205 Works

A database of radionuclide biological half-life values for wildlife

Jacky Chaplow
Data comprise biological and ecological half-life values for marine, freshwater, terrestrial and riparian organisms. The database includes 1908 biological half-life values for 52 elements across a range of wildlife groups (marine, freshwater, terrestrial and riparian). The compilation of values from a range of sources was conducted by an international working group under the auspices of an International Atomic Energy Agency programme. radioecology

Proteome analysis of irradiated endothelial cells reveals persistent alteration of RhoGDI and NO signalling pathways

Omid Azimzadeh
Background: Recent epidemiological studies indicate that radiation doses as low as 0.5 Gy may increase the risk of cardiovascular disease. The aim of the present study was to investigate whether this radiation dose causes molecular alterations in endothelial cells that could support the suspicion of low-dose cardiovascular risk raised by population studies. Materials and Methods: Radiation-induced changes in the proteome of human coronary artery endothelial cell line were analysed using triplex isotope-coded protein labelling technology...

Radioecology data for wildlife and human assessments (UK)

Jacky Chaplow
Data comprise: Observations of Fukushima fallout in Great Britain, Element and radionuclide concentrations in representative species of the ICRP's Reference Animals and Plants and associated soils from a forest in north-west England, Exposure of burrowing mammals to Radon Rn-222 in Northwest England, Natural radionuclide concentrations in soil, water, sediment and biota in England and Wales, A database of radionuclide biological half-life values for wildlife, Post Chernobyl surveys of radiocaesium in soil, vegetation, wildlife and fungi...

Single Dose Fe Ion Irradiation Highlights the Radiation Quality Dependent Nature of the Endothelial Cell Response to Ionizing Radiation Exposure

Omid Azimzadeh
Background and Purpose. Radiotherapy is an essential tool for cancer treatment. In order to spare normal tissue and to reduce the risk of normal tissue complications, particle therapy is a method of choice. Although a large part of the healthy tissue can be spared due to improved depth dose characteristics, little is known about the underlying biological and molecular mechanisms of particle irradiation in healthy tissues, such as the vasculature. Elucidation of these vascular effects...

Spatial datasets of radionuclide contamination in the Ukrainian Chernobyl Exclusion Zone

Jacky Chaplow
Data comprise radionuclide deposition, radioactivity dose measurements, radioactive particle activity and physical characteristic information from soil samples collected within and around the Chernobyl Exclusion Zone (CEZ) following the Chernobyl nuclear accident in 1986. Data include radiocaesium, radiostrontium and soil chemistry parameters from soils collected in 1997, plutonium isotope measurements in soil samples and soil layers collected in 2000 and 2001, ‘Hot particle’ dataset presenting radionuclide activity and some physical characteristics of ‘hot particles’ extracted from...

Comparative Radiosensitivity of Developing Brain Structures in the Rat After Gamma Irradiation

Michael Gruenberger
Purpose: To compare the radiosensitivities of proliferative layers of the olfactory bulb (OB), the dentate gyrus of the hippocampus (DG) and the cerebellum (C) Status: 1990 - 1992, terminated Treatment: Single whole body gamma irradiation with doses from 0.1 to 12 Gy (dose rate 0.19 Gy/min) from a Co-60 gamma source irradiation. Animals sacrificed and brains removed 3, 6 or 9 h after exposure Dosimetry: Ionization chamber Endpoints: Quantification of radiation-induced apoptosis in semi-thin sections,...

Regional Gamma Irradiation of Pigs

Michael Gruenberger
Purpose: To study the gastro-intestinal syndrome in pigs exposed to the posterior part of the body with the aim to improve the management of accidental over-exposure in man. Status: 1970 - 1978, terminated Treatment: Single partial body irradiation of the posterior half part of the body of pigs from the xyphoid appendix downwards; the upper part of the body was shielded with lead plates. The midplane dose from eight Co-60 sources delivered at dose rates...

Low-dose radiation differentially regulates protein acetylation and histone deacetylase expression in human coronary artery endothelial cells

Zarko
Ionizing radiation induces cardiovascular disease, the endothelium being the main target. The exact mechanism of the damage is unclear but the involvement of multiple signaling pathways is probable. Reversible lysine acetylation is a posttranslational protein modification that regulates activity across a broad range of signaling pathways. The goal of this study was to determine if a low radiation dose (0.5 Gy) results in acetylome alteration in a human coronary artery endothelial cell line. Nearly a...

Radiation alters the cargo of exosomes released from squamous head and neck cancer cells to promote migration of recipient cells

Omid Azimzadeh
Radiation is a highly efficient therapy in squamous head and neck carcinoma (HNSCC) treatment. However, local recurrence and metastasis are common complications. Recent evidence shows that cancer-cell-derived exosomes modify tumour cell movement and metastasis. In this study, we link radiation-induced changes of exosomes to their ability to promote migration of recipient HNSCC cells. We demonstrate that exosomes isolated from irradiated donor cells boost the motility of the HNSCC cells BHY and FaDu. Molecular data identified...

Elemental and radionuclide concentrations for several vegetation species from a site in Extremadura, Spain

Jacky Chaplow
Data comprise elemental and radionuclide concentrations in freeze-dried Mediterranean plants, seeds and oven dried soil. The samples were collected in June 2014 along a transect located in the Monfragüe National Park which is within the province of Cáceres, western Spain (start: N 33° 49' 47.2'', W 006° 01' 55.4'', end: N 390 49'46.8'', W 0060 02' 05.1'' (geocentric World Geodetic System 1984 (GPS WG 884)). Thirty plant species (Agrostis pourretii; Campanula rapunculus; Taraxacum sp.; Taraxacum...

Effect of Paternal Exposure to Pu-239 on the Incidence of Cancer

Michael Gruenberger
Purpose: To determine whether internal contamination with Pu-239 increases the incidence of cancer, in particular leukemias, in the F1 generation of CBA mice. Status: 1993 - ongoing Treatment: Intravenous injection with Pu-239 citrate or trisodium citrate of male mice. After 54 days, each male was mated with 2 females for up to 2 weeks and the offspring was followed for a life-time Dosimetry: Amount injected, determination of Pu-239 in tissues of the injected males including...

Observations of Fukushima fallout in Great Britain

Jacky Chaplow
Following the Fukushima accident in March 2011, grass samples were collected from 42 sites around Great Britain during April 2011. Iodine-131 was measurable in grass samples across the country with activity concentrations ranging from 10 to 55 Bq per kg dry matter. Concentrations were similar to those reported in other European countries. Rainwater and some foodstuffs were also analysed from a limited number of sites. Of these, I-131 was only detectable in sheep's milk (c....

Long-term Survival and Tumor Induction After Exposure to High- and Low-LET Radiation

Michael Gruenberger
Purpose: To investigate the influence of sex on long-term survival and tumor induction after exposure to high- and low-LET radiation Status: 1989- 1993 terminated Treatment: Single exposure to 250 kVp X-rays (126 mGy/min, 1.5 mm HVL) or fission neutrons (0.4 MeV, doses of 0.1 and 0.2 Gy given at a dose rate of 0.08 Gy/min, larger doses at 0.18 Gy/min) from the biological facility of the RSV-TAPIRO reactor at Casaccia. Dosimetry: Twin ionization chamber method,...

Spatial datasets of radionuclide contamination in the Ukrainian Chernobyl Exclusion Zone

Jacky Chaplow
Data comprise radionuclide deposition, radioactivity dose measurements, radioactive particle activity and physical characteristic information from soil samples collected within and around the Chernobyl Exclusion Zone (CEZ) following the Chernobyl nuclear accident in 1986. Data include radiocaesium, radiostrontium and soil chemistry parameters from soils collected in 1997, plutonium isotope measurements in soil samples and soil layers collected in 2000 and 2001, ‘Hot particle’ dataset presenting radionuclide activity and some physical characteristics of ‘hot particles’ extracted from...

miRNA profile of extracellular vesicles isolated from bone marrow following in vivo irradiation

Katalin Lumniczky
Male C57Bl/6 mice were irradiated with low and high dose X-ray irradiation. Mice were sacrificed 24 hours later and bone marrow-derived extracellular vesicles were isolated and microRNAs prepared. A miRNA profiling was performed by Exiqon (Vedbaek, Denmark), using qPCR panel with the miRNA Ready-to-Use PCR, Mouse&Rat panel I+II using ExiLENT SYBR® Green master mix. The amplification was performed in a LightCycler® 480 Real-Time PCR System (Roche) in 384 well plates The amplification curves were analysed...

The role of PPAR alpha in radiation induced heart disease

Vikram Subramanian
The PPAR alpha, important regulator of fatty acid metabolism in heart shown to be involved in development of cardiovascular disease. The radiation induced impairment of fatty acid metabolism was observed due to increased phosphorylation of PPAR alpha that leads to reduction in the expression of key proteins involved in fatty acid oxidation and transport with 16 Gy irradiation after 16 weeks and 40 weeks in C57BL/6J mice. The aim of our present study is to...

Tumours and Lifespan in Rats After Irradiation From Neutrons or Co-60 Gamma Rays and Treatment with Chemicals

Michael Gruenberger
Purpose: To evaluate the influence of cofactors on the effects from Triton neutrons or gamma rays. Status: 1982 - 1985, terminated; data in ERAD except for unavailable groups indicated in italics Treatment: Exposure at the TRITON facility (fission neutrons 0.01-0.1 Gy/h) Silène reactor: see under 02.12 Co-60 source: (0.12 Gy/min) Dosimetry: Neutrons: Carbon coated ionization chamber, Gamma source: Ionization chamber Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology Animal: Male Sprague-Dawley SPF rats at an...

3-generation Exposure Study

Paul Schofield
The Semipalatinsk nuclear test site (STS) is located approximately 150 km west of the city of Semipalatinsk (now called Semey), and was a major site for nuclear weapons testing by the former Soviet Union. It was here that the Soviet Union conducted their first nuclear test on 29 August 1949. Later, 465 nuclear explosions were carried out between 1949 and 1989, including 118 atmospheric events (88 air events and 30 surface events) from 1949-1962. The...

Observations of Fukushima fallout in Great Britain

Jacky Chaplow
Following the Fukushima accident in March 2011, grass samples were collected from 42 sites around Great Britain during April 2011. Iodine-131 was measurable in grass samples across the country with activity concentrations ranging from 10 to 55 Bq per kg dry matter. Concentrations were similar to those reported in other European countries. Rainwater and some foodstuffs were also analysed from a limited number of sites. Of these, I-131 was only detectable in sheep's milk (c....

Cardiac mitochondrial acetylome after chronic TBI

Omid Azimzadeh
ABSTRACT Epidemiological studies show that irradiation increases the risk of cardiovascular disease decades after the exposure. Alteration in cardiac energy metabolism has been suggested to contribute to radiation-induced heart pathology. A hallmark of this radiation-associated metabolic impairment is mitochondrial dysfunction and deactivation of the transcription factor PPAR alpha. The goal of this study was to investigate the role of acetylation in heart mitochondria in the long-term response to chronic radiation. ApoE-deficient (ApoE-/-) C57Bl/6J mice were...

Air sampe archive from STAR Partners

Paul Schofield
The STAR Network of Excellence holds a variety of samples from the terrestrial and aquatic environment, and samples from a variety of air samplers collected by various methods. The linked table provides a summary of what is currently accessible and the contact details of the person responsible for the samples. https://radioecology-exchange.org/sites/default/files/Air_sample%20archives.xlsx

Elemental concentrations in representative species of the ICRP's Reference Animals and Plants and associated soils in terrestrial Mediterranean ecosystems in Spain

Jacky Chaplow
Data comprise stable element concentrations in terrestrial Reference Animals and Plants (RAPs) and corresponding whole-body concentration ratios determined in two different Mediterranean ecosystems: a Pinewood and a Dehesa (grassland with disperse tree cover). The International Commission on Radiological Protection (ICRP) RAPs considered in the Pinewood ecosystem were Pine Tree and Wild Grass; whereas in the Dehesa ecosystem those considered were Deer, Rat, Earthworm, Bee, Frog, Duck and Wild Grass. The data include: elemental concentrations in...

Element and radionuclide concentrations in representative species of the ICRP's Reference Animals and Plants and associated soils from a forest in north-west England

Jacky Chaplow
This dataset presents the results of an initial sampling exercise conducted at a terrestrial site in northwest England in summer 2010. The following samples of terrestrial Reference Animals and Plants (RAPs) were obtained from an area of circa 0.4 km squared: Molinia caerulea (ICRP RAP Wild Grass defined as Poaceae); Picea sitchensis (ICRP RAP Pine Tree defined as Pinaceae); Apis spp., Bombus spp., Nomada spp. (ICRP RAP Bee defined as Apidea); Apodemus sylvaticus (ICRP RAP...

Thyroid diseases near Semipalatinsk Nuclear Test Site - Data

Bernd Grosche
A description of the study is given in STOREDB:STUDY1008 (http://dx.doi.org/doi:10.20348/STOREDB/1108) . The data stored here include all the EXCEL and SPSS system files that were relevant for preparing the data used for Grosche et al., 2017 (http://www.storedb.org/store_v3/download.jsp?fileId=11331) . The steps taken for data preparation are described in http://www.storedb.org/store_v3/download.jsp?fileId=11333, the codebook is given in http://www.storedb.org/store_v3/download.jsp?fileId=11334. The original data set, including information of all 1,287 examinations which were carried out among 1,067 study participants is available in...

Registration Year

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  • 2019
    36

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