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Targeting of BMI-1 with PTC-209 inhibits glioblastoma development

Yu Kong, Chunbo Ai, Feng Dong, Xianyou Xia, Xiujuan Zhao, Chao Yang, Chunsheng Kang, Yan Zhou, Qian Zhao, Xiujing Sun & Xudong Wu
Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor and refractory to existing therapies. The oncogene BMI-1, a member of Polycomb Repressive Complex 1 (PRC1) plays essential roles in various human cancers and becomes an attractive therapeutic target. Here we showed that BMI-1 is highly expressed in GBM and especially enriched in glioblastoma stem cells (GSCs). Then we comprehensively investigated the anti-GBM effects of PTC-209, a novel specific inhibitor of BMI-1. We found...

test.dat

Pritesh Parmar
This is just a test to see how figshare work. Not a real data.

test.dat

Pritesh Parmar
This is just a test to see how figshare work. Not a real data.

A rhodamine hydrazide–4-nitroindole-3-carboxaldehyde based turn on Hg2+ chemosensor: Cytoplasmic live cell imaging, logic gate and memory device applications and computational studies

Rahul Bhowmick, Abu Saleh Musha Islam, Mihir Sasmal, Atul Katarkar & Mahammad Ali
A new, highly sensitive probe L2 for the selective detection of Hg2+ in organo-aqueous (H2O:CH3CN, 1:1, v/v, HEPES buffer, pH 7.2) medium has been synthesized from rhodamine 6G-hydrazide and 4-nitroindole-3-carboxaldehyde. It was thoroughly characterized by physicochemical techniques including single crystal X-ray diffraction studies. The reaction of L2 with Hg2+ gives a 1:1 stoichiometry resulting in a 146 fold fluorescence enhancement and a binding constant (Kf) of 3×104 M−1. The spirolactam form of the probe is...

A rhodamine hydrazide–4-nitroindole-3-carboxaldehyde based turn on Hg2+ chemosensor: Cytoplasmic live cell imaging, logic gate and memory device applications and computational studies

Rahul Bhowmick, Abu Saleh Musha Islam, Mihir Sasmal, Atul Katarkar & Mahammad Ali
A new, highly sensitive probe L2 for the selective detection of Hg2+ in organo-aqueous (H2O:CH3CN, 1:1, v/v, HEPES buffer, pH 7.2) medium has been synthesized from rhodamine 6G-hydrazide and 4-nitroindole-3-carboxaldehyde. It was thoroughly characterized by physicochemical techniques including single crystal X-ray diffraction studies. The reaction of L2 with Hg2+ gives a 1:1 stoichiometry resulting in a 146 fold fluorescence enhancement and a binding constant (Kf) of 3×104 M−1. The spirolactam form of the probe is...

COMP

Tomonobu Hasegawa

COMP

Tomonobu Hasegawa

EGFR

Takayuki Yokoi

EGFR

Takayuki Yokoi

BRCA2

Angelo Minucci

Anomaly-Detection in Diabetes using SVM

Dr Jabez Jones
It's is an predominant anomaly detection technique , which is compared with many anomaly detection techniques

Analysis of Dynamic Characteristics of Grease Lubricated Tapered Roller Bearings

Zhenghai Wu
Analysis of Dynamic Characteristics of Grease Lubricated Tapered Roller Bearings

Redescription of Ceriagrion mourae with notes on its position in the genus Ceriagrion (Odonata: Coenagrionidae)

Rafał Bernard, Bogusław Daraż & Miroslawa Dabert
The poorly known Ceriagrion mourae is redescribed based on the first material from Zambia and compared with the similar C. banditum, C. junceum and C. suave. Molecular data place C. mourae as a sister taxon to the clade (C. bakeri (C. banditum, C. junceum)). Genetic distances between the above-mentioned species are similar at c.7–9% (K2P). Analysis of all published Ceriagrion COI sequences revealed a barcoding gap (c.2–6.5%) in the pairwise distance distribution and grouped African...

Three Cd(II) coordination polymers based on a pyridyldicarboxylate: Effect of coordinated water

Hui-Fang Zhou, Zi-Yu Wang, Bo Liu, Gui-Lin Wen & Yao-Yu Wang
By systematic change of the solvothermal synthesis, three new coordination polymers, [Cd(L)∙(H2O)]∙2H2O (1), [Cd(L)∙(H2O)]∙H2O (2) and [Cd(L)] (3), have been synthesized based on a tritopic ligand 4-(pyridin-3-yl)isophthalic acid (H2L). Compounds 1 and 2 show very similar two-dimensional (2D) bilayers further linked by interlayer hydrogen bonds into three-dimensional (3D) supramolecular structures, while 3 displays a 3D structure constructed form one-dimensional (1D) Cd-carboxyl chains. Notably, 1 and 2 have a pair of unusual isomers with the opposite...

Three Cd(II) coordination polymers based on a pyridyldicarboxylate: Effect of coordinated water

Hui-Fang Zhou, Zi-Yu Wang, Bo Liu, Gui-Lin Wen & Yao-Yu Wang
By systematic change of the solvothermal synthesis, three new coordination polymers, [Cd(L)∙(H2O)]∙2H2O (1), [Cd(L)∙(H2O)]∙H2O (2) and [Cd(L)] (3), have been synthesized based on a tritopic ligand 4-(pyridin-3-yl)isophthalic acid (H2L). Compounds 1 and 2 show very similar two-dimensional (2D) bilayers further linked by interlayer hydrogen bonds into three-dimensional (3D) supramolecular structures, while 3 displays a 3D structure constructed form one-dimensional (1D) Cd-carboxyl chains. Notably, 1 and 2 have a pair of unusual isomers with the opposite...

Lack of a Pharmacokinetic Interaction Between SYM-1219 Granules Containing 2 Grams of Secnidazole and a Combined Oral Contraceptive in a Phase 1, Randomized, Open-Label Study in Healthy Female Volunteers

Helen S. Pentikis, Nikki Adetoro & Carol J. Braun
Article full text
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Lack of a Pharmacokinetic Interaction Between SYM-1219 Granules Containing 2 Grams of Secnidazole and a Combined Oral Contraceptive in a Phase 1, Randomized, Open-Label Study in Healthy Female Volunteers

Helen S. Pentikis, Nikki Adetoro & Carol J. Braun
Article full text
The full text of this article can be found here.

Provide enhanced digital features for this article
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(withdrawn)

Masao Takaku
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How to present your research

Masao Takaku
研究室配属学生向けのプレゼンテーション法の入門編チェック項目です(筑波大学知識情報・図書館学類)。
This is an introductory material for beginners on how to present your research.

(withdrawn)

Masao Takaku
(withdrawn)

Clinical Evaluation of the Immune Colloidal Gold Method for Rapid Qualitative and Quantitative Measurement of Thyroid-Stimulating Hormone as an Assay for Hypothyroidism

Tingting Wang, Shiwei Sheng, Meifang Ruan, Jing Yan, Jianying Gu, Yumin Jiang, Yunchao Gao & Hankui Lu
Article full text

The full text of this article can be found here. https://link.springer.com/article/10.1007/s12325-016-0401-y

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There are currently no enhanced digital features for this article. If you are an author of this publication and would like to provide additional enhanced digital features for your article then please contact adisrapidplus@springer.com.


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Clinical Evaluation of the Immune Colloidal Gold Method for Rapid Qualitative and Quantitative Measurement of Thyroid-Stimulating Hormone as an Assay for Hypothyroidism

Tingting Wang, Shiwei Sheng, Meifang Ruan, Jing Yan, Jianying Gu, Yumin Jiang, Yunchao Gao & Hankui Lu
Article full text

The full text of this article can be found here. https://link.springer.com/article/10.1007/s12325-016-0401-y

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There are currently no enhanced digital features for this article. If you are an author of this publication and would like to provide additional enhanced digital features for your article then please contact adisrapidplus@springer.com.


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Effect of herbal feed additives on performance parameters, intestinal microbiota, intestinal morphology and meat lipid oxidation of broiler chickens

Ilias Giannenas, Eleftherios Bonos, Ioannis Skoufos, Athina Tzora, Ioanna Stylianaki, Diamanto Lazari, Anastasios Tsinas, Efterpi Christaki & Panagiota Florou-Paneri
1. This feeding trial investigated the effects of herbal feed additives on performance of broiler chickens, jejunal and caecal microbiota, jejunal morphology, and meat chemical composition and oxidative stability during refrigerated storage. 2. In a 42 days trial, 320 one-day-old broiler chickens were randomly allocated to four groups with four replicate pens each containing 20 chicks. The control group was fed maize–soybean-based diets. The diets of the other three groups were supplemented with herbal feed...

Effect of herbal feed additives on performance parameters, intestinal microbiota, intestinal morphology and meat lipid oxidation of broiler chickens

Ilias Giannenas, Eleftherios Bonos, Ioannis Skoufos, Athina Tzora, Ioanna Stylianaki, Diamanto Lazari, Anastasios Tsinas, Efterpi Christaki & Panagiota Florou-Paneri
1. This feeding trial investigated the effects of herbal feed additives on performance of broiler chickens, jejunal and caecal microbiota, jejunal morphology, and meat chemical composition and oxidative stability during refrigerated storage. 2. In a 42 days trial, 320 one-day-old broiler chickens were randomly allocated to four groups with four replicate pens each containing 20 chicks. The control group was fed maize–soybean-based diets. The diets of the other three groups were supplemented with herbal feed...

LT962964-LT963174

Marko Premzl
Curated third party data gene data set including 211 eutherian adiponectin genes.

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