62,520 Works

Births, Rebirths, and Horace’s genius : A Study of Odes IV, 11

Aaron Kachuck
This paper gives a new account of Roman birthday-cult and the genius in the works of Horace. Horace’s implicit theology of genius, it argues, related the public sphere of the nascent State (itself buttressed by birthday cult) to the private sphere of his relationship to Maecenas, and to the solitary sphere of his relationship to himself. At its core, this paper solves two problems raised by his final birthday-poem, Odes IV,11, “The Blood-Offering Problem” and...

Underestimating harm in mindfulness-based stress reduction.

Nicholas T Van Dam & Julieta Galante

Expected values for gastrointestinal and pancreatic hormone concentrations in healthy volunteers in the fasting and postprandial state

Claire Meek, HB Lewis, K Burling, Frank Reimann & Fiona Gribble
Background: Gastrointestinal hormones regulate intestinal transit, control digestion, influence appetite and promote satiety. Altered production or action of gut hormones, including glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and peptide YY (PYY), may contribute to the biological basis of obesity and altered glucose homeostasis. However, challenges in analytical methodology and lack of clarity on expected values for healthy individuals has limited progress in this field. The aim of this study was to describe expected concentrations...

Circulating microRNAs as biomarkers to assist the management of the malignant germ-cell-tumour subtype choriocarcinoma.

Matthew Murray, Stephen Smith, Dawn Ward, Lorena Verduci, James C Nicholson, Cinzia Scarpini & Nicholas Coleman
Germ-cell-tumours (GCTs) are heterogeneous and management is complex. The current conventional biomarkers, alpha-fetoprotein and human-chorionic-gonadotropin (HCG), have limited utility for diagnosis/follow-up as secretion is restricted to specific malignant-GCT subtypes and long half-life can make interpretation and clinical decision-making challenging. We sought to identify circulating microRNAs that reflected choriocarcinoma disease activity more accurately than HCG in a metastatic primary mediastinal nonseminomatous-GCT (PMNSGCT) case with elevated diagnostic serum HCG (>250,000U/L), consistent with pure choriocarcinoma. We undertook comprehensive...

The influence of temperature on thixotropic behaviour of cement mortar

Jacek Gołaszewski, Grzegorz Cygan & Michal Drewniok
This paper presents methods of measurement and results of rheological properties including thixitropic stiffening of designed cement mortars. The aim of the study is to determine the temperature rheological properties of selected mortars. It will help the industry to better understand and describe the nature of the previously observed decreasing formwork pressure using self-compacting concrete.

Fractionating autism based on neuroanatomical normative modeling.

Mariam Zabihi, Dorothea L Floris, Seyed Mostafa Kia, Thomas Wolfers, Julian Tillmann, Alberto Llera Arenas, Carolin Moessnang, Tobias Banaschewski, Rosemary Holt, Simon Baron-Cohen, Eva Loth, Tony Charman, Thomas Bourgeron, Declan Murphy, Christine Ecker, Jan K Buitelaar, Christian F Beckmann, Andre Marquand & EU-AIMS LEAP Group

Research data supporting \"Real-time intrinsic fluorescence visualisation and sizing of proteins and protein complexes in microfluidic devices\"

Maya Wright, Pavan Challa, Quentin Peter & Yuewen Zhang
Images of proteins intrinsic florescence in microfluidic channels

Superconducting hydrides under pressure

Christopher Pickard, Ion Errea & Mikhail Eremets
The measurement of superconductivity at above 200K in compressed samples of hydrogen sulfide and in lanthanum hydride at 250K is rein- vigorating the search for conventional high temperature superconduc- tors. At the same time it exposes a fascinating interplay between the- ory, computation and experiment. Conventional superconductivity is well understood, and theoretical tools are available for accurate predic- tions of the superconducting critical temperature. These predictions depend on knowing the microscopic structure of the material...


Li Wan & Luoyi YIN
Inspired by the fast take-up of data analytics and modelling in urban planning and design in Chinese cities, this paper aims to address a serious knowledge gap in terms of using data to deliver better policy outcomes rather than technical outputs. Such a knowledge gap is discussed in the wider context of smart city development where technology deployment failed to deliver the expected policy benefits. Lessons thus can be, and should be, learnt from early...

Understanding parameter differences between analyses employing nested data subsets

Steven Gratton & Anthony Challinor
We provide an analytical argument for understanding the likely nature of parameter shifts between those coming from an analysis of a dataset and from a subset of that dataset, assuming differences are down to noise and any intrinsic variance alone. This gives us a measure against which we can interpret changes seen in parameters and make judgements about the coherency of the data and the suitability of a model in describing those data.


Mansoor Ahmed-Rengers

Cohort Profile: A prospective cohort study of objective physical and cognitive capability and visual health in an ageing population of men and women in Norfolk (EPIC-Norfolk 3)

Shabina Hayat, Robert Luben, Victoria Keevil, Steph Moore, Nichola Dalzell, Amit Bhaniani, Anthony Khawaja, Paul Foster, Carol Brayne, Nicholas Wareham & K Khaw
The European Prospective Investigation of Cancer (EPIC) is a 10- country collaborative study in which EPIC-Norfolk is one of the UK centres. EPIC-Norfolk examined 25 639 men and women resident in East Anglia (aged 40–79 years), between 1993 and 1997. The EPIC collaboration was set up to examine the dietary determinants of cancer, but the remit in the EPIC-Norfolk cohort was broadened from the outset to include determinants of other health conditions and chronic diseases....

On Double-Diasporicity: Notes From a Pilgrimage Ethnography to the Grave of Amran Ben Diwan

Sami Everett
Each year, towards the end of spring, many Moroccan Jews undertake Hiloulot (festive-pilgrimagessimilar to ziyārāt) to the tombs of local Sayyid (or Tsadikim, Saints). One such pilgrimage is held near Ouazzane in a douar (village) called Asjen where Amran Ben Diwan’s grave is located. While some claim that Amran Ben Diwan, who is venerated by Muslims and Jews alike, was a Rabbi from the holy land, others report that he was a local healer. Amid...

Climate Emergency Politics Is Dangerous

Michael Hulme
A widespread popular movement over the last year or so has been insisting that on-going climate change warrants the formal declaration of a ‘climate emergency’. This movement has been most salient in western Europe and North America, with climate emergencies being voted through in recent months by parliaments in the UK, France, Canada and Ireland. Declarations of emergencies create ‘states of exception,’ often justified by governments under conditions of war, insurrection, or terrorist threat. Emergencies...

How Collections End: Objects, Meaning and Loss in Laboratories and Museums

Boris Jardine, Emma Kowal & Jenny Bangham
Collections are made and maintained for pleasure, status, nation or empire building, cultural capital, as a substrate for knowledge production, and everything in between. In asking how collections end, we shift the focus from acquisition and growth to erosion, loss and decay, and expose the intellectual, material and curatorial labour required to maintain collections. In this introductory essay, we draw together insights from the history of science and from science and technology studies to investigate...

Random-walk simulation of non-conservative pollutant transport in shallow water flows

Fan Yang & Dongfang Liang
The random-walk method is inherently simple and numerically stable. However, when used in hydro-environmental analyses, most of the existing random-walk methods ignore the influence of the non-uniform water depth and only consider the transport of inert materials, hence the inability of modelling biochemical reactions. In addition, they mainly examine the instantaneous-release problems, with a fixed number of particles moving in the computational domain. This paper first presents examples to showcase the capability of the newly...

The Impact of Including Costs and Outcomes of Dementia in a Health Economic Model to Evaluate Lifestyle Interventions to Prevent Diabetes and Cardiovascular Disease.

Penny Breeze, Chloe Thomas, Praveen Thokala, Louise Lafortune, Carol Brayne & Alan Brennan
Objectives Economic evaluations of lifestyle interventions, which aim to prevent Diabetes/Cardiovascular Disease (CVD), have not included dementia. Lifestyle interventions decrease dementia risk and extend life expectancy, leading to competing effects on healthcare costs. We aim to demonstrate the feasibility of including dementia in a public health cost-effectiveness analysis, and quantify the overall impacts accounting for these competing effects. Methods The School for Public Health Research (SPHR) Diabetes Prevention Model describes individuals’ risk of type 2...

Presume It Not: True Causes in the Search for the Basis of Heredity

Aaron Novick & Raphael Scholl
Kyle Stanford has recently given substance to the problem of unconceived alternatives, which challenges the reliability of inference to the best explanation (IBE) in remote domains of nature. Conjoined with the view that IBE is the central inferential tool at our disposal in investigating these domains, the problem of unconceived alternatives leads to scientific anti-realism. We argue that, at least within the biological community, scientists are now and have long been aware of the dangers...

Distinct genetic changes reveal evolutionary history and heterogeneous molecular grade of DLBCL with MYC / BCL2 double-hit

Francesco Cucco, Sharon Barrans, Chulin Sha, Alexandra Clipson, Simon Crouch, Rachel Dobson, Zi Chen, Joe Sneath Thompson, Matthew A. Care, Thomas Cummin, Josh Caddy, Hongxiang Liu, Anne Robinson, Anna Schuh, Jude Fitzgibbon, Daniel Painter, Alexandra Smith, Eve Roman, Reuben Tooze, Catherine Burton, Andrew J. Davies, David R. Westhead, Peter W. M. Johnson & Ming-Qing Du
Abstract: Using a Burkitt lymphoma-like gene expression signature, we recently defined a high-risk molecular high-grade (MHG) group mainly within germinal centre B-cell like diffuse large B-cell lymphomas (GCB-DLBCL), which was enriched for MYC/BCL2 double-hit (MYC/BCL2-DH). The genetic basis underlying MHG-DLBCL and their aggressive clinical behaviour remain unknown. We investigated 697 cases of DLBCL, particularly those with MYC/BCL2-DH (n = 62) by targeted sequencing and gene expression profiling. We showed that DLBCL with MYC/BCL2-DH, and those...

A novel, sensitive dual-indicator cell line for detection and quantification of inducible, replication-competent latent HIV-1 from reservoir cells

Fanny Salasc, David W. Gludish, Isobel Jarvis, Saikat Boliar, Mark R. Wills, David G. Russell, Andrew M. L. Lever & Hoi-Ping Mok
Funder: DH | National Institute for Health Research (NIHR); doi: https://doi.org/10.13039/501100000272

Gender and active travel: a qualitative data synthesis informed by machine learning

Emily Haynes, Judith Green, Ruth Garside, Michael P. Kelly & Cornelia Guell
Abstract: Background: Innovative approaches are required to move beyond individual approaches to behaviour change and develop more appropriate insights for the complex challenge of increasing population levels of activity. Recent research has drawn on social practice theory to describe the recursive and relational character of active living but to date most evidence is limited to small-scale qualitative research studies. To ‘upscale’ insights from individual contexts, we pooled data from five qualitative studies and used machine...

Measurements of the Higgs boson inclusive and differential fiducial cross sections in the 4 ℓ decay channel at s = 13 TeV

G. Aad, B. Abbott, D. C. Abbott, A. Abed Abud, K. Abeling, D. K. Abhayasinghe, S. H. Abidi, O. S. AbouZeid, N. L. Abraham, H. Abramowicz, H. Abreu, Y. Abulaiti, B. S. Acharya, B. Achkar, L. Adam, C. Adam Bourdarios, L. Adamczyk, L. Adamek, J. Adelman, M. Adersberger, A. Adiguzel, S. Adorni, T. Adye, A. A. Affolder, Y. Afik … &
Abstract: Inclusive and differential fiducial cross sections of the Higgs boson are measured in the H→ZZ∗→4ℓ (ℓ=e, μ) decay channel. The results are based on proton−proton collision data produced at the Large Hadron Collider at a centre-of-mass energy of 13 TeV and recorded by the ATLAS detector from 2015 to 2018, equivalent to an integrated luminosity of 139 fb-1. The inclusive fiducial cross section for the H→ZZ∗→4ℓ process is measured to be σfid=3.28±0.32 fb, in...

Ti Alloyed α -Ga 2 O 3: Route towards Wide Band Gap Engineering

Armin Barthel, Joseph Roberts, Mari Napari, Martin Frentrup, Tahmida Huq, András Kovács, Rachel Oliver, Paul Chalker, Timo Sajavaara & Fabien Massabuau
The suitability of Ti as a band gap modifier for α-Ga2O3 was investigated, taking advantage of the isostructural α phases and high band gap difference between Ti2O3 and Ga2O3. Films of (Ti,Ga)2O3 were synthesized by atomic layer deposition on sapphire substrates, and characterized to determine how crystallinity and band gap vary with composition for this alloy. We report the deposition of high quality α-(TixGa1−x)2O3 films with x = 3.7%. For greater compositions the crystalline quality...

Risk stratification for early-onset fetal growth restriction in women with abnormal serum biomarkers: a retrospective cohort study

L. Ormesher, L. Warrander, Y. Liu, S. Thomas, L. Simcox, G. C. S. Smith, J. E. Myers & E. D. Johnstone
Funder: Tommy's Baby Charity; doi: http://dx.doi.org/10.13039/501100000306

The cucumber mosaic virus 1a protein regulates interactions between the 2b protein and ARGONAUTE 1 while maintaining the silencing suppressor activity of the 2b protein

Lewis G. Watt, Sam Crawshaw, Sun-Ju Rhee, Alex M. Murphy, Tomás Canto & John P. Carr
The cucumber mosaic virus (CMV) 2b viral suppressor of RNA silencing (VSR) is a potent counter-defense and pathogenicity factor that inhibits antiviral silencing by titration of short double-stranded RNAs. It also disrupts microRNA-mediated regulation of host gene expression by binding ARGONAUTE 1 (AGO1). But in Arabidopsis thaliana complete inhibition of AGO1 is counterproductive to CMV since this triggers another layer of antiviral silencing mediated by AGO2, de-represses strong resistance against aphids (the insect vectors of...

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