is the condition they are in, which is greatly shaped by globalization and the Spanish economic crisis. The name chosen by the movement ‘indignados’, meaning indignation, is the reason for the present focus on emotions in academic research on social movements. The movement finds itself in an alienated context,...

Beaten by the chord to nail the melody: Influence of metric and irregular submerged dissonance accents on auditory sequence learning

Anna Sophie Wagner
Dynamic attending theory (Jones, 1976; Large & Jones, 1999) suggests that isochronously repeating salient points in time are predictable and facilitate processing by synchronizing attentional oscillations in the brain. By manipulating amount and spacing of such salience, this design attempts to enhance accuracy of reproduced melodies. Salience was introduced by dissonant harmonies. All subjects seemed to get distracted by the harsh sound of dissonance. However, non-musicians seemed to benefit from a regular ¾ meter. More...

Overweight Mothers with Stunted Children

Christiaan Van Den Berg & Sebastiaan Van Kooten
This paper investigates prevalence of stunted child-overweight mother pairs using cross-sectional data (N=89,941) from 17 Low- and Middle-Income Countries. We examine the association of this ‘Double Burden of Malnutrition’ (DBM) with wealth, urbanisation and education. DBM is present in roughly 7% of all households studied. Pooled logistic regressions reveal that the probability a child-mother pair exhibits DBM increases as the mother is older and less educated, the child is older and male, and the household...

Realization of an in-situ Fluorescence & Raman Spectroscopy Setup for studying Quantum Dot Films

Jurgen Dijkema
A new experimental setup for studying charge transfer in Quantum Dot (QD) films has been designed, built and tested. The setup combines three spectroscopic methods; Raman, Fluorescence and Absorption Spectroscopy. First data on a Cadmium Selenide (CdSe) films reveals that radiative emission quenches while charging, attributed to Auger-decay. When fully discharged, the emission remains partly quenched, indicating that not all electrons are removed. Since charge transfer is a fundamental process in solar cells, the setup...

Optimizing the core business processes of financial asset management companies using blockchain technology

Nick Van De Luijtgaarden
The aim of this paper is to look at how blockchain technology can be used for the core business processes of an asset management company and what the best tools are to set up a blockchain. This study followed a qualitative and quantitive case study research methodology at a small to mediumsized asset management company. This paper argued that Corda was the best blockchain platform because of scalability, auditing for regulators and offering a specific...

Return of human capital development and training investments on corporate valuation

Florian Knaeple
The dynamic environments evolving in most markets led to the necessity of recruiting and retaining highly educated employees for a company's success. This research paper investigates the economic return of human capital investments on corporate valuation and identifies organizational activities that could signal these investments. For economic return estimations, an event study with the reception of training awards, as a signal for exceptional human capital activities, is used. It is revealed that training-award winners experience...

The Sound of Semana Santa

Jip Lensink
This anthropological research gives insight in the meaning of music for the religious experience of participants of the processions in Antigua, Guatemala. By placing the theories of lived religion, material religion and aesthetics at the central stage, the process whereby the marchas fúnebres, the music played in the processions, mediate religious experience for the participants is explained. The material-sensorial elements of the processions, the practice of carrying, and the emotional effect of the music which...

Feasibility study of nano plating for the visualisation of hydrogen in steels

Renee Coryn, Liesbet Deconinck & Ellen Lambrechts
Visualisation of hydrogen in metals is a very challenging topic as microscopic techniques are not yet able to visualise hydrogen atoms accurately. Several micrometre sized techniques were already developed to visualise hydrogen in a qualitative way and link it to the metal’s microstructure. However, many disadvantages still limit these techniques. Two innovative approaches have been evaluated in the present work. Both are based on the nano plating principle where a redox reaction occurs between metal...

Determinants of Loan Performance in P2P Lending

Nilas Möllenkamp
This research paper investigates the influential factors of loan performance in the online P2P lending industry. The study analysed 143,654 P2P loans that were funded on the P2P lending platform Lending Club between 2012 and 2013 and found evidence that the assigned credit grade of loans is the most influential factor on loan success and default. Furthermore, loan amount and annual income are significant predictors. The variables debt-toincome ratio, inquires in the last 6 months,...

Het verband tussen religie en interetnische solidariteit

Simon De Jong
Het doel van deze verkennende studie was inzicht te verkrijgen in de relatie tussen de religieuze identiteit van orthodox-protestanten en hun solidariteit met vluchtelingen. Door de multidimensionaliteit van hun religieuze identiteit hebben orthodox-protestanten een ambigue houding tegenover immigranten. Vanuit hun horizontale identiteit in brede zin, i.e. hun relatie tot medemensen, zijn zij op microniveau solidair met vluchtelingen. Op macroniveau bepleiten orthodox-protestanten echter restricties op het immigratiebeleid uit bezorgdheid wat een numerieke meerderheid van moslims zal...

Effects of differential hillslope-scale water retention characteristics on rainfall-runoff response at the Landscape Evolution Observatory

Daniël B. Van Den Heuvel
To be able to collect the reliable data necessary for understanding and modeling various Earth system processes in real catchments, controlled experiments are being conducted at the Landscape Evolution Observatory (LEO) within Biosphere2, The University of Arizona. Rainfall experiments have revealed differences in hydrological response between two landscapes within LEO, despite the landscapes’ identical design and equipment. In an attempt to discover where the observed differences stem from, we use a full 3D hydrological model...

Insulin sensitivity and fat mass in young male sedentary adults

Gereon Hecht, Esther Phielix, Yvo Op Den Kamp & Joris Hoeks
We live in an obesogenic environment, spending a lot of time sitting neglecting physical activity. This study aims to determine the impact of a sedentary lifestyle on insulin sensitivity by comparing insulin sensitivity of healthy athletes and sedentary subjects. Twelve athletes and 12 sedentary subjects underwent a two-step hyperinsulinemic euglycemic clamp test to assess insulin sensitivity and a DEXA scan to assess body fat mass. Insulin sensitivity was significantly lower in sedentary subjects (p=0.009) and...

“De Stenen Man”: strong guardian or weak link?

Marc Frankena & Koen Berends
De ‘Stenen Man’, standing on top of the Westerzeedijk near Harlingen, was built to commemorate the construction of the sea defenses. However, there is reason to believe this monument to flood safety endangers the stability of the dike. In our study, we quantify the effect of the statue on the failure probability of the dike. This is achieved through a combination of archive research, ground survey, and probabilistic assessment within the new legal framework. Results...

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