16,829 Works

2018 Update on Protein-Protein Interaction Data in WormBase

Jaehyoung Cho, Christian Grove, Kimberly Van Auken, Juancarlos Chan, Sibyl Gao & Paul W. Sternberg
Protein interaction is an important data type to understand the biological function of proteins involved in the interaction, and helps researchers to deduce the biological nature of unknown proteins from the well-characterized functions of their interaction partners. High-throughput studies, coupled with the aggregation of individual experiments, provides a global 'snapshot' of the protein interactions occurring at all levels of biological processes or circumstances. This snapshot of the interaction network, the interactome, is important to understand...

Confirmed Planets Table

NASA Exoplanet Archive
The Confirmed Planets table contains physical and orbital parameters for the planet and the host star, as available from the default literature reference for each planet.

Expanding the repertoire of DNA-mediated signaling in DNA repair

Timothy Paul Mui
DNA damage is extremely detrimental to the cell and must be repaired to protect the genome. DNA is capable of conducting charge through the overlapping π-orbitals of stacked bases; this phenomenon is extremely sensitive to the integrity of the π-stack, as perturbations attenuate DNA charge transport (CT). Based on the E. coli base excision repair (BER) proteins EndoIII and MutY, it has recently been proposed that redox-active proteins containing metal clusters can utilize DNA CT...

Microfluidic EPG Recordings Show Striking Pharyngeal Pumping Phenotype in a C. elegans Alzheimer's Disease Model

Janis C Weeks, Kristen J Robinson, Benedicta Wanjeri, Philip F Copenhaver & William M Roberts
Strain CL4176 accumulates human amyloid-β1-42 in body wall muscles after animals are shifted from 15 to 25 oC, causing paralysis (Link et al. 2003). We temperature-shifted worms at early L4 and quantified pharyngeal pumping at 48 h using a microfluidic electropharyngeogram (EPG) recording platform (Lockery et al. 2012; Weeks et al. 2016). Recordings were made in M9 buffer with 10 mM serotonin and analyzed by automated pump-recognition software. At 48 h, control CL802 worms showed...

On the Concentration of Space Charge in the Vicinity of an Insulating Surface

Benedict Cassen
The purpose of this investigation is the determination of the order of magnitude of the highest densities of space charge experimentally producible in the immediate vicinity of an insulating surface. The first section of the paper is a theoretical analysis of the problem while the second section describes some simple experiments undertaken in order to obtain the necessary data to get a numerical answer for some particular insulating surfaces.

Kepler Objects of Interest Cumulative Table

NASA Exoplanet Archive
The Kepler Objects of Interest (KOI) cumulative table gathers information from the individual KOI activity tables that describe the current results of different searches of the Kepler light curves. The intent of the cumulative table is to provide the most accurate dispositions and stellar and planetary information for all KOIs in one place. All the information in this table has provenance in other KOI activity tables.

Optical Phase Conjugation and Its Applications in Biology

Mooseok Jang
Optical phase conjugation is a process where an incoming electromagnetic wave is reflected with a reversed phase. The propagation direction of an incoming beam (equivalently, local phase gradient) can thereby be precisely reversed by the phase conjugate beam. This intriguing effect, so called "time-reversal of electromagnetic waves," allows cancellation of spatial distortion introduced into the incoming beam. Recently, this concept has provided a new avenue to overcome or utilize random scattering in the field of...

SapTrap Builder: a desktop utility for CRISPR edit design

Matthew L Schwartz & Erik M Jorgensen
Designing and building DNA reagents for CRISPR edits can be complicated as well as tedious. To streamline reagent design for our SapTrap CRISPR plasmid assembly system, we developed the SapTrap Builder software utility. SapTrap Builder provides an intuitive graphical user interface for visualizing the design of reagents for CRISPR-based genetic tag insertion and point mutagenesis. Our program guides users through several steps of CRISPR edit design, alerts the user when incompatibilities arise, and generates sequences...

The bodies of dpy-10(e128) are twice as stiff as wild type

Sylvia Fechner, Frédéric Loizeau, Adam L Nekimken, Beth L Pruitt & Miriam B Goodman
DPY-10 is a collagen protein in the nematode's cuticle. Mutations in the dpy-10 gene induce various morphological changes that lead to animals with a dumpy or roller phenotype (Levy, Yang & Kramer, 1993). Here, we asked how such mutations affect body stiffness by comparing force-indentation curves in dpy-10(e128) and wild type worms. On average, dpy-10(e128) worms have a steeper force-indentation relationship, leading to a higher body stiffness (Fig 1.C). Average stiffness values were 2.5 0.9...

K2 Candidates Table

NASA Exoplanet Archive
The K2 candidates table lists objects from the published literature identified as candidates or false positives. If objects are confirmed as planets, their status in this table is updated but the objects remain.

Materials Experiment and Analysis Database: Material library with Bi,V,Sb,Ar deposited by PVD on 2013-10-15 from Plate 00008884

Edwin Soedarmadji, John Gregoire & Contributors

Characteristics of transverse mixing in open-channel flows

W. M. Keck Laboratory Of Hydraulics And Water Resources

Delta-9 Fatty Acid Desaturase Mutants Display Increased Body Size

James F.; Savage-Dunn Clark
C. elegans contain three Δ9 fatty acid desaturases (FADs), fat-5, fat-6, and fat-7, responsible for the initial desaturation step in the synthesis of complex polyunsaturated fatty acids (PUFAs). Production of PUFAs is vital for survival, as simultaneous loss-of-function in all three genes results in synthetic lethality (Brock et al. 2006). Animals containing mutations in any one of the three Δ9 FADs, fat-5, fat-6, and fat-7, display an increase in body length. fat-5 mutants display a...

Searches for New Physics at the Compact Muon Solenoid Experiment and Precision Timing Calorimetry

Cristián Peña Herrera
In this thesis, we present several searches for beyond the standard model physics in proton-proton collisions recorded by the Compact Muon Solenoid Experiment at center-of-mass energy of 8 and 13\TeV. We search for particle dark matter in events with two or more jets and missing transverse momentum at $\sqrt{s} = 8$ TeV, in this search we use the razor variables to discriminate signal from background events and thus improve the overall sensitivity of the analysis....

A new mutation with a polycystin phenotypic spectrum in Caenorhabditis elegans

Allyson Whittaker, Gary Schindelman, Shahla Gharib & Paul W. Sternberg
lov-1 and pkd-2, which encode the C. elegans orthologs of human polycystin-1 and -2, are necessary for three particular aspects of male mating behavior. In a screen for male mating defective mutants with similar spectrum of mating defects, we identified a mutation that apparently defines a new locus, lov-3. We isolated the sy682 mutation in an ethyl-methane sulphonate (EMS)-screen of Caenorhabditis elegans strain PS1395 [genotype: plg-1(e2001d); him-5(e1490)] for mutant males that do not mate efficiently...

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