74 Works

The Chemistry of Fungi

James Hanson

Pre-Vaccine Era COVID-19 Infection Fatality Ratio Estimates by Age, Time, and Location 2020-2021

This dataset contains estimates of the COVID-19 infection-fatality ratio (IFR) for global populations during the period April 15, 2020 to January 1, 2021. IFR is defined as the probability of an individual dying from COVID-19 once infected with the SARS-CoV-2 virus. In these files, IFR is expressed as a percent: deaths divided by infections multiplied by 100. Location-specific estimates include 190 countries and territories, as well as subnational locations in 11 countries and territories. Specific...

Fir and Empire

Ian Miller
The disappearance of China’s naturally occurring forests is one of the most significant environmental shifts in the country’s history, one often blamed on imperial demand for lumber. China’s early modern forest history is typically viewed as a centuries-long process of environmental decline, culminating in a nineteenth-century social and ecological crisis. Pushing back against this narrative of deforestation, Ian Miller charts the rise of timber plantations between about 1000 and 1700, when natural forests were replaced...

The Objectionable Li Zhi

Rivi Handler-Spitz, Pauline Lee & Haun Saussy
Iconoclastic scholar Li Zhi (1527–1602) was a central figure in the cultural world of the late Ming dynasty. His provocative and controversial words and actions shaped print culture, literary practice, attitudes toward gender, and perspectives on Buddhism and the afterlife. Although banned, his writings were never fully suppressed, because they tapped into issues of vital significance to generations of readers. His incisive remarks, along with the emotional intensity and rhetorical power with which he delivered...

The Scholar and the State

Liangyan Ge
In imperial China, intellectuals devoted years of their lives to passing rigorous examinations in order to obtain a civil service position in the state bureaucracy. This traditional employment of the literati class conferred social power and moral legitimacy, but changing social and political circumstances in the Ming (1368–1644) and Qing (1644–1911) periods forced many to seek alternative careers. Politically engaged but excluded from their traditional bureaucratic roles, creative writers authored critiques of state power in...

The Nuosu Book of Origins

Mark Bender, Wuwu Aku & Zopqu Jjivot
The Nuosu people, who were once overlords of vast tracts of farmland and forest in the uplands of southern Sichuan and neighboring provinces, are the largest division of the Yi ethnic group in southwest China. Their creation epic plots the origins of the cosmos, the sky and earth, and the living beings of land and water. This translation is a rare example in English of Indigenous ethnic literature from China. Transmitted in oral and written...

The Tibetan Nun Mingyur Peldrön

Alison Melnick Dyer
Born to a powerful family and educated at the prominent Mindröling Monastery, the Tibetan Buddhist nun and teacher Mingyur Peldrön (1699–1769) leveraged her privileged status and overcame significant adversity, including exile during a civil war, to play a central role in the reconstruction of her religious community. Alison Melnick Dyer employs literary and historical analysis, centered on a biography written by the nun's disciple Gyurmé Ösel, to consider how privilege influences individual authority, how authoritative...

The Story of Han Xiangzi

Erzeng Yang & Philip Clart
In this seventeenth-century Chinese novel, Han Xiangzi, best known as one of the Eight Immortals, seeks and achieves immortality and then devotes himself to converting his materialistic, politically ambitious Confucian uncle - Han Yu, a real historical figure - to Daoism. Written in lively vernacular prose interspersed with poems and songs, the novel takes its readers across China, to the heavens, and into the underworld. Readers listen to debates among Confucians, Daoists, and Buddhists and...

Casharka 2: Waa Maxay Sababta 2000 ee Maalmood ee ugu Horreeya ay muhiim u tahay: Fiirin Gudaha Maskaxda [cashar onlayn ah].

Ogow sida khibradaha ugu horeeya ay saameyn ugu yeeshaan koritaanka maskaxda caruurta.

Casharka 3: Ahmiyadda Macaamillada Xilli Hore [cashar onlayn ah].

Ogow wax ku saabsan muhiimada dhexgalka bulshada ee nolosha canuga yar.

HDL Proteomics in Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study

Atherosclerotic cardiovascular disease (CVD) is the major cause of death in patients with type 1 diabetes mellitus (T1DM). Alterations in the HDL proteome associate with prevalent CVD in T1DM. We therefore determined which proteins carried by HDL might predict incident CVD in T1DM patients. Using targeted MS/MS, we quantified 50 proteins in HDL from 181 T1DM subjects enrolled in the prospective Coronary Artery Calcification in Type 1 Diabetes study (CACTI). We used Cox proportional regression...

Upland Geopolitics

Michael Dwyer
In the twenty-first century, transnational land deals in the Global South have become increasingly prevalent and controversial. Widely seen as a new global land grab, transnational access to arable land in impoverished "land-rich" countries in Latin America, Sub-Saharan Africa, and Southeast Asia highlights the link between the shifting geopolitics of economic development and problems of food security, climate change, and regional and international trade. Drawing on ethnographic and archival research, Upland Geopolitics uses the case...

Three Early Mahāyāna Treatises from Gandhāra

Andrea Schlosser
The Gandhāran birch-bark scrolls preserve the earliest remains of Buddhist literature known today and provide unprecedented insights into the history of Buddhism. This volume presents three manuscripts from the Bajaur Collection (BC), a group of nineteen scrolls discovered at the end of the twentieth century and named after their findspot in northwestern Pakistan. The manuscripts, written in the Gāndhārī language and Kharoṣṭhī script, date to the second century CE. The three scrolls—BC 4, BC 6,...

PrP concentration in the central nervous system: regional variability, genotypic effects, and pharmacodynamic impact

Prion protein (PrP) concentration controls the kinetics of prion replication and is a genetically and pharmacologically validated therapeutic target for prion disease. In order to evaluate PrP concentration as a pharmacodynamic biomarker and assess its contribution to known prion disease risk factors, we developed and validated a plate-based immunoassay reactive for PrP across six species of interest and applicable to brain and cerebrospinal fluid (CSF). PrP concentration varies dramatically between different brain regions in mice,...

Diagnosing pleural effusions using mass spectrometry-based multiplexed targeted proteomics quantitating mid- to high-abundance markers of cancer, infection/inflammation and tuberculosis

Pleural effusion (PE) is excess fluid that appears in the pleural cavity of many lung cancer patients, as well as in those suffering from other ailments like extra-pulmonary tuberculosis (TB) and pneumonia, or stems from a variety of more benign diseases. Diagnosing the cause of the PE is often a clinical challenge and we have applied targeted proteomic methods with the aim of aiding the determination of PE etiology. We developed a mass spectrometry (MS)-based...

Multiple reaction monitoring (MRM) based data for targeted validation of proteins in Labeo rohita

A set of peptides was taken for targeted validation using targeted proteomic approach of Multiple reaction monitoring (MRM)/selected reaction monitoring (SRM). We have performed targeted experiment for two proteins in female gonad tissue of Labeo rohita. Results were matched with a spectral library for the reliability of the data. TSQ Altis Triple Quadrupole Mass spectrometer (Thermo) coupled to an HPLC system was used for acquiring the data. This data represents the significance of PeptideAtlas in...

Jesuits and Matriarchs

Nadine Amsler
In early modern China, Jesuit missionaries associated with the male elite of Confucian literati in order to proselytize more freely, but they had limited contact with women, whose ritual spaces were less accessible. Historians of Catholic evangelism have similarly directed their attention to the devotional practices of men, neglecting the interior spaces in Chinese households where women worshipped and undertook the transmission of Catholicism to family members and friends. Nadine Amsler’s investigation brings the domestic...

Mitochondrial inorganic polyphosphate (polyP) is a contributor towards maintaining cellular bioenergetics in SH-SY5Y cells: a proteomics and metabolomics approach

Inorganic polyphosphate (polyP) is an ancestral, ubiquitous, and well-conserved polymer, which is present in all the studied organisms. It is formed by individual subunits of orthophosphate which are linked together by bonds structurally similar and isoenergetic to those found in ATP. While the metabolism and the physiological roles of polyP in some organisms, including bacteria and yeast, have already been described, the exact role of this polymer in mammalian physiology remains still poorly explored. In...

Cov²MS: an automated matrix-independent assay for mass spectrometric detection and measurement of SARS-CoV-2 nucleocapsid protein

Introduction. The pandemic readiness toolbox needs to be extended, providing diagnostic tools that target different biomolecules, using orthogonal experimental setups and fit-for-purpose specification of detection. Here, we build on a previous Cov-MS effort to use liquid chromatography coupled to mass spectrometry (LC-MS) and describe a method developed to allow accurate, high throughput measurement of SARS-CoV-2 nucleocapsid (NCAP) protein. Methods. We use Stable Isotope Standards and Capture by Anti-Peptide Antibodies (SISCAPA) technology to enrich and quantify...

MRM quantification of circulating CFP-10 in TB patients

Liquid chromatography coupled mass spectrometry (LC-MS) operating in targeted mass spectrometry (MS) including multiple reaction monitoring (MRM) mode is an accurate analytical method. Integrating with nanoelectrospray-tandem MS (NanoES-MS/MS) and immunoprecipitation (IP), it becomes a promising method in detecting pathogen derived antigens which are at extremely low concentrations, such as mycobacterium tuberculosis (Mtb) secreted 10 kDa culture filtrate antigen (CFP-10). We employed an optimum denaturing condition for trypsin digestion and imunoprecipitation of targeted peptides and applied...

Prediction and experimental validation of a new salinity-responsive cis-regulatory element (CRE) in tilapia

Quantitative DIA proteomics in combination with the transcription inhibitor actinomycin D was performed on the tilapia OmB cell line to identify proteins that are upregulated by transcriptional regulation during hyperosmotic stress. This analysis revealed proteins that are transcriptionally up-regulated by hyperosmolality in these cells. The promoter regions of these proteins were compared and a novel hyperosmolality-induced cis-regulatory element (CRE) and corresponding transcription factor candidate were identified. The CRE was experimentlly validated by site-directed mutagenesis in...

SARS-CoV-2 Daily and Cumulative Infection Estimates 2019-2021

This dataset contains estimates of daily and cumulative infections with SARS-CoV-2 from the beginning of the pandemic through November 14, 2021, as well as estimates of cumulative COVID-19 deaths (adjusted for under-reporting) and estimates of the infection-detection ratio, infection-hospitalization ratio, and infection-fatality ratio. These are made available by day for 190 countries and territories – and subnational locations in 10 of those countries – aggregated into 21 regions and 7 super-regions and globally. Methods and...

Bài 2: Tại sao 2000 Ngày Đầu Đời Lại Quan Trọng: Tìm Hiểu Bên Trong Não Bộ [bài học trong mạng].

Tìm hiểu xem những trải nghiệm đầu đời định hình nên sự phát triển não bộ của trẻ như thế nào.

C.auto_3gas_absquant: Spike-in SIL-protein stock absolute quantification

Microbes that can recycle one-carbon (C1) greenhouse gases into fuels and chemicals are vital for the biosustainability of future industries. Acetogens are the most efficient known microbes for fixing carbon oxides CO2 and CO. Understanding proteome allocation is important for metabolic engineering as it dictates metabolic fitness. Here, we use absolute proteomics to quantify intracellular concentrations for >1,000 proteins in the model-acetogen Clostridium autoethanogenum grown on three gas mixtures. We detect prioritisation of proteome allocation...

Elevation of fatty acid desaturase 2 in esophageal adenocarcinoma increases polyunsaturated lipids and may exacerbate bile acid-induced genotoxicity

Background: Risk of esophageal adenocarcinoma (EAC) is associated with gastro-esophageal reflux disease (GERD) and obesity. Lipid metabolism-targeted therapies decrease the risk of progressing from Barrett’s esophagus (BE) to EAC, but the precise lipid metabolic changes and their roles in genotoxicity during EAC development are yet to be established. Methods: Esophageal biopsies from normal epithelium (NE), BE and EAC, were analysed using concurrent lipidomics and proteomics (n=30) followed by orthogonal validation on independent samples using RNAseq...

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