17,166 Works

Materials Experiment and Analysis Database:

Edwin Soedarmadji, John Gregoire & Contributors

On Ultrafast Time-Domain TeraHertz Spectroscopy in the Condensed Phase: Linear Spectroscopic Measurements of Hydrogen-Bond Dynamics of Astrochemical Ice Analogs and Nonlinear TeraHertz Kerr Effect Measurements of Vibrational Quantum Beats

Marco Alberto Allodi
Much of the chemistry that affects life on planet Earth occurs in the condensed phase. The TeraHertz (THz) or far-infrared (far-IR) region of the electromagnetic spectrum (from 0.1 THz to 10 THz, 3 cm-1 to 300 cm-1, or 3000 μm to 30 μm) has been shown to provide unique possibilities in the study of condensed-phase processes. The goal of this work is to expand the possibilities available in the THz region and undertake new investigations...

Software Design System

Computer Science Technical Reports

Algorithmic Challenges in Green Data Centers

Minghong Lin
With data centers being the supporting infrastructure for a wide range of IT services, their efficiency has become a big concern to operators, as well as to society, for both economic and environmental reasons. The goal of this thesis is to design energy-efficient algorithms that reduce energy cost while minimizing compromise to service. We focus on the algorithmic challenges at different levels of energy optimization across the data center stack. The algorithmic challenge at the...

2018 Update on Protein-Protein Interaction Data in WormBase

Jaehyoung Cho, Christian Grove, Kimberly Van Auken, Juancarlos Chan, Sibyl Gao & Paul W. Sternberg
Protein interaction is an important data type to understand the biological function of proteins involved in the interaction, and helps researchers to deduce the biological nature of unknown proteins from the well-characterized functions of their interaction partners. High-throughput studies, coupled with the aggregation of individual experiments, provides a global 'snapshot' of the protein interactions occurring at all levels of biological processes or circumstances. This snapshot of the interaction network, the interactome, is important to understand...

Extending the CRISPR toolbox for C. elegans: Cpf1 as an alternative gene editing system for AT-rich sequences

Annabel Ebbing, Peng Shang, Niels Geijsen & Hendrik C. Korswagen
The CRISPR/Cas9 system has become a powerful tool for genome-editing in C. elegans. Sequence specificity of the system is determined by a guide RNA which targets the Cas9 endonuclease to the genomic region of interest. In addition, Cas9 needs to interact with a so-called protospacer-adjacent motif (PAM) next to the target sequence. In case of Cas9 from Streptococcus pyogenes (SpCas9), the most commonly used Cas9, this sequence is NGG. Because the C. elegans genome sequence...

Charged Pion Contribution to the Anomalous Magnetic Moment of the Muon

Kevin Thomas Engel
The model dependence inherent in hadronic calculations is one of the dominant sources of uncertainty in the theoretical prediction of the anomalous magnetic moment of the muon. In this thesis, we focus on the charged pion contribution and turn a critical eye on the models employed in the few previous calculations of $a_\mu^{\pi^+\pi^-}$. Chiral perturbation theory provides a check on these models at low energies, and we therefore calculate the charged pion contribution to light-by-light...

Multilayer Active Shell Mirrors

John Bradley Steeves
This thesis presents a novel active mirror technology based on carbon fiber composites and replication manufacturing processes. Multiple additional layers are implemented into the structure in order to provide the reflective layer, actuation capabilities and electrode routing. The mirror is thin, lightweight, and has large actuation capabilities. These features, along with the associated manufacturing processes, represent a significant change in design compared to traditional optics. Structural redundancy in the form of added material or support...

me98 is a new allele of rad-54

Baptiste Roelens, Karl A Zawadzki & Anne M Villeneuve
We isolated the me98 mutant in a genetic screen for C. elegans mutants with an altered number of GFP::COSA-1 foci, which mark the sites of crossovers in wild-type C. elegans germ cells (ROSU et al. 2013). After multiple rounds of outcrossing, we confirmed that the me98 mutant is defective in meiotic prophase as i) chromosomes in diakinesis oocytes appear partially decondensed and structurally compromised (Fig. 1A), ii) me98 fails to form the six GFP::COSA-1 foci...

Materials Experiment and Analysis Database:

Edwin Soedarmadji, John Gregoire & Contributors

Theory of Plasma Wave Resonances in a Hot Nonuniform Plasma

Jerald V. Parker
This work is concerned with the resonant motion exhibited by a plasma column which is excited by an oscillating electric field transverse to the column. A theory is considered which includes the effects of electron temperature and of nonuniformities in the plasma electron density. In order to have a quantitative theory, the nonuniform electron densities used are calculated numerically using a theory due to Tonks and Langmuir. The theory yields a fourth order differential equation...

GABA Receptor mutant gbb-1 accelerates morphological aging of GABA neurons in Caenorhabditis elegans

I. Dhillon, A. Momin & I. Chin-Sang
The aging of an organism is heterogeneous, that is to say, tissues and organs may age at unique rates compared to overall organism longevity. Inhibition of the insulin/insulin-like growth factor signaling (IIS), such as the daf-2 IIS receptor increases Caenorhabditis elegans longevity. The daf-2 pathway plays a key role in the regulation of metabolism and stress responses and as such, impacts the longevity of the organism (Uno and Nishida 2016). Evidence suggests that an increase...

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