Annotated heart scaffold for rat available for registration of segmented neural anatomical-functional mapping of cardiac neural circuits.

Annotated mouse stomach scaffold available for registration of segmented neural anatomical-functional mapping of enteric neural circuits.

Quantified vagus nerve morphology across species

Example use of voila - a JupyterLab extension that creates interactive web pages from an iPython Notebook. The example goes through data exploration and analysis of effects of stimulation on colon motility, based on a SPARC dataset.

A dataset containing high-resolution confocal images of tranverse cross-sections of the C57BL/6J and C3H/HeJ femur and tibia that have been stained with anti-CGRP (sensory nerve), anti-TH (sympathetic nerve), anti-perilipin (adipocytes), and dapi (nuclei)

Example JupyterLab environment used to compile, run and display results of neural computational models, based on a SPARC dataset (https://doi.org/10.26275/iiwv-k07f)

A FitBit for the Bladder

Annotated heart scaffold for human available for registration of segmented neural anatomical-functional mapping of cardiac neural circuits.

whole-body

The generated body scaffold was fitted to data and the organ fiducial markers were embedded in the human whole-body. The landmarks were obtained from image data and also were defined in the body scaffold.

ViNERS (Visceral Nerve Ensemble Recording & Stimulation) peripheral neural interface modelling environment

Annotated human stomach scaffold available for registration of segmented neural anatomical-functional mapping of enteric neural circuits.

Annotated bladder scaffold for cat available for registration of segmented neural anatomical-functional mapping of LUT neural circuits.

This network is designed to study the interactions of different types of synaptic potentials in a realistic enteric neuron and the effects of varying the voltage-dependent ion channels in the output neuron membrane. Caption: Simulated neuron voltage

A computational workflow for integration and implementation of a reusable and reproducible rabbit cardiac multi-scale electrophysiology model. Caption: Illustration of ion channels and action potential propogation in cardiac tissue

Three-dimensional representation of the effects of a stimulating electrode around a bundle of nerve fibers. Caption: Image of neuron stimulation model with electric field lines and gradient.

Acute thoracolumbar nerve electrical stimulation; monitor colon manometry in all regions (proximal, transverse and distal) before, during and post stimulation.

A computational workflow for integration and implementation of a reusable and reproducible rabbit cardiac multi-scale electrophysiology model. Caption: Illustration of ion channels and action potential propogation in cardiac tissue.

A computational workflow for integration and implementation of a reusable and reproducible human cardiac multi-scale electrophysiology model. Caption: Illustration of ion channels and action potential propogation in cardiac tissue

A computational workflow for integration and implementation of a reusable and reproducible rabbit cardiac multi-scale electrophysiology model. Caption: Illustration of ion channels and action potential propogation in cardiac tissue.

CellML version of the Fabbri et al. 2017 human sinoatrial node (SAN) cell model and an ODE-based version of the Gerstner & Kistler 2002 brain stem model combined to demonstrate the effect of brain stem activity on heart rate

Tension files of the colon after chemogenetic activation and inhibition of of cholinergic or nitrergic myenteric neurons

Tension files of the colon after optogenetic inhibition of cholinergic or nitrergic myenteric neurons

Annotated mouse colon scaffold available for registration of segmented neural anatomical-functional mapping of enteric neural circuits.

3D imaging, colon, innervation, enteric nerve system, phenotyping