608,984 Works

WhitmanZhaoTodd2017plosOne.xlsm

Jen Whitman
Data for all experiments in Whitman, Zhao and Todd (2017) PlosOne

WhitmanZhaoTodd2017plosOne.xlsm

Jen Whitman
Data for all experiments in Whitman, Zhao and Todd (2017) PlosOne

mornand_fic4150.txt

Pierre MORNAND, Catherine VERRET, Philippe MINODIER, Albert FAYE, Patrick IMBERT & The Pediatric Imported Malaria Study Group For The 'Centre National De Référence Du Paludisme'
manuscript in review (PLOS ONE - PONE-D-16-14934R1)

Pimenteletal_sequence_alignment.nex

Manuel Pimentel, Marcial Escudero, Elvira Sahuquillo, Miguel Minaya & Pilar Catalán
Sequence alignment used in the paper "Diversification rates and chromosome evolution in the temperate grasses (Pooideae) are associated with major environmental changes in the Oligocene-Miocene" by Pimentel M, Escudero M, Sahuquillo E, Minaya MA & Catalán P, submitted to PeerJ

Hybridization and Species Delimitation in Oregon Buttercups

Jessica Persinger, Pamela G. Thompson, Brendan F. Kohrn & Mitchell B. Cruzan
Preliminary results from determining whether Ranunculus occidentalis and Ranunculus austro-oreganus are the same species or not.

Hybridization and Species Delimitation in Oregon Buttercups

Jessica Persinger, Pamela G. Thompson, Brendan F. Kohrn & Mitchell B. Cruzan
Preliminary results from determining whether Ranunculus occidentalis and Ranunculus austro-oreganus are the same species or not.

Deep Dog Track, photogrammetric model, Dee Estuary

Peter Falkingham
Deep dog tracks in very soft mud. Dataset includes 3D model and texture.

Deep Dog Track, photogrammetric model, Dee Estuary

Peter Falkingham
Deep dog tracks in very soft mud. Dataset includes 3D model and texture.

Comparing self- and provider-collected swabbing for HPV DNA testing in female-to-male transgender adult patients: a mixed-methods biobehavioral study protocol

Sari Reisner, Madeline Deutsch, Sarah Peitzmeier, Jaclyn White Hughto, Timothy Cavanaugh, Dana Pardee, Sarah McLean, Elliot Marrow, Matthew Mimiaga, Lori Panther, Marcy Gelman, Jamison Green & Jennifer Potter
Abstract Background Cervical cancer, nearly all cases of which are caused by one of several high-risk strains of the human papillomavirus (hr-HPV), leads to significant morbidity and mortality in individuals with a cervix. Trans masculine (TM) individuals were born with female reproductive organs and identify as male, man, transgender man, or another diverse gender identity different from their female assigned sex at birth. Routine preventive sexual health screening of TM patients is recommended, including screening...

Additional file 3: of Comparing self- and provider-collected swabbing for HPV DNA testing in female-to-male transgender adult patients: a mixed-methods biobehavioral study protocol

Sari Reisner, Madeline Deutsch, Sarah Peitzmeier, Jaclyn White Hughto, Timothy Cavanaugh, Dana Pardee, Sarah McLean, Elliot Marrow, Matthew Mimiaga, Lori Panther, Marcy Gelman, Jamison Green & Jennifer Potter
Patient Satisfaction Survey. (DOC 48 kb)

Additional file 2: of Comparing self- and provider-collected swabbing for HPV DNA testing in female-to-male transgender adult patients: a mixed-methods biobehavioral study protocol

Sari Reisner, Madeline Deutsch, Sarah Peitzmeier, Jaclyn White Hughto, Timothy Cavanaugh, Dana Pardee, Sarah McLean, Elliot Marrow, Matthew Mimiaga, Lori Panther, Marcy Gelman, Jamison Green & Jennifer Potter
Provider Assessment and Interaction Tool. (DOCX 34 kb)

Additional file 1: of Comparing self- and provider-collected swabbing for HPV DNA testing in female-to-male transgender adult patients: a mixed-methods biobehavioral study protocol

Sari Reisner, Madeline Deutsch, Sarah Peitzmeier, Jaclyn White Hughto, Timothy Cavanaugh, Dana Pardee, Sarah McLean, Elliot Marrow, Matthew Mimiaga, Lori Panther, Marcy Gelman, Jamison Green & Jennifer Potter
Diagram & Definition of Terms. (PDF 311 kb)

Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected

Stephanie Cumberworth, Jennifer Barrie, Madeleine Cunningham, Daniely De Figueiredo, Verena Schultz, Adrian Wilder-Smith, Benjamin Brennan, Lindomar Pena, Rafael Freitas De Oliveira Franรงa, Christopher Linington, Susan Barnett, Hugh Willison, Alain Kohl & Julia Edgar
Abstract The recent global outbreak of Zika virus (ZIKV) infection has been linked to severe neurological disorders affecting the peripheral and central nervous systems (PNS and CNS, respectively). The pathobiology underlying these diverse clinical phenotypes are the subject of intense research; however, even the principal neural cell types vulnerable to productive Zika infection remain poorly characterised. Here we used CNS and PNS myelinating cultures from wild type and Ifnar1 knockout mice to examine neuronal and...

Additional file 2: Figure S2. of Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected

Stephanie Cumberworth, Jennifer Barrie, Madeleine Cunningham, Daniely De Figueiredo, Verena Schultz, Adrian Wilder-Smith, Benjamin Brennan, Lindomar Pena, Rafael Freitas De Oliveira FrançA, Christopher Linington, Susan Barnett, Hugh Willison, Alain Kohl & Julia Edgar
ZIKV-related diminution of CNS myelin can be observed using markers of various myelin compartments. Antibody O4 labels the lipid sulphatide (a, e) whilst Z2 labels myelin oligodendrocyte glycoprotein (MOG) (c, g); both of which are present on oligodendroglia and their myelin sheaths. a-d Representative images of mock infected CNS myelinating cultures at DIV 24 show a dense network of myelinated and non-myelinated axons. e-h In contrast, ZIKV infected CNS myelinating cultures have a less dense...

Additional file 1: Figure S1. of Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected

Stephanie Cumberworth, Jennifer Barrie, Madeleine Cunningham, Daniely De Figueiredo, Verena Schultz, Adrian Wilder-Smith, Benjamin Brennan, Lindomar Pena, Rafael Freitas De Oliveira Franรงa, Christopher Linington, Susan Barnett, Hugh Willison, Alain Kohl & Julia Edgar
Cultured E13 spinal cord cells and DRG explants contain myelinated axons. (a, b) Wild type and Ifnar1 knockout mouse spinal cord cultures at 28 DIV, labelled with antibodies to phosphorylated neurofilament (NF) and myelin basic protein (MBP). (c, d) Wild type and Ifnar1 knockout mouse DRG explant cultures at 28 DIV, labelled with antibodies to NF and MBP. (TIFF 304742 kb)

Additional file 1: of Identification of the flotillin-1/2 heterocomplex as a target of autoantibodies in bona fide multiple sclerosis

S. Hahn, G. Trendelenburg, M. Scharf, Y. Denno, S. Brakopp, B. Teegen, C. Probst, K. Wandinger, M. Buttmann, A. Haarmann, F. Szabados, M. Vom Dahl, T. KĂźmpfel, P. Eichhorn, H. Gold, F. Paul, S. Jarius, N. Melzer, W. StĂścker & L. Komorowski
Novel antibody against flotillin. (ZIP 138728 kb).

Identification of the flotillin-1/2 heterocomplex as a target of autoantibodies in bona fide multiple sclerosis

S. Hahn, G. Trendelenburg, M. Scharf, Y. Denno, S. Brakopp, B. Teegen, C. Probst, K. Wandinger, M. Buttmann, A. Haarmann, F. Szabados, M. Vom Dahl, T. Kümpfel, P. Eichhorn, H. Gold, F. Paul, S. Jarius, N. Melzer, W. Stöcker & L. Komorowski
Abstract Background Autoantibodies, in particular those against aquaporin-4 and myelin-oligodendrocyte glycoprotein (MOG), aid as biomarkers in the differential diagnosis of demyelination. Here, we report on discovery of autoantibodies against flotillin in patients with multiple sclerosis (MS). Methods The target antigen was identified by histo-immunoprecipitation using the patients’ sera and cryosections of rat or pig cerebellum combined with mass spectrometrical analysis. Correct identification was ascertained by indirect immunofluorescence and neutralization tests using the target antigens recombinantly...

Evolution of the vertebrate insulin receptor substrate (Irs) gene family

Ahmad Al-Salam & David Irwin
Abstract Background Insulin receptor substrate (Irs) proteins are essential for insulin signaling as they allow downstream effectors to dock with, and be activated by, the insulin receptor. A family of four Irs proteins have been identified in mice, however the gene for one of these, IRS3, has been pseudogenized in humans. While it is known that the Irs gene family originated in vertebrates, it is not known when it originated and which members are most...

Additional file 13: Figure S9. of Evolution of the vertebrate insulin receptor substrate (Irs) gene family

Ahmad Al-Salam & David Irwin
This file is in PDF format. ModelFinder results for the coding sequences used in the phylogenetic analyses. (PDF 224 kb)

Additional file 12: Figure S8. of Evolution of the vertebrate insulin receptor substrate (Irs) gene family

Ahmad Al-Salam & David Irwin
This file is in PDF format. Alignment of Irs protein sequences with conserved residues highlighted. (PDF 450 kb)

Additional file 11: Table S4. of Evolution of the vertebrate insulin receptor substrate (Irs) gene family

Ahmad Al-Salam & David Irwin
This file is in Excel format. JS Divergence Scores from alignments of Irs proteins from 10 vertebrates. (PDF 499 kb)

Additional file 10: Table S3. of Evolution of the vertebrate insulin receptor substrate (Irs) gene family

Ahmad Al-Salam & David Irwin
This file is in Excel format. Relative rates of evolution of Irs genes in mammals and non-mammals. (PDF 518 kb)

Socioeconomic status is associated with symptom severity and sickness absence in people with infectious intestinal disease in the UK

Tanith Rose, Natalie Adams, Benjamin Barr, Jeremy Hawker, Sarah O’Brien, Mara Violato, Margaret Whitehead & David Taylor-Robinson
Abstract Background The burden of infectious intestinal disease (IID) in the UK is substantial. Negative consequences including sickness absence are common, but little is known about the social patterning of these outcomes, or the extent to which they relate to disease severity. Methods We performed a cross-sectional analysis using IID cases identified from a large population-based survey, to explore the association between socioeconomic status (SES) and symptom severity and sickness absence; and to assess the...

Additional file 1: of Socioeconomic status is associated with symptom severity and sickness absence in people with infectious intestinal disease in the UK

Tanith Rose, Natalie Adams, Benjamin Barr, Jeremy Hawker, Sarah O’Brien, Mara Violato, Margaret Whitehead & David Taylor-Robinson
Supplementary material and sensitivity analyses. (PDF 387 kb)

Additional file 9: Figure S7. of Evolution of the vertebrate insulin receptor substrate (Irs) gene family

Ahmad Al-Salam & David Irwin
This file is in PDF format. Alignment of primate Irs3 genomic sequences. (PDF 518 kb)

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