38,144 Works

Doketisch, pelagianisch, sarkisch? Transhumanismus und technologische Modifikationen des Körpers in einer theologischen Perspektive

Mathias Wirth
Der menschliche Körper ist auffällig mit der Aufforderung zur Veränderung und Überschreitung eines vorgefundenen Zustands verbunden. Die Plastizität des Körpers erlaubt dabei ein gehöriges Quantum Transition. Der Transhumanismus, eine neuere philosophisch-naturwissenschaftliche Bewegung, antwortet entsprechend auf die Grundfrage der Anthropologie mit dem Hinweis auf diese Überschreitungspotentiale und auf die Grundfrage der Ethik mit einem Imperativ zur akzelerierten technischen Verbesserung menschlicher Körper. Auf die Frage nach der Methode antwortet der Transhumanismus unter anderem mit Verweis auf Nanotechnologien...

Das Projekt "Von Bauern - für Bauern" aus transdisziplinärer Sicht

Silvano Allenbach, Stephan Rist, Patricia Fry & Flurina Schneider

Probing the accuracy and precision of Hirshfeld atom refinement with HARt interfaced with Olex2

Piero Macchi, Oleg V. Dolomanov, Malte Fugel, Judith A. K. Howard, Hans-Beat Bürgi, Bo B. Iversen, Horst Puschmann, Emanuel Hupf, Venkatesha R. Hathwar, Jacob Overgaard, Dylan Jayatilaka, Simon Grabowsky & Michael J. Turner

On algebraic volume density property

Shulim Kaliman & Frank Kutzschebauch
A smooth affine algebraic variety X equipped with an algebraic volume form ω has the algebraic volume density property (AVDP) if the Lie algebra generated by complete algebraic vector fields of ω-divergence zero coincides with the space of all algebraic vector fields of ω-divergence zero. We develop an effective criterion of verifying whether a given X has AVDP. As an application of this method we establish AVDP for any homogeneous space X = G/R that...

The Integration of Electricity from Renewable Energy Sources in the European Union Electricity Market – The case for “Smart Grids”

Joëlle De Sépibus
The power sector is to play a central role in a low carbon economy. In all the decarbonisation scenarios of the European Union renewable energy sources (RES) will be a crucial part of the solution. Current grids constitute however major bottlenecks for the future expansion of RES. Recognising the need for a modernisation of its grids, the European Union has called for the creation of a "smart supergrid" interconnecting European grids at the continental level...

"Und was macht nicht alles einen Namen!" Reklame und symbolisches Kapital in Theodor Fontanes "Die Poggenpuhls"

Hanspeter Affolter
The following article deals with the relationship between names and their symbolic capital as a theme in Theodor Fontane’s Poggenpuhls. While the eponymous poor but noble family relies on its notable surname, different names were being popularized through advertising as part of the social and economic upheavals at the end of the 19th century. This rivalry between a genealogical and a primarily economic way of publicizing and valorizing names is not only present in the...

Thermal acclimation to 4 or 10 degrees C imparts minimal benefit on swimming performance in Atlantic cod (Gadus morhua L.).

Christian H Bock, Glenn Lurman & Hans-O Poertner
Thermal acclimation is frequently cited as a means by which ectothermic animals improve their Darwinian fitness, i.e. the beneficial acclimation hypothesis. As the critical swimming speed (U (crit)) test is often used as a proxy measure of fitness, we acclimated Atlantic cod (Gadus morhua) to 4 and 10 degrees C and then assessed their U (crit) swimming performance at their respective acclimation temperatures and during acute temperature reversal. Because phenotypic differences exist between different populations...

Prognostic Relevance of Palliative Primary Tumor Removal in 37,793 Metastatic Colorectal Cancer Patients: A Population-Based, Propensity Score-Adjusted Trend Analysis

Ignazio Tarantino, Mathias Worni, Alexis Ulrich, Bruno M Schmied, Rene Warschkow, Thomas Cerny & Ulrich Güller
OBJECTIVE To assess whether palliative primary tumor resection in colorectal cancer patients with incurable stage IV disease is associated with improved survival. BACKGROUND There is a heated debate regarding whether or not an asymptomatic primary tumor should be removed in patients with incurable stage IV colorectal disease. METHODS Stage IV colorectal cancer patients were identified in the Surveillance, Epidemiology, and End Results database between 1998 and 2009. Patients undergoing surgery to metastatic sites were excluded....

Sensitivity of DF-ICP-MS, PERALS and alpha-spectrometry for the determination of actinides: A comparison

Urs Krähenbühl, Marin Ayranov, Mario Burger & Stefan Röllin
We applied three techniques (DF-ICP-MS, PERALS and alpha-spectrometry) for the determination of minor actinides at environmental levels. For each method the limit of detection and the resolution were estimated in order to study the content and isotopic composition of the actinides. Two international reference materials, IAEA-135 (Irish Sea Sediment) and IAEA-300 (Baltic Sea sediment) were analyzed for activity concentrations of 238Pu, 239Pu, 240Pu, 241Pu and 241Am. The sensitivities of the three determination techniques were compared.

The Association Between Endurance Training and Heart Rate Variability: The Confounding Role of Heart Rate.

David Herzig, Prisca Eser, Nicolas Jacques Brugger, Babken Asatryan & Matthias Wilhelm
Heart rate variability (HRV) is a widely used marker of cardiac autonomic nervous activity (CANA). Changes in HRV with exercise training have often been interpreted as increases in vagal activity. HRV is strongly associated with heart rate, which in turn, is associated with heart size. There is strong evidence from basic studies that lower heart rate in response to exercise training is caused by morphological and electrical remodeling of the heart. In a cross-sectional study...

Possible role of Cdx2 in the serrated pathway of colorectal cancer characterized by BRAF mutation, high-level CpG Island methylator phenotype and mismatch repair-deficiency

Caroline Hammer, Dominique-Elisabeth Müller, Melina Helbling, Inti Zlobec, Alessandro Lugli, José Alberto Galván Hernández, Heather Dawson, Mary Economou, Evanthia Karamitopoulou & Viktor Kölzer
Colorectal cancer is a heterogeneous disease at the histomorphological, clinical and molecular level. Approximately 20% of cases may progress through the "serrated" pathway characterized by BRAF mutation and high-level CpG Island Methylator Phenotype (CIMP). A large subgroup are additionally microsatellite instable (MSI) and demonstrate significant loss of tumor suppressor Cdx2. The aim of this study is to determine the specificity of Cdx2 protein expression and CpG promoter hypermethylation for BRAF(V600E) and high-level CIMP in colorectal...

Conservative treatment of hepatic portal venous gas consecutive to a complicated diverticulitis: A case report and literature review.

Anita Stauffer, Manfred Essig, Alexandre Moser, André Wyss, Alexander Radke & Claudio Schneider
INTRODUCTION AND PRESENTATION OF CASE Eight days after being diagnosed with multiple small strokes a 71year old male patient is readmitted with suspicion of a petit mal seizure also complained of diarrhoea and abdominal pain. The patient was stable, not febrile and neurologically intact with a slight tenderness in the left lower quadrant. An ultrasound revealed presence of air in the hepatic portal venous system and a suspicion for sigmoid diverticulitis. A CT-scan confirmed both...

Immunization with a circumsporozoite epitope fused to Bordetella pertussis adenylate cyclase in conjunction with cytotoxic T-lymphocyte-associated antigen 4 blockade confers protection against Plasmodium berghei liver-stage malaria

Peter Sebo, Jana Kamanova, Bernhard Fleischer, Thomas Jacobs, Marcela Simsova, Stefanie Bolte, Susanne Tartz & Volker Heussler
The adenylate cyclase toxoid (ACT) of Bordetella pertussis is capable of delivering its N-terminal catalytic domain into the cytosol of CD11b-expressing professional antigen-presenting cells such as myeloid dendritic cells. This allows delivery of CD8+ T-cell epitopes to the major histocompatibility complex (MHC) class I presentation pathway. Recombinant detoxified ACT containing an epitope of the Plasmodium berghei circumsporozoite protein (CSP), indeed, induced a specific CD8+ T-cell response in immunized mice after a single application, as detected...

Molecular cloning, expression analysis and assignment of the porcine tumor necrosis factor superfamily member 10 gene (TNFSF10) to SSC13q34-->q36 by fluorescence in situ hybridization and radiation hybrid mapping

E Kemter, M Boelhauve, H Kuiper, E Wolf, U Philipp, R Klose, Tosso Leeb & O Distl
We have cloned the complete coding region of the porcine TNFSF10 gene. The porcine TNFSF10 cDNA has an ORF of 870 nucleotides and shares 85% identity with human TNFSF10, and 75% and 72% identity with rat and mouse Tnfsf10 coding sequences, respectively. The deduced porcine TNFSF10 protein consists of 289 amino acids with the calculated molecular mass of 33.5 kDa and a predicted pI of 8.15. The amino acid sequence similarities correspond to 86, 72...

Availability of secondary prevention services after stroke in Europe: An ESO/SAFE survey of national scientific societies and stroke experts

Urs Fischer, EC Sandset, G Randall, D Aguiar De Sousa, B Van Der Worp, A Webb, V Caso, Mirjam Rachel Heldner & Y Bejot
BackgroundRecurrent stroke is associated with increased disability and cognitive impairment, but the availability of secondary prevention measures after transient ischaemic attack (TIA) or stroke in Europe is uncertain. This limits prioritisation of investment and development of national stroke strategies.MethodsNational stroke representatives throughout Europe were surveyed. Consensus panels reported national data if available, or else expert opinion, estimating the availability of each intervention by quintiles of patients, dichotomised for analysis at 60. Countries were classified into...

Monitoring pulmonary health in Swiss childhood cancer survivors.

Rahel Kasteler, Florian Singer, Annette Weiss, Linda Kam, Claudia E Kuehni, Nicolas X Von Der Weid, Oncology Group (SPOG), Swiss Pediatric, Marc Ansari, Nicolas Waespe & Grit Sommer
BACKGROUND Childhood cancer survivors are at increased risk for pulmonary morbidity and mortality. International guidelines recommend pulmonary function tests (PFT) during follow-up care. This nationwide study assessed how many children received PFT within 5 years after pulmotoxic treatment in Switzerland, types of tests, and predictors for testing. METHODS We included all children from the Swiss Childhood Cancer Registry who were diagnosed with cancer from 1990 to 2013 at age 0-16 years, survived for ≥2 years...

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