Annotated heart scaffold for mouse available for registration of segmented neural anatomical-functional mapping of cardiac neural circuits.

We develop a workflow containing differential equation models of cardiac physiology that automate the execution of simulations with user defined options of outputs from a single cell, 1 or 2-Dimensional tissue, and a pseudo-ECG output.

Spatial distribution and morphometric characterization of vagal afferents (specifically: intraganglionic laminar endings (IGLEs)) associated with the myenteric plexus of the rat stomach.

Direct proximal colon, transverse colon and colorectum wall electrical stimulation; monitor colon wall bio-impedance and colon manometry in all regions (proximal, transverse and distal) before, during and post stimulation.

This network is designed to study the interactions of different types of synaptic potentials in a realistic enteric neuron.

This network is designed to study the interactions of different types of synaptic potentials in a realistic enteric neuron and the effects of varying the voltage-dependent ion channels in the output neuron membrane.

Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies

Computes the cardiac myocyte action potential for the sympathetic drive input setting on the MAP-Core portal. Caption: Illustration of a whole body flatmap (centre) and central nervous system map (left) with a neural pathway highlighted.

Interactive, AI-informed computational model of stimulus parameter-dependent vagal nerve responses resulting from bipolar, constant-current stimuli.

This network is designed to study the interactions of different types of synaptic potentials in a realistic enteric neuron and the effects of varying the voltage-dependent ion channels in the output neuron membrane. Caption: Simulated neuron voltage

Computes the cardiac myocyte action potential for the sympathetic drive input setting on the MAP-Core portal. Caption: Illustration of a whole body flatmap (centre) and central nervous system map (left) with a neural pathway highlighted.

Three-dimensional representation of the effects of a stimulating electrode around a bundle of nerve fibers. Caption: Image of neuron stimulation model with electric field lines and gradient.

A computational workflow for integration and implementation of a reusable and reproducible human cardiac multi-scale electrophysiology model. Caption: Illustration of ion channels and action potential propogation in cardiac tissue

A computational workflow for integration and implementation of a reusable and reproducible rabbit cardiac multi-scale electrophysiology model. Caption: Illustration of ion channels and action potential propogation in cardiac tissue

Micrographs of cross sections of cervical and abdominal rat vagus nerve stained with Masson's trichrome.

Interactive, AI-informed computational model of stimulus parameter-dependent vagal nerve responses resulting from bipolar, constant-current stimuli.

A computational workflow for integration and implementation of a reusable and reproducible rabbit cardiac multi-scale electrophysiology model.

Data for a patient with epilepsy obtained for clinical treatment and collected for research, consisting of a large intracranial EEG dataset (strip electrodes) with multiple seizures.

Enteroendocrine cells (EEC) are cells found in the gut that secrete hormones. This data describes EECs within the rat stomach, including their hormone content, shapes, positions within the mucosa, relationship to other cells and regional distribution.

Spatial distribution and morphometric characterization of vagal efferents associated with the myenteric plexus of the rat stomach.

Spatial distribution and morphometric characterization of vagal afferents (specifically: intramuscular arrays (IMAs)) within the longitudinal and circular muscle layers of the rat stomach.

Intracardiac neuron (ICN) samples were collected from a female rat heart using laser capture microdissection. We acquired transcriptomics data for 154 genes from the 151 samples we collected. Images of sampled neurons allow for 3D reconstruction of data.

Spatially Tracked Single Neuron Anatomical and Molecular Profiling of the Pig Right Atrial Ganglionic Plexus

Development of ACh (acetylcholine) nanosensor that detects ACh release in real-time. This dataset includes in vitro, ex vivo, and in vivo experimental results.

Spatially Tracked Single Neuron Anatomical and Molecular Profiling of the Pig Right Atrial Ganglionic Plexus