1,494 Works

Substrates and oxygen dependent citric acid production by Yarrowia lipolytica: insights through transcriptome and fluxome analyses

Wael Sabra, Rajesh Reddy Bommareddy, Garima Maheshwari, Seraphim Papanikolaou & An-Ping Zeng
Unlike the well-studied backer yeast where catabolite repression represents a burden for mixed substrate fermentation, Yarrowia lipolytica, an oleaginous yeast, is recognized for its potential to produce single cell oils and citric acid from different feedstocks. These versatilities of Y. lipolytica with regards to substrate utilization make it an attractive host for biorefinery application. However, to develop a commercial process for the production of citric acid by Y. lipolytica, it is necessary to better understand...

Engineering 'cell robots' for parallel and highly sensitive screening of biomolecules under in vivo conditions

Lifu Song & An-Ping Zeng
Cells are capable of rapid replication and performing tasks adaptively and ultra-sensitively and can be considered as cheap "biological-robots". Here we propose to engineer cells for screening biomolecules in parallel and with high sensitivity. Specifically, we place the biomolecule variants (library) on the bacterial phage M13. We then design cells to screen the library based on cell-phage interactions mediated by a specific intracellular signal change caused by the biomolecule of interest. For proof of concept,...

RUVIVAL Publication Series Volume 2

Ahmad Al Baff, Alejandro Gonzalez Alvarez, Sing Yee Ho, Lukas Huhn, Rahel Birhanu Kassaye, Claudia Lasprilla Pina, Berenice Lopez Mendez, Valerie Mehl, Julia Möller & Ayodeji Oloruntoba
The bimonthly published RUVIVAL Publication Series is part of the e-learning project RUVIVAL. All topics of RUVIVAL Volume 2 are related and part of restoration engineering. Each contribution in this publication is connected to further interactive multimedia material, which can be reached under www.ruvival.de. This volume consists of 3 literature review papers. The first reviews aquifer recharge, a hydrologic process in which water moves from surface water to groundwater. The recharge of an aquifer can...

Eine Methode zur Bewertung von Anlaufrisiken in der Produktentwicklung für die Flugzeugindustrie

Steffen Elstner
In this thesis a methodical support for early identification and minimization of ramp-up risks with the help of response strategies is developed. Therefore the approach is divided into two main phases and focusing on the support of the product development until the transition to production. Within the first phase the identification of potential risk areas will be conducted based on a new impact model. During the second main phase the identified areas will be analyzed...

„How we bec[o]me metadata“ : Beschreiben, Finden, Weitergeben und Verändern von Open Educational Resources (OER)

Thomas Hapke
Metadaten beeinflussen die Qualität des Findens und Nutzens von Open Educational Resources (OER). Aufgrund der Vielfalt der medialen Formate und inhaltlichen Komponenten von OER mit ihrer spezifischen Granularität und ihren Möglichkeiten zum Weiternutzen und Verändern steht die Integration von Metadaten in Informations-Infrastrukturen für OER vor spezifischen Herausforderungen. OER-Metadaten enthalten optimalerweise neben allgemeinen, beschreibenden Elementen auch Daten zu technischen, pädagogischen und rechtlichen Randbedingungen der Nutzung. Gleichzeitig muss die Praktikabilität der Metadaten-Erfassung und -Weitergabe berücksichtigt werden, um...

An adaptive supply chain cyber risk management methodology

Stefan Schauer, Martin Stamer, Claudia Bosse, Michalis Pavlidis, Haralambos Mouratidis, Sandra König & Spyros Papastergiou
Maritime information infrastructures have developed to highly interrelated cyber ecosystems, where ports as well as their partners are connected in dynamic Information and Communication Technology (ICT)-based maritime supply chains. This makes them open and vulnerable to the rapidly changing ICT threat landscape. Hence, attacks on a seemingly isolated system of one business partner may propagate through the whole supply chain, causing cascading effects and resulting in large-scale impacts. In this article, we want to present...

Life cycle assessment for frozen food distribution schemes

Markus Trapp, Michael Lütjen, Juan Daniel Arango Castellanos, Oliver Jelsch & Michael Freitag
The online grocery market is facing big challenges. In addition to products for daily use, it is necessary to deliver fresh, chilled and frozen foods quickly and reliably to the customer. For decades frozen products have been delivered to the customers by using small cooling vans. Since some years, also normal parcel delivery services in combination with insulated shipping containers have been used. This article examines in a comparative analysis the environmental impact based on...

Literature classification on dispatching of container terminal vehicles

Anne Schwientek, Ann-Kathrin Lange & Carlos Jahn
Horizontal transport on container terminals represents the interface between quay and yard. Efficient transport operations are essential to improve performance and productivity. Thereby, one main decision problem is dispatching the vehicles. Despite the large amount of literature in this field, there is no classification or survey of the respective literature. Based on an extensive survey of dispatching literature published between 2000 and 2016, a classification scheme is developed and applied to 81 scientific publications. The...

Literature review of drivers of sustainable supply chain management

Muhammad Amad Saeed, Ishfaque Waseek & Wolfgang Kersten
The incremental awareness regarding social and environmental issues has pushed organizations to adopt sustainable practices. Over the last few years, organizations are considered to be responsible for their business activities that affect the environment, society, and the economy of their own business as well as their supply chain participants. Different stakeholders pressurize organizations and their supply chains to follow sustainable actions in order to achieve sustainable supply chain management (SSCM) goals. However, not all stakeholders...

Topical map for continuing education: AHP expert survey

Thomas Neukirchen & Matthias Klumpp
This contribution presents an analysis of recent trend topics in logistics and supply chain management with a focus on education and training on the job, applying an Analytic Hierarchy Process (AHP).Based on a comprehensive literature survey for the identification of trends that have persisted over the ten years considered (2005-2015), expert interviews have been conducted, aggregated and evaluated with an AHP. The particular context for this contribution is the research project MARTINA, which is concerned...

Assessing and improving countries’ logistics skills and training

Alan C. McKinnon, Kai Hoberg, Moritz Petersen & Christina Busch
Evidence is mounting to suggest that there is a global shortage of people with the right skills to meet the evolving needs of the logistics industry. Especially emerging regions are lagging behind, inhibiting economic growth. Thus, governments should systematically assess and address skills shortages in logistics. Commissioned by the World Bank, we devised a toolkit for assessing the availability of logistics skills within low- and middle-income countries. We built on the maturity model concept and...

Utility evaluation of battery electric vehicles in urban distribution

Dustin Schöder
Utilizing battery electric vehicles in daily distribution operations of logistics service providers and freight forwarders goes along with major uncertainties for companies. There is no mechanism how to evaluate the technical and economical use of battery electric vehicles in companies use cases and processes in status quo in contrast to vehicles with an internal engine. This paper adopts an evaluation mechanism from literature, which is bases on a value benefit analysis with compensation factors, and...

Reducing truck congestion at ports – classification and trends

Ann-Kathrin Lange, Anne Schwientek & Carlos Jahn
Truck drayage in container ports faces several challenges. Due to the ongoing growth of container ship sizes, there are increasingly high peak situations in landside container handling at logistic nodes in the port, e.g. container terminals, empty depots, freight stations. In combination with rising demands to improve the port’s ecological footprint this requires the port and its companies to adapt to the situation in order to reduce congestion. To identify important methods, key parameters, past...

Digitalization of logistics processes and the human perspective

Adina Silvia Kuhlmann & Matthias Klumpp
This contribution presents an analysis of the increasing consequences of digitalization with a focus on self-monitoring of personnel in logistics and production processes. This is of interest as digitalization requires large-scale innovative implementation and change management approaches in logistics and production processes. Based on standard DIN ISO 10.075 (’risk assessment’) an applicationoriented instrument is developed to evaluate und test new job systems, which are impacted by digitalization. This enables the development of digitalization strategies and...

Interactive planning and control for finished vehicle logistics

Marit Hoff-Hoffmeyer-Zlotnik, Susanne Schukraft, Dirk Werthmann, Stephan Oelker & Michael Freitag
Logistic processes on sea and inland ports play an important role in the context of finished vehicle logistics as the vehicles are turned over for import and export here. Due to increasing dynamics and complexity, the planning and control of these processes requires high flexibility and reactivity. For example, changing dealer demands or delays of trucks, trains and ships may require a short-term replanning of the logistics processes on sea and inland ports. In this...

Production flow valuation through VSM modeling : an industry case study

Andrés Felipe Santos Hernández & Angel David Camargo Puentes
A special combination of lean methodologies and modeling of industrial processes has been increasingly used in the last decade between University and Industry. With lower costs, knowledge in lean tools and innovation in simulation packages, manufacturing has improved its practices in the flow of their processes detecting aggregate value. The research team describes a case in which a glove manufacturing production line and its Value Stream Mapping are simulated at the same time. The purpose...

Waste management scenario in Bangalore : scope for in-situ valorisation of biowaste

Sreenivasan Ramaswami
Due to unplanned rapid urbanisation since the last two decades, the municipality of Bangalore (Bengaluru) struggles to provide adequate waste management (WM) services in the city. In December 2015, as a measure to facilitate semi-centralised treatment, the Karnataka High Court ordered the Bengalureans to segregate waste at source. This study unveils the status quo of solid WM in Bengaluru and investigates the scope for treatment of biowaste at household level. Public awareness on and their...

Optimizing distribution logistics within cities through time-slot deliveries

Tobias Engel, Thomas Wolfenstetter & Nikolaos Sakiotis
Technological evolvement creates new business opportunities such as the optimization of distribution networks by using big data to calculate optimal delivery routes respecting individual time windows. The optimized network enhances firms to improve customer satisfaction, reduce delivery costs, and increase the utilization of the truck load by integrating reverse flows. Following the design science approach, we review and evaluate relevant data and scientific theories. Subsequently, requirements and system design are analyzed. On this basis we...

Comparative analysis of synchromodality in major European seaports

Katrin Brümmerstedt, Hendrik Meyer-Van Beek & Torsten Münsterberg
Global container throughput recorded a substantial growth over the past 25 years. The ports of Rotterdam, Hamburg and Antwerp have benefited greatly from this development. At the same time rapid increases can be observed for the dimensions of container vessels calling these ports. In 2005 the average capacity of container vessels in operation between Northern Europe and Far East amounted to 6,000 TEU. Today market actors already talk about container vessels with a capacity of...

Digitized VMI – maturity model for the FMCG sector

Johannes Dirnberger, Uwe Brunner & Helmut Zsifkovits
Optimized stocks and lean processes are prerequisites in order to keep up with the increasing consumption of goods and limited storage areas in cities due to urbanization. This paper, therefore, develops a maturity model to increase the dissemination rate of Digitized VMI to optimize supply chains in the FMCG sector. Firstly, criteria for successful VMI application are identified by literature research and expert interviews. Moreover, the respective target state descriptions are defined. Secondly, an assessment...

Smart logistics of organic waste collection in cities

Lorena Bearzotti, Javier Maturana & Maria Isabel Vega
Waste management is a growing problem all around the world with implications to society, environment, health and economy. In this context, the waste is considered as the last step in the consuming process. However, a smart waste management is possible by the generation of value from the garbage and the optimization of collection routes, landfills location and the determination of the transport fleet. This article addresses the problem of value generation from organic waste in...

Simulation of climatic effects on temperature-controlled containerized cargo

Sergio Barbarino, Oliver Klein, Rainer Müller, Cory Rosa, Philippe Sibomana & Alex Wunsch
This paper describes the so-called CORE Simulation Environment (CORE-SE), a scenario based simulation environment which was developed in the scope of the EU project CORE. CORE-SE in particular provides means for the simulation of logistics scenarios. It consists of a software agent platform that facilitates a multiagent-based simulation (MABS) approach. In MABS, the environment and the objects acting therein are modelled by a number of software agents. CORE-SE provides a platform to create and configure...

IoT-coordinated logistics in product-service systems

Jürgen Anke
Product-Service Systems (PSS) enable new value to customers compared to traditional selling of goods, e.g. through new business models such as Performancebased contracting (PBC) and Pay-per-use (PPU). This turns the manufacturer into a service provider, which has to perform maintenance, repair and operation (MRO) tasks for the products provided in a PSS. Therefore, the service provider must organize the logistics of the equipment, spare parts, and consumables in a timely manner. In this paper, we...

A peer-to-peer platform for decentralized logistics

Olivier Gallay, Kari Korpela, Niemi Tapio & Jukka K. Nurminen
We introduce a novel platform for decentralized logistics, the aim of which is to magnify and accelerate the impact offered by the integration of the most recent advances in Information and Communication Technologies (ICTs) to multi-modal freight operations. The essence of our peer-to-peer (P2P) framework distributes the management of the logistics operations to the multiple actors according to their available computational resources. As a result, this new approach prevents the dominant players from capturing the...

Data source taxonomy for supply network structure visibility

Johannes Zrenner, Ahmad Pajam Hassan, Boris Otto & Jorge Marx Gómez
The supply network structure of manufacturers is complex and non-transparent. In order to achieve a higher visibility and consequently increase the performance, the existing lack of data has to be closed. This paper answers the questions, how to identify, describe and compare suitable data sources for an end-to-end visibility. Following the design science research process, two artifacts are developed based on conceptual-to-empirical approaches. The initial conceptualizations result from literature reviews. The conceptual representation of supply...

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