652 Works

Imatinib dose reduction in major molecular response of chronic myeloid leukemia: results from the German Chronic Myeloid Leukemia-Study IV.

Cornelius F Waller, Maria-Elisabeth Goebeler, Mathias Hänel, Claus-Henning Köhne, Hans-Walter Lindemann, Rüdiger Hehlmann, Joerg Hasford, Dietrich W Beelen, Hans-Jochem Kolb, Michael Kneba, Michael Schenk, Matthias Edinger, Leopold Balleisen, Thomas Wündisch, Jörg Thomalla, Thomas Geer, Christian Michel, Stephan Bildat, Anthony Ho, Martin Bentz, Andreas Neubauer, Frank Stegelmann, Christoph Nerl, Philippe Schafhausen, Peter Brossart … & Alice Fabarius
Standard first-line therapy of chronic myeloid leukemia is treatment with imatinib. In the randomized German Chronic Myeloid Leukemia-Study IV, more potent BCR-ABL inhibition with 800mg (high-dose) imatinib accelerated achievement of a deep molecular remission. However, whether and when a de-escalation of the dose intensity under high-dose imatinib can be safely performed without increasing the risk of losing deep molecular response is unknown. To gain insights into this clinically relevant question, we analyzed the outcome of...

Collaboration to mitigate climate change – Does the institutional context matter? A comparative study of Finland, South Korea, Switzerland, and the United States

Paul Wagner, Marlene Kammerer, Antti Gronow & Tuomas Ylä-Anttila
Many scholars would agree that political decisions are the result of collective action. By joining forces and coordinating their behaviour, actors try to influence decisions and outputs. Understanding these patterns better is highly relevant for the field of environmental policy and governance, as policies target a wide range of stakeholders from different sectors. Increased collaboration efforts are needed to ensure that environmental concerns are considered particularly in sectors with traditionally contradicting interests, such as economic,...

The politicization of the climate: How and why has the Annex I – non-Annex I division affected negotiations under the climate change regime?

Marlene Kammerer & Paula Castro
Many multilateral environmental agreements include differentiated rules for groups of countries, based on the recognition of their different circumstances or contribution to the problem addressed. Under the United Nations Framework Convention on Climate Change (UNFCCC), such differential treatment was operationalized as a rigid division of the world between the Annex I countries with emission reduction targets and the non-Annex I countries without them. This article has two aims. First, it measures to what extent the...

Radikalisierung der Gesellschaft? Forschungsperspektiven und Handlungsoptionen

Klara Sinha, Christian Joppke, Oliver Decker, Magdalena Von Drachenfels, Eva Herschinger & Kemal Bozay

Searches for heavy ℤℤ and ℤW resonances in the ℓℓqq and ννqq final states in pp collisions at √s = 13 TeV with the ATLAS detector

Sigve Haug, Antonio Ereditato, Geoffrey Mullier, Claudia Merlassino, Marco Rimoldi, Federico Meloni, Michael Weber, Antonio Miucci & Hans Peter Beck
This paper reports searches for heavy resonances decaying into ZZ or ZW using data from proton-proton collisions at a centre-of-mass energy of √s = 13 TeV. The data, corresponding to an integrated luminosity of 36.1 fb⁻¹, were recorded with the ATLAS detector in 2015 and 2016 at the Large Hadron Collider. The searches are performed in final states in which one Z boson decays into either a pair of light charged leptons (electrons and muons)...

Measurement of the exclusive γγ → μ⁺μ⁻ process in proton-proton collisions at √s = 13 TeV with the ATLAS detector

Hans Peter Beck, Michael Weber, Sigve Haug, Claudia Merlassino, Antonio Miucci, Geoffrey Mullier, Antonio Ereditato, Federico Meloni & Marco Rimoldi
The production of exclusive γγ → μ⁺μ⁻events in proton–proton collisions at a centre-of-mass energy of 13 TeV is measured with the ATLAS detector at the LHC, using data corresponding to an integrated luminosity of 3.2fb⁻¹. The measurement is performed for a dimuon invariant mass of 12 GeV < mμ⁺μ⁻ < 70 GeV. The integrated cross-section is determined within a fiducial acceptance region of the ATLAS detector and differential cross-sections are measured as a function of...

Search for pair production of heavy vector-like quarks decaying into high-pT W bosons and top quarks in the lepton-plus-jets final state in pp collisions at √s=13 TeV with the ATLAS detector

Antonio Miucci, Federico Meloni, Antonio Ereditato, Hans Peter Beck, Michael Weber, Sigve Haug, Marco Rimoldi, Claudia Merlassino & Geoffrey Mullier
A search is presented for the pair production of heavy vector-like B quarks, primarily targeting B quark decays into a W boson and a top quark. The search is based on 36.1 fb⁻¹ of pp collisions at √s = 13 TeV recorded in 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. Data are analysed in the lepton-plus-jets final state, characterised by a high-transverse-momentum isolated electron or muon, large missing transverse...

Measurement of the cross-section for producing a W boson in association with a single top quark in pp collisions at √s = 13 TeV with ATLAS

Antonio Miucci, Marco Rimoldi, Hans Peter Beck, Claudia Merlassino, Geoffrey Mullier, Michael Weber, Sigve Haug, Antonio Ereditato & Federico Meloni
The inclusive cross-section for the associated production of a W boson and top quark is measured using data from proton-proton collisions at √s = 13 TeV. The dataset corresponds to an integrated luminosity of 3.2 fb⁻¹, and was collected in 2015 by the ATLAS detector at the Large Hadron Collider at CERN. Events are selected requiring two opposite sign isolated leptons and at least one jet; they are separated into signal and control regions based...

Measurement of long-range multiparticle azimuthal correlations with the subevent cumulant method in pp and p + Pb collisions with the ATLAS detector at the CERN Large Hadron Collider

Antonio Ereditato, Claudia Merlassino, Michael Weber, Antonio Miucci, Geoffrey Mullier, Federico Meloni, Hans Peter Beck, Marco Rimoldi & Sigve Haug
A detailed study of multiparticle azimuthal correlations is presented using pp data at √s = 5.02 and 13 TeV, and p+Pb data at √sNN = 5.02 TeV, recorded with the ATLAS detector at the CERN Large Hadron Collider. The azimuthal correlations are probed using four-particle cumulants cn{4} and flow coefficients vn{4}=(−cn{4})1/4 for n=2 and 3, with the goal of extracting long-range multiparticle azimuthal correlation signals and suppressing the short-range correlations. The values of cn{4} are...

Mental Illness Has a Negative Impact on Weight Loss in Bariatric Patients: a 4-Year Follow-up.

Caroline Buri, Kurt Laederach, Guido Stirnimann, Yves Michael Borbély, Philipp C. Nett, Martin Müller & Dino Kröll
BACKGROUND Mental health disorders are highly prevalent among bariatric surgery patients. Bariatric surgery induces weight loss with continuous health improvements. However, long-term follow-up data on weight loss and quality of life data of patients who have a mental illness after bariatric surgery are scarce, and it is not clear whether mental illness is associated with more pronounced weight regain. The aim was to investigate the impact of preoperative mental illness on the course of long-term...

Generation of an alveolar epithelial type II cell line from induced pluripotent stem cells.

Christiane Albrecht, Katrin E Hostettler, Jean-Sébastien Rougier, Hugues Abriel, Sampada Kallol, Luca Tamò, Thomas Geiser, Lars Knudsen, Youssef Hibaoui, Marco Alves, Amiq Gazdhar & Anis Feki
Differentiation of primary alveolar type II epithelial cells (AEC type II) to AEC type I in culture is a major barrier in the study of the alveolar epithelium in vitro. The establishment of an AEC type II cell line derived from induced pluripotent stem cells (iPSC) represents a novel opportunity to study alveolar epithelial cell biology, for instance in the context of lung injury, fibrosis and repair. In the present study, we generated long lasting...

Use of a Steerable Sheath for Retrograde Access to Antegrade Branches in Branched Stent-Graft Repair of Complex Aortic Aneurysms.

Fiona Rohlffs, Konstantinos Spanos, Vladimir Makaloski, Nikolaos Tsilimparis, Tilo Kölbel & E Sebastian Debus
PURPOSE To describe how to use a steerable sheath from a femoral access to catheterize antegrade branches in a branched aortic stent-graft. TECHNIQUE Following femoral cutdown, a stent-graft with antegrade branches destined for renovisceral target vessels was deployed in the desired position. A steerable sheath with a tip that rotates up to 180° was introduced from the common femoral artery and navigated to the antegrade branches for consecutive catheterization of the target vessels and deployment...

Group decision making in multi-user virtual reality and video conferencing

Fred W. Mast, Sandra Chiquet, Sebastian Kaspar Strahm, Ivan Moser & Per Bergamin
Head-mounted displays enable social interactions in immersive virtual environments. However, it is yet unclear whether the technology is suitable for collaborative work between distant group members. Other communication technologies such as online chat tools or video conferencing systems have repeatedly led to poorer group performance compared to face-to-face interaction. It has been argued that lack of social presence and increased cognitive load might be responsible for these results. The use of a multi-user Virtual Reality...

Mapping interactions between the sustainable development goals: lessons learned and ways forward

Peter Messerli, David McCollum, Mark Stafford-Smith, Anne-Sophie Stevance, David Griggs, Elinor Chisholm, Martin Visbeck, Philippa Howden-Chapman, Barbara Neumann & Måns Nilsson

Passive Hydrotherapy WATSU® for Rehabilitation of an Accident Survivor: A Prospective Case Report

Agnes M. Schitter & Johannes Fleckenstein
Background: WaterShiatsu (WATSU) is a passive form of hydrotherapy in warm water (35 °C) that aims at relaxation, pain relief, and a sense of security. This case report focuses on a patient's experience of integrating WATSU into her rehabilitative care. Case Report: A 52-year-old woman survived a severe motorcycle accident in which she sustained several fractures on the right side of her body, including ribs, the pelvis, and the femur. After discharge from stationary care,...

PUZZLING THE MIND: EVALUATING THE DIFFICULTY OF GENERATED PUZZLE GAME LEVELS FOR A PUZZLE GAME INTERVENTION — PRELIMINARY RESULTS

René Martin Müri, Klemens Gutbrod, Narayan Schütz, Stephan Moreno Gerber, Tobias Nef, Prabitha Urwyler, Alvin Chesham & Patric Wyss
Background: Engagement in cognitively stimulating leisure activities plays an important role in mediating cognitive decline. Recentstudies suggest that computerized puzzle games are an activityliked by older adults that offers cognitive benefits. For use as acognitive intervention, however, it is crucial that the puzzle gamedifficulty is constantly adapted to match the player’s level of skill.To this end, we generated large sets of difficulty levels for twotablet-based puzzle games. Methods: We conducted a play-teststudy in 16 healthy...

The Association Between Endurance Training and Heart Rate Variability: The Confounding Role of Heart Rate.

David Herzig, Prisca Eser, Nicolas Jacques Brugger, Babken Asatryan & Matthias Wilhelm
Heart rate variability (HRV) is a widely used marker of cardiac autonomic nervous activity (CANA). Changes in HRV with exercise training have often been interpreted as increases in vagal activity. HRV is strongly associated with heart rate, which in turn, is associated with heart size. There is strong evidence from basic studies that lower heart rate in response to exercise training is caused by morphological and electrical remodeling of the heart. In a cross-sectional study...

Availability of secondary prevention services after stroke in Europe: An ESO/SAFE survey of national scientific societies and stroke experts

Urs Fischer, EC Sandset, G Randall, D Aguiar De Sousa, B Van Der Worp, A Webb, V Caso, Mirjam Rachel Heldner & Y Bejot
BackgroundRecurrent stroke is associated with increased disability and cognitive impairment, but the availability of secondary prevention measures after transient ischaemic attack (TIA) or stroke in Europe is uncertain. This limits prioritisation of investment and development of national stroke strategies.MethodsNational stroke representatives throughout Europe were surveyed. Consensus panels reported national data if available, or else expert opinion, estimating the availability of each intervention by quintiles of patients, dichotomised for analysis at 60. Countries were classified into...

The acceptance of instruments in instrument mix situations: Citizens’ perspective on Swiss energy transition

Lorenz Kammermann, Karin Ingold & Isabelle Stadelmann
Citizens are the target group of sustainability policies, and their acceptance and subsequent behavioral change are key in transition processes. But what drives citizens to accept new instruments that will be added to a pre-existing instrument mix? To answer this question, we suggest an innovative combination of sustainability transitions and social acceptance research, and examine the case of Swiss energy turnaround. We rely on data from a representative sample of the Swiss resident population. By...

Increased subchondral bone thickness in hips with cam-type femoroacetabular impingement.

Peter Jüni, Andreas Limacher, Stephan Reichenbach, Martin Beck, Martina Bieri, Michael Leunig & Michael C Wyatt
OBJECTIVES: Increased thickness of subchondral acetabular bone with associated articular cartilage thinning in hips with femoroacetabular (FAI) cam impingement has been observed on magnetic resonance imaging (MRI). Dynamic attrition by the cam deformity moving into the acetabulum may potentiate trans-articular shear stresses thus causing these subchondral bone changes. We aimed to quantify the hypertrophic changes of subchondral acetabular bone in patients with cam-type FAI. METHODS: MRI studies were performed on an asymptomatic population of young...

Nasal microbiota and symptom persistence in acute respiratory tract infections in infants.

Philipp Latzin, Moana Mika, Binbin Xu, Urs Frey, Jakob Usemann, Loretta Müller, Roland P Neumann, Insa Korten & Markus Hilty
Acute respiratory tract infections (ARI) in infancy have been implicated in the development of chronic respiratory disease, but the complex interplay between viruses, bacteria and host is not completely understood. We aimed to prospectively determine whether nasal microbiota changes occur between the onset of the first symptomatic ARI in the first year of life and 3 weeks later, and to explore possible associations with the duration of respiratory symptoms, as well as with host, environmental and...

Research priorities to inform "Treat All" policy implementation for people living with HIV in sub-Saharan Africa: a consensus statement from the International epidemiology Databases to Evaluate AIDS (IeDEA).

April D Kimmel, Robert Agler, Amobi Onovo, Jean D'Amour Sinayobye, Stephany N Duda, Rose S Bono, Olivia Keiser, Kathryn E Lancaster, Gilles Wandeler, Jennifer L Syvertsen, Carolyn F Williams, Pamela M Murnane, Constantin T Yiannoutsos, Angela M Parcesepe, Morna Cornell, Mary-Ann Davies, Barbara Castelnuovo, Kara Wools-Kaloustian, Craig R Cohen, Ellen Brazier, Denis Nash, Annette H Sohn, Rachel C Vreeman, Valeriane Leroy, Diane Addison … & Marcel Yotebieng
INTRODUCTION "Treat All" - the treatment of all people with HIV, irrespective of disease stage or CD4 cell count - represents a paradigm shift in HIV care that has the potential to end AIDS as a public health threat. With accelerating implementation of Treat All in sub-Saharan Africa (SSA), there is a need for a focused agenda and research to identify and inform strategies for promoting timely uptake of HIV treatment, retention in care, and...

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