Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathwayGrainger, KA Smith, JP Hewitson, HJ McSorley, Y Harcus, KJ Filbey, CAM Finney, Edward James Greenwood, DP Knox, Wilson, MS, Y Belkaid, AY Rudensky & RM Maizels
Foxp3-expressing regulatory T (T reg) cells have been implicated in parasite-driven inhibition of host immunity during chronic infection. We addressed whether parasites can directly induce T reg cells. Foxp3 expression was stimulated in naive Foxp3⁻ T cells in mice infected with the intestinal helminth Heligmosomoides polygyrus. In vitro, parasite-secreted proteins (termed H. polygyrus excretory-secretory antigen [HES]) induced de novo Foxp3 expression in fluorescence-sorted Foxp3⁻ splenocytes from Foxp3-green fluorescent protein reporter mice. HES-induced T reg cells...
Sohini Kar-Narayan, Neil David Mathur & JL Prieto
In this work we study the influence of the thermal contact resistance on the temperature of a typical nanostripe used in current induced magnetic domain wall movement or depinning. The thermal contact resistance arises from an imperfect heat transport across the interface between the metallic ferromagnetic nanostripe and the substrate. We show that this parameter, which is likely non-zero in any experimental device, increases the temperature in the nanostripe considerably. When the current is injected...
Sociodemographic, lifestyle and behavioural factors associated with consumption of sweetened beverages among adults in Cambridgeshire, UK: the Fenland Study.Peter Barrett, Fumiaki Imamura, Soren Brage, Simon James Griffin, Nicholas John Wareham & Nita Gandhi Forouhi
We aimed to identify sociodemographic, lifestyle and behavioural determinants of consumption of sugar-sweetened beverages (SSB) and artificially sweetened beverages (ASB) among adults in Cambridgeshire, UK. Cross-sectional data were obtained from a cohort of 9991 adults born between 1950 and 1975. An FFQ was used to assess consumption of beverages and other dietary factors. Multivariable logistic regression was used to examine potential determinants of consuming SSB and ASB (≥1 serving/d). Recruitment from general practice surgeries to...
Tony D. James & Adam C. Sedgwick
This repository contains the experimental data discussed in the manuscript. Including, 1H NMR, 13C NMR (FID and PDF) and Mass Spectra for all the intermediates (A-H); probe 1; the hydroxylamine nitrone cyclic product; N-Methylhydroxylamine cyclic product; N,O,-BocHydroxylamine alkyne and N-Hydroxylamine alkyne. Fluorescence analysis data of probe 1 including the hydroxylamine titration curve; selectivity data against other hydroxylamines; amines and amino acids, Fluorescence intensity changes for probe 1 as a function of time with increasing concentrations...
Wasim Sardar Khan
Various materials have been used since ancient times to help immobilise fractures. In this review, we discuss the history and developments of these materials as well as plaster of Paris. There has been a recent trend away from non-operative management of fractures, and skills in the use of plaster of Paris are declining. For the successful treatment of patients, it is important to appreciate how plaster works, how it should be used, and what can...
Loss of memory CD4+ T-cells in semi-wild mandrills (Mandrillus sphinx) naturally infected with species-specific simian immunodeficiency virus SIVmnd-1Edward James Greenwood, F Schmidt, F Liégeois, I Kondova, A Herbert, B Ngoubangoye, F Rouet & Jonathan Luke Heeney
Simian immunodeficiency virus (SIV) infection is found in a number of African primate species and is thought to be generally non-pathogenic. However, studies of wild primates are limited to two species, with SIV infection appearing to have a considerably different outcome in each. Further examination of SIV-infected primates exposed to their natural environment is therefore warranted. We performed a large cross-sectional study of a cohort of semi-wild mandrills with naturally occurring SIV infection, including 39...
Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processesVM Narasimhan & Eamonn Richard Maher
Heterozygous mutations within homozygous sequences descended from a recent common ancestor offer a way to ascertain de novo mutations (DNMs) across multiple generations. Using exome sequences from 3,222 British-Pakistani individuals with high parental relatedness, we estimate a mutation rate of 1.45 ± 0.05 × 10-8 per base pair per generation in autosomal coding sequence, with a corresponding non-crossover gene conversion rate of 8.75 ± 0.05 × 10-6 per base pair per generation. This is at...
S. J. Robinson
The database of chemical composition of Central Asian forage plants contains just under 1000 desert and steppe species with information such as Latin and Russian names and family and related records of chemical composition from various sources including percentages by weight of protein, ash, cellulose and fat. Where available, it also includes data on digestible protein content, metabolisable energy and Soviet Feed Units (SFU). Records also include information on the country, location, season or month...
Data for: Wide crosses of durum wheat (Triticum durum Desf.) reveal good disease resistance, yield stability, and industrial quality across Mediterranean sitesFilippo Maria Bassi
Grain yield data across locations for a set of wide crosses vs elites vs cultivars
Data underpinning article "KLi3Fe(C2O4)3: a perovskite-like compound with 1:3 ordering at both A and B sites"Wenjiao Yao, Yuanyuan Guo & Philip Lightfoot
Raw data: powder and single crystal XRD, IR and TG data
Mukesh Kumar, M Jolly & Stephen Evans
Shifting supply chain architectures from ‘linear’ to ‘circular’ structures is imperative as businesses strive towards a circular economy ideal. Such a transformation requires innovation in the business models with impacts on value propositions, operations and revenue streams. This paper investigates the phenomenon of ‘circularity’ in supply chain operations, and proposes that product-service systems (PSS) business models can enhance restorative and regenerative effects of inner circles, circling long and cascading use circles. It adopts an exploratory...
Three-dimensional black-blood multi-contrast carotid imaging using compressed sensing: a repeatability studyJianmin Yuan, Ammara Usman, S Reid, K King, A Patterson, Jonathan Harvey Gillard & Martin Graves
OBJECTIVE: The purpose of this work is to evaluate the repeatability of a compressed sensing (CS) accelerated multi-contrast carotid protocol at 3 T. MATERIALS AND METHODS: Twelve volunteers and eight patients with carotid disease were scanned on a 3 T MRI scanner using a CS accelerated 3-D black-blood multi-contrast protocol which comprises T1w, T2w and PDw without CS, and with a CS factor of 1.5 and 2.0. The volunteers were scanned twice, the lumen/wall area...
Across the advanced capitalist states, the post-crisis conjuncture has been characterised by both marked continuity and profound change. While regressive distributional trends in place before the 2008 crisis have intensified, a number of highly unorthodox policy interventions have also emerged. In particular, a new regime of ‘loose’ monetary policy has crystallised, exemplified by record low interest rates and sustained programmes of quantitative easing. Existing approaches within economic geography are, we contend, ill-equipped to deal with...
The apparent anonymity of the Gospels is a neglected topic in NT studies. The present article offers an investigation of it. It will survey the work that has been done specifically on the subject, as well as how it is treated in Gospels scholarship more broadly. The main body of the argument is in two parts. First, anonymity cannot be defined by the lack of reference to a name in the body of the work,...
Stocklake Urban Improvement Scheme, Aylesbury, Buckinghamshire. Archaeological Watching Brief (OASIS ID: cotswold2-289396)Cotswold Archaeology
Between February and April 2016, Cotswold Archaeology carried out an archaeological watching brief during the Stocklake Urban Improvement Scheme, Aylesbury, Buckinghamshire. The Buckinghamshire Historic Environment Record (HER) shows that there have been numerous artefacts dating to the Roman period (AD 43 to AD 410) recovered from within the immediate vicinity of the site, which follows the route of the former Aylesbury to Cheddington railway line. Archaeological features encountered during the watching brief were confined to...
Data for: Life cycle impact assessment of Home Energy Management System using dynamic emission factors for electricity in FinlandJean-Nicolas Louis
The supplementary information file consists of five sections. The first section reviews the results of the method developed to get the dynamic emission factors based on the primary energy consumed for electricity production. The second section reports the values of the Figure 8 from the article, including the standard deviation for each of the 18 indicators of the ReCiPe characterisation method. The third section details the results of the dynamic model for all 18 indicators,...
S. Ormerod & T.H. Jones
The resource consists of genotype data (genetic constitution of an individual organism) for three freshwater macroinvertebrate species, Amphinemura sulcicollis, Isoperla grammatica and Baetis rhodani collected at sites in upland Wales during May 2012 and May 2013. New nucleotide tandem repeats in DNA sequences i.e. Novel microsatellites were developed for this project so that genetic analysis could be carried out within the three species. Extra data on how microsatellite scores were grouped i.e. binned into unique...
Related Article: Ryo Mizojiri, Kazuaki Takami, Tatsuya Ito, Hiroyuki Maeda, Mitsuhisa Yamano, Tetsuji Kawamoto|2017|Org.Process Res.Dev.|21|1034|doi:10.1021/acs.oprd.7b00147
The Cambridge Crystallographic Data Centre680,332
Imperial College London194,935
Archaeology Data Service44,293
Digital Repository of Ireland26,504
Oxford University Library Service Databank13,651
Faculty of 1000 Research Ltd10,589
University of Cambridge10,263
University of York10,165
UK Data Archive9,190
Science and Technology Facilities Council8,414
University of Edinburgh2,155
University of Southampton1,855
Beijing Genomics Institute1,196
London School of Hygiene and Tropical Medicine987