15 Works

Predictors of PTSD and Post Concussive Syndrome in OIF/OEF Veterans (CNRM)

Alison Garcia
Purpose: Traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) are linked to worsened physical and mental health, functional impairment, and greater healthcare utilization. TBI is a point of injury diagnosis, but Post Concussive Syndrome (PCS) is analogous to the more persistent PTSD. Current treatments are often ineffective, and many afflicted military service members (SMs) never return to duty. Upon return from deployment, many SMs experience an initial honeymoon period during which symptoms are limited...

Traumatic Brain Injury Data for FITBIR Informatics system: Maryland Retrospective Dataset

Chandler Sours
This is a retrospective study involving limited imaging data on TBI patients with GCS ranging from 3-15 who received MR imaging as part of standard of care.

Traumatic Brain Injury Data for FITBIR Informatics system: Maryland MagNeTS Dataset - FMRI TBI Subset

Chandler Sours
This is a subset of the Prospective Maryland MagNeTS (FITBIR-STUDY0000314). This is prospective study involving imaging and behavioral data on mild TBI patients ranging from GCS 13-15. Participants completed task based fMRI using the N-back working memory paradigm at variable cognitive loads. Imaging and behavioral data was obtained at a single time point (approximately 1 month following injury).

Progesterone for the Treatment of Traumatic Brain Injury (ProTECT III)

Wenle Zhao
The ProTECT study will determine if intravenous (IV) progesterone (started within 4 hours of injury and given for a total of 96 hours), is more effective than placebo for treating victims of moderate to severe acute traumatic brain injury.

Effects of Rapid-Resisted Exercise on Ambulatory Adults with Traumatic Brain Injury (CNRM)

Asma Idriss
Background: Traumatic brain injury may have a range of effects, from severe and permanent disability to more subtle functional and cognitive deficits that often go undetected during initial treatment. To improve treatments and therapies and to provide a uniform quality of care, more research is needed into different treatments for traumatic brain injury. Exercise has been shown to improve movement and balance in people with strokes, cerebral palsy, and other conditions that affect the brain,...

An Independent, Prospective, Head to Head Study of the Reliability and Validity of Neurocognitive Test Batteries for the Assessment of Mild Traumatic Brain Injury

Portal Admin
Athletes are at a higher-than-normal risk for sustaining forceful impacts to the head, which sometimes yield mild traumatic brain injury (concussion). As a result, there has been a growing interest in methods and devices that can aid in traditional clinical measures by accurately assessing the extent of concussion-related symptoms as well as their resolution over time. In line with this goal, this study examines and compares the efficacy of two neurocognitive assessment tools, DANA and...

Effect of Aerobic Exercise Training on Cardiorespiratory Function in Patients with TBI (CNRM)

Non Admin
Many people who have traumatic brain injury (TBI) have low levels of physical fitness. Low physical fitness causes severe fatigue that reduces the ability to perform routine daily activities, and may also cause increased depression, anxiety, or sadness. Aerobic exercise, such as treadmill walking or running, improves physical fitness in most people and may also decrease fatigue and improve mood. However, more information is needed to determine if exercise improves these conditions in people who...

Biomarkers-Driven Development of Experiemental Therapeutics for Traumatic Brain Injury (CNRM)

Asma Idriss
Background: - A person who has a traumatic brain injury (TBI) -- also called concussion -- can have serious and long-lasting effects. Doctors who treat TBI need more information about how the brain changes over time in people with TBI and how well a person recovers from it. To make existing TBI treatments more effective and develop new ones, researchers want to look more closely at how TBI affects people both physically and psychologically. Objectives:...


Olga Vovk
The global aim of this proposal is to test and refine Common Data Elements (CDEs), neuroimaging standards, and best practices for genetics and proteomics in Traumatic Brain Injury (TBI) studies. Testing and validating of TBI-CDEs will be performed in a multi-center prospective observational study with 3 TBI Centers (San Francisco General Hospital (SFGH), University of Pittsburgh Medical Center (UPMC), University Medical Center Brackenridge (UMCB) and a TBI Rehabilitation Center (Mount Sinai Rehabilitation Center (MSMC)). The...

Adding Legacy Clinical Data to the Federal Interagency Traumatic Brain Injury: Citicoline Brain Injury Treatment Trial (COBRIT)

Helen Pan
Traumatic brain injury (TBI) is a major cause of death and disability. In the United States alone approximately 1.4 million people sustain a TBI each year, of which 50,000 people die and over 200,000 are hospitalized. In addition, new research suggests that TBI is an independent significant risk factor of developing dementia and Alzheimer's disease. Despite the scientific and cost benefits of cross-study analyses, variability in measurement across studies has limited the ability to combine...

Addition of Pediatric TBI Data to FITBIR: Child Health After Injury (CHAI) study

Frederick Rivara
The Child Health After Injury (CHAI) study was funded by the CDC (9/2006 to 8/2012) to determine the population-based rates of disability after traumatic brain injury (TBI) to children and adolescents. This study was one of the largest prospective longitudinal studies on pediatric TBI, had outstanding follow-up over three years, included controls, provided a comprehensive examination of functional outcomes after TBI and collected a wealth of clean and validated data. These high quality data are...

Traumatic Brain Injury Data for FITBIR Informatics system: Maryland MagNeTS Prospective Dataset

Chandler Sours
This is a prospective study involving longitudinal imaging and behavioral data on TBI patients ranging from GCS 3-15. Imaging and behavioral data was obtained at four time points (within 10 days of injury, 1 month, 6 months, and 18 months following injury. There is a FMRTBI subset study (FITBIR-STUDY0000315) associated with this prospective study.

The Impact of Concussive and Sub-Concussive Blows on Brain Network Activity

Steven Broglio
This investigation will implement a novel evaluation of electroencephalogram (EEG) recordings and standard clinical assessments in high school football athletes to evaluate concussive and sub-concussive impacts.

Tauopathy Consensus Study of Pathology Images

Olga Vovk
Repetitive brain trauma is associated with a progressive neurological deterioration, originally termed dementia pugilistica, and more recently, chronic traumatic encephalopathy (CTE). Most instances of CTE occur in association with the play of collision sports, such as American football and boxing, but CTE has also been reported blast injuries from improvised explosive devices, physical abuse, poorly controlled epilepsy, and head-banging behaviors (Corsellis et al., 1973; Geddes et al., 1999; McKee et al., 2009, 2013; Omalu et...

Effects of Erythropoietin on Cerebral Vascular Dysfunction and Anemia in Traumatic Brain Injury

Claudia Robertson
Importance: There is limited information about the effect of erythropoietin or a high transfusion threshold in traumatic brain injury (TBI). Objective: To compare the effects of erythropoietin and two transfusion thresholds (7 and 10 g/dl) on neurological recovery after TBI. Design: Randomized trial using a factorial design to test: i.) whether erythropoietin would fail to improve favorable outcomes by 20%, and ii.) whether a transfusion threshold of >10 g/dl would increase favorable outcomes without increasing...

Registration Year

  • 2018

Resource Types

  • Collection

Data Centers

  • Biomedical Research Informatics Computing System