26,376 Works

Age- and sex-specific first health care use for migraine in 2016 in children and adolescents from prospectively collected health insurance data in Germany

Lucia Albers, Rüdiger Von Kries, Andreas Straube, Florian Heinen, Mirjam N Landgraf, Viola Obermeier & Ruth Ruscheweyh
BackgroundMigraine in children and adolescents is associated with significant disability and a high risk of persistence into adulthood.ObjectiveData on migraine incidence in children and adolescents are few and relatively coarse. To tailor interventions starting shortly after disease onset, detailed information on age- and sex-specific incidence of migraine in children and adolescents is needed.MethodsWe used health care data prospectively collected by the BARMER statutory health insurance, representing ∼11% of the German population. The incidence of migraine...

The use of high venous ligation as an adjunct to endovenous therapy in the management of great saphenous vein incompetence: A systematic review and meta-analysis of randomized controlled trials

Thomas M Aherne, Mekki Medani, Shaheel Sahebally, Elrasheid Kheirelseid, Edward Mulkern, Ciaran McDonnell, Stewart R Walsh & Martin K O’Donohoe
BackgroundIn recent years, endovenous intervention has emerged as a minimally invasive alternative to open venous surgery. However, endovenous intervention does not formally disconnect the deep and superficial venous systems and it is hypothesized that recurrence may be greater in the absence of high venous ligation. This study aims to compare the efficacy of a hybrid endovenous approach with adjuvant high venous ligation and standard operative intervention in the management of great saphenous incompetence.MethodsIn March 2018,...

The quality and safety of locum doctors: a narrative review

Jane Ferguson & Kieran Walshe
SummaryLocum doctors are often perceived to present greater risks of causing harm to patients than permanent doctors. After eligibility and quality assessment, eight empirical and 34 non-empirical papers were included in a narrative synthesis to establish what was known about the quality and safety of locum medical practice. Empirical literature was limited and weak methodologically. Locums enabled healthcare organisations to maintain appropriate staffing levels and allowed staffing flexibility, but they also gave rise to concerns...

The quality and safety of locum doctors: a narrative review

Jane Ferguson & Kieran Walshe
SummaryLocum doctors are often perceived to present greater risks of causing harm to patients than permanent doctors. After eligibility and quality assessment, eight empirical and 34 non-empirical papers were included in a narrative synthesis to establish what was known about the quality and safety of locum medical practice. Empirical literature was limited and weak methodologically. Locums enabled healthcare organisations to maintain appropriate staffing levels and allowed staffing flexibility, but they also gave rise to concerns...

The Safety of Blood Flow Restriction Training as a Therapeutic Intervention for Patients With Musculoskeletal Disorders: A Systematic Review

Melissa C. Minniti, Andrew P. Statkevich, Ryan L. Kelly, Victoria P. Rigsby, Meghan M. Exline, Daniel I. Rhon & Derek Clewley
Background:The effectiveness of blood flow restriction training (BFRT) as compared with other forms of training, such as resistance training, has been evaluated in the literature in clinical and nonclinical populations. However, the safety of this intervention has been summarized only in healthy populations and not in clinical populations with musculoskeletal disorders.Purpose:To evaluate the safety and adverse events associated with BFRT in patients with musculoskeletal disorders.Study Design:Systematic review.Methods:A literature search was conducted with 3 online databases...

The Safety of Blood Flow Restriction Training as a Therapeutic Intervention for Patients With Musculoskeletal Disorders: A Systematic Review

Melissa C. Minniti, Andrew P. Statkevich, Ryan L. Kelly, Victoria P. Rigsby, Meghan M. Exline, Daniel I. Rhon & Derek Clewley
Background:The effectiveness of blood flow restriction training (BFRT) as compared with other forms of training, such as resistance training, has been evaluated in the literature in clinical and nonclinical populations. However, the safety of this intervention has been summarized only in healthy populations and not in clinical populations with musculoskeletal disorders.Purpose:To evaluate the safety and adverse events associated with BFRT in patients with musculoskeletal disorders.Study Design:Systematic review.Methods:A literature search was conducted with 3 online databases...

Video Analysis of Shoulder Dislocations in Rugby: Insights Into the Dislocating Mechanisms

Connor Montgomery, David E. O’Briain, Eoghan T. Hurley, Leo Pauzenberger, Hannan Mullett & Cathal J. Moran
Background:Mechanisms previously described for traumatic shoulder injuries in rugby may not adequately describe all the mechanisms that result in shoulder dislocations.Purpose:To investigate the mechanism of shoulder dislocation events in professional rugby players through use of systematic video analysis.Study Design:Case series; Level of evidence, 4.Methods:In our series, 39 cases of shoulder dislocations from games played in top professional leagues and international matches across a 2-year period were available for video analysis. All cases were independently assessed...

Video Analysis of Shoulder Dislocations in Rugby: Insights Into the Dislocating Mechanisms

Connor Montgomery, David E. O’Briain, Eoghan T. Hurley, Leo Pauzenberger, Hannan Mullett & Cathal J. Moran
Background:Mechanisms previously described for traumatic shoulder injuries in rugby may not adequately describe all the mechanisms that result in shoulder dislocations.Purpose:To investigate the mechanism of shoulder dislocation events in professional rugby players through use of systematic video analysis.Study Design:Case series; Level of evidence, 4.Methods:In our series, 39 cases of shoulder dislocations from games played in top professional leagues and international matches across a 2-year period were available for video analysis. All cases were independently assessed...

Lipid Profiles at Birth Predict Teacher-Rated Child Emotional and Social Development 5 Years Later

Erika M. Manczak & Ian H. Gotlib
The fetal environment has been increasingly implicated in later psychological health, but the role of lipids is unknown. Drawing on the ethnically diverse Born in Bradford (BiB) birth cohort, the current study related levels of high-density lipoprotein (HDL), very-low-density lipoprotein (VLDL), and triglycerides in umbilical cord blood to 1,369 children’s teacher-rated psychosocial competence approximately 5 years later. Results of ordinal logistic regressions indicated that low levels of HDL, high levels of VLDL, and high levels...

Lipid Profiles at Birth Predict Teacher-Rated Child Emotional and Social Development 5 Years Later

Erika M. Manczak & Ian H. Gotlib
The fetal environment has been increasingly implicated in later psychological health, but the role of lipids is unknown. Drawing on the ethnically diverse Born in Bradford (BiB) birth cohort, the current study related levels of high-density lipoprotein (HDL), very-low-density lipoprotein (VLDL), and triglycerides in umbilical cord blood to 1,369 children’s teacher-rated psychosocial competence approximately 5 years later. Results of ordinal logistic regressions indicated that low levels of HDL, high levels of VLDL, and high levels...

Cinnarizine and sodium valproate as the preventive agents of pediatric migraine: A randomized double-blind placebo-controlled trial

Man Amanat, Mansoureh Togha, Elmira Agah, Mahtab Ramezani, Ali Reza Tavasoli, Reza Azizi Malamiri, Fariba Fashandaky, Morteza Heidari, Mona Salehi, Hamid Eshaghi & Mahmoud Reza Ashrafi
BackgroundFew migraine preventive agents have been assessed in a pediatric population. We evaluated the safety and efficacy of cinnarizine and sodium valproate for migraine prophylaxis in children and adolescents.MethodsWe carried out a randomized double-blind placebo-controlled trial in the Children’s Medical Center and Sina hospital, Tehran, Iran. Eligible participants were randomly assigned in 1:1:1 ratio via interactive web response system to receive either cinnarizine, sodium valproate, or placebo. The primary endpoints were the mean change in...

Cinnarizine and sodium valproate as the preventive agents of pediatric migraine: A randomized double-blind placebo-controlled trial

Man Amanat, Mansoureh Togha, Elmira Agah, Mahtab Ramezani, Ali Reza Tavasoli, Reza Azizi Malamiri, Fariba Fashandaky, Morteza Heidari, Mona Salehi, Hamid Eshaghi & Mahmoud Reza Ashrafi
BackgroundFew migraine preventive agents have been assessed in a pediatric population. We evaluated the safety and efficacy of cinnarizine and sodium valproate for migraine prophylaxis in children and adolescents.MethodsWe carried out a randomized double-blind placebo-controlled trial in the Children’s Medical Center and Sina hospital, Tehran, Iran. Eligible participants were randomly assigned in 1:1:1 ratio via interactive web response system to receive either cinnarizine, sodium valproate, or placebo. The primary endpoints were the mean change in...

Long-term tolerability and nonvascular safety of erenumab, a novel calcitonin gene-related peptide receptor antagonist for prevention of migraine: A pooled analysis of four placebo-controlled trials with long-term extensions

Messoud Ashina, David Kudrow, Uwe Reuter, David Dolezil, Stephen Silberstein, Stewart J Tepper, Fei Xue, Hernan Picard, Feng Zhang, Andrea Wang, Yanchen Zhou, Frank Hong, Jan Klatt & Daniel D Mikol
BackgroundEfficacy and safety of erenumab have been evaluated in a comprehensive clinical development program resulting in approval for migraine prevention in over 40 countries to date.MethodsThis integrated safety analysis included four double-blind randomized trials and their extensions (up to three-plus years). Safety endpoints included exposure-adjusted patient incidences of adverse events, serious adverse events, and anti-erenumab antibodies.ResultsIn all, 2375 of the patients randomized across the four studies received at least one dose of erenumab (70 mg...

Long-term tolerability and nonvascular safety of erenumab, a novel calcitonin gene-related peptide receptor antagonist for prevention of migraine: A pooled analysis of four placebo-controlled trials with long-term extensions

Messoud Ashina, David Kudrow, Uwe Reuter, David Dolezil, Stephen Silberstein, Stewart J Tepper, Fei Xue, Hernan Picard, Feng Zhang, Andrea Wang, Yanchen Zhou, Frank Hong, Jan Klatt & Daniel D Mikol
BackgroundEfficacy and safety of erenumab have been evaluated in a comprehensive clinical development program resulting in approval for migraine prevention in over 40 countries to date.MethodsThis integrated safety analysis included four double-blind randomized trials and their extensions (up to three-plus years). Safety endpoints included exposure-adjusted patient incidences of adverse events, serious adverse events, and anti-erenumab antibodies.ResultsIn all, 2375 of the patients randomized across the four studies received at least one dose of erenumab (70 mg...

Spontaneous attribution of false beliefs in adults examined using a signal detection approach

Tian Ye, Stephen M Fleming & Antonia FDC Hamilton
Understanding other people have beliefs different from ours or different from reality is critical to social interaction. Previous studies suggest that healthy adults possess an implicit mentalising system, but alternative explanations for data from reaction time false belief tasks have also been given. In this study, we combined signal detection theory (SDT) with a false belief task. As application of SDT allows us to separate perceptual sensitivity from criteria, we are able to investigate how...

Spontaneous attribution of false beliefs in adults examined using a signal detection approach

Tian Ye, Stephen M Fleming & Antonia FDC Hamilton
Understanding other people have beliefs different from ours or different from reality is critical to social interaction. Previous studies suggest that healthy adults possess an implicit mentalising system, but alternative explanations for data from reaction time false belief tasks have also been given. In this study, we combined signal detection theory (SDT) with a false belief task. As application of SDT allows us to separate perceptual sensitivity from criteria, we are able to investigate how...

I Should Have Known Better: Development of a Self-Report Measure of Gullibility

Alessandra K. Teunisse, Trevor I. Case, Julie Fitness & Naomi Sweller
The aim of this research was to explore the predictors of gullibility and to develop a self-report measure of the construct. In Studies 1 to 3, exploratory and confirmatory factor analyses were conducted on a large pool of items resulting in a 12-item scale with two factors: Persuadability and Insensitivity to cues of untrustworthiness. Study 4 confirmed the criterion validity of the scale using two distinct samples: scam victims and members of the Skeptics Society....

I Should Have Known Better: Development of a Self-Report Measure of Gullibility

Alessandra K. Teunisse, Trevor I. Case, Julie Fitness & Naomi Sweller
The aim of this research was to explore the predictors of gullibility and to develop a self-report measure of the construct. In Studies 1 to 3, exploratory and confirmatory factor analyses were conducted on a large pool of items resulting in a 12-item scale with two factors: Persuadability and Insensitivity to cues of untrustworthiness. Study 4 confirmed the criterion validity of the scale using two distinct samples: scam victims and members of the Skeptics Society....

I Should Have Known Better: Development of a Self-Report Measure of Gullibility

Alessandra K. Teunisse, Trevor I. Case, Julie Fitness & Naomi Sweller
The aim of this research was to explore the predictors of gullibility and to develop a self-report measure of the construct. In Studies 1 to 3, exploratory and confirmatory factor analyses were conducted on a large pool of items resulting in a 12-item scale with two factors: Persuadability and Insensitivity to cues of untrustworthiness. Study 4 confirmed the criterion validity of the scale using two distinct samples: scam victims and members of the Skeptics Society....

Pharmacy students’ beliefs in popular myths about health and therapy

Magdalena Jasińska-Stroschein, Urszula Kurczewska & Daria Orszulak-Michalak
Objective:Pharmacy students are among the next generation of health-care providers who can promote medical knowledge based on scientific data or low-quality health content. Their susceptibility to popular myths related to health and medicine however threatens the proper selection and use of the best available evidence when dealing with patients in community and hospital pharmacies. The objective of this study was to explore such beliefs held by pharmacy students.Methods:A self-administered survey was completed by a sample...

Pharmacy students’ beliefs in popular myths about health and therapy

Magdalena Jasińska-Stroschein, Urszula Kurczewska & Daria Orszulak-Michalak
Objective:Pharmacy students are among the next generation of health-care providers who can promote medical knowledge based on scientific data or low-quality health content. Their susceptibility to popular myths related to health and medicine however threatens the proper selection and use of the best available evidence when dealing with patients in community and hospital pharmacies. The objective of this study was to explore such beliefs held by pharmacy students.Methods:A self-administered survey was completed by a sample...

Environmental competencies for healthcare educators and trainees: A scoping review

Gillian Parker, Whitney Berta, Christine Shea & Fiona Miller
Background:The health-care community has a responsibility to address the environmental impact of delivering health-care services. Educational programmes present ideal fora to confer ‘environmental competencies’ to future health system leaders, managers, practitioners and researchers. The aim of this review is to synthesise the literature on health-care competencies, education and training of relevance to issues of environmental sustainability and climate change in the health sector.Methods:We conducted a systematic review of English language articles on environmental competencies in...

Environmental competencies for healthcare educators and trainees: A scoping review

Gillian Parker, Whitney Berta, Christine Shea & Fiona Miller
Background:The health-care community has a responsibility to address the environmental impact of delivering health-care services. Educational programmes present ideal fora to confer ‘environmental competencies’ to future health system leaders, managers, practitioners and researchers. The aim of this review is to synthesise the literature on health-care competencies, education and training of relevance to issues of environmental sustainability and climate change in the health sector.Methods:We conducted a systematic review of English language articles on environmental competencies in...

Peripheral cannulae selection for veno-arterial extracorporeal life support: a paradox

Yuri M Ganushchak, Eva R Kurniawati, Jos G Maessen & Patrick W Weerwind
Explosive penetration of veno-arterial extracorporeal life support in everyday practice has drawn awareness to complications of peripheral cannulation, resulting in recommendations to use smaller size cannulae. However, using smaller cannulae may limit the effectiveness of extracorporeal support and thereby the specific needs of the patient. Selection of proper size cannulae may therefore pose a dilemma, especially since pressure-flow characteristics at different hematocrits are lacking. This study evaluates the precision of cannula pressure drop prediction with...

Peripheral cannulae selection for veno-arterial extracorporeal life support: a paradox

Yuri M Ganushchak, Eva R Kurniawati, Jos G Maessen & Patrick W Weerwind
Explosive penetration of veno-arterial extracorporeal life support in everyday practice has drawn awareness to complications of peripheral cannulation, resulting in recommendations to use smaller size cannulae. However, using smaller cannulae may limit the effectiveness of extracorporeal support and thereby the specific needs of the patient. Selection of proper size cannulae may therefore pose a dilemma, especially since pressure-flow characteristics at different hematocrits are lacking. This study evaluates the precision of cannula pressure drop prediction with...

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