38,144 Works

Septic peritonitis from pyloric and non-pyloric gastrointestinal perforation: prognostic factors in 44 dogs and 11 cats

J. Howard, David Spreng & Thomas Dayer
OBJECTIVES To identify potential prognostic factors affecting outcome in septic peritonitis caused by gastrointestinal perforation in dogs and cats. METHODS A retrospective study. Animals operated on for septic peritonitis because of gastrointestinal perforation were evaluated. Risk factors assessed included age, duration of clinical signs, recent prior abdominal surgery, recent prior anti-inflammatory drug administration, placement of a closed-suction drain and location of perforation. RESULTS Fifty-five animals (44 dogs and 11 cats) were included. The overall mortality...

Science in the Context of Climate Change Adaptation: Case Studies from the Peruvian Andes

Pierluigi Calanca, Boris Orlowsky, Christian Huggel, Norina Andres, Fabian Drenkhan, Mario Rohrer, Nadine Salzmann, Christine Jurt, Luis Vicuña & Raphael Neukom

Lattice simulations of technicolour theories with adjoint fermions and supersymmetric Yang-Mills theory

Stefano Piemonte, Pietro Giudice, Istvan Montvay, Gernot Münster & Georg Bergner
Theories with fermions in the adjoint representation have several interesting applications in extensions of the standard model. The conformal window for these theories is of particular interest for technicolour extensions. We present here our newest results for the spectrum of Nf = 2 adjoint QCD and compare them with the predictions for a conformal behaviour. The comparison with supersymmetric Yang-Mills theory, investigated with the same methods, will help to distinguish more clearly the conformal and...

Surgical management of urolithiasis - a systematic analysis of available guidelines.

Valentin Zumstein, Hans-Peter Schmid, Cedric Michael Panje, Dominik Abt, Paul Martin Putora & Patrick Betschart
BACKGROUND Several societies around the world issue guidelines incorporating the latest evidence. However, even the most commonly cited guidelines of the European Association of Urology (EAU) and the American Urological Association (AUA) leave the clinician with several treatment options and differ on specific points. We aimed to identify discrepancies and areas of consensus between guidelines to give novel insights into areas where low consensus between the guideline panels exists, and therefore where more evidence might...

Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma.

G L Patman, Q M Anstee, Jean-François Dufour, A K Daly, H L Reeves, C P Day, Anne Christine Piguet, A D Burt, Y-L Liu & J B S Leathart
BACKGROUND & AIMS Subtle inter-patient genetic variation and environmental factors combine to determine disease progression in non-alcoholic fatty liver disease (NAFLD). Carriage of the PNPLA3 rs738409 c.444C >G minor allele (encoding the I148M variant) has been robustly associated with advanced NAFLD. Although most hepatocellular carcinoma (HCC) is related to chronic viral hepatitis or alcoholic liver disease, the incidence of NAFLD-related HCC is increasing. We examined whether rs738409 C >G was associated with HCC-risk in patients...

Do relocated villages experience more forest cover change? Resettlements, shifting cultivation and forests in the Lao PDR

Sébastien Boillat, Joan Bastide, Corinna Stich, Michael Epprecht, Sithong Thongmanivong & Andreas Heinimann
This study explores the relationships between forest cover change and the village resettlement and land planning policies implemented in Laos, which have led to the relocation of remote and dispersed populations into clustered villages with easier access to state services and market facilities. We used the Global Forest Cover Change (2000–2012) and the most recent Lao Agricultural Census (2011) datasets to assess forest cover change in resettled and non-resettled villages throughout the country. We also...

Talent development in football: The specialised sampling model

Achim Conzelmann, Roland Sieghartsleitner, Marc Zibung & Claudia Zuber

Immunoregulation in larval Echinococcus multilocularis infection.

Junhua Wang & Bruno Gottstein
Alveolar echinococcosis (AE) is a clinically very severe zoonotic helminthic disease, characterized by a chronic progressive hepatic damage caused by the continuous proliferation of the larval stage (metacestode) of Echinococcus multilocularis. The proliferative potential of the parasite metacestode tissue is dependent on the nature/function of the periparasitic immune-mediated processes of the host. Immune tolerance and/or down-regulation of immunity are a marked characteristic increasingly observed when disease develops towards its chronic (late) stage of infection. In...

Vegetationsdynamik, Landnutzung und Siedlungstätigkeit im Einzugsbereich der Seeufersiedlungen im unteren Zürichseebecken

Willy Tinner, Erika Gobet & Jacqueline Van Leeuwen
Zürich-Parkhaus Opéra übertrifft vergleichbare Fundstellen deutlich an Fläche und Fundmenge und erlaubt dank der Repräsentativität und hohen Datendichte Einblicke in die Gesellschaft, Wirtschaft und Umwelt der damaligen Bevölkerung. Der vorliegende Band präsentiert die Ergebnisse der naturwissenschaftlichen Analysen – erstmals in der Feuchtbodenarchäologie unter Einbezug der Chironomiden- und Cladocerenfossilien sowie ausführlicherer Mykologie – und führt die Erkenntnisse der gesamten Auswertung dieser vor allem horgenzeitlichen Fundstelle in einer Synthese zusammen. Die taphonomischen Resultate aller Disziplinen belegen, dass...

A Donor-Acceptor Tetrathiafulvalene Ligand Complexed to Iron(II): Synthesis, Electrochemistry, and Spectroscopy of Fe(phen)(2)(TTF-dppz)(PF6)(2)

Shi-Xia Liu, A. Hauser, N. Dupont, E. Vauthey, Ying-Fen Ran, Silvio Decurtins & J. Grilj
The synthesis and photophysical properties of the complex Fe(phen)(2)(TTF-dppz)(2+) (TTF-dppz = 4',5'-bis-(propylthio)tetrathiafulvenylidipyrido3,2-a:2',3'-c-phenazine, phen = 1,10-phenanthroline) are described. In this complex, excitation into the metal ligand charge transfer bands results in the population of a high-spin state of iron(II), with a decay lifetime of approximately 1.5 ns, in dichloromethane, at room temperature. An intraligand charge transfer state can also be obtained and has a lifetime of 38 ps. A mechanism for the different states reached is...

Prognostic Value of Biochemical Recurrence Following Treatment with Curative Intent for Prostate Cancer: A Systematic Review

Marcus Cumberbatch, Yuhong Yuan, Matthew Liew, Jakub Pecanka, Erik Briers, Olivier Rouvière, Nicola Fossati, Theo H. Van Der Kwast, Nicolas Arfi, Thomas Van Den Broeck, Tobias Gross, Philip Cornford, Henk G. Van Der Poel, Ann M. Henry, Maria De Santis, Peter-Paul M. Willemse, Ivo G. Schoots, Lisa Moris, Thomas Wiegel, Roderick C.N. Van Den Bergh, Michael Lardas, Nicolas Mottet, Derya Tilki, Jeremy P. Grummet, Thomas B. Lam … & Silke Gillessen

Where to return to? Rural Urban Interlinkages in Times of Internal and International Migration

Susan Thieme
Economic and social activities of migrants transcend internal and international as well as rural and urban divides. Migration circuits are not bipolar but rather develop towards amulti-local network of family members putting into question “return” as an often assumed conclusion to a successful migration. This briefing explores the multi-local migration patterns of Kyrgyzstan’s mobile population placing return in a wider context and providing recommendations how to facilitate circular migration and ties to places of origin...

How reliable is Ki-67 immunohistochemistry in grade 2 breast carcinomas? A QA study of the Swiss Working Group of Breast- and Gynecopathologists

Gad Singer, Ellen Obermann, Barbara Padberg, Aurelia Noske, Corina Dommann-Scherrer, Heide Schreiber-Facklam, Giuseppe Viale, Daniela Kaup, Christiane Rakozy, Harald Frick, Christian Ohlschlegel, Hans-Anton Lehr, Sylviane Schobinger-Clement, Coya Tapia, Joachim Diebold, Urs Wagner, Zsuzsanna Varga, Sara Sancho Oliver & Mauro G. Mastropasqua
Adjuvant chemotherapy decisions in breast cancer are increasingly based on the pathologist's assessment of tumor proliferation. The Swiss Working Group of Gyneco- and Breast Pathologists has surveyed inter- and intraobserver consistency of Ki-67-based proliferative fraction in breast carcinomas. Methods Five pathologists evaluated MIB-1-labeling index (LI) in ten breast carcinomas (G1, G2, G3) by counting and eyeballing. In the same way, 15 pathologists all over Switzerland then assessed MIB-1-LI on three G2 carcinomas, in self-selected or...

Swiss road history between state consolidation and private interests

Benjamin Spielmann
This paper discusses major development steps in the emergence of the modern road network in Switzerland. It considers connections between state authorities and actors from the private sector. Before the Swiss Federal State was founded in 1848, the country consisted of regional and largely independent territories with only few institutional bonds between them. Neither a strong central political instance nor a comprehensive master plan existed, yet these regional governments together with foreign states, managed to...

Lipid-mediated Protein-protein Interactions Modulate Respiration-driven ATP Synthesis

Gustav Nordlund, Tobias Nilsson, Peter Brzezinski, Camilla Rydström Lundin, Pia Ädelroth & Christoph Von Ballmoos
Energy conversion in biological systems is underpinned by membrane-bound proton transporters that generate and maintain a proton electrochemical gradient across the membrane which used, e.g. for generation of ATP by the ATP synthase. Here, we have co-reconstituted the proton pump cytochrome bo3 (ubiquinol oxidase) together with ATP synthase in liposomes and studied the effect of changing the lipid composition on the ATP synthesis activity driven by proton pumping. We found that for 100 nm liposomes,...

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