39 Works

The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition

SP Bottomley, AM Buckle, RE Butcher, LD Cabrita, KF Fulton, JA Irving, AM Lesk, SL Reeve, J Rossjohn, I Smith & JC Whisstock

X-ray crystal structure of the fibrinolysis inhibitor {alpha}2-antiplasmin

James Whisstock & Ruby Law

The Crystal Structure of the Transthyretin-like Protein from Salmonella dublin, a Prokaryote 5-Hydroxyisourate Hydrolase

Ashley Buckle, Ruby Law & James Whisstock

The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+ / enzyme interactions

CG Langendorf, TLG Key, G Fenalti, WT Kan, AM Buckle, T Caradoc-Davies, KL Tuck, RHP Law & JC Whisstock

Structure-Informed Design of an Enzymatically Inactive Vaccine Component for Group A Streptococcus

Anna Henningham, Daniel Ericsson, Karla Langer, Lachlan Casey, Blagojce Jovcevski, G. Singh Chhatwal, J. Andrew Aquilina, Michael Batzloff, Bostjan Kobe & Mark Walker

Defining the interaction of perforin with calcium and the phospholipid membrane

Daouda Traore & James Whisstock

Synthesis of new (-)-Bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase.

Geetha Velmourougane, Michael Harbut, Seema Dalal, Sheena McGowan, Christine Oellig, James Whisstock, Michael Klemba & Doron Greenbaum

X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation

Ashley Buckle, JA Irving, Sheena McGowan & James Whisstock

Synthesis of new (-)-Bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase.

Geetha Velmourougane, Michael Harbut, Seema Dalal, Sheena McGowan, Christine Oellig, James Whisstock, Michael Klemba & Doron Greenbaum

Crystal structure of scabies mite inactivated protease paralogue S-D1 (SMIPP-S-D1)

Ashley Buckle

Structure of the heterodimer of human NONO and paraspeckle protein component 1

Charlie Bond, Daniel Passon & Mihwa Lee

The structure of granzyme C reveals an unusual mechanism of protease auto-inhibition

AM Buckle, D Kaiserman, RHP Law, JC Whisstock & PI Bird

A common fold mediates vertebrate defense and bacterial attack

Ashley Buckle, Michelle Dunstone, Ruby Law & James Whisstock

Structure of the Plasmodium falciparum PfA-M17_ZnZn

Sheena McGowan

A bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases

Sheena McGowan, M Klemba & DC Greenbaum

X-ray crystal structure of the streptococcal specific phage lysin PlyC

Sheena McGowan, Ashley Buckley & James Whisstock

Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

Ashley Buckle, Chris Porter, James Whisstock & Sheena McGowan

X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation

Ashley Buckle, JA Irving, Sheena McGowan & James Whisstock

Structure of the Plasmodium falciparum PfA-M17

Sheena McGowan

Registration Year

  • 2015
    32
  • 2016
    7