12 Works

Voxel-wise co-analysis of macro- and microstructural brain alteration in Mild Cognitive Impairment and Alzheimer's disease using anatomical and diffusion MRI

Cardenas, Valerie ; Tosun, Duygu ; Chao, Linda ; Fletcher, P. Thomas ; Joshi, Sarang; Weiner, Michael; Schuff, Norbert

Posttraumatic Stress Disorder (PTSD)

Michael W. Weiner & Norbert Schuff
This data set was acquired to study various aspects associated with PTSD and includes structural neuroimaging data as well as clinical assessments including history of physical and sexual abuse or neglect, family history of violence, veteran status, presence of alcoholism, and scores on the clinician-administered PTSD scale (CAPS).

Changes in brain anatomy during the course of PTSD

Valerie Cardenas, Kristin Samuelson, Maryanne A. Lenoci, Colin Studholme, Thomas C. Neylan, Charles R. Marmar, Norbert Schuff & Michael W. Weiner
Longitudinal structural T1-weighted images from middle-aged controls and veterans with PTSD (post-traumatic stress disorder). Most patients were Vietnam veterans. The goal of this study was to determine whether PTSD was associated with an increase in time-related decline in macrostructural brain volume and whether these changes were associated with accelerated cognitive decline. To quantify brain structure, 3 dimensional T1-weighted MRI scans were performed at baseline and again after a minimum of 24 months in 25 patients...

Associations between vascular risk factors, carotid atherosclerosis and cortical volume and thickness in older adults

Valerie Cardenas, Bruce Reed, Linda Chao, Helena Chui, Nerses Sanossian, Charles DeCarli, Wendy Mack, Joel Kramer, Howard Hodis, Mingzhu Yan, Michael Buonocore, Owen Carmichael, William J. Jagust & Michael W. Weiner
Data from healthy and cognitively impaired elderly, enriched for cerebrovascular disease. Background and Purpose: To investigate whether the Framingham Cardiovascular Risk Profile (FCRP) and carotid artery intima-media thickness (CIMT) are associated with cortical volume and thickness. Results: 152 subjects (82 men) were aged 78 (±7) years old, 94 had a CDR of 0, 58 had a clinical dementia rating (CDR) of 0.5 and the mean mini-mental status examination (MMSE) was 28 ±2. FCRP score was...

Patterns of age-related water diffusion changes in human brain by concordance and discordance analysis.

Yu Zhang, An-Tao Du, Satoru Hayasaka, Geon-Ho Jahng, Jennifer Hlavin, Wang Zhan, Michael W. Weiner, Norbert Schuff & Memory And Aging Center
In diffusion tensor imaging (DTI), interpreting changes in terms of fractional anisotropy (FA) and mean diffusivity or axial (D(||)) and radial (D(?)) diffusivity can be ambiguous. The main objective of this study was to gain insight into the heterogeneity of age-related diffusion changes in human brain white matter by analyzing relationships between the diffusion measures in terms of concordance and discordance instead of evaluating them separately, which is difficult to interpret. Fifty-one cognitively normal subjects...

CSF Biomarker and PIB-PET Derived Beta-Amyloid Signature Predicts Metabolic, Grey Matter and Cognitive Changes in Non-Demented Subjects

Michael Ewers, Philip Insel, William J. Jagust, Leslie Shaw, John Q. Trojanowski, Paul Aisen, Ronald C. Petersen, Norbert Schuff & Michael W. Weiner
Beta-amyloid (Aß is a histopathological hallmark of Alzheimer's disease dementia, but high levels of Aß in the brain can also be found in a substantial proportion of nondemented subjects. Here we investigated which 2-year rate of brain and cognitive changes are present in nondemented subjects with high and low Aß levels, as assessed with cerebrospinal fluid and molecular positron emission tomography (PET)-based biomarkers of Aß. In subjects with mild cognitive impairment, increased brain Aß levels...

Progression of white matter degeneration in amyotrophic lateral sclerosis: A diffusion tensor imaging study

Yu Zhang, Norbert Schuff, Susan Woolley, Gloria Chiang, Lauren Boreta, Joel Laxamana, Jonathon Katz & Michael W. Weiner
Whether longitudinal diffusion tensor MRI imaging (DTI) can capture disease progression in patients with amyotrophic lateral sclerosis (ALS) is unclear. The primary goal of this study was to determine if DTI detects progression of the corticospinal tracts (CST) degeneration in ALS. Seventeen ALS patients and 19 ageand gender-matched healthy controls were scanned with DTI at baseline for cross-sectional analyses. For longitudinal analyses, the ALS patients had repeat DTI scans after eight months. Tractography of the...

Changes in brain anatomy during the course of PTSD

Cardenas, Valerie ; Samuelson, Kristin ; Lenoci, Maryann; Studholme, Colin ; Neylan, Thomas ; Marmar, Charles ; Schuff, Norbert; Weiner, Michael

Predicting Cognitive Decline

Michael W. Weiner
These data were acquired with the overall goal of determining the regional and longitudinal pattern of changes in the brain which best predict future cognitive decline and dementia due to Alzheimer's disease (AD). The data set includes longitudinal clinical evaluation, cognitive testing, and neuroimaging assessments from a non-demented study population aged 65 and up who complain of memory problems and show some indication of memory and/or executive functioning below age/gender/education adjusted norm.

White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI

Yu Zhang, Norbert Schuff, An-Tao Du, Howard J. Rosen, Joel H. Kramer, Maria Luisa Gorno-Tempini, Bruce L. Miller, Michael W. Weiner & Memory And Aging Center
Frontotemporal dementia (FTD) and Alzheimer's disease are sometimes difficult to differentiate clinically because of overlapping symptoms. Using diffusion tensor imaging (DTI) measurements of fractional anisotropy (FA) can be useful in distinguishing the different patterns of white matter degradation between the two dementias. In this study, we performed MRI scans in a 4 Tesla MRI machine including T1-weighted structural images and diffusion tensor images in 18 patients with FTD, 18 patients with Alzheimer's disease and 19...

Voxel-wise co-analysis of macro- and microstructural brain alteration in Mild Cognitive Impairment and Alzheimer's disease using anatomical and diffusion MRI

Valerie Cardenas, Duygu Tosun, Linda Chao, P. Thomas Fletcher, Sarang Joshi, Sarang Joshi, Michael W. Weiner & Norbert Schuff
Structural and diffusion data from cognitively normal elderly and those with mild cognitive impairment. Background and Purpose: To determine if a voxel-wise "co-analysis" of structural and diffusion tensor magnetic resonance imaging (MRI) together reveals additional brain regions affected in mild cognitive impairment (MCI) and Alzheimer's Disease (AD) than voxel-wise analysis of the individual MRI modalities alone. Conclusion: These results suggest that in corpus callosum and temporal regions macroand microstructural variations in MCI can be congruent,...


UCSF Clinical DataShare Project Team At UCSF Library

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  • 2012

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