From disorder to order: the importance of context in protein folding and binding mechanisms

Carolina Altomar Testa Furtado De Mendonca
Anfinsen’s seminal work has shown that the information required for a protein to fold into its specific three-dimensional structure is encoded into its amino acid sequence. The protein structure was believed to determine its activity, meaning that a protein needs to fold in order to function. More recently, intrinsically disordered proteins (IDPs) have been shown to represent a significant portion of the proteome. Despite the lack of a predefined structure, they still play important roles...
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