Quanatitative Morphology, Transcriptomics and Function of Enteric Neurons Expressing VIP

We used immunohistochemistry to visualize the expression of molecular markers in stellate ganglia from mice and human. Data consist of images (CZI format) of SG cryosections stained with antibodies combinations, acquired with a Zeiss 710 microscope.

Phasic calcium transient responses to different physiological stimuli, as well as neurochemical expression, in nitrergic and cholinergic myenteric neurons of the murine colon

Patch clamp recording of L-type Ca2+ current and slow delayed rectifier K+ current responses to norepinephrine and acetylcholine.

Annotated pig stomach scaffold available for registration of segmented neural anatomical-functional mapping of enteric neural circuits.

Computes the cardiac myocyte action potential for the sympathetic drive input setting on the MAP-Core portal. Caption: Illustration of a whole body flatmap (centre) and central nervous system map (left) with a neural pathway highlighted.

Ultrastructural studies of cervical and sub-diaphragmatic human vagus nerve segments

Annotated lung scaffold for pig available for registration of segmented neural anatomical-functional mapping of pulmonary neural circuits.

Comprehensive mapping of lower urinary tract afferent projections within the lumbosacral spinal cord of male and female rats, using 3D reconstruction of sectioned cord (TissueMaker) and cleared intact cord (iDisco, light sheet microscopy).

We combined experiments and computational modeling to investigate the effects of sympathetic nerve stimulation on mouse and rabbit hearts.

This network is designed to study the interactions of different types of synaptic potentials in a realistic enteric neuron and the effects of varying the voltage-dependent ion channels in the output neuron membrane. Caption: Simulated neuron voltage

This dataset includes lung and heart inserted into the pig whole-body using an automated workflow.

Electrode design characterization for electrophysiology from peripheral nervous system

Annotated brainstem scaffold for pig available for registration of segmented neural anatomical-functional mapping of neural circuits.

Annotated human stomach scaffold available for registration of segmented neural anatomical-functional mapping of enteric neural circuits.

Annotated pig colon scaffold available for registration of segmented neural anatomical-functional mapping of enteric neural circuits.

Calcium imaging videos of mouse enteric neurons

Microstructural analysis of food intake was used as a behavioral endpoint to determine the effect of chronic gastric electrical stimulation on the consumption of a 45% high fat diet by adult female Sprague-Dawley rats.

Electrical impedance tomography, selective stimulation, and micro-computed tomography data for porcine vagus nerves to decipher the fascicular structural and functional anatomy of the cardiac, pulmonary and recurrent laryngeal fascicles at cervical level.

Annotated lung scaffold for mouse available for registration of segmented neural anatomical-functional mapping of pulmonary neural circuits.

The generated body scaffold was fitted to data and the organ fiducial markers were embedded in the human whole-body. The landmarks were obtained from image data and also were defined in the body scaffold.

Characterisation of human colon longitudinal muscle motor neurons

Annotated bladder scaffold for human available for registration of segmented neural anatomical-functional mapping of LUT neural circuits.

Annotated bladder scaffold for pig available for registration of segmented neural anatomical-functional mapping of lower urinary tract (LUT) neural circuit.

Single neurons were mapped and cardiac anatomy was annotated in image volumes of male and female rat hearts to compare the intrinsic cardiac nervous system between individuals and across sexes.