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Chi Yang
55 ggg m gg

30LAYER.tif

Chi Yang
55 ggg m gg

Bigger than bedload: Size distribution, residence time, and channel evolution implications of bedrock blocks in rapidly incising rivers

Charles Shobe, Moana Sato & Greg Tucker
This is a poster presented in November 2015 at the Geological Society of America annual meeting in Baltimore, MD, USA. The poster describes modeling work on the influence of hillslope-derived blocks on river erosion. It also presents field data from Boulder Creek, Colorado and the Middle Fork Popo Agie River, Wyoming. Field data from Boulder Creek was collected and analyzed by Moana Sato, who was an intern with the NSF-funded Research Experience for Community College...

Bigger than bedload: Size distribution, residence time, and channel evolution implications of bedrock blocks in rapidly incising rivers

Charles Shobe, Moana Sato & Greg Tucker
This is a poster presented in November 2015 at the Geological Society of America annual meeting in Baltimore, MD, USA. The poster describes modeling work on the influence of hillslope-derived blocks on river erosion. It also presents field data from Boulder Creek, Colorado and the Middle Fork Popo Agie River, Wyoming. Field data from Boulder Creek was collected and analyzed by Moana Sato, who was an intern with the NSF-funded Research Experience for Community College...

A new framework for modeling the effects of sediment size distribution on fluvial erosion: Theory and a case study

Charles Shobe, Greg Tucker & Robert Anderson
This is a poster presented in July 2015 at the Summer Institute for Earth Surface Dynamics, hosted at Tulane University in New Orleans, LA, USA by the National Center for Earth-Surface Dynamics. The poster describes an approach to modeling fluvial erosion, transport, and deposition of multiple grain sizes as well as theory for the comminution of larger grains into smaller ones. Some of the ideas in this poster were incorporated into Shobe et al (2016,...

A new framework for modeling the effects of sediment size distribution on fluvial erosion: Theory and a case study

Charles Shobe, Greg Tucker & Robert Anderson
This is a poster presented in July 2015 at the Summer Institute for Earth Surface Dynamics, hosted at Tulane University in New Orleans, LA, USA by the National Center for Earth-Surface Dynamics. The poster describes an approach to modeling fluvial erosion, transport, and deposition of multiple grain sizes as well as theory for the comminution of larger grains into smaller ones. Some of the ideas in this poster were incorporated into Shobe et al (2016,...

Boulders and bedrock: Modeling dynamic feedbacks between hillslope-derived blocks and transient channel evolution

Charles Shobe, Greg Tucker & Robert Anderson
This is a poster presented on May 17th, 2016 at the Community Surface Dynamics Modeling System (CSDMS) annual meeting in Boulder, CO, USA. The poster presents a numerical model for 1-D river channel evolution in the presence of hillslope-derived blocks of rock. It also shows initial progress towards a 2-D landscape evolution model incorporating these channel-hillslope feedbacks.
Abstract:
Steep reaches of mountain rivers often host clusters of large (>1 m) blocks of rock despite having high transport...

Additional file 8: of Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury

Melania Cusimano, Elena Brambilla, Alessia Capotondo, Donatella De Feo, Antonio Tomasso, Giancarlo Comi, Patrizia D’Adamo, Luca Muzio & Gianvito Martino
Figure S6. Upregulation of inflammatory cues in GCV-NestinTK mice. Real-time PCR analysis of pro-inflammatory genes (A–D) in T11–T13 spinal cord tissues at different time points after the injury induction. GCV-NestinTK mice (red bars) have a increased expression of pro-inflammatory genes after injury compared with control mice (blue bars). Values indicate mean fold changes ± S.E.M (n = 3–6 for each group). Comparisons were done using the t Student test: TNFα:* p = 0.021; IL-1β:* p = 0.046; Vegfa: p = 0.008. (TIFF 7997 kb)

Additional file 8: of Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury

Melania Cusimano, Elena Brambilla, Alessia Capotondo, Donatella De Feo, Antonio Tomasso, Giancarlo Comi, Patrizia D’Adamo, Luca Muzio & Gianvito Martino
Figure S6. Upregulation of inflammatory cues in GCV-NestinTK mice. Real-time PCR analysis of pro-inflammatory genes (A–D) in T11–T13 spinal cord tissues at different time points after the injury induction. GCV-NestinTK mice (red bars) have a increased expression of pro-inflammatory genes after injury compared with control mice (blue bars). Values indicate mean fold changes ± S.E.M (n = 3–6 for each group). Comparisons were done using the t Student test: TNFα:* p = 0.021; IL-1β:* p = 0.046; Vegfa: p = 0.008. (TIFF 7997 kb)

Additional file 7: of Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury

Melania Cusimano, Elena Brambilla, Alessia Capotondo, Donatella De Feo, Antonio Tomasso, Giancarlo Comi, Patrizia D’Adamo, Luca Muzio & Gianvito Martino
Figure S5. macrophages/macrophages activation affects both GCV-WT and GCV-NestinTK mice. (A) Histological analysis of a SC region located 3 mm far from the injury site from a GCV-WT mice (18 days post injury). Microglia/macrophages are labeled for Iba1 and F4/80. Arrowhead indicates cells that are shown at high magnification in panel A’. Panel B shows the site of the injury in the SC of GCV-WT mouse. Arrowhead indicates cells that are shown at high magnification in panel...

Additional file 7: of Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury

Melania Cusimano, Elena Brambilla, Alessia Capotondo, Donatella De Feo, Antonio Tomasso, Giancarlo Comi, Patrizia D’Adamo, Luca Muzio & Gianvito Martino
Figure S5. macrophages/macrophages activation affects both GCV-WT and GCV-NestinTK mice. (A) Histological analysis of a SC region located 3 mm far from the injury site from a GCV-WT mice (18 days post injury). Microglia/macrophages are labeled for Iba1 and F4/80. Arrowhead indicates cells that are shown at high magnification in panel A’. Panel B shows the site of the injury in the SC of GCV-WT mouse. Arrowhead indicates cells that are shown at high magnification in panel...

Additional file 4: of Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury

Melania Cusimano, Elena Brambilla, Alessia Capotondo, Donatella De Feo, Antonio Tomasso, Giancarlo Comi, Patrizia D’Adamo, Luca Muzio & Gianvito Martino
Figure S4. Catwalk assay on GCV-NestinTK mice. Histogram in panel A, shows locomotor functions of GCV-WT mice (blued dots, n = 6) and GCV-NestinTK mice (red dots, n = 6). Data are represented as Basso Mouse Scale (± S.E.M.) mean values of the locomotor score of each group. Statistical analysis in panel A has been done comparing at each time point GCV-WT and GCV-NestinTK mice. Day 3 p = 0.015; day 5 p = 0.00047; day 7 p = 0.00014; day 10 p = 0.00031; day 14...

Additional file 4: of Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury

Melania Cusimano, Elena Brambilla, Alessia Capotondo, Donatella De Feo, Antonio Tomasso, Giancarlo Comi, Patrizia D’Adamo, Luca Muzio & Gianvito Martino
Figure S4. Catwalk assay on GCV-NestinTK mice. Histogram in panel A, shows locomotor functions of GCV-WT mice (blued dots, n = 6) and GCV-NestinTK mice (red dots, n = 6). Data are represented as Basso Mouse Scale (± S.E.M.) mean values of the locomotor score of each group. Statistical analysis in panel A has been done comparing at each time point GCV-WT and GCV-NestinTK mice. Day 3 p = 0.015; day 5 p = 0.00047; day 7 p = 0.00014; day 10 p = 0.00031; day 14...

Additional file 3: of Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury

Melania Cusimano, Elena Brambilla, Alessia Capotondo, Donatella De Feo, Antonio Tomasso, Giancarlo Comi, Patrizia D’Adamo, Luca Muzio & Gianvito Martino
Figure S3. GCV treatment ablates proliferating SC-eNSCs in NestinTK mice. Panels A and B show representative confocal images of VIM (red) and Brdu (green) in the ependymal layer of GCV-WT (A) and GCV-NestinTK (B) mice (n = 3 for each group). Mice were sacrificed at the end of the GCV treatment. Quantifications (means ± S.E.M.) are shown in panel C. Two-way ANOVA followed by Bonferroni’s multiple Comparison test has been used to analyze data. ** p = 0.011 and...

Additional file 3: of Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury

Melania Cusimano, Elena Brambilla, Alessia Capotondo, Donatella De Feo, Antonio Tomasso, Giancarlo Comi, Patrizia D’Adamo, Luca Muzio & Gianvito Martino
Figure S3. GCV treatment ablates proliferating SC-eNSCs in NestinTK mice. Panels A and B show representative confocal images of VIM (red) and Brdu (green) in the ependymal layer of GCV-WT (A) and GCV-NestinTK (B) mice (n = 3 for each group). Mice were sacrificed at the end of the GCV treatment. Quantifications (means ± S.E.M.) are shown in panel C. Two-way ANOVA followed by Bonferroni’s multiple Comparison test has been used to analyze data. ** p = 0.011 and...

Additional file 2: of Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury

Melania Cusimano, Elena Brambilla, Alessia Capotondo, Donatella De Feo, Antonio Tomasso, Giancarlo Comi, Patrizia D’Adamo, Luca Muzio & Gianvito Martino
Figure S2. Sorted GFP+ cells from Nestin floxGFPflox-TK mice give rise to neurospheres. Panel A and B show the gating strategy for sorting GFP+ cells from SCs bulk cultures obtained from Nestin floxGFPflox-TK mice. WT litters (A) were used to set up the gating strategy that we used to sort GFP+ cells (B). GFP+ cells were plated at the density of 8000 cells/cm2 and daily examined for the presence of neurospheres. Small spheres were observed...

Additional file 2: of Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury

Melania Cusimano, Elena Brambilla, Alessia Capotondo, Donatella De Feo, Antonio Tomasso, Giancarlo Comi, Patrizia D’Adamo, Luca Muzio & Gianvito Martino
Figure S2. Sorted GFP+ cells from Nestin floxGFPflox-TK mice give rise to neurospheres. Panel A and B show the gating strategy for sorting GFP+ cells from SCs bulk cultures obtained from Nestin floxGFPflox-TK mice. WT litters (A) were used to set up the gating strategy that we used to sort GFP+ cells (B). GFP+ cells were plated at the density of 8000 cells/cm2 and daily examined for the presence of neurospheres. Small spheres were observed...

Additional file 1: of Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury

Melania Cusimano, Elena Brambilla, Alessia Capotondo, Donatella De Feo, Antonio Tomasso, Giancarlo Comi, Patrizia D’Adamo, Luca Muzio & Gianvito Martino
Figure S1. Characterization of the spinal cord ependymal canal of a Nestin floxGFPflox-TK mouse. Representative confocal images showing immunofluorescences for GFP/GFAP (A), and GFP/Id1 (B) in the ependymal layer of a Nestin floxGFPflox-TK mice (n = 3). Scale bar is 30 μm. (TIFF 1498 kb)

Additional file 1: of Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury

Melania Cusimano, Elena Brambilla, Alessia Capotondo, Donatella De Feo, Antonio Tomasso, Giancarlo Comi, Patrizia D’Adamo, Luca Muzio & Gianvito Martino
Figure S1. Characterization of the spinal cord ependymal canal of a Nestin floxGFPflox-TK mouse. Representative confocal images showing immunofluorescences for GFP/GFAP (A), and GFP/Id1 (B) in the ependymal layer of a Nestin floxGFPflox-TK mice (n = 3). Scale bar is 30 μm. (TIFF 1498 kb)

Boulders and bedrock: Modeling dynamic feedbacks between hillslope-derived blocks and transient channel evolution

Charles Shobe, Greg Tucker & Robert Anderson
This is a poster presented on May 17th, 2016 at the Community Surface Dynamics Modeling System (CSDMS) annual meeting in Boulder, CO, USA. The poster presents a numerical model for 1-D river channel evolution in the presence of hillslope-derived blocks of rock. It also shows initial progress towards a 2-D landscape evolution model incorporating these channel-hillslope feedbacks.
Abstract:
Steep reaches of mountain rivers often host clusters of large (>1 m) blocks of rock despite having high transport...

Big blocks and river incision: A numerical modeling perspective

Charles Shobe, Greg Tucker & Robert Anderson
This is a poster presented on December 18th, 2015 at the American Geophysical Union fall meeting in San Francisco, CA, USA. The poster presents a numerical model for 1-D river channel evolution in the presence of hillslope-derived blocks of rock. The model is fully described in Shobe et al (2016, Geophysical Research Letters).
Abstract:
Sediment supply dynamics affect fluvial erosion in steep landscapes. Workers have explored the effects of changing sediment flux and uniform grain size on...

Big blocks and river incision: A numerical modeling perspective

Charles Shobe, Greg Tucker & Robert Anderson
This is a poster presented on December 18th, 2015 at the American Geophysical Union fall meeting in San Francisco, CA, USA. The poster presents a numerical model for 1-D river channel evolution in the presence of hillslope-derived blocks of rock. The model is fully described in Shobe et al (2016, Geophysical Research Letters).
Abstract:
Sediment supply dynamics affect fluvial erosion in steep landscapes. Workers have explored the effects of changing sediment flux and uniform grain size on...

Treespace explorations

John Lees & 0000-0001-7344-7071
An interactive version of some of the treespace plots from 'Evaluation of phylogenetic reconstruction methods using bacterial whole genomes: a simulation based study'

PBPK Models: Reproducibility of Methods and Results

Risa Sayre
Poster for presentation at 2018 SOT.

A Biopsychosocial Model for the Management of Patients With Sickle-Cell Disease Transitioning to Adult Medical Care

Lori E. Crosby, Charles T. Quinn & Karen A. Kalinyak
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