124 Works

Dosage matters – Tramadol applied via the drinking water for pain management in a mouse-osteotomy model

Annemarie Lang
Fracture healing disorders occur in approximately 10% of human patients and cause severe pain and reduced quality of life. To develop and test new therapeutic strategies, the mouse is a frequently used laboratory animal in bone healing research. Stable fixated osteotomies lead to moderate strain for the animals. However, the identification and assessment of pain and strain in the mouse is still challenging. In addition, the selection of analgesics in bone healing models is restricted...

Allocated ICD-10 codes to each NTS submitted to AnimalTestInfo in 2014 and 2015

Bettina Bert, Antje Doerendahl, Nora Leich, Julia Vietze, Matthias Steinfath, Justyna Chmielewska, Andreas Hensel, Barbara Grune & Gilbert Schoenfelder
The AnimalTestInfo database was developed in Germany to make non-technical summaries (NTSs) available in a searchable, web-based format in order to address the requirements stipulated in the European Directive 2010/63/EU regarding transparency and publication of animal experiments. In our meta-analysis, we classified duly completed NTSs submitted in 2014 and 2015 to AnimalTestInfo according to the ‘International Classification of Diseases and Related Health Problems’ (ICD) system. This dataset contains the allocated ICD-10 codes for each NTS...

Antibiotika und Antibiotikaresistenzen im Spiegel der Medien: Eine Analyse der Medienberichterstattung 01/2008 – 02/2015

Epp, A. (BfR), Lohmann, M. (BfR), Boel, G.-F. (BfR), Hoffmann, P. Und Numrich, O. (Preceptor Medienforschung & Beratung)

Social enrichment by partner-housing of C57BL/6JRj mice

Kristina Ullmann
Due to aggression or experimental conditions, mice are often housed individually, though social isolation causes welfare issues and differences in behaviour. To provide social enrichment for individually housed mice, we will separate two mice for 8 weeks in cages divided by transparent, perforated walls allowing sensory contact.The effects on partner-housing on behaviour and stress hormones will be compared with data obtained from single- and group-housed mice. Besides comfort behaviour, we will assess anxiety-related behaviour and...

Dataset from Martin, A, Gremse, C, Selhorst, T, Bandick, N, Müller-Graf, C, Greiner, M, Lahrssen-Wiederholt, M. 2017 Hunting of roe deer and wild boar in Germany: Is non-lead ammunition suitable for hunting? Plos One

Annett Martin, Carl Gremse, Thomas Selhorst, Niels Bandick, Christine Müller-Graf, Matthias Greiner & Monika Lahrssen-Wiederholt
The data are part of the research project on the topic “Safety of game meat obtained through hunting (LEMISI)”. On behalf of the Federal Ministry of Food and Agriculture (BMEL), the Federal Institute for Risk Assessment (BfR) collected the data jointly with the responsible authorities of the Federal States of Saxony-Anhalt, Mecklenburg-Western Pomerania, Lower Saxony, Hesse and Bavaria. The project was supported by various institutions such as the German Hunting Association (DJV), the Bavarian Hunting...

Scaling of preferences for different liquids by means of binary choice tests in mice.

Lars Lewejohann
The overall aim is to develop a scaling, which allows to rate certain goods against each other in order to conduct severity assessment for future animal experiments. In this experiment mice will choose between various liquids that will be tested against each other in binary preference tests. The preference will be measured by means of a modified two bottle choice test which will be conducted in the IntelliCage. The tested liquids are 10 mM HCl,...

Non-technical Summaries (NTS) of Animal Experiments Indexed with ICD-10 Codes (Version 1.0)

Mariana Neves, Daniel Butzke, Antje Dörendahl, Nora Leich, Barbara Grune & Gilbert Schönfelder
Dataset containing 8,386 non-technical summaries (NTS) of animal experiments recently carried out in Germany (as of September 19, 2018) and originally on-line available at the AnimalTestInfo database (http://animaltestinfo.de). Each NTS contains a title, uses (goals) of the experiments, possible harms caused to the animals, and comments about replacement, reduction and refinement (in the scope of the 3R principles). All documents are in the German language. The dataset includes the ICD-10 codes manually assigned by experts...

Severity assessment of experimental procedures by means of conditioned place preference/aversion - improving the procedure

Lars Lewejohann
It has been proposed to use conditioned place aversion and place preference tests to assess the severity of different experimental procedures and behavioural tests. However, this method was not used in this context before. After first experiments (see DOI: 10.17590/asr.0000112) we will now conduct further experiments to improve the procedure. For this, two experimental procedures (unconditioned stimuli) are paired with two kinds of flooring (neutral stimuli becoming conditioned stimuli). After conditioning, the flooring materials will...

Procedure for indexing NTS with ICD-10 codes, published in German

Bettina Bert, Antje Doerendahl, Nora Leich, Julia Vietze, Matthias Steinfath, Justyna Chmielewska, Andreas Hensel, Barbara Grune & Gilbert Schoenfelder
The general public shall be informed about planned animal experiments by non-technical summaries (NTSs) as stipulated in the European Directive 2010/63/EU. In Germany, NTS are made available in the searchable, web-based database AnimalTestInfo. In our meta-analysis, we classified duly completed German NTSs submitted in 2014 and 2015 to AnimalTestInfo according to the ‘International Classification of Diseases and Related Health Problems’ (ICD) system. Here, we present the standardised procedure for indexing NTSs with ICD-10 codes in...

Severity assessment of experimental procedures by means of conditioned place preference/aversion

Lars Lewejohann
It has been proposed to use conditioned place aversion and place preference tests to assess the severity of different experimental procedures and behavioural tests. However, this method was not used in this context before, and thus, a first study shall be conducted to test the applicability. Here, four experimental procedures (unconditioned stimuli) are paired with four kinds of bedding material (neutral stimuli becoming conditioned stimuli). After conditioning, the bedding materials will be tested in conditioned...

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