Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H2O2-Dependent Mechanism.

Nuno Almeida, Guia Carrara, Carlos M Palmeira, Ana S Fernandes, Maddy Parsons, Geoffrey Smith & Nuno Saraiva
The mechanisms by which the Golgi apparatus (GA) impacts on cell invasion are The mechanisms by which the Golgi apparatus (GA) impacts on cell invasion are TMBIM4) is a highly conserved Golgi cation channel that modulates intracellular Ca2+ fluxes. Human GAAP is expressed in all human tissues, is essential for cell viability and provides resistance against a range of apoptotic stresses. Furthermore, hGAAP enhances adhesion and cell migration by increasing the turnover of focal adhesions...

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