1,055 Works

The Effect of Two Educational Methods on Knowledge and Adherence to Treatment in Hemodialysis Patients: Clinical Trial

Kobra Parvan, Hadi Hasankhani, Allehe Seyyedrasooli, Seyed Mohammad Riahi & Mahmoud Ghorbani
Introduction: Patients with chronic renal disease (CRD) deal with many potential problems with hemodialysis for all their life. Regarding the importance of preventing dialysis adverse effects, which are in close connection with lack of knowledge and report on how to train the patients? This study aims at comparing the impact of two methods of face to face training and training pamphlet on complying and informing of hemodialysis treatments. Methods: This clinical trial study was conducted...

Attitude toward Child Abuse among Mothers Referring Health Centers of Tabriz

Mahnaz Jabraeili, Maliheh Asadollahi, Mohhammad Asghari Jafarabadi & Marzieh Hallaj
Introduction: Parental attitude is an important factor in prediction of child abuse. Awareness of people's attitudes is important in the prediction of their behavior and controlling it. This study was conducted to determine the mothers' attitudes toward child abuse. Methods: In this cross-sectional study, 261 mothers referred to the 13 health centers of Tabriz with children aged 2-12, they were selected by a multistage method and their attitudes were assessed using a questionnaire within 2...

Effect of Lavender Cream with or without Foot-bath on Anxiety, Stress and Depression in Pregnancy: a Randomized Placebo-Controlled Trial

Fatemeh Effati-Daryani, Sakineh Mohammad-Alizadeh-Charandabi, Mojgan Mirghafourvand, Mohsen Taghizadeh & Azam Mohammadi
Introduction: Psychological disorders are associated with maternal and neonatal morbidities. We aimed to evaluate the effect of Lavender cream with or without foot-bath on depression, anxiety and stress of pregnant women. Methods: In this trial, 141 women at 25 to 28 weeks gestation were randomly assigned into three groups (47 at each group); receiving Lavender cream with foot-bath, only Lavender cream, or placebo, 2g every night for two months. Depression, anxiety and stress were assessed...

Nursing Students’ Perception of Instructors’ Caring Behaviors in Tabriz University of Medical Sciences

Vahid Zamanzadeh, Masoumeh Shohani & Tina Palmeh
Introduction: Caring behaviors of clinical teachers is one of the most important and influential factors in the process of clinical instruction, so far has not been paid enough attention. In other words, there has been so little research done in this area, so that the researchers couldn't present the clear image of caring dimensions. Therefore, the present study was conducted to determine nursing students’ perception of instructors’ caring behavior. Methods: This descriptive study was performed...

Nurses’ Knowledge Regarding Hand Hygiene and Its Individual and Organizational Predictors

Malihe Asadollahi, Mohammad Arshadi Bostanabad, Mahnaz Jebraili, Majid Mahallei, Alehe Seyyed Rasooli & Marzieh Abdolalipour
Introduction: Based on recommendations from World Health Organization, hand hygiene is the most important way to control the hospital infections. Due to the critical role of nurses in patient care, they should have essential and updated information regarding hand hygiene. So this study aims at determining the knowledge of hand hygiene and its individual and organizational predictors among nurses in neonatal units. Methods: This descriptive and cross-sectional study was conducted in neonatal units in the...

The Effect of Vitamin D and Calcium plus Vitamin D during Pregnancy on Pregnancy and Birth Outcomes: a Randomized Controlled Trial

Sakineh Mohammad-Alizadeh-Charandabi, Mojgan Mirghafourvand, Ameneh Mansouri, Moslem Najafi & Farzane Khodabande
Introduction: Evidence suggests a high prevalence of calcium and vitamin D deficiencies exists in both pregnant women and babies. Adequate intake of micronutrients has great importance especially during pregnancy and lactation period. Thus, the present study aimed at assessing the effect of vitamin D and calcium-vitamin D on pregnancy and birth outcomes (including duration of pregnancy, type of delivery and infant anthropometric indicators). Methods: A randomized, controlled, clinical, triple-blind trial conducted on 126 pregnant women...

Going Beyond-The-Routines View in Nursing: a Qualitative Study

Leila Valizadeh, Vahid Zamanzadeh, Madineh Jasemi, Fariba Taleghani, Brian Keoch & Charlotte M Spade
Introduction: Nurses' practice of beyond-the-routine view leads to a better treatment process and higher professional status for nurses. However, most studies show that such care is ignored in nursing. The objective of the present study is to analyze nurses' experiences with regard to beyond-the-routine care in order to know this type of better care and encourage nurses to practice it. Methods: This is a qualitative study based on conventional content analysis. Eighteen nurses participated in...

Mothers' Strategies in Handling the Prematurely Born Infant: a Qualitative Study

Afsaneh Arzani, Leila Valizadeh, Vahid Zamanzadeh & Easa Mohammadi
Introduction: Family, especially mother, is faced with numerous challenges by experiencing a premature birth. Since knowing about mother’s efforts regarding prematurely born infant helps us in our comprehensive understanding of the impact of this incident on the family system and its performance. The present study was carried out to explore the mothers' strategies regarding prematurely born infant. Methods: In a conventional qualitative content analysis, data was collected through purposive sampling by semi-structured deep interviews with...

Factors Affecting the Decision to Quit Smoking of the Participants of a Hospital-Based Smoking Cessation Program in Greece

Charikleia Georgiadou, Maria Lavdaniti, Maria Psychogiou, Anastassios Tzenalis, Markos Sgantzos & Despina Sapountzi-Krepia
Introduction: The purpose of this study was to investigate the factors that affect people who are in the process of quitting smoking. Methods: A randomly selected sample of 110 participants in a smoking cessation program (SCP) of a hospital in Thessaloniki Greece. Instruments of data collection were: i) the Demographic Data Lifestyle Questionnaire and ii) the Fragerstrom Tolerance Questionnaire. ANOVA tests between the Demographic Data Lifestyle Questionnaire and the Fagerstrom Tolerance Questionnaire relating to the...

Evaluation of Association Between HLA Class II DR4–DQ8 Haplotype and Type I Diabetes Mellitus in Children of East Azerbaijan State of Iran

Nasrin Sohrabi, Mahmoud Shekari Khaniani & Sima Mansoori Derakhshan
Association between HLA-DR4–DQ8 haplotype and type 1 Diabetes Mellitus (DM-1A) was investigated in children of East Azerbaijan state of Iran because such an association has not been previously studied in this population. Methods: HLA-typing was performed by polymerase chain reaction sequence-specific priming. For haplotype analysis, the logistic regression model was performed. Results: Of the three investigated alleles, the frequency of DRB1*0401 was significantly higher among patients compared with that in healthy subjects (76.74% vs. 23.26%)....

Optimized and Validated RP-UPLC Method for the Determination of Losartan Potassium and Chlorthalidone in Pharmaceutical Formulations

Tadiboyina Sirisha, Bannimath Gurupadayya & Sridhar Siddiraju
Purpose: A validated ultra performance liquid chromatography (UPLC) method has been developed and validated for the simultaneous determination of losartan potassium and chlorthalidone in pharmaceutical preparations. Methods: Waters-Acquity UPLC system equipped with Auto Sampler, PDA detector and operated with Empower-2 software was used for the present study. Detection was done at wavelength of 230 nm, HSS C18, 100 mm x 2.1x 1.8 µm column with a reverse phase elution and mobile phase composed of A...

The Effect of Regular Moderate Exercise on miRNA-192 Expression Changes in Kidney of Streptozotocin-Induced Diabetic Male Rats

Hajar Oghbaei, Naser Ahmadi Asl, Farzam Sheikhzadeh, Mohammad Reza Alipour & Amir Mahdi Khamaneh
Purpose: The purpose of this study was to investigate the regular moderate exercise effect on the miR-192 expression changes in kidney of Streptozotocin- induced diabetic rats. Methods: Forty adult male Wistar rats were divided into four groups of 10, including Sedentary Control group, Healthy 60 days Exercise group, diabetic group and Diabetic 60 days Exercise. Diabetes was induced by injection of 60 mg/kg Streptozotocin and after 48 hour blood glucose levels higher than 250 mg/dl...

Investigating the Mutagenic Effects of Three Commonly Used Pulpotomy Agents Using the Ames Test

Mohammad Samiei, Saeed Asgary, Malak Farajzadeh, Nasrin Bargahi, Majid Abdolrahimi, Usef Kananizadeh & Siavoush Dastmalchi
Purpose: The mutagenic potency of materials used in dentistry is of great concern. The Ames test is a bacterial reverse mutation assay, which is used to determine the mutagenicity potential of chemicals. In this study, the Ames test was used to compare mutagenic effects of three pulpotomy agents, namely, CEM cement, formocresol and ferric sulfate. Methods: TA100 strain of Salmonella typhimurium was used to evaluate mutagenicity of different concentrations of pulpotomy materials in the presence...

pH-Triggered Magnetic-Chitosan Nanogels (MCNs) For Doxorubicin Delivery: Physically vs. Chemically Cross Linking Approach

Somayeh Sadighian, Hassan Hosseini-Monfared, Kobra Rostamizadeh & Mehrdad Hamidi
Purpose: This paper evaluates the impact of cross linking strategy on the characteristics of magnetic chitosan nanogels (MCNs) as targeted drug delivery system for doxorubicin. Methods: Sodium tripolyphosphate (TPP) and glutaraldehyde were used as physical (electrostatic) and chemical (covalent binding) cross-linker agents, respectively. MCNs were characterized by means of X-ray diffraction (XRD), Scanning electron microscopy (SEM), fourier transform infrared (FT-IR) spectroscopy and vibrating sample magnetometer (VSM). Scanning electron microscopy (SEM) indicated the formation of spherical...

Production and Purification of a Polyclonal Antibody Against Purified Mouse IgG2b in Rabbits Towards Designing Mouse Monoclonal Isotyping Kits

Sadeq Eivazi, Jafar Majidi, Leili Aghebati Maleki, Jalal Abdolalizadeh, Mehdi Yousefi, Majid Ahmadi, Somayeh Dadashi, Zahra Moradi & Elmira Zolali
Purpose: Mouse IgG subclasses containing IgG1, IgG2a, IgG2b and IgG3 have been defined and described both physiochemically and immunologically. Methods: Sepharose beads conjugated with protein A affinity chromatography was used for purification of mouse IgG2b. Sodium citrate buffer (0.1 M, pH: 3.5) was used for separation of mouse IgG2b. Verification of the purified fractions was monitored by SDS-PAGE (polyacrylamide gel electrophoresis) in reducing condition. Immunized rabbit serum was collected and precipitated at the final concentration...

Effect of Taurine on Febrile Episodes in Acute Lymphoblastic Leukemia

Mina Islambulchilar, Iraj Asvadi, Zohreh Sanaat, Ali Esfahani & Mohammadreza Sattari
Purpose: The purpose of our study was to evaluate the effect of oral taurine on the incidence of febrile episodes during chemotherapy in young adults with acute lymphoblastic leukemia. Methods: Forty young adults with acute lymphoblastic leukemia, at the beginning of maintenance course of their chemotherapy, were eligible for this study. The study population was randomized in a double blind manner to receive either taurine or placebo (2 gram per day orally). Life quality and...

Large Scale Generation and Characterization of Anti-Human IgA Monoclonal Antibody in Ascitic Fluid of Balb/c Mice

Fatemeh Ezzatifar, Jafar Majidi, Behzad Baradaran, Leili Aghebati Maleki, Jalal Abdolalizadeh & Mehdi Yousefi
Purpose: Monoclonal antibodies are potentially powerful tools used in biomedical research, diagnosis, and treatment of infectious diseases and cancers. The monoclonal antibody against Human IgA can be used as a diagnostic application to detect infectious diseases. The aim of this study was to improve an appropriate protocol for large-scale production of mAbs against IgA. Methods: For large-scale production of the monoclonal antibody, hybridoma cells that produce monoclonal antibodies against Human IgA were injected intraperitoneally into...

Vasorelaxant Effect of 17α-Ethynylestradiol on Human Saphenous Vein

Ahmad Reza Jodati, Hossein Babaei, Yadollah Azarmi, Sahar Fallah, Afsaneh Gharebageri, Danial Fadaei Fouladi & Naser Safaei
Purpose: A protective effect for estrogens against cardiovascular problems has long been known. The aim of this study was to investigate the vasorelaxant effect of 17α Ethynylestradiol (17α EE) on human saphenous vein. Methods: The veins were suspended horizontally between two triangular stainless steel hooks for the measurement of isometric tension in individual organ baths containing 10ml Krebs solution, at 37°C and gassed with carbogen under 3gr optimum tension. The effect of different concentrations of...

Effect of Intrahippocampal Administration of Vitamin C and Progesterone on Learning in a Model of Multiple Sclerosis in Rats

Shirin Babri, Faezeh Mehrvash, Gisou Mohaddes, Homeira Hatami & Fariba Mirzaie
Purpose: The purpose of this study was to evaluate the effect of intrahippocampal injection of vitamin C and progesterone, alone or in combination, on passive avoidance learning (PAL) in multiple sclerosis. Methods: Sixty- three male wistar rats were divided into nine groups (n=7) as following: control (saline), lesion, vitamin C (0.2, 1, 5 mg/kg), progesterone (0.01, 0.1, 1 μg/μl) and combination therapy. Lesion was induced by intrahippocampal injection of ethidium bromide. In combination therapy, animals...

Comparison of the Analgesic Effect of Diclofenac Sodium-Eudragit® RS100 Solid Dispersion and Nanoparticles Using Formalin Test in the Rats

Khosro Adibkia, Alireza Mohajjel Nayebi, Mohammad Barzegar-Jalali, Siavash Hosseinzadeh, Saeed Ghanbarzadeh & Afshin Shiva
Purpose: In this study the intensity and duration of analgesic effect of diclofenac Na - Eudragit® RS100 solid dispersion and nanoparticles were evaluated by using formalin test in the rats. Methods: The animals received different formulations of diclofenac Na and subsequently 50 µl of formalin solution (2.5%) was injected subcutaneously in the right paws after 1 h, 2 h and 3 h. The paw licking behavior was then evaluated in two phases. A dose of...

Preparation of Proper Immunogen by Cloning and Stable Expression of cDNA coding for Human Hematopoietic Stem Cell Marker CD34 in NIH-3T3 Mouse Fibroblast Cell Line

Farzaneh Shafaghat, Hajar Abbasi-Kenarsari, Jafar Majidi, Ali Akbar Movassaghpour, Dariush Shanehbandi & Tohid Kazemi
Purpose: Transmembrane CD34 glycoprotein is the most important marker for identification, isolation and enumeration of hematopoietic stem cells (HSCs). We aimed in this study to clone the cDNA coding for human CD34 from KG1a cell line and stably express in mouse fibroblast cell line NIH-3T3. Such artificial cell line could be useful as proper immunogen for production of mouse monoclonal antibodies. Methods: CD34 cDNA was cloned from KG1a cell line after total RNA extraction and...

Selection of a Suitable Method for the Preparation of Polymeric Nanoparticles: Multi-Criteria Decision Making Approach

Manikandan Mahalingam & Kannan Krishnamoorthy
Purpose: The present study is aimed to select the suitable method for preparation of camptothecin loaded polymeric nanoparticles by utilizing the multi-criteria decision making method. Novel approaches of drug delivery by formulation using nanotechnology are revolutionizing the future of medicine. Recent years have witnessed unprecedented growth of research and application in the area of nanotechnology. Nanoparticles have become an important area of research in the field of drug delivery because they have the ability to...

Synthesis of PCEC Copolymers with Controlled Molecular Weight Using Full Factorial Methodology

Leila Barghi, Davoud Asgari, Jaleh Barar & Hadi Valizadeh
Purpose: Polycaprolactone (PCL) is a biodegradable polyester and has attracted attention as a suitable carrier for development of controlled drug delivery due to its non-toxicity and biocompatibility. It has been reported that the biodegradability of PCL can be enhanced by copolymerization with PEG. Molecular weight (Mw) and CL block lengths optimization in a series of synthesized PCEC copolymers was the main purpose of this study. Methods: The composition of copolymers was designed using full factorial...

Synthesis and In Vitro Evaluation of Amphiphilic Peptides and Their Nanostructured Conjugates

Samaneh Mohammadi, Javid Shahbazi Mojarrad, Parvin Zakeri-Milani, Ali Shirani, Samad Mussa Farkhani, Naser Samadi & Hadi Valizadeh
Purpose: Breast cancer is the second leading cancer type among people of advanced countries. Various methods have been used for cancer treatment such as chemotherapy and radiotherapy. In the present study we have designed and synthesized a new group of drug delivery systems (DDS) containing a new class of Cell Penetrating Peptides (CPPs) named Peptide Amphiphiles (PAs). Methods: Two PAs and anionic peptides were synthesized using solid phase peptide synthesis (SPPS), namely [KW]4, [KW]5, E4...

Cyclodextrine Screening for the Chiral Separation of Amlodipine Enantiomers by Capillary Electrophoresis

Gabriel Hancu, Monica Budău, Lajos Kristóf Kántor & Anca Cârje
Purpose: Amlodipine is a long acting, dihydropyridine type calcium channel blocker frequently used in the treatment of hypertension and coronary insufficiency. The calcium channel blocking activity resides primarily in the S-amlodipine enantiomer, while R-amlodipine is a potent inhibitor of smooth muscle cell migration. Methods: In this study capillary electrophoresis was applied for the enantiomeric separation of amlodipine using different native and derivatized; neutral and charged cyclodextrines as chiral selectors. The effects of pH and composition...

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