Intracardiac neuron (ICN) samples were collected from a female rat heart using laser capture microdissection. We acquired transcriptomics data for 154 genes from the 151 samples we collected. Images of sampled neurons allow for 3D reconstruction of data.
Interactive example for plotting gene expression using the RAW Graphs platform. Data are obtained from Prof. Leah Reznikov at University of Florida.
A computational workflow for integration and implementation of a reusable and reproducible human cardiac multi-scale electrophysiology model.
This is the first approach to publish a dataset from osparc
Two carbon nanotube yarn electrodes were implanted in the rat glossophayrngeal nerve. Under isoflurane, hypoxia challenges (11 total) were administered on days 7, 10 and 16 post-implant and the resulting neural activity was captured.
Colleen Clancy Single Cell solver with a file picker and PostPro viewer
2D RawGraphs viewer with one input
Influence of left vagal stimulus pulse parameters on vagal and gastric activity in rat.
Functional mapping of the stomach neural circuitry - gastric electrical stimulation (GES) evoked duodenal motility in ratsZhenjun T Tan, Matthew Ward, Robert Phillips, Xueguo Zhang, Deborah Jaffey, Logan Chesney, Bartek Rajwa, Elizabeth A Baronowsky, Jennifer L McAdams & Terry Powley
A detailed topographic map of regional gastric effects on duodenal motility, using duodenal motor responses elicited by gastric stimulation in different regions.
Micrographs of cross sections of cervical and abdominal rat vagus nerve stained with Masson's trichrome.
This dataset provides binary traces of cross sections of rat vagus nerves from which we quantified the effective nerve diameters, the effective fascicle diameters, the number of fascicles, and the perineurium thickness.
Interactive, AI-informed computational model of stimulus parameter-dependent vagal nerve responses resulting from bipolar, constant-current stimuli. Caption: Simulation of compound action potential propagation
Computes the cardiac myocyte action potential for the sympathetic drive input setting on the MAP-Core portal. Caption: Illustration of a whole body flatmap (centre) and central nervous system map (left) with a neural pathway highlighted.
This network is designed to study the interactions of different types of synaptic potentials in a realistic enteric neuron and the effects of varying the voltage-dependent ion channels in the output neuron membrane. Caption: Simulated neuron voltage
Annotated lung scaffold for pig available for registration of segmented neural anatomical-functional mapping of pulmonary neural circuits.
Single neurons were mapped and cardiac anatomy was annotated in image volumes of male and female rat hearts to compare the intrinsic cardiac nervous system between individuals and across sexes.
Computational analysis of the human sinus node action potential - Model development and effects of mutationsAlan Garny & Peter Hunter
CellML version of the Fabbri et al. 2017 mathematical model of the spontaneous electrical activity of a human sinoatrial node (SAN) pacemaker cell
Ultrastructural studies of cervical and sub-diaphragmatic human vagus nerve segments
This dataset includes lung and heart inserted into the pig whole-body using an automated workflow.
Characterisation of human colon longitudinal muscle motor neurons
Annotated pig stomach scaffold available for registration of segmented neural anatomical-functional mapping of enteric neural circuits.
Patch clamp recording of L-type Ca2+ current and slow delayed rectifier K+ current responses to norepinephrine and acetylcholine.
Calcium dynamics imaging of vasoactive intestinal peptide-expressing (VIP) enteric nervous system (ENS) neuronsJoseph Margiotta & Marthe Howard
Quanatitative Morphology, Transcriptomics and Function of Enteric Neurons Expressing VIP
Annotated pig colon scaffold available for registration of segmented neural anatomical-functional mapping of enteric neural circuits.
Annotated human stomach scaffold available for registration of segmented neural anatomical-functional mapping of enteric neural circuits.