861,620 Works

Figures S1 - S4 and Table S1 from Alginate foam-based three-dimensional culture to investigate drug sensitivity in primary leukaemia cells

Mahroo Karimpoor, Eva Yebra-Fernandez, Maryam Parhizkar, Mine Orlu, Duncan Craig, Jamshid S. Khorashad & Mohan Edirisinghe
Figure S1: (a) The process of producing microbubbles using a microfluidic V-junction. (b) Optical micrograph of the alginate microbubbles collected in calcium chloride and their changes during time laps immediately after collection (zero time).; Figure S2: The relative proliferation of primary leukaemia cells from AML patients (n=3) in foam-based scaffold (3D) compared to 2D is shown. The experiment was done in triplicate and shows higher proliferation of the cells in (3D) compared to 2D culture...

Figures S1 - S4 and Table S1 from Alginate foam-based three-dimensional culture to investigate drug sensitivity in primary leukaemia cells

Mahroo Karimpoor, Eva Yebra-Fernandez, Maryam Parhizkar, Mine Orlu, Duncan Craig, Jamshid S. Khorashad & Mohan Edirisinghe
Figure S1: (a) The process of producing microbubbles using a microfluidic V-junction. (b) Optical micrograph of the alginate microbubbles collected in calcium chloride and their changes during time laps immediately after collection (zero time).; Figure S2: The relative proliferation of primary leukaemia cells from AML patients (n=3) in foam-based scaffold (3D) compared to 2D is shown. The experiment was done in triplicate and shows higher proliferation of the cells in (3D) compared to 2D culture...

Supplementary material from "Alginate foam-based three-dimensional culture to investigate drug sensitivity in primary leukaemia cells"

Mahroo Karimpoor, Eva Yebra-Fernandez, Maryam Parhizkar, Mine Orlu, Duncan Craig, Jamshid S. Khorashad & Mohan Edirisinghe
The development of assays for evaluating the sensitivity of leukaemia cells to anti-cancer agents is becoming an important aspect of personalized medicine. Conventional cell cultures lack the three-dimensional (3D) structure of the bone marrow (BM), the extracellular matrix and stromal components which are crucial for the growth and survival of leukaemia stem cells. To accurately predict the sensitivity of the leukaemia cells in an in vitro assay a culturing system containing the essential components of...

P versus NP

Frank Vega
P versus NP is considered as one of the most important open problems in computer science. This consists in knowing the answer of the following question: Is P equal to NP? This question was first mentioned in a letter written by John Nash to the National Security Agency in 1955. A precise statement of the P versus NP problem was introduced independently in 1971 by Stephen Cook and Leonid Levin. Since that date, all efforts...

Data of Grassi Talamini Lazzerini: Pitch discrimination of low and high pitch tones by bassists, violinists and nonmusicians

Massimo Grassi
Dataset of the study that compared the pitch discrimination threshold of musicians and nonmusicians.

Data of Grassi Talamini Lazzerini: Pitch discrimination of low and high pitch tones by bassists, violinists and nonmusicians

Massimo Grassi
Dataset of the study that compared the pitch discrimination threshold of musicians and nonmusicians.

Data of Grassi, Meneghetti, Toffalini, Borella ("Auditory and cognitive performance in elderly musicians and nonmusicians"), PloS ONE.

Massimo Grassi
The dataset includes the data of Grassi, Meneghetti, Toffalini, Borella ("Auditory and cognitive performance in elderly musicians and nonmusicians"), PloS ONE.

Exploring researcher engagement with open access using emergent open science services: Data Artefacts

David Walters & Christopher Daley
This collection holds the data artefacts collected in a research project that led to a paper submission in an MDPI special issue: "Exploring researcher engagement with open access using emergent open science infrastructure".

P versus NP

Frank Vega
P versus NP is considered as one of the most important open problems in computer science. This consists in knowing the answer of the following question: Is P equal to NP? This question was first mentioned in a letter written by John Nash to the National Security Agency in 1955. A precise statement of the P versus NP problem was introduced independently in 1971 by Stephen Cook and Leonid Levin. Since that date, all efforts...

Episodic, rapid flow of fluids in a mineralised fault system in the Peak District UK - supplementary information

Paul Dennis, Daniel Myhill, Alina Marca & Ruth Kirk
Supplemetary information for the paper:
Episodic, rapid flow of fluids in a mineralised fault system in the Peak District UK
submitted to the Journal of the Geological Society, London

Episodic, rapid flow of fluids in a mineralised fault system in the Peak District UK - supplementary information

Paul Dennis, Daniel Myhill, Alina Marca & Ruth Kirk
Supplemetary information for the paper:
Episodic, rapid flow of fluids in a mineralised fault system in the Peak District UK
submitted to the Journal of the Geological Society, London

Effects of peptidyl-prolyl isomerase 1 depletion in animal models of prion diseases

Giuseppe Legname, Tommaso Virgilio, Edoardo Bistaffa, Chiara Maria Giulia De Luca, Marcella Catania, Paola Zago, Elisa Isopi, Ilaria Campagnani, Fabrizio Tagliavini, Giorgio Giaccone & Fabio Moda
Pin1 is a peptidyl-prolyl isomerase that induces the cis-trans conversion of specific Ser/Thr-Pro peptide bonds in phosphorylated proteins, leading to conformational changes through which Pin1 regulates protein stability and activity. Since down-regulation of Pin1 has been described in several neurodegenerative disorders, including Alzheimer's Disease (AD), Parkinson's Disease (PD) and Huntington's Disease (HD), we investigated its potential role in prion diseases. Animals generated on wild-type (Pin1+/+), hemizygous (Pin1+/−) or knock-out (Pin1−/−) background for Pin1 were experimentally...

Effects of peptidyl-prolyl isomerase 1 depletion in animal models of prion diseases

Giuseppe Legname, Tommaso Virgilio, Edoardo Bistaffa, Chiara Maria Giulia De Luca, Marcella Catania, Paola Zago, Elisa Isopi, Ilaria Campagnani, Fabrizio Tagliavini, Giorgio Giaccone & Fabio Moda
Pin1 is a peptidyl-prolyl isomerase that induces the cis-trans conversion of specific Ser/Thr-Pro peptide bonds in phosphorylated proteins, leading to conformational changes through which Pin1 regulates protein stability and activity. Since down-regulation of Pin1 has been described in several neurodegenerative disorders, including Alzheimer's Disease (AD), Parkinson's Disease (PD) and Huntington's Disease (HD), we investigated its potential role in prion diseases. Animals generated on wild-type (Pin1+/+), hemizygous (Pin1+/−) or knock-out (Pin1−/−) background for Pin1 were experimentally...

Supplemental Material by Freitas et al., 2018. Next-generation sequencing of the complete mitochondrial genome of the endangered species Black Lion Tamarin Leontopithecus chrysopygus (Primates) and mitogenomic phylogeny focusing on the Callitrichidae family. G3 Genes Genomes Genetics.

Patricia Freitas, Fernando Luis Mendez, Karla Chávez-Congrains, Pedro Manoel Galetti Junior, Luiz Lehmann Coutinho, Alcides Pissinatti & Carlos Daniel Bustamante
Figure S1 contains the quartiles for the distribution of fragment lengths for the mitochondrial genome assembly; Figure S2 contains the ilustration for the tRNA mitochondrial; Figure S3 contains the full phylogenetic tree, using Maximum Likelihood for 124 primates and three outgroup species; and Table S1 contains the list of the GenBank accession numbers for the complete mitochondrial genome sequences previously published by different authors and used in our phylogenetic analysis. Details of the methodology employed...

Więckowska et al 2018- Open Data.pdf

Olga Gajewska-Wozniak
Repository of raw data for Wieckowska et al., 2018

Real-World Clinical Effectiveness and Cost Savings of Liraglutide versus Sitagliptin in Treating Type 2 Diabetes for One and Two Years

Qian Li, Rahul Ganguly, Michael Ganz, Cory Gamble & Tam Dang-Tan
Article full text
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Factors Influencing the Prescribing Preferences amongst Physicians in Drug-Naive Patients with Type 2 Diabetes Mellitus in the Real-World Setting in Japan: Insight from a Web Survey

Hiroki Murayama, Kota Imai & Masato Odawara
Article full text

The article associated with this content has been accepted for online publication and is in the final stages of production. The link to the full text will be made available on this page in the next few days.

Provide enhanced digital features for this article
If you are an author of this publication and would like to provide additional enhanced digital features for your article then please contact adisrapidplus@springer.com.
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Concrete fracture energy tests

Martin Poncelet
Several test results on standard 40x40x280 mm specimens.
Material is a mortar (w/c=0.42).Bending test following 50-FMC Draft Recommendation.

Concrete fracture energy tests

Martin Poncelet
Several test results on standard 40x40x280 mm specimens.
Material is a mortar (w/c=0.42).Bending test following 50-FMC Draft Recommendation.

A COMPREHENSIVE STUDY AND PERFORMANCE COMPARISON OF M-ARY MODULATION SCHEMES FOR AN EFFICIENT WIRELESS MOBILE COMMUNICATION SYSTEM

Md. Emdadul Haque, Md. Golam Rashed & M. Hasnat Kabir
ABSTRACT
Wireless communications has become one of the fastest growing areas in our modern life and creates enormous impact on nearly every feature of our daily life. In this paper, the performance of M-ary modulations schemes (MPSK, MQAM, MFSK) based wireless communication system on audio signal transmission over Additive Gaussian Noise (AWGN) channel are analyzed in terms of bit error probability as a function of SNR. Based on the results obtained in the present study, MPSK...

A COMPREHENSIVE STUDY AND PERFORMANCE COMPARISON OF M-ARY MODULATION SCHEMES FOR AN EFFICIENT WIRELESS MOBILE COMMUNICATION SYSTEM

Md. Emdadul Haque, Md. Golam Rashed & M. Hasnat Kabir
ABSTRACT
Wireless communications has become one of the fastest growing areas in our modern life and creates enormous impact on nearly every feature of our daily life. In this paper, the performance of M-ary modulations schemes (MPSK, MQAM, MFSK) based wireless communication system on audio signal transmission over Additive Gaussian Noise (AWGN) channel are analyzed in terms of bit error probability as a function of SNR. Based on the results obtained in the present study, MPSK...

Ag/Cd coordination architecture and photoluminescence behaviors

Jiyong Hu, Yujie Zhao, Fan Yang, Chunli Liao & Jin’An Zhao
Three coordination architectures, {[Ag4(pbmb)4·(BF4)4](CH3OH)2·H2O}n (1), {[Cd2(pbmb)4](ClO4)4·(CH3OH)5}n (2) and [Cd4(pbmb)4·I8(CH3OH)2]n (3) (pbmb = 1-((2-(pyridin-2-yl)-1H-benzoimidazol-1-yl)methyl)-1H-benzotriazole), are built up from Ag(I)/Cd(II) salts and a flexible pyridyl-benzimidazole-based organic spacer. Single crystal analysis shows that 1 and 2 have one-dimensional (1-D) chains, while 3 displays a tetranuclear structure. All complexes exhibit different coordination geometries and properties, which can be attributed to the difference between the metal centers or anions. In the case of 1 in particular, the Ag···Ag interactions play...

Ag/Cd coordination architecture and photoluminescence behaviors

Jiyong Hu, Yujie Zhao, Fan Yang, Chunli Liao & Jin’An Zhao
Three coordination architectures, {[Ag4(pbmb)4·(BF4)4](CH3OH)2·H2O}n (1), {[Cd2(pbmb)4](ClO4)4·(CH3OH)5}n (2) and [Cd4(pbmb)4·I8(CH3OH)2]n (3) (pbmb = 1-((2-(pyridin-2-yl)-1H-benzoimidazol-1-yl)methyl)-1H-benzotriazole), are built up from Ag(I)/Cd(II) salts and a flexible pyridyl-benzimidazole-based organic spacer. Single crystal analysis shows that 1 and 2 have one-dimensional (1-D) chains, while 3 displays a tetranuclear structure. All complexes exhibit different coordination geometries and properties, which can be attributed to the difference between the metal centers or anions. In the case of 1 in particular, the Ag···Ag interactions play...

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