1,131 Works

Translational Approaches towards Cancer Gene Therapy: Hurdles and Hopes

Jaleh Barar & Yadollah Omidi
Introduction: Of the cancer gene therapy approaches, gene silencing, suicide/apoptosis inducing gene therapy, immunogene therapy and targeted gene therapy are deemed to sub­stantially control the biological consequences of genomic changes in cancerous cells. Thus, a large number of clinical trials have been conducted against various malignancies. In this review, we will discuss recent translational progresses of gene and cell therapy of cancer. Methods: Essential information on gene therapy of cancer were reviewed and discussed towards...

Root Canal Configuration of One-rooted Mandibular Canine in an Iranian Population:An In Vitro Study

Pejman Bakianian Vaziri, Shahin Kasraee, Hamid Reza Abdolsamadi, Shermin Abdollahzadeh, Farzad Esmaeili, Shahrzad Nazari & Mohammad Vahedi
Background and aims. A perfect endodontic treatment necessitates proper understanding of the morphology of canal and pulpal variations. This in vitro study was conducted to demonstrate the internal anatomy of mandibular canine teeth in an Iranian population. Materials and methods. The samples consisted of 100 extracted mandibular permanent canines. The roots of the teeth were molded in acrylic boxes. The crowns of the teeth were cut and 2 mm cross sections were made from CEJ...

Serum Levels of Melatonin and Oxidative Stress Markers and Correlation between Them in Infertile Men

Sara Soleimani Rad, Shamsi Abbasalizadeh, Amir Ghorbani Haghjo, Mehzad Sadagheyani, Azadeh Montaseri & Jafar Soleimani Rad
Introduction: Infertility is the problem of 15% of young couples in different societies. One of the factors that could affect fertility is oxidative stress. Therefore, the aim of the present study is to investigate the level of Melatonin, a free radical scavenger, and its correlation with oxidative biomarkers in infertile men. Methods:For this purpose, fertile and infertile men in 2 groups, 30 people in each group, were studied. The fertile men were selected from husbands...

Effects of Low-level Laser in the Treatment of Myofascial Pain Dysfunction Syndrome

Arash Azizi, Mahnaz Sahebjamee, Shirin Lawaf, Fereydoon Jamalee & Nader Maroofi
Background and aims. Muscular pain in the facial region is the most common cause of facial pains. Myofascial pain dysfunction syndrome (MPDS) is one of the most important facial muscle disorders comprising of signs and symptoms including pain during function, tenderness in the muscles of mastication and restricted jaw movement. Due to the lack of an accepted therapeutic approach, the purpose of this paper was to find an effective treatment to decrease the pain of...

A case of thrombocytopenia due to odontogenic infection

Dinesh Kumar Verma & Ritesh Rajan
Thrombocytopenia in surgical patients is a potentially serious condition, faced by surgeons. A close relationship between sepsis and thrombocytopenia has been suggested. Thrombocytopenia has even been suggested to be indicative of an acute infection. Platelet count in a septicemic patient may also serve as a prognostic tool. There are many reports of thrombocytopenia due to septicemia in the literature but the occurrence of thrombocytopenia in maxillofacial infections is rare. Thrombocytopenia in a patient with odontogenic...

Iranian Expert Opinion about Necessary Criteria for Hospitals Management Performance Assessments

Elham Dadgar, Ali Janati, Jafar Sadegh Tabrizi, Mohammad Asghari-Jafarabadi & Omid Barati
Background: Managers in the hospital should have enough managerial skill to be coordinated with the complex environment. Defining a competency framework assessment for hospital man-agement will help to establish core competencies for hospital managers. The aim of this study was to develop concrete and suitable performance assessment criteria using expert's view. Methods: In this qualitative study in total, 20 professionals participated in the interview and Fo¬cus Group Discussions (FGD). Two of informants were interviewed and...

What are important for patient centered care? A quantitative study based on perception of patients' with cancer

Roghayeh Azimzadeh, Leila Valizadeh, Vahid Zamanzadeh & Azad Rahmani
Introduction: Today in all aspects of health care, there is a considerable emphasis on the provision of patient centered care. Various researches in cancer wards have demonstrated that from view of patients, there were some similarities and differences in importance of care in different cultural area. This study aimed to assess what are important for patient centered care in cancer wards. Methods: This is a descriptive study conducted with participation of 200 patients with cancer...

Sexual Function in Breastfeeding Women in Family Health Centers of Tabriz, Iran, 2012

Jamileh Malakoti, Vahid Zamanzadeh, Ahdieh Maleki & Azizeh Farshbaf Khalili
Introduction:There are conflicting evidences about the effects of breastfeeding on postpartum maternal sexual functioning. With regard to the methodological weaknesses of previous studies and cultural differences affecting their issue, the present study aims to evaluate sexual functions of lactating women and its components. Methods:This is a descriptive study in which 200 eligible postpartum women were selected from eight health centers of Tabriz (25 from each center). The eligible women were called and invited to attend...

Assessment of Autonomic Dysfunction in Childhood Guillain-Barré Syndrome

Mahmood Samadi, Babak Kazemi, Sona Golzari Oskoui & Mohammad Barzegar
Introduction: Autonomic dysfunction (AD) is a common and important complication in Guillain-Barré syndrome (GBS) and may be the cause of significant morbidity or death. Limited studies have evaluated this complication in childhood GBS. Our objectives were to show the prevalence of AD in children with GBS and investigate its association with the severity of the disease. Methods: Study included 28 children admitted with a diagnosis of GBS. Heart rate variability (HRV), motor function disability of...

Health-promoting Lifestyle and its Demographic Predictors in Infertile Couples Referred to Infertility Clinic of Tabriz Al-Zahra Hospital, 2013

Mojgan Mirghafourvand, Fahimeh Sehhati & Mareieh Rahimi
ABSTRACT Introduction: Improving the lifestyle of infertile couples led to the preservation of their performance, increase their quality of life, and reduce health cost. So, the aims of this study were to determine the health-promoting lifestyle and its predictors among infertile couples. Methods: In a cross-sectional, analytical study 322 infertile couples referred to an infertility clinic in Tabriz was participated with convenience sampling method. The demographic and the standard Health Promoting Lifestyle-II (HPLP II) questionnaires...

Effect of Iranian Propolis on Salivary Total Antioxidant Capacity in Gamma-irradiated Rats

Sara Aghel, Mahdi Pouramir, Ali Akbar Moghadamnia, Dariush Moslemi, Tahere Molania, Leila Ghassemi & Mina Motallebnejad
Background and aims. The antioxidant and anti-inflammatory properties of propolis were studied. Since saliva containsantioxidants and radiotherapy of the head and neck mainly affects the saliva, salivary antioxidant defensive mechanism iscompromised with oxidative stress produced by radiation therapy. Therefore, the aim of the present study was to investigatethe effect of propolis on salivary total antioxidant capacity in irradiated rats. Materials and methods. The study was conducted on 28 rats, 7‒11 weeks of age (160±20 g),...

Comparison of the Analgesic Effect of Diclofenac Sodium-Eudragit® RS100 Solid Dispersion and Nanoparticles Using Formalin Test in the Rats

Khosro Adibkia, Alireza Mohajjel Nayebi, Mohammad Barzegar-Jalali, Siavash Hosseinzadeh, Saeed Ghanbarzadeh & Afshin Shiva
Purpose: In this study the intensity and duration of analgesic effect of diclofenac Na - Eudragit® RS100 solid dispersion and nanoparticles were evaluated by using formalin test in the rats. Methods: The animals received different formulations of diclofenac Na and subsequently 50 µl of formalin solution (2.5%) was injected subcutaneously in the right paws after 1 h, 2 h and 3 h. The paw licking behavior was then evaluated in two phases. A dose of...

Functional Status, Anxiety, Cardiac Self-Efficacy, and Health Be­liefs of Patients with Coronary Heart Disease

Hamid Allahverdipour, Mohammad AsghariJafarabadi, Rasoul Heshmati & Mina Hashemiparast
Background: Beliefs and emotions could effect on functional status, quality of life, and mortality amongst patients who are suffering coronary heart disease (CHD). Current study examined the role of anxiety: trait/ state, self-efficacy, health beliefs, and functional status among patient with history of CHD.Method: In this correlational study, 105 hospitalized and outpatients patients suffering CHD in Tehran Heart Center Hospital participated by using conven¬ience sampling method in 2012. Cardiac self-efficacy, Seattle Angina, and re¬search-designed health...

Psychometric Properties of the Iranian Version of the Behavioral Regulation in Exercise Questionnaire-2 (BREQ-2)

Rabiollah Farmanbar, Shamsaddin Niknami, Alireza Hidarnia & David Revalds Lubans
Background: The Behavioral Regulation in Exercise Questionnaire (BREQ) and the BREQ-2 are the most commonly used measures of behavioural regulation in exercise psychology. The purpose of the study was to assess the validity and reliability of the Iranian version of the BREQ-2 on a sample of university students. Methods: The BREQ-2 was translated into Persian by qualified experts and the psychometric properties of the instrument were assessed. Content validity was established, using a panel of...

Evaluating the Antimicrobial Activity of Methonolic Extract of Rhus Succedanea Leaf Gall

Savitri Shrestha, Sundara Rajan Subaramaihha, Sujan Ganapathy Parthiv Subbaiha, Ravi Shankara Birur Eshwarappa & Dhananjaya Bhadrapura Lakkappa
Introduction: The worldwide increased bacterial resistance to antibiotics and the undesirable side effects associated with constant use of synthetic drugs has prompted the search for novel antimicrobial agents, particularly those manufactured from plants. This study is designed to ascertain the antibacterial potential of Rhus succedanea leaf gall extracts on the growth of gram-positive and gram–negative bacteria. Methods: The methanolic and hexane extract of different concentrations (100, 250, and 500 μg/ml) were prepared and their antibacterial...

Protective Effects of N-acetylcysteine Against the Statins Cytotoxicity in Freshly Isolated Rat Hepatocytes

Narges Abdoli, Yadollah Azarmi & Mohammad Ali Eghbal
Purpose: Hepatotoxicity is one of the most important side effects of the statins therapy as lipid-lowering agents. However, the mechanism(s) of hepatotoxicity induced by these drugs is not clearly understood yet, and no hepatoprotective agent has been developed against this complication. Methods: The protective effect of N-acetylcysteine (NAC) against statins-induced cytotoxicity was evaluated by using freshly isolated rat hepatocytes. Hepatocytes were prepared by the method of collagenase enzyme perfusion via portal vein. This technique is...

Cost-Effectiveness of Cardiac Biomarkers as Screening Test in Acute Chest Pain

Samad Shams-Vahdati, Zahra Vand-Rajavpour, Seyed-Pouya Paknezhad, Reza Piri, Elnaz Moghaddasi-Ghezeljeh, Saba Mirabolfathi & Mohammad Naghavi-Behzad
Introduction: Acute chest pain is an important and frequently occurring symptom in patients. Chest pain is often a sign of ischemic heart disease. Associated findings of electrocardiograph (ECG) are rather heterogeneous, and traditional cardiac biomarkers such as Creatine Kinase-MB (CK-MB) suffer from low cardiac specificity and sensitivity. In this study cost effectiveness of cardiac biomarkers single quantitative measurement was examined.Methods: The present descriptive-analytic study conducted on patients who were asked for troponin I and CK-MB....

Outcome of Diabetic and Non-Diabetic Patients Undergoing Successful Percutaneous Coronary Intervention of Chronic Total Occlusion

Bahram Sohrabi, Samad Ghaffari, Afshin Habibzadeh & Parastoo Chaichi
Introduction: Diabetes mellitus is associated with an increased risk of adverse clinical outcomes after percutaneous coronary intervention (PCI). The prognosis of patients with diabetes mellitus and chronic total occlusion (CTO) treated with PCI is poorly investigated. Current study evaluates outcome of successful PCI on CTO in patients with and without diabetes. Methods: One hundred and sixty three patients treated with successful PCI on CTO between January 2009 and March 2011 were prospectively identified from the...

Surface modified multifunctional nanomedicines for simultaneous imaging and therapy of cancer

Jaleh Barar & Yadollah Omidi
Introduction: To date, a growing number of advanced anticancer nanomedicines (e.g., Doxil®, Lipoxal®, DepoCyte®) have entered into different phases of clinical trials. However, most of these medicaments fail to differentiate between diseased and normal cells. They also do not have capability of real time monitoring of disease status trough on-demand imaging/sensing of target molecule(s). Multifunctional nanomedicines and theranostics can resolve such limitations, while formulation of these advanced seamless systems appear to involve various sophisticated process,...

Comparing the Effects of Two Teaching Methods on Healing of Diabetic Foot Ulcer

Mohsen Adib-Hajbaghery & Tahereh Alinaqipoor
Introduction: Some studies have reported that diabetic patients do not adhere well to the foot care recommendations. Reasons for non-adherence are less evident and the methods used in education programs may have an effect. Therefore, the aim of the present study was to compare the effects of lecture method and combined method of education on foot care of patients and healing rates of diabetic foot ulcers. Methods: A matched controlled trial study was conducted on...

The Impact of Aloe vera and Calendula on Perineal Healing after Episiotomy in Primiparous Women: A Randomized Clinical Trial

Farideh Eghdampour, Fereshteh Jahdie, Masomeh Kheyrkhah, Mohsen Taghizadeh, Somayeh Naghizadeh & Hamid Hagani
Introduction: Episiotomy is used for enlarging the perineum. Aloe vera and Calendula have been used for treating different diseases from ancient times, limited researches have been done regarding the healing of these plants. Since the effect of their ointment on episiotomy healing has not been studied, this study is being done for determining the impact of Aloe vera and Calendula on episiotomy healing in primiparous women. Methods: This clinical trial involves 111 qualified primiparous women...

The effect of disinfection by spray atomization on dimensional accuracy of condensation silicone impressions

Fariba Saleh Saber, Nader Abolfazli & Maryam Kohsoltani
Background and aims. The condensation silicone impression materials are available, but there is little knowledge of their accuracy after disinfection. The objective of this study was to evaluate the effect of the disinfection by spray atomization on dimensional accuracy of condensation silicone impressions. Materials and methods. Impressions were made on a stainless steel master model containing a simulated two complete crown preparation with an edentulous space interposed using Spidex® and Rapid® impression materials. 44 impressions...

Lifestyle of Hemodialysis Patients in Comparison with Outpatients

Sima Moghadasian, Mohammad Hasan Sahebi Hagh & Leila Aghaallah Hokmabadi
Introduction: Nowadays, the chronic diseases are known to be associated with lifestyle risk factors. Hemodialysis patients encounter considerable amount of physical, mental and social pressure. Lifestyle is important because it affects quality of life and has important role in prevention. This study aimed to compare the lifestyle of hemodialysis patients and outpatients in health clinics of Tabriz. Methods: This was a case-control study on 155 hemodialysis patients and 155 outpatients referring to five dialysis centers...

Serum Level of Interleukin-17 in Patients with Erosive and Non-erosive Oral Lichen Planus

Firoz Pouralibaba, Zohre Babaloo, Farzaneh Pakdel & Marziye Aghazadeh
Background and aims. Oral lichen planus is a relatively common chronic oral mucosal disease of unknown etiology. Regarding numerous studies on the immunologic factors involved in the etiology of lichen planus, the present study evaluated the serum interleukin-17 (IL-17) level in patients with erosive and non-erosive oral lichen planus. Materials and methods. This descriptive analytical study included 24 patients with erosive oral lichen planus (EOLP), 24 patients with non-erosive oral lichen planus (NEOLP) and 24...

A study of parallelism of the occlusal plane and ala-tragus line

Katayoun Sadr & Makan Sadr
Background and aims. Orientation of the occlusal plane is one of the most important clinical procedures in prosthodontic rehabilitation of edentulous patients. The aim of this study was to define the best posterior reference point of ala-tragus line for orientation of occlusal plane for complete denture fabrication. Materials and methods. Fifty-three dental students (27 females and 26 males) with complete natural dentition and Angel's Class I occlusal relationship were selected. The subjects were photographed in...

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