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Data for: "Thinking outside the Laboratory: Analyses of Antibody Structure and Dynamics within Different Solvent Environments in Molecular Dynamics (MD) Simulations"

Paul Mulheran, Mohammed Al Qaraghuli & Karina Kubiak-Ossowska
Data used in the paper "Thinking outside the Laboratory: Analyses of Antibody Structure and Dynamics within Different Solvent Environments in Molecular Dynamics (MD) Simulations". A 'readme' document explains the organisation of the data, and users of NAMD and VMD will be able to use the files provided.

A Putative Multiple-Demand System in the Macaque Brain.

Daniel Mitchell, Andrew H Bell, Mark J Buckley, Anna S Mitchell, Jerome Sallet & John Duncan

Midwives' and health visitors' collaborative relationships: A systematic review of qualitative and quantitative studies.

Ryc Aquino, Ellinor K Olander, Justin J Needle & Rosamund M Bryar

The nature and frequency of abdominal symptoms in cancer patients and their associations with time to help-seeking: evidence from a national audit of cancer diagnosis.

Minjoung Monica Koo, Christian Von Wagner, Gary A Abel, Sean McPhail, William Hamilton, Greg P Rubin & Georgios Lyratzopoulos

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes.

Sebastian Mueller, Thomas Engleitner, Roman Maresch, Magdalena Zukowska, Sebastian Lange, Thorsten Kaltenbacher, Björn Konukiewitz, Rupert Öllinger, Maximilian Zwiebel, Alex Strong, Hsi-Yu Yen, Ruby Banerjee, Sandra Louzada, Beiyuan Fu, Barbara Seidler, Juliana Götzfried, Kathleen Schuck, Zonera Hassan, Andreas Arbeiter, Nina Schönhuber, Sabine Klein, Christian Veltkamp, Mathias Friedrich, Lena Rad, Maxim Barenboim … & Roland Rad
The poor correlation of mutational landscapes with phenotypes limits our understanding of the pathogenesis and metastasis of pancreatic ductal adenocarcinoma (PDAC). Here we show that oncogenic dosage-variation has a critical role in PDAC biology and phenotypic diversification. We find an increase in gene dosage of mutant KRAS in human PDAC precursors, which drives both early tumorigenesis and metastasis and thus rationalizes early PDAC dissemination. To overcome the limitations posed to gene dosage studies by the...

Single-molecule localization microscopy reveals molecular transactions during RAD51 filament assembly at cellular DNA damage sites.

Kalina T Haas, Miyoung Lee, Alessandro Esposito & Ashok Ramakrishnan Venkitaraman
RAD51 recombinase assembles on single-stranded (ss)DNA substrates exposed by DNA end-resection to initiate homologous recombination (HR), a process fundamental to genome integrity. RAD51 assembly has been characterized using purified proteins, but its ultrastructural topography in the cell nucleus is unexplored. Here, we combine cell genetics with single-molecule localization microscopy and a palette of bespoke analytical tools, to visualize molecular transactions during RAD51 assembly in the cellular milieu at resolutions approaching 30–40 nm. In several human...

Identification and characterization of the novel colonization factor CS30 based on whole genome sequencing in enterotoxigenic Escherichia coli (ETEC).

Astrid Von Mentzer, Joshua Tobias, Gudrun Wiklund, Stefan Nordqvist, Martin Aslett, Gordon Dougan, Åsa Sjöling & Ann-Mari Svennerholm

Needs and Expectations for Fully Autonomous Vehicle Interfaces

Theocharis Amanatidis, P Langdon & Peter John Clarkson
Fully autonomous vehicles provide an opportunity to improve current transportation solutions; both for drivers and for people unable to drive. In this paper we present the preliminary results of a study aiming to understand user needs and expectations for autonomous vehicle interfaces. We found that users expect a different type of information to be fed back to them depending on whether the vehicles are privately owned or shared. The results of this study will be...

Preterm Infant-Associated Clostridium tertium, Clostridium cadaveris, and Clostridium paraputrificum Strains: Genomic and Evolutionary Insights.

Raymond Kiu, Shabhonam Caim, Cristina Alcon-Giner, Gusztav Belteki, Paul Clarke, Derek Pickard, Gordon Dougan & Lindsay J Hall

Group Sequential Clinical Trial Designs for Normally Distributed Outcome Variables

Michael Grayling, James Wason & Adrian Paul Mander
In a group sequential clinical trial, accumulated data are analysed at numerous time-points in order to allow early decisions about a hypothesis of interest. These designs have historically been recommended for their ethical, administrative and economic bene fits. In this work, we discuss a collection of new Stata commands for computing the stopping boundaries and required group size of various classical group sequential designs, assuming a normally distributed outcome variable. Following this, we demonstrate how...

Constructing early graduate careers

Fiona Christie
There has been a growing pressure on higher education to be seen to deliver positive graduate outcomes. The prospects of graduates attract the attention of many commentators including the media, employers, government and universities themselves. Literature about graduate career destinations has tended to draw upon quantitative data about trends while more local and qualitative commentary about the experience of graduates has been scarcer. This study seeks to address this gap by exploring the meaning-making that...

Typical smartphone usage dataset

David Ellis & Heather Shaw
Summary data for participant smartphone usage over a 13 day period. This includes the number of hours a smartphone was used each day and the number of times a devices was checked. Checks are defined as any period of usage lasting less than 15 seconds. Totals for each week and over the entire testing period are also provided.

Supporting Mental Health in Schools and Colleges, 2016-2017

NatCen Social Research

1810775

Dr Helena Alberto, Professor Roger Lichti, Dr Alan Drew, Dr P.W. Mengyan, Mr Jarryd Horn, Dr Rui Vilao, Ms Mariah Goeks, Dr James Lord & Dr Koji Yokoyama

1820331

Dr Anthony Phillips & Dr Dominic Fortes

1720389

Mr Jarryd Horn, Professor Roger Lichti, Ms Mariah Goeks, Dr P.W. Mengyan & Dr James Lord

1810428

Professor Jiqian Wang, Mr Xuzhi Hu, Mr Zhiming Lu, Professor Jian Lu, Dr Steve King, Dr Zongyi Li, Professor Hai Xu & Mr Huayang Liu

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