480 Works

The influence of size, depth and histologic characteristics of invasive ductal breast carcinoma on thermographic properties of the breast

Marko Mance, Krešimir Bulić, Anko Antabak & Milan Milošević
Invasive breast carcinoma is the most common oncologic disease worldwide. The existing diagnostic methods use morphologic changes in the breast to diagnose a carcinoma when it has reached a certain size. Therefore, it is important to augment the morphologic diagnostic examinations with a new method that focuses on characteristics other than morphology such as electromagnetic changes produced by cancer. 50 adult female patients with confirmed ductal carcinoma following a core biopsy due to a suspicious...

Exenatide induces autophagy and prevents the cell regrowth in HepG2 cells

Gabriele Catyana Krause, Kelly Goulart Lima, Vitor Levorse, Gabriela Viegas Haute, Rodrigo Benedetti Gassen, Maria Cláudia Garcia, Leonardo Pedrazza, Márcio Vinícius Fagundes Donadio, Carolina Luft & Jarbas Rodrigues De Oliveira
The incidence of hepatocellular carcinoma (HCC) keeps rising year by year, and became the second leading cause of cancer-related death. Some studies have found that liraglutide, a GLP-1 analog, may decrease the tumor cells proliferation. Due to this, the aim of this work is to investigate the antiproliferative potential of exenatide, another GLP-1 analog. Cell proliferation was assessed by direct count with Trypan blue dye exclusion. Flow cytometry was used to determinate autophagy and nuclear...

Fibroblast growth factor-10 and epithelial-mesenchymal transition in colorectal cancer

Fatemeh Farajihaye Qazvini, Nasser Samadi, Mojtaba Saffari, Amir Nader Emami-Razavi & Reza Shirkoohi
As an inducer of epithelial-mesenchymal transition (EMT), fibroblast growth factor-10 (FGF-10) has a role in cell proliferation and differentiation in the embryo in addition to invasion and metastasis during carcinogenesis. In this study, we aimed to investigate the FGF-10 gene expression in tumor tissues based on the pathological feature of tumor related to EMT and metastasis. 62 tumors were obtained from 62 colorectal cancer patients during surgery. The pathological characteristics of the patients were carefully...

Analysis of association of potentially functional genetic variants within genes encoding miR-34b/c, miR-378 and miR-143/145 with prostate cancer in Serbian population

Nevena Kotarac, Zorana Dobrijevic, Suzana Matijasevic, Dusanka Savic-Pavicevic & Goran Brajuskovic
MiRNA-associated genetic variants occurring in regulatory regions can affect the efficiency of transcription and potentially modify pri-miRNA or pre-miRNA processing. Since miRNA-based mechanisms are shown to be involved in the pathogenesis of prostate cancer (PCa), the aim of the present study was to evaluate the effect of rs4938723, rs1076064 and rs4705343 occurring in regulatory regions of miR-34b/c, miR-143/145 and miR-378, respectively, on PCa risk and progression in Serbian population. We examined a total of 1060...

Which protocol reflects more reliable facts about learning and memory in fruit flies?

Mohammad Haddadi
EXCLI Journal; 18:Doc513; ISSN 1611-2156

Human-based dynamics of mental workload in complicated systems

Mohammad-Javad Jafari, Farid Zaeri, Amir H. Jafari, Amir T. Payandeh Najafabadi & Narmin Hassanzadeh-Rangi
As a dynamic system in which different factors affect human performance via dynamic interactions, mental workload needs a dynamic measure to monitor its factors and evidence in a complicated system, an approach that is lacking in the literature. The present study introduces a system dynamics-based model for designing feedback mechanisms related to the mental workload through literature review and content analysis of the previous studies. A human-based archetype of mental workload was detected from the...

LIPG supports adaption to oxidative stress

Gregor Leonhardt
EXCLI Journal; 18:Doc499; ISSN 1611-2156

Induction of apoptosis and modulation of homologous recombination DNA repair pathway in prostate cancer cells by the combination of AZD2461 and valproic acid

Saman Sargazi, Ramin Saravani, Javad Zavar Reza, Hossein Zarei Jaliani, Shekoufeh Mirinejad, Zohreh Rezaei & Sadegh Zarei
Cancer therapies using defects in homologous recombination (HR) DNA repair pathway of tumor cells are not yet approved to be applicable in patients with malignancies other than BRCA1/2-mutated tumors. This study was designed to determine the efficacy of combination therapy of a histone deacetylase inhibitor, valproic acid (VPA) and a novel PARP inhibitor AZD2461 in both PC-3 (PTEN-mutated) and DU145 (PTEN-unmutated) prostate cancer cell lines. The Trypan blue dye exclusion assay and the tetrazolium-based colorimetric...

Metabolic dyshomeostasis by organophosphate insecticides: insights from experimental and human studies

Apurva Kumar Ramesh Joshi & Bindhu Omana Sukumaran
EXCLI Journal; 18:Doc479; ISSN 1611-2156

Hesperidin, a plant flavonoid accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats: role of TGF-β/Smads and Ang-1/Tie2 signaling pathways

Wenbin Li, Amit D. Kandhare, Anwesha A. Mukherjee & Subhash L. Bodhankar
Background: Delayed wound healing is a diverse, multifactorial, complex and inter-related complication of diabetes resulting in significant clinical morbidity. Hesperidin possesses potent antidiabetic and wound healing activity. Aim: To evaluate the potential of hesperidin against experimentally induced diabetes foot ulcers. Methods: Diabetes was induced experimentally by streptozotocin (STZ, 55 mg/kg, i.p.) in Sprague Dawley rats (180-220 g) and wounds were created on the dorsal surface of the hind paw of rats. Hesperidin (25, 50 and...

Immunoregulatory, proliferative and anti-oxidant effects of nanocurcuminoids on adipose-derived mesenchymal stem cells

Forouzan Yousefi, Fahimeh Lavi Arab, Mahmoud Reza Jaafari, Maryam Rastin, Nafiseh Tabasi, Mahdi Hatamipour, Karim Nikkhah & Mahmoud Mahmoudi
Curcuminoids are dietary complexes extracted from the seeds of Curcuma longa L. that contain curcumin, bisdemethoxycurcumin and desmethoxycurcumin. Curcuminoids are popular for their pleiotropic therapeutic functions, such as their anti-inflammatory and anti-oxidant effects. Nonetheless, their clinical use is associated with poor systemic bioavailability and insolubility. The nano-formulation of curcuminoids eliminates these shortcomings. In the present study, we explored immunoregulatory, proliferative and anti-oxidant effects of nanocurcuminoids on adipose-derived mesenchymal stem cells (AT-MSCs). Flow cytometry analysis and...

An updated review of cucurbitacins and their biological and pharmacological activities

Sun Ok Chung, Yong Joo Kim & Sang Un Park
EXCLI Journal; 14:Doc562; ISSN 1611-2156

Knockdown of SLC39A7 suppresses cell proliferation, migration and invasion in cervical cancer

Yongqing Wei, Jie Dong, Fuli Li, Zhuqing Wei & Yuling Tian
Cervical cancer is the fourth leading cause of malignancy related mortality in women worldwide. SLC39A7 (ZIP7) is a zinc transporter that plays a key role in intestinal epithelial self-renewal. However, whether or not SLC39A7 is involved in human cervical cancer remains unclear. In this study, we investigated the effects of SLC39A7 in cervical cancer in vitro and elucidate related underlying mechanisms. Using Oncomine data analysis, we first found SLC39A7 is commonly upregulated in cervical cancer...

Immunization enhances the natural antibody repertoire

Dylan Beinart, Daniel Ren, Cinthia Pi, Susan Poulton, Zoie E. Holzknecht, Chelsea Swanson & William Parker
The role of immunization in the production of antibodies directed against immunogens is widely appreciated in laboratory animals and in humans. However, the role of immunization in the development of “natural antibodies” has not been investigated. Natural antibodies are those antibodies present without known history of infection or immunization, and react to a wide range of targets, including “cryptic” self-antigens that are exposed upon cell death. In this study, the ability of immunization to elicit...

The predictive value of pre- and post-induction chemotherapy plasma EBV DNA level and tumor volume for the radiosensitivity of locally advanced nasopharyngeal carcinoma

Yang Song, He Xiao, Zhenzhou Yang, Mingying Geng, Jungang Ma, Yujiang Ren, Yun Liu & Ge Wang
This study was dedicated to investigate the predictive value of pre- and post-induction chemotherapy plasma EBV (Epstein-Barr Virus) DNA level and tumor volume for the radiosensitivity of locally advanced NPC. 129 previously untreated locally advanced NPC patients were enrolled. Plasma EBV-DNA copy number and tumor volume was detected before and after induction chemotherapy. The tumor volume was also measured after radiotherapy. Among 129 patients, 98 were positive for EBV DNA. The residual gross target volume...

Chemical profile and antioxidant capacity verification of Psidium guajava (Myrtaceae) fruits at different stages of maturation

Heverton M. Araújo, Fabíola F. G. Rodrigues, Wégila D. Costa, Carla De F. A. Nonato, Fábio F. G. Rodrigues, Aline A. Boligon, Margareth L. Athayde & José G. M. Costa
Psidium guajava (Myrtaceae), a common plant in Cariri region, Ceara, Brazil, as well as in various parts of the world, contains high concentrations of bioactive compounds and in many communities its parts are used for therapeutic purposes. Studies describe antioxidant, antimicrobial and anti-diarrheal actions from extracts obtained from leaves, but information about the activities of the fruits and comparison of these at different maturity stages (immature, partially mature and mature) are scarce. This study aims...

Anti-inflammatory activity of hydrosols from Tetragonia tetragonoides in LPS-induced RAW 264.7 cells

Eun-Yi Ko, Su-Hyeon Cho, Kyungpil Kang, Gibeom Kim, Ji-Hyeok Lee, You-Jin Jeon, Daekyung Kim, Ginnae Ahn & Kil-Nam Kim
The present study was performed to investigate the anti-inflammatory activity of Tetragonia tetragonoides hydrosols (TTH) and its underlying mechanism in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Gas chromatography (GC) coupled with mass spectrometry and retention index calculations showed that TTH were mainly composed of tetratetracontane (29.5 %), nonacosane (27.6 %), and oleamide (17.1 %). TTH significantly decreased the production of nitric oxide (NO), prostaglandin E2 (PGE2), interleukin (IL)-6, and IL-1β in LPS-stimulated RAW 264.7 cells. Consistent...

Study on genotoxicity, oxidative stress biomarkers and clinical symptoms in workers of an asbestos-cement factory

Azam Afaghi, Shahrbanoo Oryan, Kobra Rahzani & Mohammad Abdollahi
The purpose of the present study was to investigate whether the markers of oxidative stress could be altered in workers exposed to asbestos. A comparative cross-sectional research was conducted in a group of 50 subjects exposed to asbestos and another group of 50 with the same age and sex unexposed to asbestos. Malondialdehyde (MDA), total thiol molecule (TTM), total antioxidant capacity (TAC), and DNA damage, were measured in the blood samples of workers and controls....

Prevalence of measles in vaccinated and non-vaccinated children

Muhammad Asif Zahoor, Muhammad Hidayat Rasool, Muhammad Waseem, Bilal Aslam, Muhammad Kashif Zahoor, Muhammad Saqalein, Zeeshan Nawaz & Rabia Sahar
EXCLI Journal; 14:Doc504; ISSN 1611-2156

Highlight report: Imaging of bile ducts and the bile canalicular network

Regina Stoeber
EXCLI Journal; 18:Doc477; ISSN 1611-2156

Regulatory RNAs controlling vascular (dys)function by affecting TGF-β family signalling

Kondababu Kurakula, Marie-Jose Goumans & Peter Ten Dijke
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Over the last few years, microRNAs (miRNAs) have emerged as master regulators of gene expression in cardiovascular biology and disease. miRNAs are small endogenous non-coding RNAs that usually bind to 3′ untranslated region (UTR) of their target mRNAs and inhibit mRNA stability or translation of their target genes. miRNAs play a dynamic role in the pathophysiology of many CVDs through their effects on...

Effects of hesperidin on formaldehyde-induced toxicity in pregnant rats

Sameha Merzoug & Mohamed Lamine Toumi
This experimental study aimed to investigate the protective effect of a bioflavonoid, hesperidin (HP), on formaldehyde (FA)-related pathophysiological and behavioral outcomes in pregnant rats and developmental aspects in their offspring. Female Wistar rats were subjected to perigestational exposure to FA (2 mg/kg/day per os) with a concomitant treatment with HP (50 mg/kg/day per os). Pregnant rats were weighed throughout gestation and tested in two behavioral paradigms (elevated plus-maze and open field) at gestational days (GD)...

A meta-analysis of the relationship between body mass index and risk of rheumatoid arthritis

Ying Zhou & Mingfang Sun
The present meta-analysis aimed to evaluate the relationship between body mass index (BMI) and rheumatoid arthritis (RA). A systematic search of the Cochrane, Pubmed, and Embase databases was conducted to identify relevant studies published before September 2017 using terms related to BMI and RA. Fixed or random-effect models were used to estimate the pooled relative risk (RR) with 95 % confidence interval (CI). Subgroup analyses by sex were performed to investigate the association between BMI...

The inflammatory cytokine TNF contributes with RAC3-induced malignant transformation

Mileni Soares Machado, Francisco D. Rosa, María C. Lira, Alejandro J. Urtreger, María F. Rubio & Mónica A. Costas
RAC3 is a coactivator of steroid receptors and NF-κB. It is usually overexpressed in several tumors, contributes to maintain cancer stem cells and also to induce them when is overexpressed in non-tumoral cells. In this work, we investigated whether the inflammatory cytokine TNF may contribute to the transforming effects of RAC3 overexpression in the non-tumoral HEK293 cell line. The study model included the HEK293 tumoral transformed cell line constitutively overexpressing RAC3 by stable transfection and...

Comparison of melatonin with growth factors in promoting precursor cells proliferation in adult mouse subventricular zone

Areechun Sotthibundhu, Kasima Ekthuwapranee & Piyarat Govitrapong
Melatonin, secreted mainly by the pineal gland, plays roles in various physiological functions including protecting cell death. We showed in previous study that the proliferation and differentiation of precursor cells from the adult mouse subventricular zone (SVZ) can be modulated by melatonin via the MT1 melatonin receptor. Since melatonin and epidermal growth factor receptor (EGFR) share some signaling pathway components, we investigated whether melatonin can promote the proliferation of precursor cells from the adult mouse...

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