572,176 Works

Additional file 1: of Traditional Birth Attendant reorientation and Motherpacks incentiveâ s effect on health facility delivery uptake in Narok County, Kenya: An impact analysis

John Kitui, Vaughan Dutton, Dirk Bester, Rachel Ndirangu, Susan Wangai & Stephen Ngugi
Kitui_MCHKenya CodeBook and Kitui_MCHKenyaData. (ZIP 23 kb)

Traditional Birth Attendant reorientation and Motherpacks incentive’s effect on health facility delivery uptake in Narok County, Kenya: An impact analysis

John Kitui, Vaughan Dutton, Dirk Bester, Rachel Ndirangu, Susan Wangai & Stephen Ngugi
Abstract Background A community health programme in Narok County in Kenya aimed to improve skilled birth assistance during childbirth through two demand side interventions. First, traditional birth attendants (TBAs) were co-opted into using their influence to promote use of skilled birth attendants (SBAs) at health facilities during delivery, and to accompany pregnant women to health facilities in return for a Ksh500 (Approximately USD5 as of August 2016) cash incentive for each pregnant mother they accompanied....

Sacroiliitis mimics: a case report and review of the literature

Maria Antonelli & Marina Magrey
Abstract Background Radiographic sacroiliitis is the hallmark of ankylosing spondylitis (AS), and detection of acute sacroiliitis is pivotal for early diagnosis of AS. Although radiographic sacroiliitis is a distinguishing feature of AS, sacroiliitis can be seen in a variety of other disease entities. Case presentation We present an interesting case of sacroiliitis in a patient with Paget disease; the patient presented with inflammatory back pain which was treated with bisphosphonate. This case demonstrates comorbidity with...

Additional file 1: of Sacroiliitis mimics: a case report and review of the literature

Maria Antonelli & Marina Magrey
Timeline of Case Patient. This timeline depicted is the presentation of the case patient with physical exam, imaging, laboratory findings. (DOCX 29 kb)

The effect of vitamin B12 supplementation in Nepalese infants on growth and development: study protocol for a randomized controlled trial

Tor Strand, Manjeswori Ulak, Ram Chandyo, Ingrid Kvestad, Mari Hysing, Merina Shrestha, Sudha Basnet, Suman Ranjitkar, Laxman Shrestha & Prakash Shrestha
Abstract Background Vitamin B12 deficiency is one of the most common micronutrient deficiencies and is associated with poor cognitive development and growth. Vitamin B12 is crucial for normal cell division and differentiation, and it is necessary for the development and myelination of the central nervous system. The aim of the present study is to measure the effect of daily supplementation of vitamin B12 on the neurodevelopment and growth of young children in Nepal. Methods/design We...

Membrane-enriched proteome changes and prion protein expression during neural differentiation and in neuroblastoma cells

J. Macedo, D. Schrama, I. Duarte, E. Tavares, J. Renaut, M. Futschik, P. Rodrigues & E. Melo
Abstract Background The function of the prion protein, involved in the so-called prion diseases, remains a subject of intense debate and the possibility that it works as a pleiotropic protein through the interaction with multiple membrane proteins is somehow supported by recent reports. Therefore, the use of proteomic and bioinformatics combined to uncover cellular processes occurring together with changes in the expression of the prion protein may provide further insight into the putative pleiotropic role...

Additional file 3: Figure S2. of Membrane-enriched proteome changes and prion protein expression during neural differentiation and in neuroblastoma cells

J. Macedo, D. Schrama, I. Duarte, E. Tavares, J. Renaut, M. Futschik, P. Rodrigues & E. Melo
Venn diagram displaying intersections as common number of physical interactions between the five databases used to retrieve the data for the bioinformatics analysis. (TIF 240 kb)

Additional file 2: of The effect of vitamin B12 supplementation in Nepalese infants on growth and development: study protocol for a randomized controlled trial

Tor Strand, Manjeswori Ulak, Ram Chandyo, Ingrid Kvestad, Mari Hysing, Merina Shrestha, Sudha Basnet, Suman Ranjitkar, Laxman Shrestha & Prakash Shrestha
Randomized trial on daily Vitamin B12 supplementation in Nepali infants: main activities (enrollment, interventions, and assessments). (PDF 403 kb)

Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene

Yvonne Davidson, Louis Flood, Andrew Robinson, Yoshihiro Nihei, Kohji Mori, Sara Rollinson, Anna Richardson, Bridget Benson, Matthew Jones, Julie Snowden, Stuart Pickering-Brown, Christian Haass, Tammaryn Lashley & David Mann
Abstract Frontotemporal Lobar Degeneration (FTLD) encompasses certain related neurodegenerative disorders which alter behaviour, personality and language. Heterogeneous ribonuclear proteins (hnRNPs) maintain RNA metabolism and changes in their function may underpin the pathogenesis of FTLD. Immunostaining for hnRNP A1, A2/B1 and A3 was performed on sections of temporal cortex with hippocampus from 61 patients with FTLD, stratified by pathological hallmarks into FTLD-tau and FTLD-TDP type A, B and C subtypes, and by genetics into patients with...

Genetic variants of Helicobacter pylori type IV secretion system components CagL and CagI and their association with clinical outcomes

Hirofumi Ogawa, Akira Iwamoto, Toshihito Tanahashi, Rina Okada, Koji Yamamoto, Shin Nishiumi, Masaru Yoshida & Takeshi Azuma
Abstract Background Helicobacter pylori infection is associated with risk for chronic gastritis (CG), gastric ulcer (GU), duodenal ulcer (DU), and gastric cancer (GC). The H. pylori Cag type IV secretion system (TFSS) translocates the virulence factor cytotoxin-associated gene A protein into host cells and plays an important role in initiating gastric carcinogenesis. The CagL and CagI proteins are components of the TFSS. The Arg-Gly-Asp (RGD) motif of CagL, and the six most distal C-terminal amino...

Additional file 1: of A highly pathogenic simian/human immunodeficiency virus effectively produces infectious virions compared with a less pathogenic virus in cell culture

Shoya Iwanami, Yusuke Kakizoe, Satoru Morita, Tomoyuki Miura, Shinji Nakaoka & Shingo Iwami
Technical details of MCMC computations. (PDF 49 kb)

Comparative analyses of structural features and scaffold diversity for purchasable compound libraries

Jun Shang, Huiyong Sun, Hui Liu, Fu Chen, Sheng Tian, Peichen Pan, Dan Li, Dexin Kong & Tingjun Hou
Abstract Large purchasable screening libraries of small molecules afforded by commercial vendors are indispensable sources for virtual screening (VS). Selecting an optimal screening library for a specific VS campaign is quite important to improve the success rates and avoid wasting resources in later experimental phases. Analysis of the structural features and molecular diversity for different screening libraries can provide valuable information to the decision making process when selecting screening libraries for VS. In this study,...

Additional file 2: Figure S1. of Membrane-enriched proteome changes and prion protein expression during neural differentiation and in neuroblastoma cells

J. Macedo, D. Schrama, I. Duarte, E. Tavares, J. Renaut, M. Futschik, P. Rodrigues & E. Melo
Hierarchical representation of the full interactome displaying all the physical interactions found on the queried databases between our first set of differentially abundant proteins, including prion protein (magenta diamonds) and their first interacting neighbours (green circles). (TIF 569 kb)

Assessment of the significance of patent-derived information for the early identification of compound–target interaction hypotheses

Stefan Senger
Abstract Background Patents are an important source of information for effective decision making in drug discovery. Encouragingly, freely accessible patent-chemistry databases are now in the public domain. However, at present there is still a wide gap between relatively low coverage-high quality manually-curated data sources and high coverage data sources that use text mining and automated extraction of chemical structures. To secure much needed funding for further research and an improved infrastructure, hard evidence is required...

MOESM2 of Comparative analyses of structural features and scaffold diversity for purchasable compound libraries

Jun Shang, Huiyong Sun, Hui Liu, Fu Chen, Sheng Tian, Peichen Pan, Dan Li, Dexin Kong & Tingjun Hou
Additional file 2: Fig. S1. Tree Maps for the studied datasets; Figure S2. The most frequent scaffolds served as the representatives of the clusters; Figure S3. Cluster centers served as the representatives of the clusters; Figure S4. Maximum Common Substructures (MCS) for 39 out of the 40 representative molecules; Table S1. Potential targets of the 39 similar molecules found in BindingDB for the 40 representative molecules.

Additional file 1: of Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene

Yvonne Davidson, Louis Flood, Andrew Robinson, Yoshihiro Nihei, Kohji Mori, Sara Rollinson, Anna Richardson, Bridget Benson, Matthew Jones, Julie Snowden, Stuart Pickering-Brown, Christian Haass, Tammaryn Lashley & David Mann
Selected clinical, pathological and genetic details on cases studied. (XLSX 17 kb)

MOESM3 of Assessment of the significance of patent-derived information for the early identification of compoundâ target interaction hypotheses

Stefan Senger
Additional file 3. Earliest patent in SureChEMBL and earliest publication in ChEMBL for the 130 compounds from the annotated set.

Additional file 1: of The effect of vitamin B12 supplementation in Nepalese infants on growth and development: study protocol for a randomized controlled trial

Tor Strand, Manjeswori Ulak, Ram Chandyo, Ingrid Kvestad, Mari Hysing, Merina Shrestha, Sudha Basnet, Suman Ranjitkar, Laxman Shrestha & Prakash Shrestha
SPIRIT 2013 checklist: recommended items to address in a clinical trial protocol and related documents. (DOC 123 kb)

MOESM2 of Genetic variants of Helicobacter pylori type IV secretion system components CagL and CagI and their association with clinical outcomes

Hirofumi Ogawa, Akira Iwamoto, Toshihito Tanahashi, Rina Okada, Koji Yamamoto, Shin Nishiumi, Masaru Yoshida & Takeshi Azuma
Additional file 2: Table S2. CagA motifs of 40 clinical isolates.

Additional file 1: Table S1. of Membrane-enriched proteome changes and prion protein expression during neural differentiation and in neuroblastoma cells

J. Macedo, D. Schrama, I. Duarte, E. Tavares, J. Renaut, M. Futschik, P. Rodrigues & E. Melo
and Table S2. Oligonucleotides used for qPCR of mouse specific genes & Protein spots differentially abundant during neural differentiation of ES cells (set #1, fold change ± 1.5) and between neuroblastoma cells expressing the prion protein and knockdown for the prion protein (set #2, fold change ± 2). (DOCX 22 kb)

Additional file 1: Table S1. of More complications in uncemented compared to cemented hemiarthroplasty for displaced femoral neck fractures: a randomized controlled trial of 201 patients, with one year follow-up

Sophie Moerman, Nina Mathijssen, Dieu Niesten, Roeland Riedijk, Willard Rijnberg, Sander KoĂŤter, Keetie Kremers Van De Hei, Wim Tuinebreier, Tim Molenaar, Rob Nelissen & Anne Vochteloo
Perioperative details of uncemented and cemented hemiarthroplasty. length of stay, loss in hemoglobin, estimated blood loss and transfusion rate of uncemented and cemented hemiarthroplasty (DOCX 11 kb)

More complications in uncemented compared to cemented hemiarthroplasty for displaced femoral neck fractures: a randomized controlled trial of 201 patients, with one year follow-up

Sophie Moerman, Nina Mathijssen, Dieu Niesten, Roeland Riedijk, Willard Rijnberg, Sander Koëter, Keetie Kremers Van De Hei, Wim Tuinebreier, Tim Molenaar, Rob Nelissen & Anne Vochteloo
Abstract Background It is unclear whether cemented or uncemented hemiarthroplasty is the best treatment option in elderly patients with displaced femoral neck fractures. Previous randomized trials comparing cemented and uncemented hemiarthroplasty have conflicting results. We conducted a randomized controlled trial to compare cemented and uncemented hemiarthroplasty. Methods This multicenter parallel-randomized controlled trial included patients of 70 years and older with a displaced femoral neck fracture (Garden type III or IV). Inclusion was between August 2008 and...

MOESM1 of Comparative analyses of structural features and scaffold diversity for purchasable compound libraries

Jun Shang, Huiyong Sun, Hui Liu, Fu Chen, Sheng Tian, Peichen Pan, Dan Li, Dexin Kong & Tingjun Hou
Additional file 1: File S1. Studied structures in the SAR map.zip.

MOESM1 of Genetic variants of Helicobacter pylori type IV secretion system components CagL and CagI and their association with clinical outcomes

Hirofumi Ogawa, Akira Iwamoto, Toshihito Tanahashi, Rina Okada, Koji Yamamoto, Shin Nishiumi, Masaru Yoshida & Takeshi Azuma
Additional file 1: Table S1. Average coverage (fold) of 28 cagPAI genes in 43 clinical H. pylori isolates mapped to the ATCC26695 sequence.

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