54,356 Works

Long-term follow up in young patients with brain AVM – participation in social life

Nazife Dinc, Sae-Yeon Won, Johanna Quick-Weller, Eva Hermann, Volker Seifert & Gerhard Marquardt
Objective: Seizures before and after brain AVM treatment, intracerebral hemorrhage due a ruptured AVM in childhood are incriminating for brain and neurocognitve function with sequelaes for further social life. Long-term follow up data on pediatric brain AVMs are rare, making it difficult to compare [for full text, please go to the a.m. URL]

Is active follow-up by serial imaging justified in patients with multiple cerebral cavernous malformations?

Julia Velz, Oliver Bozinov, Martin Nikolaus Stienen, Marian Christoph Neidert, Yang Yang & Luca Regli
Objective: The best strategy to perform follow-up of patients with multiple cerebral cavernous malformations (mCCM) is unclear due to the mainly unknown and unpredictable clinical course. Still, serial radiological follow-up is often performed. The objective of this work was to critically question whether[for full text, please go to the a.m. URL]

Comparative analysis of fibrinolytic properties of rtPA, Tenecteplase and Urokinase in a clot model of intracerebral haemorrhage

Naureen Keric, DöBel, Melanie, Axel Heimann, Sven Rainer Kantelhardt, Florian Ringel & Julia Masomi-Bornwasser
Objective: Hematoma lysis with recombinant tissue plasminogen activator (rtPA) has emerged as an alternative therapy for spontaneous intracerebral and intraventricular haemorrhage (ICH and IVH). However the CLEAR III trial failed to show significant improvement of favourable outcomes. Besides experimental[for full text, please go to the a.m. URL]

Spreading depolarization is associated with infarct growth in patients with malignant hemispheric stroke

Johannes Woitzik, Nils Hecht, Alexandra Pinczolits, Nora F. Dengler, Anna Zdunczyk, Sebastian Major, Jens P. Dreier, Christina Kowoll, Christian Dohmen, Rudolf Graf & Peter Vajkoczy
Objective: Lesion progression is one of the most serious in-hospital complications of ischemic stroke. Recently, we demonstrated that a significant proportion of patients with malignant hemispheric stroke (MHS) suffer from delayed infarct progression even after decompressive hemicraniectomy. Among many[for full text, please go to the a.m. URL]

The role of anticoagulants and platelet inhibitors in the treatment of chronic subdural hematoma – a computer assisted volumetric 3D analysis

Anna Margarete Bohrer, Sami Ridwan, Alexander Grote, Hans Joachim Hoff & Matthias Simon
Objective: Toanalyze our institutional experience with anticoagulants and platelet inhibitors in patients with CSDH. Furthermore, we used a computer assisted volumetric analysis to identify possible additional predictors for recurrent hematoma. Methods: Pertinent data from all patients (n=335)[for full text, please go to the a.m. URL]

Second-look strokectomy of cerebral infarction areas in patients with refractory intracranial pressure

Michael Schwake, Stephanie Schipmann, MüTher, Michael, StöGbauer, Louise, Uta Hanning, Peter Sporns, Christian Ewelt, Rainer Dziewas, Markus Holling & Walter Stummer
Objective: Decompressive craniectomies (DC) are performed on patients suffering large cerebral infarction with elevated intracranial pressure (ICP). The efficacy of this procedure has been shown in several studies. In some cases, however, this procedure alone is not sufficient and patients still develop[for full text, please go to the a.m. URL]

Comprehensive analysis of angioarchitectural risk factors for hemorrhage and clinical outcome of adult and pediatric patients suffering from cerebral arteriovenous malformations.

Franz Lennard Ricklefs, Matthias Reitz, Eik Vettorazzi, Niklas Von Sprechelsen, Friederike Fritzsche, Ullrich Gryzska, Jens Fiehler, Manfred Westphal, Nils Ole Schmidt & Jan Regelsberger
Objective: Intracranial arteriovenous malformation (AVM) is seen in children and adults. While pediatric patients present more likely with hemorrhage it remains unclear whether this affects neurological outcome. In this study we reviewed a consecutive series of pediatric and adult patients from one [for full text, please go to the a.m. URL]

The impact of hypo- and hyperthermia on Spreading Depolarization and delayed infarct progression after focal ischemia in C57BL/6 mice

Leonie Schumm, Anna Zdunczyk, Sebastian Major, Nils Hecht, Peter Vajkoczy & Johannes Woitzik
Objective: Spreading depolarization (SD) occurs in high frequency in patients with malignant hemispheric stroke (MHS) and is coupled to different hyperaemic or hypoaemic blood flow responses. Body temperature is a major trigger for SDs and influences the accompanied flow coupling. Here, we investigated[for full text, please go to the a.m. URL]

Early predictors during acute care of intra-hospital outcome in patients with spontaneous intracerebral haemorrhage

Michael Bender, Tim Naumann, Katharina Graf, Eberhard Uhl & Marco Stein
Objective: Spontaneous intracerebral haemorrhage (SICH) is with 10-15% the second most common cause of stroke and is associated with a high morbidity and mortality. This study was conducted to investigate the influence of early clinical predictors during acute care on intra-hospital outcome in [for full text, please go to the a.m. URL]

Glasgow Coma Scale is an independent predictor for the endvolume of malignant cerebral infarction in patients undergoing decompressive hemicraniectomy

Christoph Bettag, Alexandra Sachkova, Dorothee Mielke, Veit Rohde & Vesna Malinova
Objective: Although decompressive hemicraniectomy (DHC) significantly reduces the mortality of malignant cerebral infarction (MCI), still a high rate of moderate to severe disability is observed among the survivors. Particularly the right point in time performing DHC has not been defined yet. In this[for full text, please go to the a.m. URL]

Hemorrhage risk management of cavernous malformations

Sepide Kashefiolasl, Markus Bruder, Nina Brawanski, Eva Herrmann, Volker Seifert, Stephanie Tritt & Konczalla, JüRgen
Objective: Despite of the low annual risk of hemorrhage associated with a cavernous malformation (CM) (0,6% to 1,1% per year), the risk of rehemorrhage rate and severity of neurological deficits is significantly higher. We aimed to evaluate different hemorrhage risk factors, particularly in[for full text, please go to the a.m. URL]

A systematic literature-review concerning contralateral approaches to paraclinoidal ICA-aneurysms

Lucas Serrano, Sven Rainer Kantelhardt, Florian Ringel & Eleftherios Archavlis
Objective: Paraclinoidal ICA-aneurysms constitute a challenge to surgeons. Some neurosurgeons have advocated the application of a contralateral approach, claiming that the anatomy of the paraclinoid region is best exposed from the contralateral side. Small case-series have been published reporting favourable[for full text, please go to the a.m. URL]

Anatomic variations of the distal basilar artery and basilar tip aneurysms: Epidemiologic and morphologic correlations

Angelo Tortora, Hans-Jakob Steiger & Kerim Beseoglu
Objective: Anatomical variations of distal basilar artery are common findings during diagnostic of cerebral circulation and are mostly interpreted as benign conditions. The goal of this study was to investigate if these alternative patterns are related to the formation and rupture of aneurysms in this[for full text, please go to the a.m. URL]

Early temporary occlusion of the contralateral A1 for anterior communicating artery aneurysms in standardized right-sided approaches

Friedrich Mrosk, Ondra Petr, Claudia Unterhofer, Thomé, Claudius & Martin Ortler
Objective: Temporary artery occlusion (TAO) to provide proximal control and facilitate aneurysm dissection may cause ischemic brain injury. In our department, anterior communicating artery aneurysms (AcomA) are preferentially treated by a right-sided approach regardless of vessel dominance. In cases[for full text, please go to the a.m. URL]

Predictors of neurological deficits in patients with brain stem compression caused by giant intracranial aneurysms of the posterior circulation

Pavlina Lenga, Christian Hohaus, Bujung Hong, KuršUmović, Adisa, Nicolai Maldaner, Jan-Karl Burkhardt, Philippe Bijlenga, RüFenacht, Daniel, Nils Ole Schmidt, Peter Vajkoczy & Julius Dengler
Objective: Giant intracranial aneurysms of the posterior circulation (GPCirA) often cause compression of the brainstem and adjacent structures, resulting in neurological deficits. Using data from the Giant Intracranial Aneurysm (GIA) Registry, we designed a study to investigate potential predictors [for full text, please go to the a.m. URL]

Microsurgical clipping of unruptured intracranial aneurysms with multiple sacs

GöRtz, Lukas, Gerrit Brinker, Christina Hamisch, Sergej Telentschak, Boris Krischek & Roland Goldbrunner
Objective: Aneurysms with multiple sacs account for approximately 30% of unruptured intracranial aneurysms (UIAs), but data on their particular treatment are rare. We therefore analyzed patients that underwent microsurgical clipping of these morphologically complex aneurysms at our center. [for full text, please go to the a.m. URL]

Impact of parent vessel diameters on aneurysm rupture risk

Tobias Pantel, Axel Neulen, Florian Ringel & Sven Rainer Kantelhardt
Objective: Studies on contrast uptake in aneurysm walls raised the hypothesis that contrast enhancement and hence rupture risk of aneurysms may not only depend on aneurysm size, but also on the relation of aneurysm and parental vessel diameter. We therefore examined the distribution of aneurysm sizes[for full text, please go to the a.m. URL]

Aneurysm wall enhancement in black blood MRI correlates with aneurysm size. A study on 71 Patients with 90 Aneurysms

Athanasios Petridis, Elias Chasoglou, Igor Fischer, Jan Frederick Cornelius, Marcel Alexander Kamp, Hans-Jakob Steiger & Rebecca May
Objective: Finding of incidental intracranial aneurysms leads to the dilemma to treat or to observe. Even though clinical scoring systems consider risk factors for aneurysm rupture, objective parameters for assessment of aneurysms stability are needed. Methods: Retrospective analysis was performed[for full text, please go to the a.m. URL]

Montreal Cognitive Assessment (MoCA) test as a screening instrument for cognitive deficits in patients with primary brain tumors – first results of a prospective investigation

GrüBel, Nadja, Mirjam Renovanz, Jan Coburger & Christian Rainer Wirtz
Objective: Neurocognitive deficits are common symptoms in patients with primary brain tumors and might be underestimated in routine clinical assessment. They can be caused by the lesions themselves but also by the tumor treatment. Aim of the current analysis is to screen patients with regard to latent[for full text, please go to the a.m. URL]

Glioma patients in the outpatient setting: optimizing the assessment of distress and unmet needs – results of 50 structured interviews and an expert analysis

Voß, Hannah, Mirjam Renovanz, Jan Coburger, Peter Scholz-Kreisel, Florian Ringel & Susanne Singer
Objective: Distress and need of support in glioma patients may remain unrecognized as these patients may not be able (mentally or physically) to complete self-report instruments applied in screening procedures. An alternative approach is to (re-)integrate the assessment in the doctor-patient consultation.[for full text, please go to the a.m. URL]

Intra- and interindividual differences in quality of life and preference perception in patients with eloquent intracranial tumors

ButenschöN, Vicki, Stefanie Maurer, Tamara Pircher, Sebastian Ille, Nico Sollmann, Bernhard Meyer & Sandro Krieg
Objective: Quality of life years (QALY) are nowadays commonly used to estimate the efficiency and benefits of the chosen treatment. Despite its universal presence in health-economical papers, the utilities used to assess QALYs often lack evidence and are mostly extrapolated by other neurological disorders[for full text, please go to the a.m. URL]

Pregnancy in brain tumor patients

Forster, Marie-ThéRèSe, Patrick Harter, Volker Seifert & Kea Franz
Objective: Data about the influence of pregnancy on glioma patients are sparse and controversial. We aimed at providing further evidence on this relationship. Methods: The course of 19 brain tumor patients giving birth to 24 children after tumor surgery was reviewed. Results were compared to the[for full text, please go to the a.m. URL]

The role of dorsal decompression without stabilization in patients with symptomatic spine metastases

MüLler, Mareike, Yousef Abusabha, Hans-Jakob Steiger, Alexander Sebastian Ahmadi & Richard Bostelmann
Objective: Five to ten percent of carcinomas with bone metastases show spinal metastases (Barron KD, Hirano A, Araki S, Terry RD 1959; Schaberg J, Gainor BJ. 1985). As the long-term survival of patients with carcinoma is rising, the amount of patients with symptomatic spine metastases increases as well[for full text, please go to the a.m. URL]

Case series meningeal melanocytoma – “Chameleon in the spinal canal”

Max Schneider, Jan Coburger, Bernd Schmitz & Christian Rainer Wirtz
Objective: Numerous differential diagnoses are considered for patients presenting with intraspinal tumors. Intraspinal melanocytomas originating from leptomeningeal melanocytes are a very rare entity. Inconsistent appearances from magnetic resonance images can be misleading and make diagnosis uncertain.[for full text, please go to the a.m. URL]

Differential diagnosis of thoracic meningioma: thoracic manifestation of inflammatory pseudotumor

Sabrina Giese, Kristofer Fingerle-Ramina, Georgios Naros & Sasan Darius Adib
Objective: Inflammatory pseudotumor represents a heterogeneous group of benign tumor-like lesions with diverse localization and histopathological presentation. The aetiology of inflammatory pseudotumor still remains unclear. It is a rare disease occurring in various organs such as the lung, gastrointestinal[for full text, please go to the a.m. URL]

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