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Additional file 7: of Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions

A. Johnston, W. Bu, S. Hein, S. Garcia, L. Camacho, L. Xue, L. Qin, C. Nagi, S. Hilsenbeck, J. Kapali, K. Podsypanina, J. Nangia & Y. Li
Figure S7. Effects of ruxolitinib on pSTAT5 and tumor latency. (A) Serum prolactin levels of mice. (B) Immunohistochemistry analysis and the accompanying dot plot for pSTAT5+ cells. The p values were determined using the Mann-Whitney test. Each dot in this plot represents one mouse. (C) Kaplan-Meier tumor-free survival curve of mice infected by RCAS-HRasQ61L. The p value was determined by generalized Gehan-Wilcoxon test with Rhoâ =â 1. (AI 6247 kb)

Additional file 6: of Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions

A. Johnston, W. Bu, S. Hein, S. Garcia, L. Camacho, L. Xue, L. Qin, C. Nagi, S. Hilsenbeck, J. Kapali, K. Podsypanina, J. Nangia & Y. Li
Figure S6. Effects of genetic ablation of STAT5a on downstream factors of STAT5. Immunohistochemistry analysis of β-casein in caErbB2 early lesions. (AI 4570 kb)

Additional file 6: of Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions

A. Johnston, W. Bu, S. Hein, S. Garcia, L. Camacho, L. Xue, L. Qin, C. Nagi, S. Hilsenbeck, J. Kapali, K. Podsypanina, J. Nangia & Y. Li
Figure S6. Effects of genetic ablation of STAT5a on downstream factors of STAT5. Immunohistochemistry analysis of β-casein in caErbB2 early lesions. (AI 4570 kb)

Additional file 5: of Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions

A. Johnston, W. Bu, S. Hein, S. Garcia, L. Camacho, L. Xue, L. Qin, C. Nagi, S. Hilsenbeck, J. Kapali, K. Podsypanina, J. Nangia & Y. Li
Figure S5. Effects of aripiprazole and clomipramine on biomarkers and lesion burden. (A) Serum prolactin levels of mice in the aripiprazole study. (B) Lesion burden determined by immunohistochemical staining for the HA tag on RCAS-caErbB2. (C) Ki67+ cells determined by immunofluorescence staining. (D) TUNEL+ cells. (E) Serum prolactin levels of mice in the clomipramine study. (F) Lesion burden determined by immunohistochemical staining for the HA tag on RCAS-caErbB2. The p values were determined using the...

Additional file 5: of Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions

A. Johnston, W. Bu, S. Hein, S. Garcia, L. Camacho, L. Xue, L. Qin, C. Nagi, S. Hilsenbeck, J. Kapali, K. Podsypanina, J. Nangia & Y. Li
Figure S5. Effects of aripiprazole and clomipramine on biomarkers and lesion burden. (A) Serum prolactin levels of mice in the aripiprazole study. (B) Lesion burden determined by immunohistochemical staining for the HA tag on RCAS-caErbB2. (C) Ki67+ cells determined by immunofluorescence staining. (D) TUNEL+ cells. (E) Serum prolactin levels of mice in the clomipramine study. (F) Lesion burden determined by immunohistochemical staining for the HA tag on RCAS-caErbB2. The p values were determined using the...

Additional file 4: of Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions

A. Johnston, W. Bu, S. Hein, S. Garcia, L. Camacho, L. Xue, L. Qin, C. Nagi, S. Hilsenbeck, J. Kapali, K. Podsypanina, J. Nangia & Y. Li
Figure S4. Pimozide accelerates the development of early lesions initiated by RCAS-caErbB2 while lowering the anticancer barrier of apoptosis. (A) Immunohistochemical staining for the HA tag on the RCAS-ErbB2 provirus with the corresponding dot plot. (B) Immunofluorescence staining for Ki67 with the accompanying dot plot. (C and D) Immunofluorescence staining for cleaved caspase 3 (C) and TUNEL assay (D) with the accompanying dot plots. The Mann-Whitney test was used to determine the p values. Each...

Additional file 4: of Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions

A. Johnston, W. Bu, S. Hein, S. Garcia, L. Camacho, L. Xue, L. Qin, C. Nagi, S. Hilsenbeck, J. Kapali, K. Podsypanina, J. Nangia & Y. Li
Figure S4. Pimozide accelerates the development of early lesions initiated by RCAS-caErbB2 while lowering the anticancer barrier of apoptosis. (A) Immunohistochemical staining for the HA tag on the RCAS-ErbB2 provirus with the corresponding dot plot. (B) Immunofluorescence staining for Ki67 with the accompanying dot plot. (C and D) Immunofluorescence staining for cleaved caspase 3 (C) and TUNEL assay (D) with the accompanying dot plots. The Mann-Whitney test was used to determine the p values. Each...

Additional file 3: of Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions

A. Johnston, W. Bu, S. Hein, S. Garcia, L. Camacho, L. Xue, L. Qin, C. Nagi, S. Hilsenbeck, J. Kapali, K. Podsypanina, J. Nangia & Y. Li
Figure S3. Pimozide increases serum prolactin levels, pSTAT5 in early lesions, and β-casein, while aripiprazole does not impact pSTAT5. (A) Serum prolactin levels. (B) pSTAT5+ cells determined by immunohistochemistry analysis. (C) Immunohistochemistry analysis of β-casein. (D) pSTAT5+ cells determined by immunohistochemistry analysis. The p values were determined using the Mann-Whitney test. Each dot in these plots represents one mouse. (AI 6764 kb)

Additional file 3: of Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions

A. Johnston, W. Bu, S. Hein, S. Garcia, L. Camacho, L. Xue, L. Qin, C. Nagi, S. Hilsenbeck, J. Kapali, K. Podsypanina, J. Nangia & Y. Li
Figure S3. Pimozide increases serum prolactin levels, pSTAT5 in early lesions, and β-casein, while aripiprazole does not impact pSTAT5. (A) Serum prolactin levels. (B) pSTAT5+ cells determined by immunohistochemistry analysis. (C) Immunohistochemistry analysis of β-casein. (D) pSTAT5+ cells determined by immunohistochemistry analysis. The p values were determined using the Mann-Whitney test. Each dot in these plots represents one mouse. (AI 6764 kb)

Magnetic resonance imaging for detecting root avulsions in traumatic adult brachial plexus injuries: protocol for a systematic review of diagnostic accuracy

Ryckie Wade, Yemisi Takwoingi, Justin Wormald, John Ridgway, Steven Tanner, James Rankine & Grainne Bourke
Abstract Background Adult brachial plexus injuries (BPI) are becoming more common. The reconstruction and prognosis of pre-ganglionic injuries (root avulsions) are different to other types of BPI injury. Preoperative magnetic resonance imaging (MRI) is being used to identify root avulsions, but the evidence from studies of its diagnostic accuracy are conflicting. Therefore, a systematic review is needed to address uncertainty about the accuracy of MRI and to guide future research. Methods We will conduct a...

Magnetic resonance imaging for detecting root avulsions in traumatic adult brachial plexus injuries: protocol for a systematic review of diagnostic accuracy

Ryckie Wade, Yemisi Takwoingi, Justin Wormald, John Ridgway, Steven Tanner, James Rankine & Grainne Bourke
Abstract Background Adult brachial plexus injuries (BPI) are becoming more common. The reconstruction and prognosis of pre-ganglionic injuries (root avulsions) are different to other types of BPI injury. Preoperative magnetic resonance imaging (MRI) is being used to identify root avulsions, but the evidence from studies of its diagnostic accuracy are conflicting. Therefore, a systematic review is needed to address uncertainty about the accuracy of MRI and to guide future research. Methods We will conduct a...

Additional file 4: of Magnetic resonance imaging for detecting root avulsions in traumatic adult brachial plexus injuries: protocol for a systematic review of diagnostic accuracy

Ryckie Wade, Yemisi Takwoingi, Justin Wormald, John Ridgway, Steven Tanner, James Rankine & Grainne Bourke
QUADAS-2 tool. (DOCX 18 kb)

Additional file 4: of Magnetic resonance imaging for detecting root avulsions in traumatic adult brachial plexus injuries: protocol for a systematic review of diagnostic accuracy

Ryckie Wade, Yemisi Takwoingi, Justin Wormald, John Ridgway, Steven Tanner, James Rankine & Grainne Bourke
QUADAS-2 tool. (DOCX 18 kb)

Additional file 2: of Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions

A. Johnston, W. Bu, S. Hein, S. Garcia, L. Camacho, L. Xue, L. Qin, C. Nagi, S. Hilsenbeck, J. Kapali, K. Podsypanina, J. Nangia & Y. Li
Figure S2. Risperidone treatment accelerates early lesion development of MMTV-Wnt1 transgenic mice. (A) Carmine whole mount staining of mammary glands from MMTV-Wnt1 transgenic mice. (B) H&E staining of mammary gland sections of MMTV-Wnt1 mice. (C) pSTAT5 immunohistochemical staining of mammary gland sections of MMTV-Wnt1 mice. (AI 22593 kb)

Additional file 2: of Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions

A. Johnston, W. Bu, S. Hein, S. Garcia, L. Camacho, L. Xue, L. Qin, C. Nagi, S. Hilsenbeck, J. Kapali, K. Podsypanina, J. Nangia & Y. Li
Figure S2. Risperidone treatment accelerates early lesion development of MMTV-Wnt1 transgenic mice. (A) Carmine whole mount staining of mammary glands from MMTV-Wnt1 transgenic mice. (B) H&E staining of mammary gland sections of MMTV-Wnt1 mice. (C) pSTAT5 immunohistochemical staining of mammary gland sections of MMTV-Wnt1 mice. (AI 22593 kb)

Additional file 3: of Magnetic resonance imaging for detecting root avulsions in traumatic adult brachial plexus injuries: protocol for a systematic review of diagnostic accuracy

Ryckie Wade, Yemisi Takwoingi, Justin Wormald, John Ridgway, Steven Tanner, James Rankine & Grainne Bourke
Screening form. (DOCX 23 kb)

Additional file 3: of Magnetic resonance imaging for detecting root avulsions in traumatic adult brachial plexus injuries: protocol for a systematic review of diagnostic accuracy

Ryckie Wade, Yemisi Takwoingi, Justin Wormald, John Ridgway, Steven Tanner, James Rankine & Grainne Bourke
Screening form. (DOCX 23 kb)

Additional file 1: of Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions

A. Johnston, W. Bu, S. Hein, S. Garcia, L. Camacho, L. Xue, L. Qin, C. Nagi, S. Hilsenbeck, J. Kapali, K. Podsypanina, J. Nangia & Y. Li
Figure S1. Risperidone treatment does not affect tumor histopathology or lung metastatic potential. (A) H&E staining of tumor sections. (B) qPCR analysis of lung metastasis and the resulting dot plot analyzed using the Mann-Whitney test. Each dot in this plot represents one mouse. (AI 4884 kb)

Additional file 1: of Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions

A. Johnston, W. Bu, S. Hein, S. Garcia, L. Camacho, L. Xue, L. Qin, C. Nagi, S. Hilsenbeck, J. Kapali, K. Podsypanina, J. Nangia & Y. Li
Figure S1. Risperidone treatment does not affect tumor histopathology or lung metastatic potential. (A) H&E staining of tumor sections. (B) qPCR analysis of lung metastasis and the resulting dot plot analyzed using the Mann-Whitney test. Each dot in this plot represents one mouse. (AI 4884 kb)

Additional file 2: of Magnetic resonance imaging for detecting root avulsions in traumatic adult brachial plexus injuries: protocol for a systematic review of diagnostic accuracy

Ryckie Wade, Yemisi Takwoingi, Justin Wormald, John Ridgway, Steven Tanner, James Rankine & Grainne Bourke
Search strategies. (DOCX 17 kb)

Additional file 2: of Magnetic resonance imaging for detecting root avulsions in traumatic adult brachial plexus injuries: protocol for a systematic review of diagnostic accuracy

Ryckie Wade, Yemisi Takwoingi, Justin Wormald, John Ridgway, Steven Tanner, James Rankine & Grainne Bourke
Search strategies. (DOCX 17 kb)

Relevance of the Mann Whitney Wilcoxon test in the survival analysis of newly established companies in Tunisia (Case of the sfax region)

Sahar Ayadi & Sonia Ghorbel
Abstract This research focuses on the factors of survival and growth of new enterprises in Tunisia. Based on previous research, we hypothesize that three factors influence the survival and growth of these firms: factors related to the entrepreneur, factors related to organizational characteristics and characteristics of the environment from start-up. We test these assumptions on a sample of 60 companies. The results show that human capital and the experience of the entrepreneur have a relatively...

MOESM1 of Establishing an innovative carbohydrate metabolic pathway for efficient production of 2-keto-l-gulonic acid in Ketogulonicigenium robustum initiated by intronic promoters

Cai-Yun Wang, Ye Li, Zi-Wei Gao, Li-Cheng Liu, Meng-Yue Zhang, Tian-Yuan Zhang, Chun-Fu Wu & Yi-Xuan Zhang
Additional file 1: Table S1. Codon frequency of K. robustum SPU_B003. Table S2. Optimization parameters. Table S3. Primers used in this study. Table S4. DNA sequences used in this study. Table S5. Growth characteristics of K. robustum SPU_B003. Figure S1. Phylogenetic analysis of K. robustum SPU_B003 with other species. Figure S2. Orthogonality test of the promoters and heterologous genes.

MOESM1 of Establishing an innovative carbohydrate metabolic pathway for efficient production of 2-keto-l-gulonic acid in Ketogulonicigenium robustum initiated by intronic promoters

Cai-Yun Wang, Ye Li, Zi-Wei Gao, Li-Cheng Liu, Meng-Yue Zhang, Tian-Yuan Zhang, Chun-Fu Wu & Yi-Xuan Zhang
Additional file 1: Table S1. Codon frequency of K. robustum SPU_B003. Table S2. Optimization parameters. Table S3. Primers used in this study. Table S4. DNA sequences used in this study. Table S5. Growth characteristics of K. robustum SPU_B003. Figure S1. Phylogenetic analysis of K. robustum SPU_B003 with other species. Figure S2. Orthogonality test of the promoters and heterologous genes.

Establishing an innovative carbohydrate metabolic pathway for efficient production of 2-keto-l-gulonic acid in Ketogulonicigenium robustum initiated by intronic promoters

Cai-Yun Wang, Ye Li, Zi-Wei Gao, Li-Cheng Liu, Meng-Yue Zhang, Tian-Yuan Zhang, Chun-Fu Wu & Yi-Xuan Zhang
Abstract Background 2-Keto-l-gulonic acid (2-KGA), the precursor of vitamin C, is currently produced by two-step fermentation. In the second step, l-sorbose is transformed into 2-KGA by the symbiosis system composed of Ketogulonicigenium vulgare and Bacillus megaterium. Due to the different nutrient requirements and the uncertain ratio of the two strains, the symbiosis system significantly limits strain improvement and fermentation optimization. Results In this study, Ketogulonicigenium robustum SPU_B003 was reported for its capability to grow well...

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