1,131 Works

Marrubium vulgare L. methanolic extract inhibits inflammatory response and prevents cardiomyocyte fibrosis in isoproterenol-induced acute myocardial infarction in rats

Keyvan Yousefi, Fatemeh Fathiazad, Hamid Soraya, Maryam Rameshrad, Nasrin Maleki-Dizaji & Alireza Garjani
Introduction: Nowadays, finding new therapeutic compounds from natural products for treatment and prevention of a variety of diseases including cardiovascular disorders is getting a great deal of attention. This approach would result in finding new drugs which are more effective and have fewer side effects than the conventional medicines. The present study was designed to investigate the anti-inflammatory effect of the methanolic extract of Marrubiumvulgare, a popular traditional medicinal herb, on isoproterenol-induced myocardial infarction (MI)...

Growth-Inhibitory and Apoptosis-Inducing Effects of Punica granatum L. var. spinosa (Apple Punice) on Fibrosarcoma Cell Lines

Koushan Sineh Sepehr, Behzad Baradaran, Masoumeh Mazandarani, Bahman Yousefi, Meghdad Abdollahpour Alitappeh & Vahid Khori
Purpose: Punica granatum L. var. granatum (Pomegranate), an herbaceous plant found in Iran, The aim of this study was to investigate the cytotoxic effects, induction of apoptosis, and the mechanism of cell death of ethanol extract from Punica granatum L. var. spinosa on the mouse fibrosarcoma cell line, WEHI-164. Methods: Various parts of the herbs were extracted from fruit using ethanol as the solvent, and the cytotoxicity and cell viability of the ethanolic extract were...

A comparative Study of Deficiency in Theory of Mind and Emotion Regulation in Bipolar Patients and Normal Individuals

Ali Fakhari, Khalegh Minashiri, Abolfazl Fallahi & Mohammad Taher Panah
Objective: This study compared patterns of deficit in theory of mind and emotion regulation in patients with bipolar disorder and normal individuals. Method: In this causal-comparative study subjects were 20 patients with bipolar disorder and 20 normal individuals. Patients were selected via method of access sampling among hospitalized patients at Razi hospital of Tabriz. The data was collected through two scales: reading the mind in the eyes test and emotion regulation questionnaire. The data was...

Analgesic Activity of Some 1,2,4-Triazole Heterocycles Clubbed with Pyrazole, Tetrazole, Isoxazole and Pyrimidine

Shantaram Gajanan Khanage, Appala Raju, Popat Baban Mohite & Ramdas Bhanudas Pandhare
Purpose: In the present study in vivo analgesic activity of some previously synthesized 1,2,4-triazole derivatives containing pyrazole, tetrazole, isoxazole and pyrimidine ring have been evaluated. Methods: Acetic acid induced writhing method and Hot plate method has been described to study analgesic activity of some 1,2,4-triazole derivatives containing pyrazole, tetrazole, isoxazole and pyrimidine as a pharmacological active lead. Results: Thirty six different derivatives containing 1,2,4-triazole ring were subjected to study their in vivo analgesic activity. Chloro,...

Dose-Dependent Effect of Flouxetine on 6-OHDA-Induced Catalepsy in Male Rats: A Possible Involvement of 5-HT1A Receptors

Hamdolah Sharifi, Alireza Mohajjel Nayebi & Safar Farajnia
Purpose: Progressive loss of dopaminergic neurons of the substantia nigra pars compacta (SNc) in Parkinson’s disease (PD) leads to impairment of motor skills. Several evidences show that the role of serotonergic system in regulation of normal movement is pivotal and mediates via 5-HT1A receptors. Our previous study has shown that fluoxetine in acute injections able to attenuate catalepsy in 6-hydroxydopamine (6-OHDA)-lesioned rats. Since drugs are used chronically in clinic, in this study we attempted to...

Comparison of ADM and Connective Tissue Graft as the Membrane in Class II Furcation Defect Regeneration: A Randomized Clinical Trial

Vahid Esfahanian, Shirin Farhad & Mehrnaz Sadighi Shamami
Background and aims. Furcally-involved teeth present unique challenges to the success of periodontal therapy and influence treatment outcomes. This study aimed to assess to compare use of ADM and connective tissue membrane in class II furcation defect regeneration. Materials and methods. 10 patient with 2 bilaterally class II furcation defects in first and/or second maxilla or man-dibular molar without interproximal furcation involvement, were selected. Four weeks after initial phase of treatment, be-fore and thorough the...

Comparison of the influence of two flap designs on periodontal healing after surgical extraction of impacted third molars

Seyed Ahmad Arta, Reza Pourabbas Kheyradin, Ali Hossein Mesgarzadeh & Bahador Hassanbaglu
Background and aims. Impacted lower third molar is found in 90% of the general population. Impacted lower third molar surgery may result in periodontal complications on the distal surface of the adjacent second molar. The aim of this study was to evaluate the effect of flap design on the periodontal status of the second molar after lower third molar surgery. Materials and methods. Twenty patients, with an age range of 18-26 years, participated in the...

On the mechanism of agglomeration in suspension

Maryam Maghsoodi, Katayoun Derakhshandeh & Zahra Yari
Purpose: Agglomeration in suspension is a size enlargement method that facilitates operation of solid processing and preserves the solubilization properties of fine particles. A small quantity of binder liquid is added into a suspension of microparticles, directly in the stirred vessel where the precipitation or crystallization took place. This study deals with the evaluation of the effect of agitation time before and after addition of binder liquid on agglomerates properties in order to give some...

Aberrant Behaviors and Road Accidents among Iranian Truck Drivers, 2010

Damon Ketabi, Abalfazl Barkhordari, Seyyed Jalil Mirmohammadi & Amir Houshang Mehrparvar
Background: Road accidents are a social phenomenon in different communities that its infra¬structural dimensions of which as well as technologic failures such as road quality, and tech¬nical faults of automobiles, need to be assessed in detail. Iran has the first order in the world for deadly road accidents. This study was designed to assess the association between aberrant behaviors of truck drivers and the incidence of road accidents in Yazd, center of Iran, in 2010....

Student's Body Dimensions in Relation to Classroom Furniture

Samira Baharampour, Jalil Nazari, Iman Dianat & Mohamad AsghariJafarAbadi
Background: This study was carried out to investigate the fit between university student's anthropometry and classroom furniture dimensions.Method: In this cross-sectional and descriptive-analyzing study conducted in 2012, a total of 194 students (aged 18 through 30 years), were recruited randomly from Tabriz University of Medical Science community. The body size of each student was assessed using anthropometric measurements including shoulder height, elbow height, popliteal height, buttock-popliteal length, hip breadth and distance between elbows. Combinational equations...

Should a Double-Lumen Catheter be withdrawn?

Samad Shams Vahdati
Introduction: Haemodialysis needs a credible and recurrent access to the systemic circula-tion which can be accomplished by way of central vein catheterization. We report the case of bleeding after withdrawal of the double lumen catheter. Case Presentation: A 36-year-old woman who was a known case of end-stage renal disease referred to a dialysis center because of her arteriovenous fistula malfunction. A double-lumen catheter was inserted via the right internal jugular vein but failed to become...

The Relation between the Number of Hours That Authorize the Sale of Alcoholic Beverages and Violence

Hernán Malaga, Marco Gonzalez, Carlos Huaco & Manuel Sotelo
Background: La Victoria was considered, the most violent area in Lima City, the local govern-ment enforced a public policy regarding number of hours for selling of alcoholic beverages in January 2007. The study was designed to compare its results in Violence between one district with the law and other without the law. Methods: This retrospective cross-sectional was an ecological study with a chronological and geographical comparison between La Victoria, with the restriction and Cercado de...

Construction of pPIC9 Recombinant Vector Containing Human Stem Cell Factor

Behrooz Farhadi, Mahmoud Shekari Khaniani & Sima Mansoori Derakhshan
Purpose: Various cytokine regulates hematopoesis; they promote number of stages in stem cells biology such as proliferation, differentiation and endurance. Biological effects of SCF, as a hematopoietic cytokine; is triggered by binding to its ligand c-kit. Potential therapeutic applications of SCF include hematopoietic stem cell mobilization, exvivo stem/progenitor cell expansion, gene therapy, and immunotherapy. In this study we tried to construct of pPIC9 recombinant vector containing human SCF. Methods: hSCF cDNA was amplified by PCR...

Antioxidant, total phenol and flavonoid contents of two Pedicularis L. species from Eastern Azarbaijan, Iran

Laleh Khodaie, Sedigheh Bamdad, Abbas Delazar & Hossein Nazemiyeh
Introduction: Pedicularis sibthorpii and P. wilhelmsiana are endemic species mainly found in North-West of Iran. Plants of genus Pedicularis produce some important polyphenols and flavonoids. In the present work, total phenol and flavonoid contents of the mentioned species as well as their antioxidant capacity have been evaluated. Methods: Methanol extract of samples was fractionated by SPE method using an ODS cartridge and their 1H-NMR spectra were recorded. Total phenols and flavonoids of methanol extracts were...

Contamination of Dental Unit Water and Air Outlets Following Use of Clean Head System and Conventional Handpieces

Lida Toomarian, Sahand Rikhtegaran, Mehrnoosh Sadighi, Siavash Savadi Oskoee & Parnian Alizadeh Oskoee
Background and aims. Dental handpiece is a source of contamination because it is in constant touch with the oral cavity. Sterilization does not seem to be sufficient to prevent penetration of microorganisms into air and water lines of the unit, because negative pressure developed by valves (which are placed in water outlets) and post shut-off inertial rotation of handpiece result in water and debris being sucked into air and water outlets of dental unit. The...

Simultaneous Operation of Hydatid Cyst of the Heart and Liver:A Case Report

Rezayat Parvizi, Hossein Namdar, Eissa Bilehjani, Amrollah Bayat & Mohammad Ali Sheikhalizadeh
Primary echinococcosis of the heart is exceptionally uncommon and is reported 0.5% to 2% of all hydatid cyst sites in comparison with liver (70%) or lung (20%) involvement. Hydatid disease of the heart is caused by the cestode tapeworm echinococcosis granulosis or alveolaris. We present a 29-year-old female with hydatid disease of the liver and heart. She only complained of abdominal pain and palpitation. Echocardiography and multi-slice computed tomography (MSCT) showed a 120×101 mm cyst...

The Analysis of Learning Styles and Their Relationship to Academic Achievement in Medical Students of Basic Sciences Program

Reza Ghaffari, Fariba Salek Ranjbarzadeh, Eskandar Fathi Azar, Susan Hassanzadeh, Naser Safaei, Parisa Golanbar, Hossein Mazouchian & Elham Abbasi
Introduction: Learning style is an individual’s preferred method of encountering information in specific situations in order to acquire knowledge, skills and attitudes through study or experience. Students and Planers’ awareness of learning styles facilitate the teaching process, increases satisfaction and makes the future choices easier. This study aimed to examine different learning styles and their relation to academic achievement in medical students of basic sciences program at Tabriz University of Medical Sciences. Methods: In this...

Differential detection of Entamoeba histolytica from Entamoeba dispar by parasitological and nested multiplex polymerase chain reaction methods

Majid Yazdanjoii, Esmaiel Fallah, Abbas Shahbazi & Bahman Rahimi-Esboei
BACKGROUND: Amebiasis is an intestinal illness caused by a one-celled parasite (amoeba) called Entamoeba (E) histolytica. E histolytica and E dispar are morphologically undistinguishable but have genetic and functional differences. E. histolytica is invasive and cause amoebiasis, but E dispar cause an asymptomatic colonization which does not need to be medically treated. We have performed a nested multiplex Polymerase Chain Reaction (PCR) targeting small subunit rRNA (Ribosomal ribonucleic acid) gene for differential detection of E...

Diagnostic Values of Plasma, Fresh and Frozen Urine NT-proBNP in Heart Failure Patients

Mehrnoush Toufan, Hossein Namdar, Mohsen Abbasnezhad, Afshin Habibzadeh, Heidarali Esmaeili, Saeid Yaraghi & Zhila Samani
Introduction: The plasma N-terminal probrain natriuretic peptide (NT-proBNP) level is animportant diagnostic and prognostic marker of heart failure. Recent studies have suggestedurinary NT-proBNP as a new and simple test for diagnosis of heart failure. We aim to comparediagnostic value of plasma, fresh and frozen urine levels of N-terminal probrain natriureticpeptide (NT-proBNP) for detecting heart failure.Methods: Between January 2010 and January 2012, we measured urine and plasma levels of NTproBNPin 98 patients with chronic heart failure...

In Vitro Comparison of Compressive and Tensile Strengths ofAcrylic Resins Reinforced by Silver Nanoparticles at 2% and0.2% Concentrations

Tahereh Ghaffari, Fahimeh Hamedirad & Baharak Ezzati
Background and aims. Polymethyl methacrylate, PMMA, is widely used in prosthodontics for fabrication of removable prostheses. This study was undertaken to investigate the effect of adding silver nanoparticles (AgNPs) to PMMA at 2% and 0.2% concentrations on compressive and tensile strengths of PMMA.Materials and methods. The silver nanoparticles were mixed with heat-cured acrylic resin in an amalgamator in two groups at 0.2 and 2 wt% of AgNPs. Eighteen 2×20×200-mm samples were prepared for tensile strength...

Assessment of Intra- and Inter-examiner Reproducibility of Probing Depth Measurements with a Manual Periodontal Probe

Ardeshir Lafzi, Adileh Shir Mohammadi, Amir Eskandari & Sohrab Pourkhamneh
Background and aims. The main purpose of this study was to assess intra- and inter-examiner reproducibility of probing depth measurements with a manual periodontal probe. Materials and methods. In this study, 32 dental students in Tabriz Faculty of Dentistry with normal periodontium were evaluated. Each tooth of the upper right quadrants, except the third molars, was examined. Probing depths were measured in 6 surfaces of each tooth (mesiofacial, midfacial, distofacial, mesiolingual, midlingual and distolingual). Each...

Development of a Rheumatoid Arthritis Education Program using the PRECEDE_PROCEED Model

Haidar Nadrian, Ali Morowatisharifabad & Kaveh Bahmanpour
Background: In order to help rheumatoid arthritis (RA) patients in carrying out and at¬taining relevant self-care behaviors and adaptation to the physical limitations of this dis¬ease and, conse¬quently, promoting their level of health status, an education program based on the PRECEDE component of the PRECEDE–PROCEED model targeting patients with RA was developed. This paper describes the planning of a RA Patient Education Program (RAPEP) designed to promote their quality of life. Methods: The development of...

Radiographic Assessment and Chair Time of Rotary Instruments in the Pulpectomy of Primary Second Molar Teeth: A Randomized Controlled Clinical Trial

Abbas Makarem, Navid Ravandeh & Masoumeh Ebrahimi
Background and aims. The superiority of rotary systems has been reported in several clinical studies on permanent teeth. This study consisted of radiographic assessment and chair time of rotary instruments in the pulpectomy of primary second molar teeth. Materials and methods. In this randomized controlled clinical study, 46 children, 3-6 years of age, were selected. The patients were divided randomly into two groups. In the first group (group A) pulpectomy was carried out with hand...

Maternal Body Mass Index, Dietary Intake and Socioeconomic Status: Differential Effects on Breast Milk Zinc, Copper and Iron Content

Leila Nikniaz, Reza Mahdavi, Bahram Pourghassem Gargari, Seyed Jamal Gayemagami & Zeinab Nikniaz
Background: As breast milk micronutrients content are essential for health and growth of the infants, this study was conducted to determine the breast milk zinc, copper and iron concen¬trations and their possible correlations with maternal nutritional status, dietary intakes as well as socioeconomic status. Methods: Breast milk samples and information on maternal anthropometric characteristics and dietary intake were collected from 90 Iranian lactating women with 3 different socioeco¬nomic status who exclusively breastfed their infants. Concentrations...

Effects of Zinc Supplementation on the Anthropometric Measurements, Lipid Profiles and Fasting Blood Glucose in the Healthy Obese Adults

Laleh Payahoo, Alireza Ostadrahimi, Majid Mobasseri, Yaser Khaje Bishak, Nazila Farrin, Mohammad Asghari Jafarabadi & Sepide Mahluji
Purpose: The aim of this study was to assess the effects of zinc supplementation on anthropometric measures, improving lipid profile biomarkers, and fasting blood glucose level in obese people. Methods: This randomized, double- blind clinical trial was carried out on 60 obese participants in the 18-45 age range for one month. The participants were randomly divided into the intervention group, who received 30 mg/d zinc gluconate, and the placebo group who received 30mg/d starch. Anthropometric...

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