179 Works

Lung Tumours in Rats After Inhalation of Actinides

Michael Gruenberger
Purpose: To assess the risks of lung tumors after inhalation of different alpha-emitting actinides and help to understand the problem of "hot spots" Status: 1965 - 1975, terminated; data in ERAD. Treatment: Inhalation, intramuscular (IM) or intravenous (IV) injection of Th-227 (chloride) Pu-238 (oxide and nitrate), Pu-239 (oxide and nitrate), Am-241, (oxide and nitrate), Cm-244 (nitrate) with or without cofactor. Dosimetry: Activity inhaled, activity retained, calculated average lung doses for a group. Endpoints: Life-span study...

Tumours and Lifespan in Rats After High and Low Dose Rate Gamma Irradiation

Michael Gruenberger
Purpose: To determine the dose rate reduction factor for gamma irradiation Status: 1979 - 1985, data in ERAD Treatment: Exposure to a Co-60 gamma source Dosimetry: Ionization chamber Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology Animal: Male Sprague-Dawley SPF rats aged 3 months, controls see 02.01

3-generation Exposure Study

Paul Schofield
The Semipalatinsk nuclear test site (STS) is located approximately 150 km west of the city of Semipalatinsk (now called Semey), and was a major site for nuclear weapons testing by the former Soviet Union. It was here that the Soviet Union conducted their first nuclear test on 29 August 1949. Later, 465 nuclear explosions were carried out between 1949 and 1989, including 118 atmospheric events (88 air events and 30 surface events) from 1949-1962. The...

Rotterdam mouse study - synaptogenesis

Stefan J. Kempf
null

Elemental concentrations in fish from lakes in Northwest England

Jacky Chaplow
Data comprise concentrations of elements in ashed fish sampled from lakes in the English Lake District in 2012 and 2013. Fish were collected from three lakes (Windermere, Bassenthwaite Lake and Derwent Water) by the Centre for Ecology Hydrology (CEH) Lake Ecosystems group. Fish species collected were Roach (Rutilus rutilus), Perch (Perca fluviatilis), Ruffe (Gymnocephalus cernuus), Brown trout (Salmo trutta), Pike (Esox lucius) and Vendace (Coregonus albula). All samples were ashed prior to analysis by ICPMS...

Ovarian tumours in mice after X-ray and neutron exposure

Michael Gruenberger
Purpose: To determine the dose relationship and RBE for ovarian murine tumors after X-ray and neutron exposure. Status: 1982 - 1987, terminated, data in ERAD Treatment: Single acute exposure to 250 kVp X-rays (1.5 mm HVL, 60 mGy/min) or 1.5 MeV neutrons from a van de Graaff accelerator at the JRC Ispra (1.83 mGy/min) Dosimetry: Twin ionization chamber method, ENDIP Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology Animal: Female (C57Bl/Cne x C3H/Cne)F1 (BC3F1) mice...

Radiation-induced Endothelial Inflammation is Transferred via Secretome to Recipient Cells in a STAT-Driven Process

Jos
Irradiation is the most common treatment of cancer. However, minimizing the normal tissue injury, especially the damage to vascular endothelium, still remains a challenge. This study aimed to analyze direct and indirect radiation effects by investigating mechanisms of signal transfer from irradiated to non-irradiated endothelial cells by means of secreted proteins. It is known that human coronary artery endothelial cells (HCAECest2) undergo radiation-induced senescence 14 days post-exposure to 10 Gy X-rays. Proteomics analysis was performed...

Radionuclide data for vertebrates in the Chernobyl Exclusion Zone

Jacky Chaplow
Data comprise radionuclide concentrations in soils and a range of terrestrial vertebrate species (reptiles, small mammals and birds) sampled in the Chernobyl Exclusion Zone (CEZ) between 1999 and 2008. Reptiles were collected in 1999, 2000, 2001, 2003 and 2007, birds, bats, and small mammals were collected in 2004, 2005, 2007 and 2008. Dose rate data are provided for one study, both as ambient dose rate measurements and also as recorded by thermoluminescent dosimeters attached to...

A dose-dependent perturbation in cardiac energy metabolism is linked to radiation-induced ischemic heart disease in Mayak nuclear workers

Paul Schofield
Epidemiological studies show a significant increase in ischemic heart disease (IHD) incidence associated with total external gamma-ray dose among Mayak plutonium enrichment plant workers. Our previous studies using mouse models suggest that persistent alteration of heart metabolism due to the inhibition of peroxisome proliferator-activated receptor (PPAR) alpha accompanies cardiac damage after high doses of ionising radiation. The aim of the present study was to elucidate the mechanism of radiation-induced IHD in humans. The cardiac proteome...

Mayak Nuclear Workers; proteomics on left ventricle

Omid Azimzadeh
A Dose-dependent Perturbation in Cardiac Energy Metabolism is Linked to Radiation-induced Ischemic Heart Disease in Mayak Nuclear Workers Background - Epidemiological studies show a significant increase in ischemic heart disease (IHD) incidence associated with total external gamma-ray dose among Mayak plutonium enrichment plant workers. Our previous studies using mouse models suggest that persistent alteration of heart metabolism due to the inhibition of peroxisome proliferator-activated receptor (PPAR) alpha accompanies cardiac damage after high doses of ionising...

Liver and Spleen Tumours in Rats After Injection of Th-230 Enriched Thorotrast

Michael Gruenberger
Purpose: To determine the respective roles of the radioactive and chemical component in Thorotrast gel-induced tumours, alpha radioactivity in Thorotrast was enriched about 50 times by addition of Th-230. Status: 1975-1979, terminated Treatment: Single i.v. injection with different amounts of variously enriched Thorotrast (see below) Dosimetry: Activity delivered Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology Animal: Female Wistar rats aged 12±2 weeks at injection. Results: The number of animals that developed liver or spleen...

Elemental and radionuclide concentrations for several vegetation species from a site in Extremadura, Spain

Jacky Chaplow
Data comprise elemental and radionuclide concentrations in freeze-dried Mediterranean plants, seeds and oven dried soil. The samples were collected in June 2014 along a transect located in the Monfragüe National Park which is within the province of Cáceres, western Spain (start: N 33° 49' 47.2'', W 006° 01' 55.4'', end: N 390 49'46.8'', W 0060 02' 05.1'' (geocentric World Geodetic System 1984 (GPS WG 884)). Thirty plant species (Agrostis pourretii; Campanula rapunculus; Taraxacum sp.; Taraxacum...

Effects of Prenatal and Postnatal Gamma Irradiation on the Rat Testis

Michael Gruenberger
Purpose: To determine the effect of acute irradiation during gestation and the neonatal period and of protracted exposure during the entire intra-uterine life on adult rat testis: influence of dose rate and threshold values. Status: 1977 - 1988, terminated Treatment: Acute and protracted Co-60 gamma irradiation: acute exposure to doses from 0 to 1.5 Gy at different dose rates on day 15 and 21 of gestation and day 0 and 2 of postnatal life. A)...

CONFIDENCE FDMT implementation in ECOLEGO

Jacky Chaplow
The ECOSYS-87/FDMT model has been successfully transferred to the ECOLEGO modelling platform. Data have been collated, primarily for element-dependent/radioecological parameters such as, soil to plant transfer factors and animal to feed transfer coefficients, to provide a ‘current state-of the-art’ update to the original ECOSYS-87/FDMT model. Unlike previous considerations of this model we have also collated underlying statistical information for parameters that enable uncertainty and sensitivity analysis. The Excel files available here present the parameters as...

Tumours and Lifespan in Rats After Treatment with Chemicals

Michael Gruenberger
Purpose: To evaluate the induction or promotion effect of inhalation (or injection) alone and together with -naphthoflavone as promotor. Status: 1977 - 1985, terminated; data in ERAD Treatment: Various chemicals inhaled or injected as indicated on the table Dosimetry: Amounts inhaled or injected Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology Animal: Male Sprague-Dawley SPF rats at an age of 3 months; for untreated controls see 02.01, controls treated with BNF only see 02.04 Results:...

A database of radionuclide biological half-life values for wildlife

Jacky Chaplow
Data comprise biological and ecological half-life values for marine, freshwater, terrestrial and riparian organisms. The database includes 1908 biological half-life values for 52 elements across a range of wildlife groups (marine, freshwater, terrestrial and riparian). The compilation of values from a range of sources was conducted by an international working group under the auspices of an International Atomic Energy Agency programme. radioecology

Lung Tumors following Low-level Radon Exposure at Different Exposure Rates

Michael Gruenberger
Purpose: To study lung cancer risks under conditions simulating the situation in mines and highly exposed homes. Status: 1996-2002, data in ERA. Treatment: Inhalation of radon (0.1-0.3 μm AMAD 6.2% unattached) daily exposure for 6 hours 5 times per week as indicated under experimental groups. Endpoints: Life-span study (spontaneous death, some animals sacrificed) with macroscopic/microscopic pathology of the lung. Animal: Male Sprague-Dawley rats of different ages

Brain Damage in 90 Day-old Rats Exposed During the Entire Gestation to Co-90 Gamma Rays or Cf-252 Neutrons At Different Dose Rates

Michael Gruenberger
Purpose: To determine the effect of dose rate and relative biological efficiency of neutron vs gamma irradiation for protracted, in utero exposure Status: 1989 - 1992, terminated Treatment: Protracted Co-60 gamma irradiation and Cf-252 neutrons plus gamma (ratio 2/1) irradiation at different dose rates delivered over the entire gestation Dosimetry: Gamma: ionization chamber; neutrons: ionization chamber filled with circulating tissue-equivalent gas Endpoints: Early and late effects on brain weight and late effects on brain histology...

Radioecology data for wildlife and human assessments (UK)

Jacky Chaplow
Data comprise: Observations of Fukushima fallout in Great Britain, Element and radionuclide concentrations in representative species of the ICRP's Reference Animals and Plants and associated soils from a forest in north-west England, Exposure of burrowing mammals to Radon Rn-222 in Northwest England, Natural radionuclide concentrations in soil, water, sediment and biota in England and Wales, A database of radionuclide biological half-life values for wildlife, Post Chernobyl surveys of radiocaesium in soil, vegetation, wildlife and fungi...

acue and chronic TBI irradiation APOE null mice

Omid Azimzadeh
null

Predicted Caesium-137 deposition from atmospheric nuclear weapons tests

Jacky Chaplow
Prediction of Caesium-137 (Cs-137) deposition from atmospheric nuclear weapons tests. The methodology uses a ratio of Cs-137 deposition and precipitation measured at Milford Haven by the Atomic Energy Authority extrapolated across Great Britain using a 5 by 5 km resolution UKCIP precipitation dataset. The prediction is for 31 December 1985. Citation: Wright, S.M. (2016). Predicted Caesium-137 deposition from atmospheric nuclear weapons tests. NERC Environmental Information Data Centre. https://doi.org/10.5285/c3e530bf-af20-43fc-8b4b-92682233ff08

Thyroid diseases near Semipalatinsk Nuclear Test Site - Data

Bernd Grosche
A description of the study is given in STOREDB:STUDY1008 (http://dx.doi.org/doi:10.20348/STOREDB/1108) . The data stored here include all the EXCEL and SPSS system files that were relevant for preparing the data used for Grosche et al., 2017 (http://www.storedb.org/store_v3/download.jsp?fileId=11331) . The steps taken for data preparation are described in http://www.storedb.org/store_v3/download.jsp?fileId=11333, the codebook is given in http://www.storedb.org/store_v3/download.jsp?fileId=11334. The original data set, including information of all 1,287 examinations which were carried out among 1,067 study participants is available in...

CEREBRAD in vitro and in vivo brain

Stefan J. Kempf
HT22 cells were irradiated with 0 Gy, 0.5 Gy, 1.0 Gy and 4.0 Gy follwed by mass spectrometry-based analysis 4 hours and 24 hours post irradition. NMRI mice were irradiated with 0 Gy or 1 Gy followed by mass spectrometry-based analysis 24 hours post irradiation using whole cortex and hippocampus

Late somatic effects in mice after fractionated X-ray and neutron exposure

Michael Gruenberger
Purpose: To determine the dose rate reduction factor and RBE for X-ray and neutron exposure. Status: 1987- ongoing Treatment: Single exposure to 250 kVp X-rays (318 mGy/min, 1.5 mm HVL) and single and fractionated (5 fractions at one day interval) exposure to fission neutrons (0.4 MeV, 4 mGy/min) from the biological facility of the RSV-TAPIRO reactor at Casaccia Dosimetry: Twin ionization chamber method, ENDIP Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology Animal: Male (C57Bl/Cne...

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