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623,352 Works

A Theory of Everything from Pure Reason

Alexandre Harvey-Tremblay
In this work, I present a formal construction of the axiomless position. This construction ultimately leads to the theory of everything in physics (ToE). The purpose of this paper is to first derive the ToE from the axiomless position, then to derive sufficient physics from it so as to convince the skeptical reader of the validity of the methodology.

Part I is the axiomless derivation of the ToE. From this derivation I obtain, in part...

Molecular Interaction Evidence Fragment Corpus

Gully Burns, Eduard Hovy & Pradeep Dasigi
This file set showcases the first presentation of an annotated text corpus of 'evidence fragments' from biomedical papers. These are short passages of text from the results sections of papers that describe the goals, methods, results and interpretations of experiments that are reported as figures in biomedical articles. These figures typically provide the evidence and justification for any underlying scientific explanation or argument being explored in any given paper. Moreover, these fragments describe the specific...

Online Labour Index: Measuring the Online Gig Economy for Policy and Research

Otto Kässi, Martin Hadley & Vili Lehdonvirta
Data repository for the data underlying the Online Labour Index. See http://ilabour.oii.ox.ac.uk online-labour-index/ for details.

Pharmaceutical Cocrystals

Maciej Przybyłek
The aims of this project is to develop relevant pharmaceutical properties through co-crystallization and to find efficient screening methods.

Degradation of sunscreens

Maciej Przybyłek
The aim of this project is to examine degradation paths of popular sunscreen agents such as octyl methoxycinnamate (OMC) in the presence of UV light and reactive oxygen and chlorine species.

Degradation of sunscreens

Maciej Przybyłek
The aim of this project is to examine degradation paths of popular sunscreen agents such as octyl methoxycinnamate (OMC) in the presence of UV light and reactive oxygen and chlorine species.

Disease relevant modifications of the methylome and transcriptome by particulate matter (PM2.5) from biomass combustion

Katharina Heßelbach, Gwang-Jin Kim, Stephan Flemming, Thomas Häupl, Marc Bonin, Regina Dornhof, Stefan Günther, Irmgard Merfort & Matjaz Humar
Exposure to particulate matter (PM) is recognized as a major health hazard, but molecular responses are still insufficiently described. We analyzed the epigenetic impact of ambient PM2.5 from biomass combustion on the methylome of primary human bronchial epithelial BEAS-2B cells using the Illumina HumanMethylation450 BeadChip. The transcriptome was determined by the Affymetrix HG-U133 Plus 2.0 Array. PM2.5 induced genome wide alterations of the DNA methylation pattern, including differentially methylated CpGs in the promoter region associated...

Disease relevant modifications of the methylome and transcriptome by particulate matter (PM2.5) from biomass combustion

Katharina Heßelbach, Gwang-Jin Kim, Stephan Flemming, Thomas Häupl, Marc Bonin, Regina Dornhof, Stefan Günther, Irmgard Merfort & Matjaz Humar
Exposure to particulate matter (PM) is recognized as a major health hazard, but molecular responses are still insufficiently described. We analyzed the epigenetic impact of ambient PM2.5 from biomass combustion on the methylome of primary human bronchial epithelial BEAS-2B cells using the Illumina HumanMethylation450 BeadChip. The transcriptome was determined by the Affymetrix HG-U133 Plus 2.0 Array. PM2.5 induced genome wide alterations of the DNA methylation pattern, including differentially methylated CpGs in the promoter region associated...

An unexpected apparition - or - old valves die hard

Takehiro Yamashita, Naoki Iwakiri, Masato Suzuki, Yohei Ohkawa & Yusuke Watanabe
An unexpected apparition - or - old valves die hard

An unexpected apparition - or - old valves die hard

Takehiro Yamashita, Naoki Iwakiri, Masato Suzuki, Yohei Ohkawa & Yusuke Watanabe
An unexpected apparition - or - old valves die hard

Tracheria Troyana (Krapovickas and Nasif, 2011): Redefinition, Environmental Distribution, and Heritage Conservation

Verónica Krapovickas, Nahuel A. Muñoz, Pablo Alonso Muruaga, Patricia L. Ciccioli, Sergio Marenssi & Sergio F. Vizcaíno
The South American caviomorph ichnogenus Tracheria troyana is reevaluated here based on recently discovered specimens that allow a more thorough investigation of footprint taphonomy and ichnotaxonomy. The footprints include detailed autopodium morphology and more complete gait patterns than previously reported. The redefinition of T. troyana involves key aspects as digit impressions of the manus asymmetrically arranged and digit V being the shortest and at times do not print. It generally lacks metacarpal pads, resulting in...

Tracheria Troyana (Krapovickas and Nasif, 2011): Redefinition, Environmental Distribution, and Heritage Conservation

Verónica Krapovickas, Nahuel A. Muñoz, Pablo Alonso Muruaga, Patricia L. Ciccioli, Sergio Marenssi & Sergio F. Vizcaíno
The South American caviomorph ichnogenus Tracheria troyana is reevaluated here based on recently discovered specimens that allow a more thorough investigation of footprint taphonomy and ichnotaxonomy. The footprints include detailed autopodium morphology and more complete gait patterns than previously reported. The redefinition of T. troyana involves key aspects as digit impressions of the manus asymmetrically arranged and digit V being the shortest and at times do not print. It generally lacks metacarpal pads, resulting in...

A synthesis of functionalized 2,5-diimino-thiazolidines from Nef-isocyanide adduct and 1-alkyl-3-arylthioureas

Liza Salehitabar & Issa Yavari
The reaction of ethyl 3-chloro-3-(alkylimino)-2-oxopropanoate (obtained from alkyl isocyanides and ethyl 2-chloro-2-oxoacetate) with 1-alkyl-3-arylthioureas (prepared from primary alkylamines and aryl isothiocyanates) in dry MeCN at room temperature affords ethyl 5-(alkylimino)-4-hydroxy-2-(arylimino)-3-alkylthiazolidine-4-carboxylates in moderate to good yields.

A synthesis of functionalized 2,5-diimino-thiazolidines from Nef-isocyanide adduct and 1-alkyl-3-arylthioureas

Liza Salehitabar & Issa Yavari
The reaction of ethyl 3-chloro-3-(alkylimino)-2-oxopropanoate (obtained from alkyl isocyanides and ethyl 2-chloro-2-oxoacetate) with 1-alkyl-3-arylthioureas (prepared from primary alkylamines and aryl isothiocyanates) in dry MeCN at room temperature affords ethyl 5-(alkylimino)-4-hydroxy-2-(arylimino)-3-alkylthiazolidine-4-carboxylates in moderate to good yields.

Reactions of sulfenyl- and selenylchlorides of boron difluoride acetylacetonate with C-H acids

Irina V. Svistunova, Galina O. Tretyakova & Ksenia A. Gaivoronskaya
The interaction of sulfenyl- and selenylchloride derivatives of boron difluoride acetylacetonate with ketones, diketones and other dicarbonyl compounds was investigated. In the majority of cases the expected products of substitution of hydrogen atom with γ-hio(selen)acetylacetonate group were obtained. The products with two chelate groups were obtained using the lack of ketone. The unusual interaction of selenylchloride with acetylacetone and acetoacetic ether was revealed. Derivatives of acetylacetone with ketone groups at the central sulfur atom were...

Reactions of sulfenyl- and selenylchlorides of boron difluoride acetylacetonate with C-H acids

Irina V. Svistunova, Galina O. Tretyakova & Ksenia A. Gaivoronskaya
The interaction of sulfenyl- and selenylchloride derivatives of boron difluoride acetylacetonate with ketones, diketones and other dicarbonyl compounds was investigated. In the majority of cases the expected products of substitution of hydrogen atom with γ-hio(selen)acetylacetonate group were obtained. The products with two chelate groups were obtained using the lack of ketone. The unusual interaction of selenylchloride with acetylacetone and acetoacetic ether was revealed. Derivatives of acetylacetone with ketone groups at the central sulfur atom were...

Expected Labor Force Activity and Retirement Behavior by Age, Gender, and Labor Force History

James E. Ciecka & Gary R. Skoog
We find and estimate probability mass functions for labor force related random variables. Complete life expectancy (by age, gender, and two years of labor force history) is decomposed into expected years of future labor force activity and inactivity as well as into expected years until final separation from the labor force and expected years in retirement. We also calculate expected age at retirement and expected years in retirement for peopl who actually retire. Two consecutive...

Expected Labor Force Activity and Retirement Behavior by Age, Gender, and Labor Force History

James E. Ciecka & Gary R. Skoog
We find and estimate probability mass functions for labor force related random variables. Complete life expectancy (by age, gender, and two years of labor force history) is decomposed into expected years of future labor force activity and inactivity as well as into expected years until final separation from the labor force and expected years in retirement. We also calculate expected age at retirement and expected years in retirement for peopl who actually retire. Two consecutive...

Synthesis and antibacterial screening of novel 2-(4-(aryl) thiazol-2-yl)-3a,4,7,7a-tetrahydro-1H-4,7-ethanoisoindole-1,3(2H)-dione derivatives

Oguz Özbek, Necibe Canan Usta, Meliha Burcu Gürdere, Osman Nuri Aslan, Yakup Budak & Mustafa Ceylan
A series of novel 2-(4-(aryl)thiazol-2-yl)-3a,4,7,7a-tetrahydro-1H-4,7-ethanoisoindole-1,3(2H)-dione derivatives were synthesized and evaluated for their antimicrobial activity. The structures of the synthesized derivatives (9a-j) were confirmed by means of IR, 1H-NMR, 13C-NMR and elemental analyses. All the compounds 9a-j showed activity against all microorganisms. Compounds 9a, 9c-d and 9j exhibit potent antibacterial activity against tested S. pyogenes. Compounds 9c showed higher activity than standards against C. perfringes. 9a-e, 9j and 9i possess good activity against A. tumefacen.

Synthesis and antibacterial screening of novel 2-(4-(aryl) thiazol-2-yl)-3a,4,7,7a-tetrahydro-1H-4,7-ethanoisoindole-1,3(2H)-dione derivatives

Oguz Özbek, Necibe Canan Usta, Meliha Burcu Gürdere, Osman Nuri Aslan, Yakup Budak & Mustafa Ceylan
A series of novel 2-(4-(aryl)thiazol-2-yl)-3a,4,7,7a-tetrahydro-1H-4,7-ethanoisoindole-1,3(2H)-dione derivatives were synthesized and evaluated for their antimicrobial activity. The structures of the synthesized derivatives (9a-j) were confirmed by means of IR, 1H-NMR, 13C-NMR and elemental analyses. All the compounds 9a-j showed activity against all microorganisms. Compounds 9a, 9c-d and 9j exhibit potent antibacterial activity against tested S. pyogenes. Compounds 9c showed higher activity than standards against C. perfringes. 9a-e, 9j and 9i possess good activity against A. tumefacen.

Pharmaceutical Cocrystals

Maciej Przybyłek
The aims of this project is to develop relevant pharmaceutical properties through co-crystallization and to find efficient screening methods.

Plant Bax Inhibitor-1 interacts with ATG6 to regulate autophagy and programmed cell death

Guoyong Xu, Shanshan Wang, Shaojie Han, Ke Xie, Yan Wang, Jinlin Li & Yule Liu
Autophagy is an evolutionarily conserved catabolic process and is involved in the regulation of programmed cell death during the plant immune response. However, mechanisms regulating autophagy and cell death are incompletely understood. Here, we demonstrate that plant Bax inhibitor-1 (BI-1), a highly conserved cell death regulator, interacts with ATG6, a core autophagy-related protein. Silencing of BI-1 reduced the autophagic activity induced by both N gene-mediated resistance to Tobacco mosaic virus (TMV) and methyl viologen (MV),...

Copper flotation waste from KGHM as potential sorbent for heavy metal removal from aqueous solutions

Bartosz Mikoda, Agnieszka Gruszecka-Kosowska & Agnieszka Klimek
Sorption affinity of copper flotation waste from KGHM toward Cd(II), Cr(III), Cu(II), and Pb(II) ions was investigated in this work. Batch sorption studies, using single-element synthetic aqueous solutions at various pH (2–12), contact time (10–300 min), initial concentration (100–5000 mg dm−3; 1–100 mg dm−3 for Cd(II)) and adsorbent dose (25–200 g dm−3), were performed. Bonding strength of adsorbed metals was tested from the degree of desorption. The maximum metal removal was observed at pH 5–8, ≥120 min reaction time,...

2895515.pdf

Gerwin Osnabrugge, Roarke Horstmeyer, Ioannis Papadopoulos, Benjamin Judkewitz & Ivo Vellekoop
Mathematical supplement

The generalized optical memory effect

Gerwin Osnabrugge, Roarke Horstmeyer, Ioannis Papadopoulos, Benjamin Judkewitz & Ivo Vellekoop
The optical memory effect is a well-known type of wave correlation that is observed in coherent fields that scatter through thin and diffusive materials. It is a fundamental physical property of scattering media that can be harnessed for deep-tissue microscopy or 'through-the-wall' imaging applications. Here we show that the optical memory effect is a special case of a far more general class of wave correlation. Our new theoretical framework explains how waves remain correlated over...

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