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Practical Considerations for the Use of Subcutaneous Treatment in the Management of Dyslipidaemia

Franck Boccara, Ricardo Dent, Luis Ruilope & Paul Valensi
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Comparison of the Systemic and Local Pharmacokinetics of Clonidine Mucoadhesive Buccal Tablets with Reference Clonidine Oral Tablets in Healthy Volunteers: An Open-Label Randomised Cross-Over Trial

Bérangère Vasseur, Alain Dufour, Laetitia Houdas, Helen Goodwin, Kathryn Harries, Neslihan Yesiltas Emul & Simon Hutchings
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Comparison of the Systemic and Local Pharmacokinetics of Clonidine Mucoadhesive Buccal Tablets with Reference Clonidine Oral Tablets in Healthy Volunteers: An Open-Label Randomised Cross-Over Trial

Bérangère Vasseur, Alain Dufour, Laetitia Houdas, Helen Goodwin, Kathryn Harries, Neslihan Yesiltas Emul & Simon Hutchings
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The Patterns of Non-vitamin K Antagonist Oral Anticoagulants (NOACs) Use in Patients with Atrial Fibrillation in Seven Balkan Countries: a Report from the BALKAN-AF Survey

Tatjana S. Potpara, Elina Trendafilova, Gheorghe-Andrei Dan, Artan Goda, Zumreta Kusljugic, Sime Manola, Ljilja Music, Viktor Gjini, Belma Pojskic, Mircea Ioakim Popescu, Catalina Arsenescu Georgescu, Elena S. Dimitrova, Delyana Kamenova, Uliks Ekmeciu, Denis Mrsic, Ana Nenezic, Sandro Brusich, Srdjan Milanov, Ivan Zeljkovic, Gregory Y. H. Lip & On Behalf Of The BALKAN-AF Investigators
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Brukenthal Acta Musei Simón Bolívar by Rafael ARREAZA SCROCCHI.pdf

Rafael Arreaza Scrocchi

This review explains how the image of Latin American Liberator, Simón Bolívar, was re-imagined by Rumanian artist, Samys Mützner, during the commemoration of the centenary of the Angostura Address celebrated in Venezuela in February 15, 1919.

Brukenthal Acta Musei Simón Bolívar by Rafael ARREAZA SCROCCHI.pdf

Rafael Arreaza Scrocchi

This review explains how the image of Latin American Liberator, Simón Bolívar, was re-imagined by Rumanian artist, Samys Mützner, during the commemoration of the centenary of the Angostura Address celebrated in Venezuela in February 15, 1919.

The Patterns of Non-vitamin K Antagonist Oral Anticoagulants (NOACs) Use in Patients with Atrial Fibrillation in Seven Balkan Countries: a Report from the BALKAN-AF Survey

Tatjana S. Potpara, Elina Trendafilova, Gheorghe-Andrei Dan, Artan Goda, Zumreta Kusljugic, Sime Manola, Ljilja Music, Viktor Gjini, Belma Pojskic, Mircea Ioakim Popescu, Catalina Arsenescu Georgescu, Elena S. Dimitrova, Delyana Kamenova, Uliks Ekmeciu, Denis Mrsic, Ana Nenezic, Sandro Brusich, Srdjan Milanov, Ivan Zeljkovic, Gregory Y. H. Lip & On Behalf Of The BALKAN-AF Investigators
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Catheter Ablation of Atrial Fibrillation: An Overview for Clinicians

Nebojša Mujović, Milan Marinković, Radoslaw Lenarczyk, Roland Tilz & Tatjana S. Potpara
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Catheter Ablation of Atrial Fibrillation: An Overview for Clinicians

Nebojša Mujović, Milan Marinković, Radoslaw Lenarczyk, Roland Tilz & Tatjana S. Potpara
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Health-Related Quality of Life in Individuals with Down Syndrome: Results from a Non-Interventional Longitudinal Multi-National Study

Diana Rofail, Daniel Froggatt, Rafael De La Torre, Jamie Edgin, Priya Kishnani, Renaud Touraine, Sarah Whitwham, Lisa Squassante, Omar Khwaja & Xavier Liogier D’Ardhuy
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Health-Related Quality of Life in Individuals with Down Syndrome: Results from a Non-Interventional Longitudinal Multi-National Study

Diana Rofail, Daniel Froggatt, Rafael De La Torre, Jamie Edgin, Priya Kishnani, Renaud Touraine, Sarah Whitwham, Lisa Squassante, Omar Khwaja & Xavier Liogier D’Ardhuy
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Prescribing Trends in a Glaucoma Clinic and Adherence to EGS Guidelines: A Retrospective, Non-Interventional, Single-Center UK Study

Mark Fajgenbaum & Ejaz Ansari
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Prescribing Trends in a Glaucoma Clinic and Adherence to EGS Guidelines: A Retrospective, Non-Interventional, Single-Center UK Study

Mark Fajgenbaum & Ejaz Ansari
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Hypoglycemia After Initiation of Basal Insulin in Patients with Type 2 Diabetes in the United States: Implications for Treatment Discontinuation and Healthcare Costs and Utilization

Mehul R. Dalal, Mahmood Kazemi, Fen Ye & Lin Xie
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Hypoglycemia After Initiation of Basal Insulin in Patients with Type 2 Diabetes in the United States: Implications for Treatment Discontinuation and Healthcare Costs and Utilization

Mehul R. Dalal, Mahmood Kazemi, Fen Ye & Lin Xie
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Identification of two integration sites in favor of transgene expression in Trichoderma reesei

Lina Qin, Xianzhang Jiang, Zhiyang Dong, Jianzhong Huang & Xiuzhen Chen
Abstract Background The ascomycete fungus Trichoderma reesei was widely used as a biotechnological workhorse for production of cellulases and recombinant proteins due to its large capacity of protein secretion. Transgenesis by random integration of a gene of interest (GOI) into the genome of T. reesei can generate series of strains that express different levels of the indicated transgene. The insertion site of the GOI plays an important role in the ultimate production of the targeted...

Genomic and probiotic characterization of SJP-SNU strain of Pichia kudriavzevii

Seung-Min Hong, Hyuk-Joon Kwon, Se-Joon Park, Won-Jin Seong, Ilhwan Kim & Jae-Hong Kim
Abstract The yeast strain SJP-SNU was investigated as a probiotic and was characterized with respect to growth temperature, bile salt resistance, hydrogen sulfide reducing activity, intestinal survival ability and chicken embryo pathogenicity. In addition, we determined the complete genomic and mitochondrial sequences of SJP-SNU and conducted comparative genomics analyses. SJP-SNU grew rapidly at 37 °C and formed colonies on MacConkey agar containing bile salt. SJP-SNU reduced hydrogen sulfide produced by Salmonella serotype Enteritidis and, after being...

Effects of linagliptin on endothelial function and postprandial lipids in coronary artery disease patients with early diabetes: a randomized, placebo-controlled, double-blind trial

Norbert Tripolt, Felix Aberer, Regina Riedl, Jasmin Url, Gudrun Dimsity, Andreas Meinitzer, Tatjana Stojakovic, Faisal Aziz, Ronald Hödl, Gabriele Brachtl, Dirk Strunk, Marianne Brodmann, Franz Hafner & Harald Sourij
Abstract Background Early glucose lowering intervention in subjects with type 2 diabetes mellitus was demonstrated to be beneficial in terms of micro- and macrovascular risk reduction. However, most of currently ongoing cardiovascular outcome trials are performed in subjects with manifest atherosclerosis and long-standing diabetes. Therefore, the aim of this study is to investigate the effects of the dipeptidylpeptidase-4 inhibitor linagliptin in subjects with coronary artery disease (CAD) but early type 2 diabetes mellitus (T2DM) on...

Risk factors for schistosomiasis in an urban area in northern Côte d’Ivoire

Richard M’Bra, Brama Kone, Yapi Yapi, Kigbafori Silué, Ibrahima Sy, Danielle Vienneau, Nagnin Soro, Guéladio Cissé & Jürg Utzinger
Abstract Background Schistosomiasis is a water-based disease transmitted by trematodes belonging to the genus Schistosoma. The aim of this study was to assess the relationship between the prevalence of schistosomiasis and access to water, sanitation and hygiene (WASH) and environmental and socioeconomic factors in the city of Korhogo, northern Côte d'Ivoire. Methods A cross-sectional study including 728 randomly selected households was conducted in Korhogo in March 2015. The heads of the households were interviewed about...

Metabolome analysis-based design and engineering of a metabolic pathway in Corynebacterium glutamicum to match rates of simultaneous utilization of d-glucose and l-arabinose

Hideo Kawaguchi, Kumiko Yoshihara, Kiyotaka Hara, Tomohisa Hasunuma, Chiaki Ogino & Akihiko Kondo
Abstract Background l-Arabinose is the second most abundant component of hemicellulose in lignocellulosic biomass, next to d-xylose. However, few microorganisms are capable of utilizing pentoses, and catabolic genes and operons enabling bacterial utilization of pentoses are typically subject to carbon catabolite repression by more-preferred carbon sources, such as d-glucose, leading to a preferential utilization of d-glucose over pentoses. In order to simultaneously utilize both d-glucose and l-arabinose at the same rate, a modified metabolic pathway...

Facile synthesis of α-alkoxymethyltriphenylphosphonium iodides: new application of PPh3/I2

Humaira Gondal, Zain Cheema, Javid Zaidi, Sammer Yousuf & M. Choudhary
Abstract An efficient one pot method for the synthesis of α-alkoxymethylphosphonium iodides is developed by using PPh3/I2 combination at room temperature. Reaction conditions are found general to synthesize wide range of structurally variant alkoxymethylphosphonium iodides in high yield (70–91%). These new functionalized phosphonium salts are further used in stereoselective synthesis of vinyl ethers as well as in carbon homologation of aldehydes.

The effect of temperature-dependent thermal conductivity on the geothermal structure of the Sydney Basin

Alexandre Lemenager, Craig O’Neill, Siqi Zhang & Morgan Evans
Abstract The thermal structure of continental crust is a critical factor for geothermal exploration, hydrocarbon maturation and crustal strength, and yet our understanding of it is limited by our incomplete knowledge of its geological structure and thermal properties such as hydrogeologic and thermo-mechanical feedbacks that come into play. One of the most critical parameters in modelling upper crustal temperature is thermal conductivity, which itself exhibits strong temperature dependence. In this study, we integrate new laboratory...

Enhanced cellulase production in Trichoderma reesei RUT C30 via constitution of minimal transcriptional activators

Jiajia Zhang, Guoxiu Zhang, Wei Wang & Dongzhi Wei
Abstract Background Cellulase can convert lignocellulosic feedstocks into fermentable sugars, which can be used for the industrial production of biofuels and chemicals. The high cost of cellulase production remains a challenge for lignocellulose breakdown. Trichoderma reesei RUT C30 serves as a well-known industrial workhorse for cellulase production. Therefore, the enhancement of cellulase production by T. reesei RUT C30 is of great importance. Results Two sets of novel minimal transcriptional activators (DBDace2-VP16 and DBDcre1-VP16) were designed...

Integrated experimental and technoeconomic evaluation of two-stage Cu-catalyzed alkaline–oxidative pretreatment of hybrid poplar

Aditya Bhalla, Peyman Fasahati, Chrislyn Particka, Aline Assad, Ryan Stoklosa, Namita Bansal, Rachel Semaan, Christopher Saffron, David Hodge & Eric Hegg
Abstract Background When applied to recalcitrant lignocellulosic feedstocks, multi-stage pretreatments can provide more processing flexibility to optimize or balance process outcomes such as increasing delignification, preserving hemicellulose, and maximizing enzymatic hydrolysis yields. We previously reported that adding an alkaline pre-extraction step to a copper-catalyzed alkaline hydrogen peroxide (Cu-AHP) pretreatment process resulted in improved sugar yields, but the process still utilized relatively high chemical inputs (catalyst and H2O2) and enzyme loadings. We hypothesized that by increasing...

Identification of two integration sites in favor of transgene expression in Trichoderma reesei

Lina Qin, Xianzhang Jiang, Zhiyang Dong, Jianzhong Huang & Xiuzhen Chen
Abstract Background The ascomycete fungus Trichoderma reesei was widely used as a biotechnological workhorse for production of cellulases and recombinant proteins due to its large capacity of protein secretion. Transgenesis by random integration of a gene of interest (GOI) into the genome of T. reesei can generate series of strains that express different levels of the indicated transgene. The insertion site of the GOI plays an important role in the ultimate production of the targeted...

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