1,017,952 Works

Variation in DNA methylation of human blood over a 1-year period using the Illumina MethylationEPIC array

Ina Zaimi, Dong Pei, Devin C. Koestler, Carmen J. Marsit, Immaculata De Vivo, Shelley S. Tworoger, Alexandra E. Shields, Karl T. Kelsey & Dominique S. Michaud
Assessing DNA methylation profiles in human blood has become a major focus of epidemiologic inquiry. Understanding variability in CpG-specific DNA methylation over moderate periods of time is a critical first step in identifying CpG sites that are candidates for DNA methylation-based etiologic, diagnostic and prognostic predictors of pathogenesis. Using the Illumina MethylationEPIC [850K] BeadArray, DNA methylation was profiled in paired whole blood samples collected approximately 1 year apart from 35 healthy women enrolled in the Nurses...

Characterization of multi-locus imprinting disturbances and underlying genetic defects in patients with chromosome 11p15.5 related imprinting disorders

L. Fontana, M. F. Bedeschi, S. Maitz, A. Cereda, C. Faré, S. Motta, A. Seresini, P. D’Ursi, A. Orro, V. Pecile, M. Calvello, A. Selicorni, F. Lalatta, D. Milani, S. M. Sirchia, M. Miozzo & S. Tabano
The identification of multilocus imprinting disturbances (MLID) appears fundamental to uncover molecular pathways underlying imprinting disorders (IDs) and to complete clinical diagnosis of patients. However, MLID genetic associated mechanisms remain largely unknown. To characterize MLID in Beckwith-Wiedemann (BWS) and Silver-Russell (SRS) syndromes, we profiled by MassARRAY the methylation of 12 imprinted differentially methylated regions (iDMRs) in 21 BWS and 7 SRS patients with chromosome 11p15.5 epimutations. MLID was identified in 50% of BWS and 29%...

Apidae

Michael Batley
Flower association records for Australian bee species in the family Apidae.

Apidae

Michael Batley
Flower association records for Australian bee species in the family Apidae.

Colletidae & Stenotritidae

Michael Batley
Flower association records for Australian bee species in the families Colletidae and Stenotritidae.

Colletidae & Stenotritidae

Michael Batley
Flower association records for Australian bee species in the families Colletidae and Stenotritidae.

Megachilidae

Michael Batley
Flower association records for Australian bee species in the family Megachilidae.

Megachilidae

Michael Batley
Flower association records for Australian bee species in the family Megachilidae.

Halictidae

Michael Batley
Flower association records for Australian bee species in the family Halictidae.

Halictidae

Michael Batley
Flower association records for Australian bee species in the family Halictidae.

UMAP

Koki Tsuyuzaki
Best Practices for OnlinePCA.jl against 1.3M Mouse Brain Data

UMAP

Koki Tsuyuzaki
Best Practices for OnlinePCA.jl against 1.3M Mouse Brain Data

Tissue-specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease

Zeyneb Kurt, Rio Barrere-Cain, Jonnby LaGuardia, Margarete Mehrabian, Calvin Pan, Simon Hui, Frode Norheim, Zhiqiang Zhou, Yehudit Hasin, Aldons Lusis & Xia Yang
Abstract Background Non-alcoholic fatty liver disease (NAFLD) encompasses benign steatosis and more severe conditions such as non-alcoholic steatohepatitis (NASH), cirrhosis, and liver cancer. This chronic liver disease has a poorly understood etiology and demonstrates sexual dimorphisms. We aim to examine the molecular mechanisms underlying sexual dimorphisms in NAFLD pathogenesis through a comprehensive multi-omics study. We integrated genomics (DNA variations), transcriptomics of liver and adipose tissue, and phenotypic data of NAFLD derived from female mice of...

Tissue-specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease

Zeyneb Kurt, Rio Barrere-Cain, Jonnby LaGuardia, Margarete Mehrabian, Calvin Pan, Simon Hui, Frode Norheim, Zhiqiang Zhou, Yehudit Hasin, Aldons Lusis & Xia Yang
Abstract Background Non-alcoholic fatty liver disease (NAFLD) encompasses benign steatosis and more severe conditions such as non-alcoholic steatohepatitis (NASH), cirrhosis, and liver cancer. This chronic liver disease has a poorly understood etiology and demonstrates sexual dimorphisms. We aim to examine the molecular mechanisms underlying sexual dimorphisms in NAFLD pathogenesis through a comprehensive multi-omics study. We integrated genomics (DNA variations), transcriptomics of liver and adipose tissue, and phenotypic data of NAFLD derived from female mice of...

Malaria elimination in remote communities requires integration of malaria control activities into general health care: an observational study and interrupted time series analysis in Myanmar

Alistair McLean, Hla Wai, Aung Thu, Zay Khant, Chanida Indrasuta, Elizabeth Ashley, Thar Kyaw, Nicholas Day, Arjen Dondorp, Nicholas White & Frank Smithuis
Abstract Background Community health workers (CHWs) can provide diagnosis and treatment of malaria in remote rural areas and are therefore key to the elimination of malaria. However, as incidence declines, uptake of their services could be compromised if they only treat malaria. Methods We conducted a retrospective analysis of 571,286 malaria rapid diagnostic tests conducted between 2011 and 2016 by 1335 CHWs supported by Medical Action Myanmar. We assessed rates of decline in Plasmodium falciparum...

Additional file 8: of Tissue-specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease

Zeyneb Kurt, Rio Barrere-Cain, Jonnby LaGuardia, Margarete Mehrabian, Calvin Pan, Simon Hui, Frode Norheim, Zhiqiang Zhou, Yehudit Hasin, Aldons Lusis & Xia Yang
Enrichment of the key driver subnetworks for the target genes of the sex hormone receptors. Enrichment is evaluated in a tissue-specific manner using the tissue-specific FANTOM5 gene regulatory networks. (XLSX 9 kb)

Malaria elimination in remote communities requires integration of malaria control activities into general health care: an observational study and interrupted time series analysis in Myanmar

Alistair McLean, Hla Wai, Aung Thu, Zay Khant, Chanida Indrasuta, Elizabeth Ashley, Thar Kyaw, Nicholas Day, Arjen Dondorp, Nicholas White & Frank Smithuis
Abstract Background Community health workers (CHWs) can provide diagnosis and treatment of malaria in remote rural areas and are therefore key to the elimination of malaria. However, as incidence declines, uptake of their services could be compromised if they only treat malaria. Methods We conducted a retrospective analysis of 571,286 malaria rapid diagnostic tests conducted between 2011 and 2016 by 1335 CHWs supported by Medical Action Myanmar. We assessed rates of decline in Plasmodium falciparum...

Additional file 8: of Tissue-specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease

Zeyneb Kurt, Rio Barrere-Cain, Jonnby LaGuardia, Margarete Mehrabian, Calvin Pan, Simon Hui, Frode Norheim, Zhiqiang Zhou, Yehudit Hasin, Aldons Lusis & Xia Yang
Enrichment of the key driver subnetworks for the target genes of the sex hormone receptors. Enrichment is evaluated in a tissue-specific manner using the tissue-specific FANTOM5 gene regulatory networks. (XLSX 9 kb)

Additional file 7: of Tissue-specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease

Zeyneb Kurt, Rio Barrere-Cain, Jonnby LaGuardia, Margarete Mehrabian, Calvin Pan, Simon Hui, Frode Norheim, Zhiqiang Zhou, Yehudit Hasin, Aldons Lusis & Xia Yang
Combined subnetworks of NAFLD processes that are shared between sexes or female-specific. (A) Liver Bayesian subnetwork comprised of NAFLD supersets that are perturbed in liver tissue of females (as a combination of female-specific processes or shared processes between sexes) and the top key drivers of each superset. (B) Adipose Bayesian subnetwork comprised of NAFLD supersets that are perturbed in adipose tissue of females (as a combination of female-specific processes or shared processes between sexes) and...

Additional file 4: of Malaria elimination in remote communities requires integration of malaria control activities into general health care: an observational study and interrupted time series analysis in Myanmar

Alistair McLean, Hla Wai, Aung Thu, Zay Khant, Chanida Indrasuta, Elizabeth Ashley, Thar Kyaw, Nicholas Day, Arjen Dondorp, Nicholas White & Frank Smithuis
Malaria incidence and RDT positivity rates by calendar year for Chin and Kayin. (A) P. falciparum incidence (per 1000 person months); (B) P. vivax incidence (per 1000 person months); (C) P. falciparum RDT positivity rate (%); (D) P. vivax RDT positivity rate (%). RDTsâ =â Rapid Diagnostic Tests. Other state/regions are presented separately in Additional file 2 for legibility. (PDF 146 kb)

Additional file 4: of Malaria elimination in remote communities requires integration of malaria control activities into general health care: an observational study and interrupted time series analysis in Myanmar

Alistair McLean, Hla Wai, Aung Thu, Zay Khant, Chanida Indrasuta, Elizabeth Ashley, Thar Kyaw, Nicholas Day, Arjen Dondorp, Nicholas White & Frank Smithuis
Malaria incidence and RDT positivity rates by calendar year for Chin and Kayin. (A) P. falciparum incidence (per 1000 person months); (B) P. vivax incidence (per 1000 person months); (C) P. falciparum RDT positivity rate (%); (D) P. vivax RDT positivity rate (%). RDTsâ =â Rapid Diagnostic Tests. Other state/regions are presented separately in Additional file 2 for legibility. (PDF 146 kb)

Additional file 7: of Tissue-specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease

Zeyneb Kurt, Rio Barrere-Cain, Jonnby LaGuardia, Margarete Mehrabian, Calvin Pan, Simon Hui, Frode Norheim, Zhiqiang Zhou, Yehudit Hasin, Aldons Lusis & Xia Yang
Combined subnetworks of NAFLD processes that are shared between sexes or female-specific. (A) Liver Bayesian subnetwork comprised of NAFLD supersets that are perturbed in liver tissue of females (as a combination of female-specific processes or shared processes between sexes) and the top key drivers of each superset. (B) Adipose Bayesian subnetwork comprised of NAFLD supersets that are perturbed in adipose tissue of females (as a combination of female-specific processes or shared processes between sexes) and...

Additional file 6: of Tissue-specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease

Zeyneb Kurt, Rio Barrere-Cain, Jonnby LaGuardia, Margarete Mehrabian, Calvin Pan, Simon Hui, Frode Norheim, Zhiqiang Zhou, Yehudit Hasin, Aldons Lusis & Xia Yang
Previously annotated NAFLD-associated genes from the literature. Genes that were identified as a key driver in our analysis are highlighted in particular colors as denoted below. (XLSX 18 kb)

Knowledge translation for public health in low- and middle- income countries: a critical interpretive synthesis

Catherine Malla, Paul Aylward & Paul Ward
Abstract Background Effective knowledge translation allows the optimisation of access to and utilisation of research knowledge in order to inform and enhance public health policy and practice. In low- and middle- income countries, there are substantial complexities that affect the way in which research can be utilised for public health action. This review attempts to draw out concepts in the literature that contribute to defining some of the complexities and contextual factors that influence knowledge...

Additional file 3: of Malaria elimination in remote communities requires integration of malaria control activities into general health care: an observational study and interrupted time series analysis in Myanmar

Alistair McLean, Hla Wai, Aung Thu, Zay Khant, Chanida Indrasuta, Elizabeth Ashley, Thar Kyaw, Nicholas Day, Arjen Dondorp, Nicholas White & Frank Smithuis
Malaria incidence and RDT positivity rates by calendar year for Kachin, Kayah, Mon, Rakhine, Sagaing, Tanintharyi. (A) P. falciparum incidence (per 1000 person months); (B) P. vivax incidence (per 1000 person months); (C) P. falciparum RDT positivity rate (%); (D) P. vivax RDT positivity rate (%). RDTsâ =â Rapid Diagnostic Tests. Chin and Kayin are presented separately in Additional file 3 for legibility. (PDF 160 kb)

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