882,922 Works

Emotions as guardians of group norms: expressions of anger and disgust drive inferences about autonomy and purity violations

Marc W. Heerdink, Lukas F. Koning, Evert A. Van Doorn & Gerben A. Van Kleef
Other people’s emotional reactions to a third person’s behaviour are potentially informative about what is appropriate within a given situation. We investigated whether and how observers’ inferences of such injunctive norms are shaped by expressions of anger and disgust. Building on the moral emotions literature, we hypothesised that angry and disgusted expressions produce relative differences in the strength of autonomy-based versus purity-based norm inferences. We report three studies (plus three supplementary studies) using different types...

Variability of attention bias in socially anxious adolescents: differences in fixation duration toward adult and adolescent face stimuli

Andrea Trubanova Wieckowski, Nicole N. Capriola-Hall, Rebecca Elias, Thomas H. Ollendick & Susan W. White
Prior research on attention bias in anxious youth, often utilising a visual dot probe task, has yielded inconsistent findings, which may be due to how bias is assessed and/or variability in the phenomenon. The present study utilises eye gaze tracking to assess attention bias in socially anxious adolescents, and explores several methodological and within-subject factors that may contribute to variability in attention bias. Attention bias to threat was measured in forty-two treatment-seeking adolescents (age 12–16...

Variability of attention bias in socially anxious adolescents: differences in fixation duration toward adult and adolescent face stimuli

Andrea Trubanova Wieckowski, Nicole N. Capriola-Hall, Rebecca Elias, Thomas H. Ollendick & Susan W. White
Prior research on attention bias in anxious youth, often utilising a visual dot probe task, has yielded inconsistent findings, which may be due to how bias is assessed and/or variability in the phenomenon. The present study utilises eye gaze tracking to assess attention bias in socially anxious adolescents, and explores several methodological and within-subject factors that may contribute to variability in attention bias. Attention bias to threat was measured in forty-two treatment-seeking adolescents (age 12–16...

Synthesis, characterization, and structural studies of two heteroleptic Mn(II) complexes with tridentate N,N,N-pincer type ligand

Saied M. Soliman & Ayman El-Faham
Molecular and supramolecular structures of two new Mn(II) complexes with tridentate N,N,N-pincer type ligand (L) are presented. [MnL(H2O)2Cl]Cl (1) and [MnL(H2O)3](NO3)2·H2O (2) have octahedral coordination environments with different degrees of distortion. The molecular packing of 1 and 2 is dominated by strong O–H⋯Cl and O–H⋯O H-bonds, respectively, as well as weak C–H⋯O interactions. The percentage of Cl⋯H and O⋯H contacts are 15.5 and 31.5% for 1 and 2, respectively, using Hirshfeld analysis. Based on atoms...

Image-guided radiation therapy for post-operative gynaecologic cancer: patient set up verification with and without implanted fiducial markers

Donna H. Murrell, Andrew Warner, Quinn Benwell, Wendy Wells, Danielle Scott, Vikram Velker, George Hajdok & David P. D’Souza
Background: Intensity modulated radiotherapy (IMRT) is increasingly being used to treat gynaecological malignancies in the postoperative setting. The purpose of this study was to evaluate the use of image-guided radiotherapy (IGRT) using cone-beam computed tomography (CBCT) with fiducial markers for daily localization. Material and methods: A single institution study was performed of consecutive cervical or endometrial cancer patients receiving adjuvant external beam radiotherapy (n = 15). Patients were set up at treatment using daily CBCT and alignment...

Image-guided radiation therapy for post-operative gynaecologic cancer: patient set up verification with and without implanted fiducial markers

Donna H. Murrell, Andrew Warner, Quinn Benwell, Wendy Wells, Danielle Scott, Vikram Velker, George Hajdok & David P. D’Souza
Background: Intensity modulated radiotherapy (IMRT) is increasingly being used to treat gynaecological malignancies in the postoperative setting. The purpose of this study was to evaluate the use of image-guided radiotherapy (IGRT) using cone-beam computed tomography (CBCT) with fiducial markers for daily localization. Material and methods: A single institution study was performed of consecutive cervical or endometrial cancer patients receiving adjuvant external beam radiotherapy (n = 15). Patients were set up at treatment using daily CBCT and alignment...

Plesiadapid mammals from the latest Paleocene of France offer new insights on the evolution of Plesiadapis during the Paleocene-Eocene transition

Eric De Bast, Cyril Gagnaison & Thierry Smith
Plesiadapidae are among the most successful mammal families of the Paleocene, but in North America they disappear abruptly around the Paleocene-Eocene boundary. In contrast, in Europe, they survive a few million years into the Eocene, although only as the genus Platychoerops. The latest Paleocene deposits of Petit-Pâtis (Paris Basin, France) have produced three new plesiadapid species, one of each genus known in Europe: Plesiadapis ploegi, sp. nov., Platychoerops boyeri, sp. nov., and Chiromyoides mauberti, sp....

Plesiadapid mammals from the latest Paleocene of France offer new insights on the evolution of Plesiadapis during the Paleocene-Eocene transition

Eric De Bast, Cyril Gagnaison & Thierry Smith
Plesiadapidae are among the most successful mammal families of the Paleocene, but in North America they disappear abruptly around the Paleocene-Eocene boundary. In contrast, in Europe, they survive a few million years into the Eocene, although only as the genus Platychoerops. The latest Paleocene deposits of Petit-Pâtis (Paris Basin, France) have produced three new plesiadapid species, one of each genus known in Europe: Plesiadapis ploegi, sp. nov., Platychoerops boyeri, sp. nov., and Chiromyoides mauberti, sp....

MATHEMATICAL NATURE OF GRAVITY – Topology Unites With the Matrix, E=mc2, Advanced Waves, Wick Rotation, Dark Matter & Higher Dimensions

Rodney Bartlett
General Relativity says gravity is a push caused by space-time's curvature. Combining it with E=mc2 results in distances being totally deleted from space-time/gravity by future technology, and in expansion or contraction of the universe as a whole being eliminated. The road to these conclusions has branches shining light on supersymmetry and superconductivity.

Advanced waves are usually discarded by most scientists because they're thought to be detectable before even being emitted, and thus to violate...

A method for combining p-values in meta-analysis by gamma distributions

Li-Chu Chien
Combining p-values from statistical tests across different studies is the most commonly used approach in meta-analysis for evolutionary biology. The most commonly used p-value combination methods mainly incorporate the z-transform tests (e.g., the un-weighted z-test and the weighted z-test) and the gamma-transform tests (e.g., the CZ method [Z. Chen, W. Yang, Q. Liu, J.Y. Yang, J. Li, and M.Q. Yang, A new statistical approach to combining p-values using gamma distribution and its application to genomewide...

A method for combining p-values in meta-analysis by gamma distributions

Li-Chu Chien
Combining p-values from statistical tests across different studies is the most commonly used approach in meta-analysis for evolutionary biology. The most commonly used p-value combination methods mainly incorporate the z-transform tests (e.g., the un-weighted z-test and the weighted z-test) and the gamma-transform tests (e.g., the CZ method [Z. Chen, W. Yang, Q. Liu, J.Y. Yang, J. Li, and M.Q. Yang, A new statistical approach to combining p-values using gamma distribution and its application to genomewide...

IMPACT OF STRAIN AND CHANNEL THICKNESS ON PERFORMANCE OF BIAXIAL STRAINED SILICON MOSFETs

Neha Sharan & Ashwani K.Rana
In this paper the impact of strain and channel thickness on the performance of biaxial strained silicon MOSFET with 40 nm channel length has been analyzed by simulation in TCAD Sentaurus Simulator. With the increase in the mole fraction of germanium at the interface of the channel region, the strain in the silicon channel increases and with it the mobility of the carriers increases and thus the drain current increases. The mole fraction in this...

IMPACT OF STRAIN AND CHANNEL THICKNESS ON PERFORMANCE OF BIAXIAL STRAINED SILICON MOSFETs

Neha Sharan & Ashwani K.Rana
In this paper the impact of strain and channel thickness on the performance of biaxial strained silicon MOSFET with 40 nm channel length has been analyzed by simulation in TCAD Sentaurus Simulator. With the increase in the mole fraction of germanium at the interface of the channel region, the strain in the silicon channel increases and with it the mobility of the carriers increases and thus the drain current increases. The mole fraction in this...

Statistical Considerations in Demonstrating CMC Analytical Similarity for a Biosimilar Product

Richard K. Burdick, Neal Thomas & Aili Cheng
Demonstration of analytical similarity between a reference product and a biosimilar product is required as part of the biosimilarity approval process. A statistical two one-sided test (TOST) based on the difference of means proposed in the literature and recommended by the FDA for Tier 1 quality attributes is demonstrated to have a Type I error rate greater than the specified level, which cannot be corrected by increasing sample size. In this article, an alternative TOST...

Lutein improves cell viability and reduces Alu RNA accumulation in hydrogen peroxide challenged retinal pigment epithelial cells

You Sheng Chong, Chun Wai Mai, Chee Onn Leong & Lai Chun Wong
Purpose: Dysfunction of the microRNA (miRNA)-processing enzyme DICER1 and Alu RNA accumulation are linked to the pathogenesis of age-related macular degeneration (AMD). This study determined the optimal dose of lutein (LUT) and zeaxanthin (ZEA) to protect human retinal pigment epithelium (RPE) cells against hydrogen peroxide (H2O2). The effect of the optimal dose of LUT and ZEA as DICER1 and Alu RNA modulators in cultured human RPE cells challenged with H2O2 was investigated. Materials and methods:...

Lutein improves cell viability and reduces Alu RNA accumulation in hydrogen peroxide challenged retinal pigment epithelial cells

You Sheng Chong, Chun Wai Mai, Chee Onn Leong & Lai Chun Wong
Purpose: Dysfunction of the microRNA (miRNA)-processing enzyme DICER1 and Alu RNA accumulation are linked to the pathogenesis of age-related macular degeneration (AMD). This study determined the optimal dose of lutein (LUT) and zeaxanthin (ZEA) to protect human retinal pigment epithelium (RPE) cells against hydrogen peroxide (H2O2). The effect of the optimal dose of LUT and ZEA as DICER1 and Alu RNA modulators in cultured human RPE cells challenged with H2O2 was investigated. Materials and methods:...

Introducing federated queries with Wikidata

Andra Waagmeester
Here are the slides and example ShEx files used in the advanced SPARQL workshop at the EuropeanaTech 2018 Wikidata workshop day in the Haque on May 14, 2018https://www.wikidata.org/wiki/Wikidata:Events/EuropeanaTech_2018_Wikidata_workshop_day

Introducing federated queries with Wikidata

Andra Waagmeester
Here are the slides and example ShEx files used in the advanced SPARQL workshop at the EuropeanaTech 2018 Wikidata workshop day in the Haque on May 14, 2018https://www.wikidata.org/wiki/Wikidata:Events/EuropeanaTech_2018_Wikidata_workshop_day

Using a Java Based Program to Produce Reduced Amino Acid Alphabet Versions of Query Sequences and Databases

Breeanna Burkinshaw, Alex Hamilton & Sharmin M. Sikich
Reduced amino acid alphabets are used to show similarity in sequence between two proteins that may not otherwise be detected. This can occur if slight changes or mutations have occurred over time through evolution and divergence of species. In this case the structure would remain similar, but the sequence would appear to be much different. It is important to explore different methods in which to determine the reduced amino acid alphabet that produces the most...

Using a Java Based Program to Produce Reduced Amino Acid Alphabet Versions of Query Sequences and Databases

Breeanna Burkinshaw, Alex Hamilton & Sharmin M. Sikich
Reduced amino acid alphabets are used to show similarity in sequence between two proteins that may not otherwise be detected. This can occur if slight changes or mutations have occurred over time through evolution and divergence of species. In this case the structure would remain similar, but the sequence would appear to be much different. It is important to explore different methods in which to determine the reduced amino acid alphabet that produces the most...

The Effect of Spironolactone on the Incidence of Contrast Induced Nephropathy in Patients Undergoing Cardiac Catheterization: Study Design and Rationale

Alhasan Mujtaba, Mohammed A. Taher, Mazin A. Hazza, Hassan M. Al-Rubaye, Asaad H. Kata, Hamid AbdulWahab, AbdulAmeer AbdulBari & Hayder K. AlRubay
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Supplementary Material PhD Thesis Anna Bove

Anna Bove
Cell competition is a quality control mechanism through which tissues eliminate unfit cells. Cell competition can result from short-range biochemical signals or long-range mechanical cues. However, little is known about how cell-scale interactions give rise to population shifts in tissues, due to the lack of experimental and computational tools to efficiently characterise interactions at the single-cell level.In the work presented in this thesis, I address these challenges by combining long-term automated microscopy with deep learning...

Supplementary Material PhD Thesis Anna Bove

Anna Bove
Cell competition is a quality control mechanism through which tissues eliminate unfit cells. Cell competition can result from short-range biochemical signals or long-range mechanical cues. However, little is known about how cell-scale interactions give rise to population shifts in tissues, due to the lack of experimental and computational tools to efficiently characterise interactions at the single-cell level.In the work presented in this thesis, I address these challenges by combining long-term automated microscopy with deep learning...

Therapists’ perspectives on adapting the Stepping On falls prevention programme for community-dwelling stroke survivors in Singapore

Tianma Xu, Kate O’Loughlin, Lindy Clemson, Natasha A. Lannin, Gerald Koh & Catherine Dean
Purpose: This study investigates the perspectives of rehabilitation therapists on the implementation of fall prevention programmes with community-dwelling stroke survivors in the Singapore context, and elicits recommendations to adapt the Stepping On programme with stroke survivors. Method: Qualitative data were elicited during 4 focus groups with 23 rehabilitation therapists (15 occupational therapists [OTs]; 8 physiotherapists [PTs]) who had received training to deliver the original Stepping On programme, and had experienced delivery of fall-prevention intervention programmes...

Therapists’ perspectives on adapting the Stepping On falls prevention programme for community-dwelling stroke survivors in Singapore

Tianma Xu, Kate O’Loughlin, Lindy Clemson, Natasha A. Lannin, Gerald Koh & Catherine Dean
Purpose: This study investigates the perspectives of rehabilitation therapists on the implementation of fall prevention programmes with community-dwelling stroke survivors in the Singapore context, and elicits recommendations to adapt the Stepping On programme with stroke survivors. Method: Qualitative data were elicited during 4 focus groups with 23 rehabilitation therapists (15 occupational therapists [OTs]; 8 physiotherapists [PTs]) who had received training to deliver the original Stepping On programme, and had experienced delivery of fall-prevention intervention programmes...

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