119,068 Works

International Clinics on Infectious Disease Dynamics and Data

Steven Bellan, Rebecca Borchering, Jonathan Dushoff, John Hargrove, Calistus Ngonghala, Travis Porco, James C Scott, Brian G Williams, Cari Van Schalkwyk & Juliet Pulliam
This collection contains pedagogic material developed by the International Clinics on Infectious Disease Dynamics and Data (ICI3D). Through annual Clinics in South Africa and the United States, the ICI3D program trains junior researchers from the US and Africa to conduct integrative research in infectious disease dynamics and to communicate their questions, methods, and findings across disciplinary boundaries.

altmetrictop1002015.xlsx

Sukumar Mandal
lisds

altmetrictop1002015.xlsx

Sukumar Mandal
lisds

Heagy et al, 2017 - 1D FDEM and TDEM Inversions

Lindsey Heagy, Rowan Cockett, Seogi Kang, Gudni Rosenkjaer & Douglas W. Oldenburg
Here, we perform a 1D inversion using both the frequency and time domaincodes. The forward simulations are conducted on a cylindrically symmetricmesh. The source is a point magnetic dipole source.
This example is used in the paper
Heagy, L.J., R. Cockett, S. Kang, G.K. Rosenkjaer, D.W. Oldenburg,2017 (in review), A framework for simulation and inversion in electromagnetics.Computers & Geosciences

Online Labour Index: Measuring the Online Gig Economy for Policy and Research

Otto Kässi, Martin Hadley & Vili Lehdonvirta
Data repository for the data underlying the Online Labour Index. See http://ilabour.oii.ox.ac.uk online-labour-index/ for details.

Executive Coaching - Affliction (Reflective Exercise)

Gabrielle Monaen
A reflective exercise for executive coaching.

Executive Coaching - Wealth (Reflective Exercise)

Gabrielle Monaen
A reflective exercise for executive coaching.

Executive Coaching - Wealth (Reflective Exercise)

Gabrielle Monaen
A reflective exercise for executive coaching.

Executive Coaching - Earnings (Reflective Exercise)

Gabrielle Monaen
A reflective exercise for executive coaching.

Executive Coaching - Earnings (Reflective Exercise)

Gabrielle Monaen
A reflective exercise for executive coaching.

Reconciling morphological and molecular systematics in tarantulas (Araneae: Theraphosidae): revision of the Mexican endemic genus Bonnetina

David Ortiz & Oscar F. Francke
Supplementary information associated with the paper:
Ortiz, D. & O.F. Francke. 2017. Reconciling morphological and molecular systematics in tarantulas (Araneae: Theraphosidae): revision of the Mexican endemic genus Bonnetina. Zoological Journal of the Linnean Society. doi: 10.1093/zoolinnean/zlw013.

Fast and robust adjustment of cell mixtures in epigenome-wide association studies with SmartSVA

Jun Chen, Ehsan Behnam, Jinyan Huang, Miriam Moffatt, Daniel Schaid, Liming Liang & Xihong Lin
Abstract Background One problem that plagues epigenome-wide association studies is the potential confounding due to cell mixtures when purified target cells are not available. Reference-free adjustment of cell mixtures has become increasingly popular due to its flexibility and simplicity. However, existing methods are still not optimal: increased false positive rates and reduced statistical power have been observed in many scenarios. Methods We develop SmartSVA, an optimized surrogate variable analysis (SVA) method, for fast and robust...

Atp8 is in the ground pattern of flatworm mitochondrial genomes

Bernhard Egger, Lutz Bachmann & Bastian Fromm
Abstract Background To date, mitochondrial genomes of more than one hundred flatworms (Platyhelminthes) have been sequenced. They show a high degree of similarity and a strong taxonomic bias towards parasitic lineages. The mitochondrial gene atp8 has not been confidently annotated in any flatworm sequenced to date. However, sampling of free-living flatworm lineages is incomplete. We addressed this by sequencing the mitochondrial genomes of the two small-bodied (about 1 mm in length) free-living flatworms Stenostomum sthenum and...

Phase I/II study of induction chemotherapy using carboplatin plus irinotecan and sequential thoracic radiotherapy (TRT) for elderly patients with limited-disease small-cell lung cancer (LD-SCLC): TORG 0604

Yuki Misumi, Hiroaki Okamoto, Jiichiro Sasaki, Noriyuki Masuda, Mari Ishii, Tsuneo Shimokawa, Yukio Hosomi, Yusuke Okuma, Makoto Nagamata, Takashi Ogura, Terufumi Kato, Masafumi Sata, Sakiko Otani, Akira Takakura, Koichi Minato, Yosuke Miura, Takuma Yokoyama, Saori Takata, Katsuhiko Naoki & Koshiro Watanabe
Abstract Background The role of irinotecan for elderly patients with LD-SCLC has been unclear, and the timing of TRT combined with chemotherapy has not been fully evaluated. Methods Patients aged > 70 years with untreated, measurable, LD-SCLC, performance status (PS) 0–2, and adequate organ function were eligible. Treatment consisted of induction with carboplatin on day 1 and irinotecan on days 1 and 8, every 21 days for 4 cycles, and sequential TRT (54Gy in 27 fractions). Carboplatin doses were based...

The Shared Health Appointments and Reciprocal Enhanced Support (SHARES) study: study protocol for a randomized trial

Michele Heisler, Jennifer Burgess, Jeffrey Cass, John Chardos, Alexander Guirguis, Sean Jeffery, Lorrie Strohecker, Adam Tremblay, Wen-Chih Wu & Donna Zulman
Abstract Background Diabetes shared medical appointments (SMAs) and reciprocal peer support programs have been found in efficacy trials to help adults with diabetes improve their self-management and achieve short-term gains in clinical and patient-centered outcomes. In order to translate this evidence to system-level interventions, there is a need for large-scale, pragmatic trials that examine the effectiveness, implementation, and costs of SMAs and reciprocal peer support across diverse settings. Methods The Shared Health Appointments and Reciprocal...

Quantitative analysis of cryptic splicing associated with TDP-43 depletion

Jack Humphrey, Warren Emmett, Pietro Fratta, Adrian Isaacs & Vincent Plagnol
Abstract Background Reliable exon recognition is key to the splicing of pre-mRNAs into mature mRNAs. TDP-43 is an RNA-binding protein whose nuclear loss and cytoplasmic aggregation are a hallmark pathology in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). TDP-43 depletion causes the aberrant inclusion of cryptic exons into a range of transcripts, but their extent, relevance to disease pathogenesis and whether they are caused by other RNA-binding proteins implicated in ALS/FTD are unknown. Methods We...

Expression of von Hippelâ Lindau tumor suppressor protein (pVHL) characteristic of tongue cancer and proliferative lesions in tongue epithelium

Hisashi Hasegawa, Yoshiaki Kusumi, Takeshi Asakawa, Miyoko Maeda, Toshinori Oinuma, Tohru Furusaka, Takeshi Oshima & Mariko Esumi
Abstract Background Patients with tongue cancer frequently show loss of heterozygosity (LOH) of the von Hippelâ Lindau (VHL) tumor suppressor gene. However, expression of VHL protein (pVHL) in tongue cancer has rarely been investigated and remains largely unknown. We performed immunohistochemical staining of pVHL in tongue tissues and dysplasia, and examined the association with LOH and its clinical significance. Methods Immunohistochemical staining of pVHL in formalin-fixed, paraffin-embedded sections of cancerous and other tissues from 19...

Novel insight into the relationship between organic substrate composition and volatile fatty acids distribution in acidogenic co-fermentation

Huijun Ma, He Liu, Lihui Zhang, Meng Yang, Bo Fu & Hongbo Liu
Abstract Background Co-fermentation is an attractive technology for improving volatile fatty acids (VFAs) production by treatment of solid organic wastes. However, it remains unclear how the composition of different organic matters in solid waste influences the VFAs distribution, microbial community structure, and metabolic pathway during acidogenic co-fermentation. In this study, different organic wastes were added into waste activated sludge (WAS) as co-fermentation substrates to explore the impact of organic matter composition on VFAs pattern and...

MicroRNA-608 inhibits proliferation of bladder cancer via AKT/FOXO3a signaling pathway

Zhen Liang, Xiao Wang, Xin Xu, Bo Xie, Alin Ji, Shuai Meng, Shiqi Li, Yi Zhu, Jian Wu, Zhenghui Hu, Yiwei Lin, Xiangyi Zheng, Liping Xie & Ben Liu
Abstract Background Current evidence indicates that miR-608 is widely down-regulated in various malignant tumors including liver cancer, colon cancer, lung cancer and glioma, and acts as a tumor suppressor by inhibiting cell proliferation, invasion and migration or by promoting apoptosis. The specific biological function of miR-608 in bladder cancer is still unknown. Methods qRT-PCR and Chromogenic in Situ Hybridization (CISH) was conducted to assess the expression of miR-608 in paired BCa tissues and adjacent non-tumor...

Is the delivery of a quality improvement education programme in obstetrics and gynaecology for final year medical students feasible and still effective in a shortened time frame?

Bridget Kool, Michelle Wise, Roshini Peiris-John, Lynn Sadler, Faith Mahony & Susan Wells
Abstract Background Teaching clinical audit skills to nascent health professionals is one strategy to improve frontline care. The undergraduate medical curriculum at the University of Auckland provides improvement science theory and skills in Year 5 teaching, and the opportunity to put this into practice during an Obstetrics and Gynaecology (O&G) clinical attachment in Year 6. In 2015, a revised medical school curriculum at the university resulted in a planned reduction of the O&G attachment from...

Detection of ALK fusion transcripts in FFPE lung cancer samples by NanoString technology

Adriane Evangelista, Maicon Zanon, Adriana Carloni, Flávia De Paula, Mariana Morini, Maressa Ferreira-Neto, Iberê Soares, Jose Miziara, Pedro De Marchi, Cristovam Scapulatempo-Neto & Rui Reis
Abstract Background ALK-rearranged lung cancers exhibit specific pathologic and clinical features and are responsive to anti-ALK therapies. Therefore, the detection of ALK-rearrangement is fundamental for personalized lung cancer therapy. Recently, new molecular techniques, such as NanoString nCounter, have been developed to detect ALK fusions with more accuracy and sensitivity. Methods In the present study, we intended to validate a NanoString nCounter ALK-fusion panel in routine biopsies of FFPE lung cancer patients. A total of 43...

Development of a SNP panel dedicated to parentage assignment in French sheep populations

F. Tortereau, C. Moreno, G. Tosser-Klopp, B. Servin & J. Raoul
Abstract Background The efficiency of breeding programs partly relies on the accuracy of the estimated breeding values which decreases when pedigrees are incomplete. Two reproduction techniques are mainly used by sheep breeders to identify the sires of lambs: animal insemination and natural matings with a single ram per group of ewes. Both methods have major drawbacks, notably time-consuming tasks for breeders, and are thus used at varying levels in breeding programs. As a consequence, the...

JS-K, a nitric oxide pro-drug, regulates growth and apoptosis through the ubiquitin-proteasome pathway in prostate cancer cells

Guobin Tan, Mingning Qiu, Lieqian Chen, Sai Zhang, Longzhi Ke & Jianjun Liu
Abstract Background In view of the fact that JS-K might regulate ubiquitin E3 ligase and that ubiquitin E3 ligase plays an important role in the mechanism of CRPC formation, the goal was to investigate the probable mechanism by which JS-K regulates prostate cancer cells. Methods Proliferation inhibition by JS-K on prostate cancer cells was examined usingCCK-8 assays. Caspase 3/7 activity assays and flow cytometry were performed to examine whether JS-K induced apoptosis in prostate cancer...

Anesthetic management of cesarean section in cases of placenta accreta, with versus without abdominal aortic balloon occlusion: study protocol for a randomized controlled trial

Qinjun Chu, Dan Shen, Long He, Hongwei Wang, Xianlan Zhao, Zhimin Chen, Yanli Wang & Wei Zhang
Abstract Background Placenta accreta (PA), a severe complication during delivery, is closely linked with massive hemorrhage which could endanger the lives of both mother and baby. Moreover, the incidence of PA has increased dramatically with the increasing rate of cesarean deliveries in the past few decades. Therefore, studies evaluating the effects of different perioperative managements based on different modalities in the treatment of PA are necessary. Among the numerous treatment measures, prophylactic abdominal aortic balloon...

Thoracolumbar epidural anaesthesia with 0.5% bupivacaine with or without methadone in goats

Priscila Dos Santos Silva, Paulo Fantinato-Neto, André Silva, Eduardo Junior & Adriano Carregaro
Abstract Background Epidural anaesthesia is one of the most commonly used locoregional techniques in ruminants. The lumbosacral epidural technique is reasonably easy to perform and requires low volumes of local anaesthetic drug to allow procedures caudal to the umbilicus. However, surgical procedures in the flank of the animal would require an increased volume of drugs. The anaesthetized area provided by thoracic epidural technique is larger than the lumbosacral technique; however the former is rather challenging...

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