47,878 Works

Manual muscle testing and hand-held dynamometry in people with inflammatory myopathy: An intra- and interrater reliability and validity study

Pierrette Baschung Pfister, Eling D. De Bruin, Iris Sterkele, Britta Maurer, Rob A. De Bie & Ruud H. Knols
Manual muscle testing (MMT) and hand-held dynamometry (HHD) are commonly used in people with inflammatory myopathy (IM), but their clinimetric properties have not yet been sufficiently studied. To evaluate the reliability and validity of MMT and HHD, maximum isometric strength was measured in eight muscle groups across three measurement events. To evaluate reliability of HHD, intra-class correlation coefficients (ICC), the standard error of measurements (SEM) and smallest detectable changes (SDC) were calculated. To measure reliability...

Usability and Effects of an Exergame-based Gait Training Program

S. Wüest, N.A. Borghese, M. Pirovano, R. Mainetti & Eling D. De Bruin
Games for Health Journal, 3 (2)

Exergames Encouraging Exploration of Hemineglected Space in Stroke Patients With Visuospatial Neglect: A Feasibility Study.

Bernadette C. Tobler-Ammann, Elif Surer, Eling D. De Bruin, Marco Rabuffetti, N. Alberto Borghese, Renato Mainetti, Michele Pirovano, Lia Wittwer & Ruud H. Knols
BACKGROUND: Use of exergames can complement conventional therapy and increase the amount and intensity of visuospatial neglect (VSN) training. A series of 9 exergames-games based on therapeutic principles-aimed at improving exploration of the neglected space for patients with VSN symptoms poststroke was developed and tested for its feasibility. OBJECTIVES: The goal was to determine the feasibility of the exergames with minimal supervision in terms of (1) implementation of the intervention, including adherence, attrition and safety,...

Sensory-motor training targeting motor dysfunction and muscle weakness in long-term care elderly combined with motivational strategies: a single blind randomized controlled study

Slavko Rogan, Lorenz Radlinger, Heiner Baur, Dietmar Schmidtbleicher, Rob A. De Bie & Eling D. De Bruin
Background This study evaluated the effects of a combined innovative training regime consisting of stochastic resonance whole-body vibration (SR-WBV) and a dance video game (DVG) on physical performance and muscle strength in long-term-care dwelling elderly. Methods Thirthy long-term-care elderly were randomly allocated to an intervention group (IG; n = 16) receiving combined SR-WBV training and DVG, or a sham group (SG; n = 14). IG performed five sets one minute of SR-WBV, with one minute...

Effects of proprioceptive exercises on pain and function in chronic neck- and low back pain rehabilitation: a systematic literature review

Michael A. McCaskey, Corinna Schuster-Amft, Brigitte Wirth, Zorica Suica & Eling D. De Bruin
Background Proprioceptive training (PrT) is popularly applied as preventive or rehabilitative exercise method in various sports and rehabilitation settings. Its effect on pain and function is only poorly evaluated. The aim of this systematic review was to summarise and analyse the existing data on the effects of PrT on pain alleviation and functional restoration in patients with chronic (≥3 months) neck- or back pain. Methods Relevant electronic databases were searched from their respective inception to...

Computational Intelligence and Game Design for Effective At-Home Stroke Rehabilitation

Nunzio A. Borghese, Michele Pirovano, Pier L. Lanzi, Seline Wüest & Eling D. De Bruin
Games for Health Journal, 2 (2)

Does multicomponent physical exercise with simultaneous cognitive training boost cognitive performance in older adults? A 6-month randomized controlled trial with a 1-year follow-up

Patrick Eggenberger, Vera Schumacher, Marius Angst, Nathan Theill & Eling D. De Bruin
Background: Cognitive impairment is a health problem that concerns almost every second elderly person. Physical and cognitive training have differential positive effects on cognition, but have been rarely applied in combination. This study evaluates synergistic effects of multicomponent physical exercise complemented with novel simultaneous cognitive training on cognition in older adults. We hypothesized that simultaneous cognitive–physical components would add training specific cognitive benefits compared to exclusively physical training. Methods: Seniors, older than 70 years, without...

T cell trafficking through lymphatic vessels

Morgan C. Hunter, Alvaro Teijeira & Cornelia Halin
T cell migration within and between peripheral tissues and secondary lymphoid organs is essential for proper functioning of adaptive immunity. While active T cell migration within a tissue is fairly slow, blood vessels and lymphatic vessels (LVs) serve as speedy highways that enable T cells to travel rapidly over long distances. The molecular and cellular mechanisms of T cell migration out of blood vessels have been intensively studied over the past 30 years. By contrast,...

Patients with chronic peripheral vestibular hypofunction compared to healthy subjects exhibit differences in gaze and gait behaviour when walking on stairs and ramps

Jaap Swanenburg, Edith Bäbler, Rolf Adelsberger, Dominik Straumann & Eling D. De Bruin
OBJECTIVE: The aim of this study was to compare gaze behaviour during stair and ramp walking between patients with chronic peripheral vestibular hypofunction and healthy human subjects. METHODS: Twenty four (24) patients with chronic peripheral vestibular hypofunction (14 unilateral and 10 bilateral) and 24 healthy subjects performed stair and ramp up and down walks at self-selected speed. The walks were repeated five times. A mobile eye tracker was used to record gaze behaviour (defined as...

Effects of postural specific sensorimotor training in patients with chronic low back pain: study protocol for randomised controlled trial

Michael A McCaskey, Corina Schuster-Amft, Brigitte Wirth & Eling D. De Bruin
Background Sensorimotor training (SMT) is popularly applied as a preventive or rehabilitative exercise method in various sports and rehabilitation settings. Yet, there is only low-quality evidence on its effect on pain and function. This randomised controlled trial will investigate the effects of a theory-based SMT in rehabilitation of chronic (>3 months) non-specific low back pain (CNLBP) patients. Methods/Design A pilot study with a parallel, single-blinded, randomised controlled design. Twenty adult patients referred to the clinic...

Rock avalanche mobility: The role of path material

Jordan Aaron & Scott McDougall
Rock avalanches are high velocity flows of fragmented rock that can dramatically alter landscapes, and impact people and infrastructure far from their source. These catastrophic events have been studied for over a century, however, a consensus regarding the mechanism(s) that govern their motion has yet to emerge. This work details the results of the back-analysis of 45 rock avalanche case histories using a semi-empirical runout model that simulates motion over 3D terrain. These simulations account...

Optimal design of multi-energy systems at different degrees of decentralization

Portia Murray, Kristina Orehounig & Jan Carmeliet
In this work, a model is built to test the optimal design and performance of a multi-energy systems at five different levels of decentralization, ranging from 225 individual buildings systems to a single district system supplying all building’s energy demands. A multi-objective analysis, minimizing both costs and emissions with the epsilon-constraint method, was used to select five Pareto optimal solutions for each level. The considered technologies include gas boilers, oil boilers, photovoltaics, solar thermal panels,...

Assessing brain-muscle connectivity in human locomotion through mobile brain/body imaging: Opportunities, pitfalls, and future directions

Federico Gennaro & Eling D. De Bruin
Assessment of the cortical role during bipedalism has been a methodological challenge. While surface electroencephalography (EEG) is capable of non-invasively measuring cortical activity during human locomotion, it is associated with movement artifacts obscuring cerebral sources of activity. Recently, statistical methods based on blind source separation revealed potential for resolving this issue, by segregating non-cerebral/artifactual from cerebral sources of activity. This step marked a new opportunity for the investigation of the brains’ role while moving and...

Interferometric Nanoparticle Detection

Sarah Kurmulis
Nanoparticles, particles with sizes between 1 and 100 nm are omnipresent in several fields ranging from high technology industries to health care and consumer goods. Biological nanoparticles include viruses, exosomes and proteins. In many applications such as health care, it is essential to detect the presence of certain nanoparticles. Moreover, it is often of high importance to measure their sizes and concentrations. Since these particles are smaller than the wavelength of light, their label-free detection...

Preliminary inconclusive results of a randomised double blinded cross-over pilot trial in long-term-care dwelling elderly assessing the feasibility of stochastic resonance whole-body vibration

Slavko Rogan, Lorenz Radlinger, Dietmar Schmidtbleicher, Rob A. De Bie & Eling D. De Bruin
Background This randomised double-blinded controlled cross-over pilot study examined feasibility and preliminary effects of stochastic resonance whole-body vibration training applied in long term care elderly. Findings Nine long term care elderly were recruited and randomized to group A (6 Hz, Noise 4 SR-WBV/ Sham) or B (Sham / 1 Hz, Noise 1 SR-WBV). Feasibility outcomes included recruitment rate, attrition, adherence and safety. Physical performance outcomes focused on the Expanded Timed Get Up-and-Go (ETGUG) test, the...

Effects of whole-body vibration on proxies of muscle strength in old adults: a systematic review and meta-analysis on the role of physical capacity level

Slavko Rogan, Eling D. De Bruin, Lorenz Radlinger, Christine Joehr, Christa Wyss, Neil-Jerome Stuck, Yvonne Bruelhart, Rob A. De Bie & Roger Hilfiker
Background Dynapenia (age-associated loss of muscle strength not caused by neurologic or muscular diseases) and functional limitations (e.g. climbing stairs, chair rising) are important problems in elderly persons. Whole body vibration, used as an adjunct to classical resistance training or even as a stand-alone alternative, might help to reduce these problems. Its value might be highest in elderly persons with very low function, where whole body vibration can be used as a skilling up training...

Older adults must hurry at pedestrian lights! A cross-sectional analysis of preferred and fast walking speed under single- and dual-task conditions

Patrick Eggenberger, Sara Tomovic, Thomas Münzer & Eling D. De Bruin
Slow walking speed is strongly associated with adverse health outcomes, including cognitive impairment, in the older population. Moreover, adequate walking speed is crucial to maintain older pedestrians’ mobility and safety in urban areas. This study aimed to identify the proportion of Swiss older adults that didn’t reach 1.2 m/s, which reflects the requirements to cross streets within the green–yellow phase of pedestrian lights, when walking fast under cognitive challenge. A convenience sample, including 120 older...

Does culture affect soil erosion? Empirical evidence from Europe

David Johannes Wüpper
I investigate whether cultural differences explain why some European regions are more effective in mitigating soil erosion than others. Specifically, I consider environmental preferences and beliefs as well as time preferences. For causal identification, I use a control function approach. The estimates suggest that a 1 standard deviation increase in pro-environmental culture increases erosion mitigation by 2–9 percentage points. This has important implications for research and policy making, which I discuss.

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