ETH Zurich

Switzerland

1,760,548 Works

Wall Slip of Polyolefin Plastomers under Oscillatory Shear

Editors@Appliedrheology.Org, Martin Kroger & Editor Applied Rheology
Peer-reviewed journal article

The Impact of Pulsatile Spiral Flow on the Wall Deformation Characteristics and Low-Density Lipoproteins Accumulation in the Aorta

Editors@Appliedrheology.Org, Martin Kroger & Editor Applied Rheology
Peer-reviewed journal article

Numerical Simulations of the Transport of Newtonian and Non-Newtonian Fluids via Peristaltic Motion

Martin Kroger, Editor Applied Rheology & Editors@Appliedrheology.Org
Applied Rheology

Rheological Properties of Kcl/Polymer Type Drilling Fluids Containing Particulate Loss Prevention Material

Editors@Appliedrheology.Org, Editor Applied Rheology & Martin Kroger
Peer-reviewed journal article

Synthèse de nouveaux ligands chélates chiraux [pi]-accepteurs et application à la catalyse asymétrique

Bernadette Bourdin
Cette thèse a abouti à la synthèse d'un nouvel acide de Lewis organométallique chiral [CpL*Fe]⁺ (L*: "trans"-1,2-bis[bis(pentafluorophényl)phosphinoxy]cyclopentane) et montré le pouvoir catalytique de ce complexe sur des réactions de Diels-Alder. Dans tous les cas, les produits de cycloaddition ont été obtenus avec un excès énantiomérique élevé (e.e. : 84->99 pour cent) dans la marge de sélectivité des systèmes catalytiques chiraux les plus performants. Ce travail a ainsi montré une nouvelle possibilité de l'utilisation de métaux...

Analogues de sucres, C-glycosides et N-nucléosides dérivés des N-hydroxypyrrolidine et N-hydroxypipéridine et radicaux libres aminoxyles correspondants

Mirna Balkadjian
Le but de notre travail est la synthèse d'une nouvelle famille de composés dérivés de sucres, des analogues de la N-hydroxypyrrolidine et de la N-hydroxypipéridine marqués à spin par un groupe nitroxyde appartenant à la copule glucidique. L'intérêt majeur de ces nouveaux produits provient de leurs propriétés antivirales potentielles et de leur facilité à subir d'autres types de réactions, avec de bons rendements permettant ainsi d'élargir l'horizon synthétique. Ces sucres possédant un azote dans le...

Génération et mode d'action du messager calcique dans la régulation de la biosynthèse d'aldostérone dans les cellules glomérulées du cortex surrénal

Christophe Pierre Python
La biosynthèse d'aldostérone est stimulée par le potassium et l'angiotensine II, deux facteurs augmentant la concentration cytosolique du calcium. Nos résultats indiquent que le potassium ouvre les canaux calciques de type T alors que l'angiotensine II agit principalement en stimulant l'influx capacitif. De plus, nos données suggèrent que le site d'action du calcium est vraisemblablement le transport du cholestérol vers la membrane interne de l'organelle. Grâce à l'aequorine recombinante dirigée vers la mitochondrie, nous avons...

The induction and effector functions of murine Th1 and Th2 cells = L'induction et les fonctions effectrices des lymphocytes Th1 et Th2 murins

Kai Michael Mueller
Deux sous-ensembles de lymphocytes T auxiliaires, Th1 et Th2, produisent des profils de cytokines distincts les amenant à exercer des fonctions différentes. A l'aide d'un système de cultures polyclonales, il est démontré que l'induction du phénotype Th2 dépend non seulement des cytokines IL-2 et IL-4, mais également d'une occupation prolongée du récepteur pour l'antigène de la cellule T. Les cellules Th2 ainsi obtenues produisent les cytokines IL-4 et IL-5, mais ni IL-2 ni IFN-γ, et...

Bleiben die Realzinsen ultraniedrig?

Aymo Brunetti

The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8 T cells.

Ruth Lyck, Philipp Germann, Bettina Stolp, Jens Volker Stein, Akitaka Ariga, Matteo Iannacone, Ingrid De Vries, Doron Merkler, Mykhailo Vladymyrov, Alba Diz-Muñoz, Mario Kreutzfeldt, Amleto Fiocchi, Federica Moalli, Xenia Ficht, Martin Bähler, Michael Hubert Stoffel, Michael Sixt, James Sharpe & Jasmin Maria Balmer
T cells are actively scanning pMHC-presenting cells in lymphoid organs and nonlymphoid tissues (NLTs) with divergent topologies and confinement. How the T cell actomyosin cytoskeleton facilitates this task in distinct environments is incompletely understood. Here, we show that lack of Myosin IXb (Myo9b), a negative regulator of the small GTPase Rho, led to increased Rho-GTP levels and cell surface stiffness in primary T cells. Nonetheless, intravital imaging revealed robust motility of Myo9b CD8 T cells...

Unternehmer finden bei wirtschaftlichen Fragen andere Lösungen (Interview mit Marc Bühlmann)

Marc Bühlmann
Am 18. Oktober stehen die National- und Ständeratswahlen an. Der Politologe Marc Bühlmann über die Rolle der beruflichen Herkunft der Gewählten und mögliche Verschiebungen.

Use of androgen deprivation and salvage radiation therapy for patients with prostate cancer and biochemical recurrence after prostatectomy.

Daniel Zips, Michael Flentje, Stefan Höcht, Tobias Hölscher, Thomas Wiegel, Daniel Aebersold, Frederik Wenz, Felix Sedlmayer, Clemens Albrecht, Pirus Ghadjar, Dirk Böhmer & Ute Ganswindt
AIM Overview on the use of androgen deprivation therapy (ADT) added to salvage radiation therapy (SRT) for prostate cancer patients with biochemical recurrence after prostatectomy. METHODS The German Society of Radiation Oncology (DEGRO) expert panel summarized available evidence published between January 2009 and May 2017, and assessed the validity of the information on outcome parameters including overall survival (OS) and treatment-related toxicity. RESULTS Two randomized controlled trials and nine relevant retrospective analyses were identified. The...

"Diese geniale Idee war sehr wichtig" (Interview mit Marc Bühlmann zu den Berner Regierungswahlen von 1986, geführt von Christine Nydegger)

Marc Bühlmann
Am Institut für Politologie der Uni Bern ist Marc Bühlmann der Spezialist für den Jura. Er findet, dass es wichtig ist, dass die Minderheit im Berner Jura bei den Wahlen mehr Gewicht hat und so respektiert wird.

Trading favors—Examining the temporal dynamics of reciprocity in congressional collaborations using relational event models

Laurence Brandenberger
The norm of reciprocity shapes social interactions over time and should therefore be analyzed using longitudinal designs. This paper examines the temporal dynamics of reciprocity in the setting of legislative cosponsorship in the 113th U.S. Congress (2013–2015). Rather than aggregating cosponsoring events into network snapshots, cosponsoring events are ordered in time and reflect an event sequence of members supporting bills at distinct points in time. The norm of reciprocity is tested to see if it...

Decision-Making Networks Across Political Systems

Laurence Brandenberger & Florence Alessa Metz
Institutions matter in policy-making. Political systems shape power structures and interac- tion patterns between actors in decision-making processes. Although the social fabric of decision-makers’ interactions is key to successful policy-making, it remains unclear which relational structures can typically be found across political systems. This paper uncov- ers the ways in which macro-political institutions shape political processes by adopting a network approach. We analyze differences in power structures and interaction patterns across four different decision-making networks...

Quantitative Analysis of Surgical Freedom and Area of Exposure in Minimal-Invasive Transcanal Approaches to the Lateral Skull Base.

Lukas Peter Anschütz, Abraam Yacoub, Stefan Weber, Wilhelm Wimmer, Marco Caversaccio, Livio Presutti, Daniel Schneider & Juergen Beck
HYPOTHESIS We aim to provide objective data regarding the area of exposure (AOE) and the surgical freedom (SF) offered by the transcanal approaches to the lateral skull base. BACKGROUND Minimal-invasive transcanal lateral skull base procedures have been recently developed and their clinical feasibility demonstrated. The reduced access size requires careful analysis and selection of suitable cases, qualifying for a minimal-invasive approach. METHODS We performed the mentioned approaches in standardized dissection using human whole heads. Surgical...

Identification of a MET-eIF4G1 translational regulation axis that controls HIF-1α levels under hypoxia.

Michaela Poliakova, Dominic Leiser, Jacopo Gavini, Lluís Nisa Hernández, Andree Blaukat, Michaela Medova, Yitzhak Zimmer, Astrid Andreina Glück, Daniel Aebersold, Lukas Bubendorf, Sabina Berezowska, Aurelie Quintin, Eleonora Orlando & Deborah M. Keogh-Stroka
Poor oxygenation is a common hallmark of solid cancers that strongly associates with aggressive tumor progression and treatment resistance. While a hypoxia-inducible factor 1α (HIF-1α)-associated transcriptional overexpression of the hepatocyte growth factor (HGF) receptor tyrosine kinase (RTK) MET has been previously documented, any regulation of the HIF-1α system through MET downstream signaling in hypoxic tumors has not been yet described. By using MET-driven in vitro as well as ex vivo tumor organotypic fresh tissue models...

Tablet Based High Accuracy Navigation on the Lateral Skull Base

Daniel Schneider, Stefan Weber, Lukas Peter Anschütz, Marco Caversaccio & Christoph Martin Rathgeb
Hypotheses: We aimed to develop a surgical navigation system which fulfils the accuracy requirements for surgical procedures on the lateral skull base, is integrable with existing surgical workflows and operating room set ups. Methods: The hardware of the navigation system consists of a light and portable high accuracy tracking system, a wireless Bluetooth communication protocol and a tablet. The software runs on the tablet, guides the user through a fiducial based registration process and allows...

Nano-scale microfluidics to study 3D chemotaxis at the single cell level

Mike Recher, Annaïse Jauch, Corina Frick, Jörg Renkawitz, Philip Dettinger, Timm Schroeder, Christoph T. Berger & Matthias Mehling
Directed migration of cells relies on their ability to sense directional guidance cues and to interact with pericellular structures in order to transduce contractile cytoskeletal- into mechanical forces. These biomechanical processes depend highly on microenvironmental factors such as exposure to 2D surfaces or 3D matrices. In vivo, the majority of cells are exposed to 3D environments. Data on 3D cell migration are mostly derived from intravital microscopy or collagen-based in vitro assays. Both approaches offer...

Leveraging energy harvesting and wake-up receivers for long-term wireless sensor networks

Olivier Berder, Michele Magno, Matthieu Gautier, Fayçal Ait Aoudia & Luca Benini
Wireless sensor nodes are traditionally powered by individual batteries, and a significant effort has been devoted to maximizing the lifetime of these devices. However, as the batteries can only store a finite amount of energy, the network is still doomed to die, and changing the batteries is not always possible. A promising solution is to enable each node to harvest energy directly in its environment, using individual energy harvesters. Moreover, novel ultra-low power wake-up receivers,...

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