303 Works

Active Filaments In and Out of Confinement

Matthew Peterson
Active matter encompasses systems whose microscopic constituents consume energy at the particle scale to produce forces and motion. Novel macroscale phenomena emerge in these systems when these forces collectively organize into mesoscale `active stresses'. Harnessing these active stresses to drive particular emergent behaviors could enable a new class of materials with life-like properties that would be impossible in traditional equilibrium materials. Similarly, many biological functions, such as cytoplasmic streaming, morphogenesis, and cell migration, are driven...

Computational and Data-Driven Studies of Active Nematics

Chaitanya Joshi
Active nematics are a class of non-equilibrium systems with constituents that consume energy at the molecular level to generate motion at macroscopic scales. In bulk, these materials exhibit turbulent behavior, and the active energy is not converted into meaningful work. One way of taming the turbulence is via confinement in regular geometries, which requires understanding the effect of boundaries on the active flows. Other approaches might involve strategies like optimal control or model-predictive control to...

The Vagueness of Dying in Epicurean Thought: A Stoic Remedy?

Julia Andrina Greig
“Death, which is the most horrifying of evils, is nothing to us; whenever we, on the one hand, exist, death is not present. On the other hand, whenever death is present, we, then, do not exist” (Ep. Men. 125). According to Epicurus, in section one hundred twenty-five of his “Letter to Menoeceus”, if death is the deprivation of all sense-perception and the annihilation of the subject, it cannot be bad, for there must be an...

Spectrum of Chromosomal Repair Mutations Associated with Mitotic Gene Conversions

Qiying Cui
The genome of a cell is continuously subject to damage. By-products from cell metabolism, irradiation, chemical agents, and ultraviolet light are all environmental factors that cause lesions that can block replication progression. Although cells have adapted checkpoint mechanisms and repair pathways, repair failure can lead to deletions, translocations, and fusions in the DNA. These genomic rearrangements are commonly found in cancer cells. Double-strand breaks (DSBs) are problematic and the most lethal type of damage if...

Microtubule-based Active Matter: Controlling Microscopic Properties and Characterizing Instabilities

Pooja Chandrakar
Active matter are internally driven non-equilibrium systems, which are made of energy consuming motile entities. They exhibit long-range self-organization phenomena such as pattern formation, collective motion and spontaneous flows. Understanding the physical principles governing these phenomena are of both fundamental and practical interest. They offer promise of improving the fundamental knowledge of non-equilibrium statistical mechanics while also providing a platform for creating novel, programmable synthetic materials with life-like properties. Studying active matter systems is difficult...

Hippocampal Rem2 in taste learning and memory

Katherine Elizabeth Kimbrell
The molecular/cellular plasticity mechanisms that ensure adaptive animal behaviors remain less than fully understood. Our lab has shown that Rem2, a small GTPase of the Ras-like superfamily, regulates multiple plasticity-related phenomena, including synapse formation and function and dendritic arbor complexity. While the above work involved examination of visual cortex, Rem2 is also expressed the hippocampus, a region that mediates a broad swath of learning and memory behaviors, including Social Transmission of Food Preference (STFP) and...

L_b-ideals at irregular CM points of weight 1

Tarakaram Gollamudi
Let $f$ be a cuspidal $CM$ modular form of weight $1$ and level $N$ which is irregular at $p$.The primary goal of this thesis is to investigate the behavior $L_b-$ideal at $f$ without knowing the modules of overconvergent modular symbols $M^+$ and $M^-$. These modules are $T-$modules which are free of finite rank $n$ over $R$. We present a full classification such modules for $n=2$ and $3$ and partial classification for $n=4$. We also establish...

China's Strategies To Undo U.S. Dollar Dominance

Jiaxin Li
The U.S. Dollar emerged as the dominant world currency after the end of World War II. Though the global economy has changed drastically since then, the U.S. Dollar is still the leading currency. This thesis provides strategies if China wishes to challenge U.S. Dollar dominance as the internationalization of the Chinese Renminbi continues to expand. First, I will evaluate the history of the U.S. Dollar’s replacement of the British Pound Sterling as the dominant world...

“Not Your Superwoman”

Zoe Ariana Fort
The United States is experiencing an infant and maternal mortality crisis across racial stratifications at more alarming rates than in the antebellum era and Jim Crow. Over the past fifteen years, these disparities have accrued significant media, scholarly, and medical attention. Scientific evidence has proven that racism and the physiological stress it causes are contributing factors to these birth outcome disparities. Even so, there has been a dearth of information on how harmful tropes have...

A D-phenylalanine-benzoxazole derivative uncovers redundancy in the pantothenate biosynthetic pathway of Mycobacterium tuberculosis

Michael Pepi
New drugs and new targets are urgently needed to treat tuberculosis. We discovered the D-phenylalanine-benzoxazole Q112 displays potent antibacterial activity against Mycobacterium tuberculosis in multiple media and in macrophage infections. Metabolomic profiling experiments indicate that Q112 has a unique mechanism of action compared to other antitubercular agents. Q112 perturbs the essential pantothenate/CoA biosynthetic pathway, depleting pantoate while increasing ketopantoate, as would be expected if ketopantoate reductase (KPR) were inhibited. We searched for alternative KPRs since...

Unnatural Histories

Jay Collay
This study examines commonalities in English-language texts dealing with queer history before 1969. The goal of this research is to expand the field of queer historiography by understanding what stories and methodologies preceded more modern histories, and especially to understand what existed before the narrative of an upward arc from the flashpoint of the Stonewall Uprisings. Material surveyed includes magazines, poetry, sexology books, novels, diaries, pamphlets, newspaper articles, and academic papers in order to collect...

Atomic Resolution Imaging of Molecular Photoswitches and Their Application in Solar Energy Storage

Mihael Gerkman
Molecular photoswitches that reversibly isomerize when exposed to external stimuli, such as light, heat, and current have been used for diverse applications in drug delivery, sensing, controlling hydrophilicity of surface, actuation, and many other fields. The wide range of applications is achieved primarily due to their significant changes in physical and optical properties upon isomerization. However, the isomerization dynamics of these compounds are typically studied in dilute solution or dispersion in polymer matrices, which is...

Exploring the Impact of Computer Science on the Future of Higher Ed

Jessica Liebowitz, Timothy J. Hickey & Matthew Ekins
We bring a new type of data-job posting analytics-to illuminate questions about data scientific expertise in the higher ed workforce. In particular, this allows us to link trends in computer science faculty hiring with demand for data science and predictive analytic skills among non-faculty jobs across the university. Within the context of the US economy as a whole, our findings identify research universities as one of the fastest growing centers of data scientific human capital...

The Mechanisms of DNA Double Strand Break Repair and Mismatch Recognition

Danielle Nicole Gallagher
DNA double-strand breaks (DSBs) are among the most toxic forms of DNA damage and pose a severe threat to genomic integrity. As such, the cell has evolved highly coordinated and complex mechanisms to repair such lesions. Improper repair of DSBs can lead to chromosomal duplication, chromosomal deletions, and chromosomal translocations, all of which are hallmarks of human cancers. Previous work in DNA damage has focused on the mechanistic characterization of how cells repair DNA DSBs,...

Reassessing Stress: Distinct Neural and Mental Health Correlates of Stress Exposure and Controllability Appraisals

Alyssa Fassett-Carman
Stress is a strong risk factor for internalizing symptoms and can lead to changes in gray matter (GM) structure associated with psychopathology. Adolescence and emerging adulthood is a time of heightened stress, onset of stress-related disorders such as depression, and GM development, and is thus posited to be a sensitive period for the effects of stress. However, not all youth who experience stress develop symptoms. Learned helplessness theory and evidence describes how having control over...

Living with 47, XXY: An Emerging Adulthood Perspective

Clare Morris
47, XXY, also known as Klinefelter’s syndrome, is a chromosomal aneuploidy syndrome that can present with a wide array of symptoms that can affect both physical and mental health.This study examines individuals in the emerging adulthood period, ages 18-29, who have 47, XXY. Participants were asked to complete an online survey that focused on their diagnostic experience, relationships, support systems and advice that they have for others. Thirty-six individuals participated and their responses were analyzed...

Relative Morality, Disagreement, & Moral Progress

Katya Ioannina Hirsch

The endoplasmic reticulum chaperone BiP is a closure-accelerating co-chaperone of Grp94

Ming Sun
Structural and functional analysis of Hsp70 and Hsp90 chaperones has advanced significantly over the last decade. However, within the cell Hsp70 and Hsp90 often work together, and little is known about the molecular mechanisms that allow these two chaperones to productively coordinate their activities. Much of my thesis is focused on discoveries that reveal a high level of regulation in how Hsp70 and Hsp90 work together. I specifically focus on the endoplasmic reticulum (ER)-specific Hsp70/Hsp90...

Structural and Functional studies of the Hsp90 molecular chaperone

Yi Jin

Structural Transitions of Colloidal Membranes in One, Two, and Three Dimensions

Joanna Robaszewski
Directing the geometry of membranes is a goal shared by many disciplines. From designing drug delivery systems in bioengineering to understanding how membranes regulate their size and shape in physics, the study of structural transitions of membranes offers many potential insights into membrane assembly. However, biological membranes operate on small length and time scales that make it difficult to examine the physics behind biomembrane configuration using standard microscopy techniques. Here, we present an experimental model...

Virtual Social Interaction and Mental Health During COVID-19

Sarah Marie Rosa
The COVID-19 pandemic is a highly stressful and unprecedented event, and its effects on mental health are relatively unknown. In-person social support and interaction are known protective factors against internalizing symptoms, however, due to social distancing regulations, people are engaging in face-to-face (FTF) interactions less and technology-mediated communication (TMC) more. The current study investigated if FTF interaction and different forms of TMC relate to internalizing symptoms. Undergraduate students from Brandeis University reported their frequency of...

Examining Sleep as a Mechanism Linking Physical Activity and Cognition

Alycia Bisson
Although both physical activity (PA) and sleep have been linked to cognitive functioning, many questions remain with regard to the nature of their relationships. Pathways that link sleep and PA to cognition have been studied separately, but recent work suggests that PA and sleep are also related. Studies have found that more active people sleep better and longer than those who are inactive. Within persons, sleep quantity and quality are better on days when one...


Arianna Arguetty
Wonderland is a novella in which a recent college graduate ends up working through her self-esteem issues--or, at least, begins the process of working through them--when she enters into a romantic B.D.S.M relationship.

Dynamics and Rigidity of the Morse Boundary

Qing Liu
Let $X$ be a proper geodesic metric space and let $G$ be a group of isometries of $X$ which acts geometrically. Cordes constructed the Morse boundary of $X$ which generalizes the contracting boundary for CAT(0) spaces and the visual boundary for hyperbolic spaces. For the first part, we characterize Morse elements in $G$ by their fixed points on the Morse boundary $\partial_MX$. The dynamics on the Morse boundary is very similar to that of a...

Paired feed-forward excitation with delayed inhibition allows high frequency computations across brain regions

Alexandra Shan Cao
The transmission of high-frequency temporal information across brain regions is critical to perception, but the mechanisms underlying such transmission remain unclear. Long-range projection patterns across brain areas are often comprised of paired feedforward excitation followed closely by delayed inhibition, including the thalamic triad synapse, thalamic projections to cortex, and projections within hippocampus. Previous studies have shown that these joint projections produce a shortened period of depolarization, sharpening the timing window over which the postsynaptic neuron...

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  • 2021

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