188 Works

Cytest - A New Platform For Training And Testing In Cytopathology

Luca Lianas, M.E. Piras, E. Musu, S. Podda, F. Frexia, E. Ovcin, G. Bussolati & G. Zanetti
Introduction/ Background Clinical training at the European level requires flexible ways to provide education across borders with the goal of a unified way to teach and assess quality. The CyTest project focuses on Cytological Training at European Standard through Telepathology. The project (2014-1-IT01-KA202-002607) has been approved and funded in 2014 by EU within the ERASMUS+ Program. The project consortium is composed of 4 leading university Institutions (COREP and University of Turin, University of Padua, Imperial...

Evolution And Revolution In Contemporary Pathology

Giampiero Duglio
Introduction/ Background Cloud Pathology Group participated in the XI European Congress on Telepathology presenting the results of its great “in vitro research” about the use of HTS scanners in surgical pathology and in the XII European Congress on Digital Pathology presenting the preliminary results of its “in vivo research” done at the Busto Arsizio Multihospital Pathology Department, ended on June 30,2015. Aims The aim of this abstract is to complete the Paris presentation and to...

Integration Of Externalized Decision Models In The Definition Of Workflows For Digital Pathology

J. Van Leeuwen, A. Ibrahim & Anca Bucur
Introduction/ Background The availability of digital pathology creates opportunities for the adoption of advanced workflow solutions focused on facilitating and improving the current way of working in pathology labs. Workflow-driven applications can help achieve increased efficiency and quality, support collaboration, and provide detailed insights into the lab processes. The implementation of workflow solutions also creates effective means to monitor and measure activities, and to detect and solve issues. Our solution helps improve processes in the...

Limits of Morphological Diagnostics

Klaus Dietmar Kunze
Background: Morphological findings have in medical diagnostics a particularly high significance. In most of diseases they are regarded as “gold standard” and as a benchmark for the results of other methods of examination. The basis of morphological diagnostics is the intuitive pattern recognition leading either to a definite medical diagnosis or to a differential diagnosis. The clarification of the differential diagnosis may be assisted by algorithms and other decision making methods. General survey: Morphological diagnostics...

How do I diagnose Pagetoid Bowen Disease

Rita Do Espírito Santo Carvalho
Bowen disease is a variant of squamous carcinoma in situ, which sometimes presents with a pagetoid growth pattern with cytologically atypical clear cells. In that case, the differencial diagnosis includes Paget disease and melanoma in situ, as well as less common entities. Here we describe a case where histological differenciation is difficult and immunohistochemical studies are necessary to make a diagnosis. Here we also highlight the heterogeneity of CK7 expression and the apparent specific expression...

Predatory Journals, Science Citation Index and Open Access Publications in Diagnostic Pathology

Klaus Kayser, Stephan Borkenfeld & Gian Kayser
Background: Predatory behavior in open access peer reviewed scientific journals seems to be increasing. It is subject to serious discussions between editors, authors, and publishers. Herein we discuss some characteristics of electronic communication in science, the reasons for potential misuse, and present some entropy calculations. Theoretical considerations: Publication of research articles uses visual information transfer, and seldom acoustic communication. Advantages of open access electronic journals include prompt and worldwide distribution, free access, and several free...

Estimating Liver Steatosis: Can Artificial Neural Network And Image Analysis Improve The Accuracy

A. Capar, I. Türkmen, A. Akhan, B. Saka, A. Cakir, S. Ramadan & G.B. Dogusoy
Introduction/ Background Liver steatosis is very important in transplantation pathology as it directly influences the graft dysfunction. Pretransplant donor biopsy materials are evaluated by the pathologists, and degree of steatosis, especially large droplet steatosis (LDS) which is described as lipid droplets with a diameter of at least 15 micron, is estimated under light microscope. But when doing so, there can be great intra- and inter-observer variability. In order to overcome this problem several automated systems...

The application of structural entropy in tissue based diagnosis

Gian Kayser, Jürgen Görtler, Cleo Aron Weis, Stephan Borkenfeld & Klaus Kayser
Background: Entropy belongs to the few basic measurable entities in nature. It measures the distance of a closed or open ‘statistical’ system from its present stage to its final stage, and analyzes the probability distribution of the included elements, independently from their meaning. The development can be predicted by use of an ‘ideal transformation’, i.e. additive formula (for example Shannon’s entropy) or by mathematical derivatives such as the more generalized q – entropy, for example...

Pathology Assistant (C) - Gamechanger Of Pathology Diagnostic

Asel Kudaybergenova & A. Remez
Introduction/ Background UNIM Ltd. specializes in pathology diagnostics and digital pathology. We have created the SAAS platform DPathology that can be used for saving and studying histological slides and it doesn’t require an installation of a special software. You can use the platform with all the modern internet browsers. The SAAS platform gives all the specialists a chance to analyze remotely digital histological slides. It increases the accuracy of diagnostics and speeds up the medical...

Cy-TEST - A new platform for training and testing in cytopathology

Luca Lianas, Marco Enrico Piras, Elodia Musu, Simona Podda, Francesca Frexia, Emanuela Ovcin, Giovanni Bussolati & Gianluigi Zanetti
Introduction/ Background Clinical training at the European level requires flexible ways to provide education across borders with the goal of a unified way to teach and assess quality. The Cy-TEST project focuses on Cytological Training at European Standard through Telepathology. The project (2014-1-IT01-KA202-002607) has been approved and funded in 2014 by EU within the ERASMUS+ Program. The project consortium is composed of 4 leading university Institutions (COREP and University of Turin, University of Padua, Imperial...

Features of an Expression of Smooth Muscle Actin by Muscle Cells of Arterioles and Venules of Ureter and Urinary Bladder of Newborns in Modeling Chronic Intrauterine Hypoxia

I. Gorianikova, I. Sorokina & M. Myroshnychenko
Introduction/ Background Chronic intrauterine hypoxia, accompanied numerous complications of pregnancy, is one of the damaging factor of the organism of fetus and newborn. Aims The purpose – to reveal the features of expression of smooth muscle actin by muscle cells of arterioles and venules of ureter and urinary bladder of newborns under the influence of experimental chronic intrauterine hypoxia. Methods An experiment was conducted on modeling high mountain hypoxia in rats of WAG line. Two...

Computer-assisted quantification of caix membrane immunoreaction destined for the clear cells in renal carcinoma. A pilot study.

J. Slodkowska, T. Markiewicz, M. Wdowiak, B. Mlot & W. Kozlowski
Introduction/ Background Carbonic Anhydrase IX [CAIX] has been considered as a candidate prognostic factor in clear-cell renal carcinoma [CCRC], however the supporting evidence is conflicting. CAIX is strongly induced by hypoxia via HIV-1α, and in CCRC via mutations to the VHL gene. CAIX expression could be identify as an immunohistochemical predictor of CCRC patients outcome but the published studies related to the patients prognosis have based on the diverse quantification protocols of CAIX expression (TMAs...

Cognitive Algorithms and digitized Tissue – based Diagnosis

Jürgen Görtler, Klaus Kayser, Stephan Borkenfeld, Rita Carvalho & Gian Kayser
Aims: To analyze the nature and impact of cognitive algorithms and programming on digitized tissue – based diagnosis. Definitions: Digitized tissue – based diagnosis includes all computerized tissue investigations that contribute to the most appropriate description and forecast of the actual patient’s disease [1]. Cognitive algorithms are programs that encompass machine learning, reasoning, and human – computer interaction [2]. Theoretical considerations: Digitized blood data, objective clinical findings, microscopic, gross, radiological images and gene alterations are...

Structure, Function, And Predictive Diagnosis Algorithms

Klaus Kayser, Stephan Borkenfeld, Rita Carvalho & Gian Kayser
Introduction/ Background Background: Predictive diagnosis (PD) is a component of tissue based diagnosis. It is based upon immunohistochemical (IHC) and molecular genetic (MG) measurements of structures and functions. It predicts the outcome of individual cancer treatment. Aims To develop computerized analysis of microscopic images in relation to prognosis evaluation of cancer patients. Methods Theory: Structures are related to object – associated visual information that remains constant within the period of observation. Functions display with changes...

Texture and object related image analysis in microscopic images

Klaus Kayser, Stephan Borkenfeld, Amina Djenouni & Gian Kayser
Background Tissue based diagnosis or surgical diagnostic pathology undergoes significant changes and focuses on image content analysis in our days. Herein we describe and discuss new approaches of content image analysis and compare their applications, benefits and constraints. Theory Any useful microscopic image contains information that can be evaluated and transferred into a tissue-based diagnosis. A correctly derived diagnosis depends upon the image information and the pathologist’s knowledge, i.e. his ability to recognize and transfer...

Regional variation of non-Hodgkin’s Lymphoma (NHL) in Mongolia and its association with Ki-67 expression

Erdenetsogt Dungubat, Enkhtuya Sharkhuu, Bayarmaa Enkhba, Tsengelmaa Jamiyan, Oyundelger Norov & Galtsog Lodon
Background: The prevalence of non-Hodgkin’s lymphoma (NHL) varies worldwide in association with demographic and environmental factors. The analysis of these associations in Asia, Africa, and less developed countries is limited by low absolute numbers and unknown etiologic factors such as in Mongolia. The geographic variations in NHL incidence and mortality rates may induce by differences in case ascertainment and registration, or disease diagnosis and classification. The interpretation of NHL patterns and trends remains difficult. Therefore,...

A Graph-Based Digital Pathology Approach To Describe Lymphocyte Clustering Patterns After Renal Transplantation

N. S. Schaadt, A. Uvarovskii, M. Meyer-Hermann, R. Schönmeyer, N. Brieu, J.H. Bräsen, W. Gwinner & F. Feuerhake
Introduction/ Background Renal transplantation (rTx) induces an adaptive immune response against foreign donor antigens mediated by lymphocytes of the recipient. Local accumulation of B- and T-cells is an important component of this response enabling and controlling immune cell interactions [1]. Combining digital microscopic images with network analysis [2][3] opens new perspectives to study the spa- tial dimension of lymphocyte clustering and to model their potential interactions. Aims The aim of this study is to characterize...

The Reproducibility Index of Pathological Diagnosis and Rare Cases. The Results of the On-line Diagnostic Competition “Final Diagnosis”

Asel Kudaybergenova, A. Artemyeva & A. Remez
Introduction/ Background UNIM Ltd. have created the SAAS platform DPathology that can be used for saving and studying histological slides and it doesn’t require an installation of a special software. You can use the platform with all the modern internet browsers. The SAAS platform gives all the specialists a chance to analyze remotely digital histological slides. It increases the accuracy of diagnostics and speeds up the medical assessment Aims To indicate the importance of collecting...

Correlation Analysis of the Feto-Placental Parameters Et Intrauterine Growth Retardation

I. Gorianikova, O. Kononenko, O. Zinchenko & O. Antonova
Introduction/ Background A number of studies suggest that some disproportions and retardations in feto-placental growth may lead to various pathologies in adults. Aims The aim of the present work was to identify alterations in correlations between placental and fetal parameters in cases of intrauterine growth restriction (IUGR) at 20-25 weeks of gestation (wg). Methods 18 cases with IUGR and high placenta/fetal weight index (PFI) have been compared with 20 controls in cases of induced abortions...

RE: Jürgen Görtler, Klaus Kayser, Stephan Borkenfeld, Rita Carvalho, Gian Kayser. Cognitive Algorithms and Digitized Tissue-based Diagnosis. Diagnostic Pathology 2017, 3:248

MD Montironi, Silvia Gasparrini, Maria Alessandra Montironi, Alesia Cimadamore, Antonio Lopez-Beltran, Liang Cheng & Marina Scarpelli
Several algorithms can be used in “Cognitive Algorithms and Digitized Tissue-based Diagnosis”. As revised by Dr. Jürgen Görtler et al, these can be grouped can be grouped in ‘self learning’, self promoting’, ‘self targeting’, ‘self exploring’ and ‘self networking’ [1]. We agree with Dr. Jürgen Görtler and his group in identifying promising similarities in the methods developed for situation assessment and tactical decision making in self-driving cars and in those needed for automated diagnostics.

Color Calibration In Digital Pathology: The Clinical Impact Of A Novel Test Object

E. Clarke, C. Revie, D. Brettle, R. Wilson, C. Mello-Thoms & D. Treanor
Introduction/ Background Guidance from the Food and Drug Administration has recommended color standardization for whole slide imaging, as with all other digital systems. However there is known, unresolved and substantial variation in color between digital slide scanners. To address this issue, we created a novel color calibration test object which uniquely utilizes histochemical stains and a tissue-like substrate, affording accurate internal calibration of WSIs. Aims We aimed to evaluate the clinical application of the novel...

Application Of Ki-67 Analysis In A Distributed Computing Infrastructure

Marco Strutz, B. Lindequist, M. Witt, H. Heßling, P. Hufnagl & D. Krefting
Introduction/ Background Over the last few years, the protein Ki-67 [1] has been established as one of the most important biomarkers for cell proliferation in breast cancer. High Ki-67 values indicate high tumor growth and have direct impact on the patient’s treatment. Several automated image anal- ysis methods for identifying Ki-67-positive and negative tumor cells have been presented. Aims For small regions of a virtual slide, the Ki-67 analysis can be realized within an acceptable...

Cytology consultations with associated image quality evaluation – experiences of the Virtual International Pathology Institute (VIPI)

Gian Kayser, Stephan Borkenfeld, Essam Ayad, Armina Djenouni, Armaz Mariamidze, Armen Mkhitaryan & Klaus Kayser
Background: The virtual international Pathology Institute (VIPI, www.diagnomx.eu/vipi) is the only image consultation forum that is organized in close organization to a conventional institute of pathology. Its approximately 160 experts in pathology and cytology consult and diagnose difficult cases on the basis of a convent weekly duty plan. Herein we report the consultation results of a specific series of cytology specimens, and discuss potential application in routine virtual cytology. Material and Methods: Still images of...

Comparative Analyses Based On WSI View Paths Recorded During Multiple Practical Exams In Oral Pathology

Slawomir Walkowski, M. Lundin, J. Szymas & J. Lundin
Introduction/ Background Data collected about the ways students view Whole Slide Images (WSIs) during their practical exams can be used for many interesting analyses. Tracking such viewing behavior over years enables multiple comparisons and leads to drawing more general conclusions about observed viewing patterns. Aims First goal of this work was to collect data about how students view WSIs attached to questions during practical exams in oral pathology conducted over several years. What is important,...

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