51,220 Works

BindingDB Entry 50033815: Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors.

BindingDB
Small molecule binding data for protein Histone deacetylase, Histone deacetylase 1, Histone deacetylase 4, and Histone deacetylase 8, Uniprot A0A024QZ26, P56524, Q13547, Q9BY41, and Q9UBN7

BindingDB Entry 50045486: Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).

BindingDB
Small molecule binding data for protein Cytochrome P450 1A, Cytochrome P450 2C9, Cytochrome P450 2D6 (2D6), Cytochrome P450 3A, GRM7, GRM8, Metabotropic glutamate receptor, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 2 (mGluR2), Metabotropic glutamate receptor 4 (mGluR4), Metabotropic glutamate receptor 6, and metabotropic glutamate 1c, Uniprot O00222, O15303, P05177, P08684, P10635, P11712, P31424, Q13255, Q14416, Q14831, Q14832, and Q14833

BindingDB Entry 50046940: Synthesis of 4-sulfamoylphenyl-benzylamine derivatives with inhibitory activity against human carbonic anhydrase isoforms I, II, IX and XII.

BindingDB
Small molecule binding data for protein Carbonic anhydrase, Carbonic anhydrase 12, Carbonic anhydrase 2, and Carbonic anhydrase 9, Uniprot O43570, P00915, P00918, and Q16790

BindingDB Entry 7763: Structural basis for the recognition of mycolic acid precursors by KasA, a condensing enzyme and drug target from Mycobacterium tuberculosis.

BindingDB
Small molecule binding data for protein β-ketoacyl-ACP synthase I (C171Q KasA) and Beta-ketoacyl-ACP synthase (KasA), Uniprot P9WQD9

BindingDB Entry 50044826: Inhibitors ofß-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718).

BindingDB
Small molecule binding data for protein Beta-secretase 1, Beta-secretase 2 (BACE2), Cathepsin D, Cathepsin E, Renin, and Voltage-gated potassium channel, Uniprot P00797, P07339, P14091, P56817, Q12809, and Q9Y5Z0

BindingDB Entry 50020923: C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols.

BindingDB
Small molecule binding data for protein Cannabinoid receptor, Uniprot P20272 and P47936

BindingDB Entry 50006298: Synthesis and analgesic effects of N-[3-[(hydroxyamino) carbonyl]-1-oxo-2(R)-benzylpropyl]-L-isoleucyl-L-leucine, a new potent inhibitor of multiple neurotensin/neuromedin N degrading enzymes.

BindingDB
Small molecule binding data for protein Angiotensin-converting enzyme, Cystinyl aminopeptidase, and Neutral Endopeptidase (NEP), Uniprot P07861, P12822, and Q9UIQ6

BindingDB Entry 50037274: Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction.

BindingDB
Small molecule binding data for protein 5-hydroxytryptamine receptor 1A, Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor, Dopamine receptor, Dopamine receptor D2L/neurotensin receptor NTS1, Dopamine receptors; D2 & D4, and Kappa-type opioid receptor, Uniprot P08908, P14416, P21917, P30729, P35462, P41145, and P61169

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  • 2019
    1,574

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  • UC San Diego
    51,220