365 Works

Application of through vial impedance spectroscopy (TVIS) for the determination of ice nucleation, solidification endpoint, and mannitol crystallization and melt-back temperature during freezing and annealing

Longinus Ogugua, Geoff Smith & Ahmet Orun
Studies of the freezing behavior of aqueous solutions of mannitol are highly relevant to lyophilization process development given the prevalent use of this excipient. Here, through-vial impedance spectroscopy (TVIS) was used to study the behaviour of an aqueous solution of 5%w/v mannitol during a freezing and re-heating cycle. Temperature calibration of the TVIS parameter FPEAK enabled the determination of the ice nucleation temperature Tn at −13 oC while the ice solidification end point was observed...

The use of through vial impedance spectroscopy (TVIS) for determination of ice nucleation, solidification end point, and mannitol crystallization during freezing and re-heating. Poster presentation at the APS PharmSci Conference Greenwish, 11-13th Sept. 2019

Longinus Ogugua, Geoff Smith & Ahmet Orun
This is a study of the freezing/reheating behavior of aqueous solutions of mannitol with respect to lyophilization process development given the prevalent use of the excipient. Here, through-vial impedance spectroscopy (TVIS) was used to study the thermophysical kinetics of an aqueous solution of 5%w/v mannitol during a freezing and re-heating phase of a freeze-drying cycle. Temperature calibration of the TVIS parameter FPEAK enabled the determination of the ice nucleation temperature Tn at −13 oC while...

Fabio Caraffini

Fabio Caraffini, Megan Hardeman & Aamir Hussain
Fabio Caraffini is a senior lecturer in Computer Science and Mathematics at De Montfort University (DMU). Fabio’s public research data is available on dmu.figshare.com and his profile page is available here.
This is a case study conducted by Megan Hardeman.
Key Points
• By sharing his high-resolution, multispectral images prior to a paper publication on DMU Figshare, Fabio and his colleagues are building public engagement with their research.
• Storing large amounts of data in DMU Figshare allows...

Sharing data in Economics

Edward Cartwright, Megan Hardeman & Aamir Hussain
Edward Cartwright is a Professor of Economics in the Department of Strategic Management and Marketing at De Montfort University (DMU). Edward’s public research data is available on dmu.figshare.com. This is a case study conducted by Megan Hardeman.
Key Points
• You can share your data easily on DMU Figshare and make your data available before the associated paperis published.
• Making data publicly available means other sources - including media - can reuse and share the data.
•...

DMU Figshare

Aamir Hussain
The DMU Figshare poster banner

A Heuristic for Engineering Data Comparison.pdf

Alistair Duffy
Recent presentation giving background of FSV and some current developments.

Understanding enzyme dosing in AD

Raffaella Villa
Dataset underpinning figure and tables of the article "Understanding enzyme dosing in anaerobic digestion". The spreadsheets contain raw data acquired from laboratory work and their manipulation. Biogas reading have been normalised to STD conditions. Volatile solids for long-term experiments have been measured at the start of the experiments only.

D5.1 Dissemination, communication, exploitation and advocacy plan

, Thamar Zijlstra, Corinna Pannofino, Rowena Rodrigues, Bernd Stahl, , Anya Gregory, Renate Klar & Lucy Peel
This deliverable elaborates the SHERPA dissemination, communication, exploitation and advocacy plans (DCEAP) that will help maximise the impact of the project and secure a legacy for it. The document covers:
1. Dissemination channels and tools (benchmarks and key performance indicators) and stakeholder analysis as developed in WP2 (Task 2.1) and dissemination measures
2. Communication with key stakeholder groups throughout the project
3. Exploitation activities
4. Advocacy strategy and activities

No Woman's Land - Film Documentary

Rosie Garton
In 1945, Rippel’s Grandmother; Lucia was violently expelled from her place of birth, Brzeznica, Silesia. She walked 220 miles to Pulspforde, Germany with her two small children. In 2015, Garton and Rippel retraced her footsteps, undergoing a physical endurance in order to gain a level of embodied understanding of a migratory experience. Garton recorded sounds, sights, and interviews from the walk, which she combined with archival footage to storyboard a short film that provided an...

No Woman's Land - Film Documentary

Rosie Garton
In 1945, Rippel’s Grandmother; Lucia was violently expelled from her place of birth, Brzeznica, Silesia. She walked 220 miles to Pulspforde, Germany with her two small children. In 2015, Garton and Rippel retraced her footsteps, undergoing a physical endurance in order to gain a level of embodied understanding of a migratory experience. Garton recorded sounds, sights, and interviews from the walk, which she combined with archival footage to storyboard a short film that provided an...

Collaborating with industrial partners and sharing conference materials online

Geoff Smith, Megan Hardeman & Aamir Hussain
Geoff Smith is a Professor of Pharmaceutical ProcessAnalytical Technology in the Leicester School ofPharmacy at De Montfort University (DMU).
Key Points
• Geoff has used DMU Figshare to collaborate with industrial partners in the area of pharmaceuticaltechnology.
• Geoff uploads his conference presentations and posters to DMU Figshare to ease the administration burdenof sharing with conference attendees and to receive DOIs (Digital Object Identifiers) for citing these outputs.

Edappalli Clinic Play Photos

Ameer Ali, , &
Photos taken from the clinic play held at Edappalli Clinic

Elappulli Clinic Play Photos

Ameer Ali, , &
Photos taken from the Clinic Play held at Elappulli, Palakkad on 6th February 2020.

Calicut Clinic Play Photos

Ameer Ali, , &
Some photos taken during the play held at MHAT institute on 9th February 2020.

freeze-drying cycle design and the phase diagram of water

Geoff Smith
Excel Workbook with
(i) a worksheet containing a table and figure showing set points in a lyophilization cycle and,(ii) a worksheet containing the phase diagram of water and showing the impact of the set points on the vapour pressure of ice at the sublimation interface and at the condenser

Data for the vapour pressure of ice and liquid water on the phase diagram worksheet are calculated from the Antoine equation
The author consents to the use of...

freeze-drying cycle design and the phase diagram of water

Geoff Smith
Excel Workbook with
(i) a worksheet containing a table and figure showing set points in a lyophilization cycle and,(ii) a worksheet containing the phase diagram of water and showing the impact of the set points on the vapour pressure of ice at the sublimation interface and at the condenser

Data for the vapour pressure of ice and liquid water on the phase diagram worksheet are calculated from the Antoine equation
The author consents to the use of...

Children stories in times of Corona

Indrani Lahiri
In response to the need for positive action during the Covid-19 Pandemic we have successfully launched a virtual ‘Children’s Stories’ platform for parents to enable their children to express themselves mainly through drawings and writing their stories. It has been very well received particularly by care homes, frontline Doctors working in the NHS who have gone on to express, to the administrators of the online platform, the power of this platform allowing them a ‘breathing...

Radio interview

Indrani Lahiri
The coronavirus lockdown has seen a spontaneous and heartfelt response from ordinary members of the public who want to help and make a difference in their communities. Here in Leicester, the Covid-19 Mutual Aid Group has been working to support, connect and make sure that volunteers across the city are working with the public authorities, universities and businesses to ensure that everyone in the city is safe, feels connected, and has someone to turn to...

Radio interview

Indrani Lahiri
The coronavirus lockdown has seen a spontaneous and heartfelt response from ordinary members of the public who want to help and make a difference in their communities. Here in Leicester, the Covid-19 Mutual Aid Group has been working to support, connect and make sure that volunteers across the city are working with the public authorities, universities and businesses to ensure that everyone in the city is safe, feels connected, and has someone to turn to...

Guidelines for the Ethical Use of AI and Big Data Systems

Philip Brey, Kevin Macnish & Mark Ryan
This report contains ethical guidelines for the deployment and use of artificial intelligence (AI) and big data systems in organisations.The guidelines differ from others in that they are directly related to practices of deployment, implementation and use. They are intended to be actionable guidelines for organisations that use these systems, rather than abstract principles that have no direct application in practice. We call such guidelines operational, meaning ready for use. Applying these guidelines in practice...

Z-FDM : Impedance spectroscopy enhanced freeze drying microscopy. Podium presentation at 2nd Annual Pharmaceutical Lyophilization Summit 12-13 Feb 2020, Berlin

Geoff Smith
Cite as :Smith, G. (2020) Z-FDM : Impedance spectroscopy enhanced freeze drying microscopy. Podium presentation at 2nd Annual Pharmaceutical Lyophilization Summit 12-13 Feb 2020, Berlin
2nd Annual Pharmaceutical Lyophilization SummitFebruary 12-13, 2020 | Berlin, Germany
NH Collection Berlin FriedrichstrasseFriedrichstraße 96
This presentation demonstrates the application in freeze-drying of a single analytical instrument (Z-FDM) combining impedance (Z) spectroscopy with freeze-drying microscopy (FDM). The electrical impedance spectra and visual appearance of frozen solutions were analysed with an inter-digitated micro-electrode array...

D5.5 Events

Corinna Pannofino
This deliverable contains information on the significant events organised by the project in year one and will be updated on an annual basis in months 24 (April 2020), 36 (April 2021), 42 (October 2021). The main events organised include project meetings, workshops with stakeholders, stakeholder board meetings, focus groups, advocacy meetings and conferences

Through Vial Impedance Spectroscopy (TVIS) Dual-electrode System for Process Parameter Determination. Podium presentation at ISL-FD Midwest Chapter Annual Meeting, April 12th 2018 Midwest Conference Centre, Northlake, IL 60164, USA

Geoff Smith
Cite as :Smith, G. and Jeeraruangrattana, Y. (2018). Through Vial Impedance Spectroscopy (TVIS) Dual-electrode System for Process Parameter Determination. ISL-FD Midwest Chapter Annual Meeting, April 12th 2018, Midwest Conference Centre, Northlake, IL 60164, USA

The first part of the talk provides a description of the TVIS measurement system followed by a brief overview of a number of applications in pharmaceutical freeze-drying. The majority of the talk then focusses on the first time reporting of the use...

Freeze-drying process optimization using through vial impedance spectroscopy. EPSRC EHDA Network International Pharmaceutical Technology Conference, November 4, Leicester, United Kingdom

Geoff Smith
Cite as : Smith, G. (2016) Freeze-drying process optimization using through vial impedance spectroscopy. Podium presentation at EPSRC EHDA Network International Pharmaceutical Technology Conference, November 4, Leicester, United Kingdom

Scope of the presentation:The talk starts with an introduction to freeze-drying and the design space for the process, then provides an introduction of Through Vial Impedance Spectroscopy (TVIS) Technology
The rest of the talk is then devoted to applications for TVIS in the determination of two important process...

D1.3 Cyberthreats and countermeasures

Andrew Patel, , Kevin Macnish, Mark Ryan & Alexey Kirichenko
While recent innovations in the machine learning domain have enabled significant improvements in a variety of computer-aided tasks, machine learning systems present us with new challenges, new risks, and new avenues for attackers. The arrival of new technologies can cause changes and create new risks for society (Zwetsloot and Dafoe, 2019) (Shushman et al., 2019), even when they are not deliberately misused. In some areas, artificial intelligence has become powerful to the point that trained...

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