81 Works

Structural characterisation of a novel E3 ligase module and activity-based probe development for UBL E3 ligases

Lu Barnsby-Greer
E3 ligase enzymes are key regulators of many aspects of eukaryotic biology via the promotion of the ubiquitylation and subsequent degradation of proteins. There have been over 700 E3s identified within the ubiquitin system with diverse mechanisms of E3 ligase activity, however, significantly less have been identified for ubiquitin-like proteins. Recently developed activity-based probes allowed for the identification of novel E3 ligase proteins involved in the ubiquitin system that carry out unconventional ubiquitylation. The development...

A Study of Care Leavers Lived Experiences of Social Orphanhood in Latvia

Zoe Kessler
This study set out to investigate social orphanhood through narratives of young people with experiences of growing up in care in Latvia. The study uses the life histories of participants to explore the phenomenon of social orphans. To date, narratives about the lived experiences of social orphans in Latvia have been told in the third person as most studies have used methodologies that kept participants passive rather than active. In this study the research process...

The Construction of the \"Mad\" Female Criminal in Medical Discourse and Legal Practice at London's Old Bailey, 1863-1913

Fiona Aisling MacHugh
This thesis looks at the practical application of medical discourse to women found insane at London’s Old Bailey between 1863 and1913. Through in-depth analysis of all cases of women found insane at the Old Bailey, 1863-1913, this PhD thesis analyses the various discourses, medical, legal and cultural which appear to have been applied to these women in order to achieve a successful insanity plea. Using trial transcripts, newspaper reports, and published medical discourse the thesis...

Investigation of the biofilm contributing eps gene operon of Bacillus subtilis

Jonathan William Archibald Blackburn

An exploration of technologies for targeted protein modification

Luke Martin Simpson
Targeted protein degradation (TPD) is a promising strategy for both therapeutics and research, providing new opportunities to overcome some of the current limitations associated with traditional small-molecule therapeutics, RNA interference (RNAi) and genome editing approaches. Proteolysis-targeting chimeras (PROTACs) are typically heterobifunctional molecules which bring a protein of interest (POI) into spatial proximity of an E3 ubiquitin ligase, triggering POI ubiquitylation and proteasomal degradation. The Sapkota lab previously developed an affinity-directed protein missile (AdPROM) system for...

Investor and Assuror perspectives on materiality for sustainability reporting: An exploratory case study of Nigeria's oil and gas industry

Osai Simeon Nnodim
This thesis utilises the materiality concept of accounting to investigate institutional investor and assuror practitioner perspectives on sustainability reporting in the Nigerian oil and gas sector. The outcome of this investigation is expected to provide some insight into the prospects of success for the Nigerian financial sector’s drive to normalise sustainability reporting. For this purpose, a qualitative case study research was undertaken, which involved interviews of investors in decision making roles and auditors with social...

Drug target deconvolution in Leishmania donovani

Luciana De Sousa Paradela
The lack of robustly validated drug targets in Leishmania spp. is a major impediment to the discovery of new drugs and effective treatments for leishmaniasis. Here, 6 phenotypically-active anti-leishmanial compounds were selected from GSKs Kinetobox compound collections for subsequent target deconvolution studies. The principal aim of these studies was to identify molecular targets that can be exploited by subsequent target-focused anti-leishmanial drug discovery. Using multiple orthogonal genome-wide genetic, chemical proteomic and biochemistry-based approaches, two compounds...

Leptin-based hexamers facilitate memory and prevent amyloid-driven AMPA receptor internalisation and neuronal degeneration

Jenni Harvey
Datasets in support of the paper Leptin-based hexamers facilitate memory and prevent amyloid-driven AMPA receptor internalisation and neuronal degeneration

New approaches to studying the GPI biosynthesis pathway in T. brucei: uncovering the missing links

Zhe Ji
Trypanosoma brucei is a protozoan that causes Human African Trypanosomiasis and nagana in cattle. The bloodstream form (BSF) of T. brucei has a dense surface-coat of variant surface glycoprotein (VSG) that acts as the first line of defence against the host immune system while the main cell surface glycoproteins of the procyclic form (PCF) are the procyclins. VSGs and procyclins are attached to the cell membrane through glycosylphosphatidylinositol (GPI) anchors. Despite its importance, the GPI...

The Development and Characterisation of a Novel and Modular Virus-like Particle Platform

Aleksandra Moleda

A study of teacher wellbeing in post-primary schools in the West of Ireland

Teresa Crawford
This thesis explores teacher wellbeing in two post-primary schools in the West of Ireland. The research was conducted using a qualitative case study methodology, through semi-structured interviews with twenty-six newly qualified and experienced teachers in two urban schools, one located in a disadvantaged area and the other in a middle-class area. Research on wellbeing suggests that it is a multi-dimensional concept and difficult to define despite a steep increase in scholarly research across a myriad...

A Ground Truth Data Set of Gas Chromatography mass spectrometry (GCMS) Analysed Synthesised Methylenedioxymethylamphetamine (MDMA)

Jonathan Miller, Niamh NicDaeid & Roberto Puch-Solis
An open source format data set of Methylenedioxymethylamphetamine. This data set was derived from a PhD project which involved the repetitive chemical synthesis of a series of methylenedioxymethylamphetamine (MDMA) samples following a series of known synthetic chemical routes. Controlled drug samples are normally chemically analysed to determine their identity and in some cases, their purity. There are also circumstances where a more broad chemical characterisation of drug samples may also be required. This involves investigating...

Macro Micro Studio

Neil Burford, Rod Jones, Stephen Reynolds & David Rodley
Supplementary Information

Image Data from Transfer and Persistence of UV powder trace material

Christian Cole, Melissa Lawson, Stephanie Green, Stewart Doyle, Emma Macneill & Bethany Hamilton
Dataset of 2718 raw images taken for the study of transfer and persistence of UV powder deposited on a variety of clothing material. This dataset constitutes a ground truth for use as a model for forensic trace evidence.

Hydrocarbon pollutant impact on spectral and biophysical properties of willow and grass species

Raquel Serrano-Calvo
Vegetation is a potential indicator of land contaminated by hydrocarbons. Remote sensing holds great potential for detecting stress in vegetation caused by the presence of hydrocarbons, but as yet this potential has not been realised, largely due to a lack of understanding of the biophysiological impacts of hydrocarbons on plant growth, and the specific spectral expression of them. Previous research has demonstrated success in laboratory simulation of hydrocarbon contamination and the analysis of the spectral...


Charlotte Cochard & Torsten Granzow

LGBT+ Experiences of Custody: Gender Non-Conformity in Overtly Gendered Social Spaces

Scott McMillan
LGBT+ people are evidenced globally as being negatively impacted by the criminal justice system and face specific challenges within custodial settings due to their sexual orientation or gender identity, in what are inherently heteronormative and overtly masculine spaces culturally, and where hard lines between sex and gender are actively enforced and even reified in policy and practice at the institutional level. This dissertation sought to explore the experience of LGBT+ people in UK prisons relative...

DRAM: A three-dimensional analytical model for the mobilisation of root reinforcement in direct shear conditions – Data repository

Gerrit Meijer, Jonathan Knappett, Glyn Bengough, Daniel Bull, Teng Liang & David Muir Wood
This dataset contains data of experiments underlying the work presented in the linked Ecological Engineering journal publication (DOI: 10.1016/j.ecoleng.2022.106621). Source code for the DRAM model (written in R) can be found in a separate repository (DOI: 10.5281/zenodo.6375587).

Multiple and Multi-dimensional Transitions of Healthcare Graduates due to COVID-19

Divya Jindal-Snape
Poster related to a study exploring the ongoing multiple and multi-dimensional transitions experienced by medicine, nursing and dentistry students due to graduate in summer 2020.

The Impact of US-Russian Security Competition on the Development of a Common European Energy Security Policy

Ioanna Mavromati
Important questions about the development of a common European energy security policy have been unexplored in the literature. The literature on European energy security focuses on the EU’s internal and external energy policy and explores issues ranging from the importance of speaking with one voice to who is leading European energy policy. Other studies focus on how much progress has been made towards the development of a common European energy security policy, what factors have...

Time Series of Media Implied Economic Sentiments (Linear Support Vector Machine)

Dooruj Rambaccussing & Andrzej Kwiatkowski
This dataset consists of economic implied sentiments based on filtering of articles based on economic policy keywords. The process of filtering is described in : Rambaccussing, D., & Kwiatkowski, A. (2020). Forecasting with news sentiment: Evidence with UK newspapers. International Journal of Forecasting, 36(4), 1501-1516. Bowden, J., Kwiatkowski, A., & Rambaccussing, D. (2019). Economy through a lens: distortions of policy coverage in UK national newspapers. Journal of Comparative Economics, 47(4), 881-906. The construction of the...

A Critical Discourse Analysis of Undergraduate Nursing Students’ Experiences of Learning Dignity-enhancing Care within the Clinical Learning Environment

Sheila Kay Douglas
Background The nursing profession has been challenged to improve standards of care in the UK. Nursing has been, and continues to be, considered a caring profession, but this reputation has been undermined since the events in Mid-Staffordshire Hospitals emerged between 2005 and 2009. The ensuing debate in the professional nursing journals sought to apportion blame under the guise of seeking solutions. Many arguments were revisited. This included scrutiny of undergraduate nursing education post-1996 when provision...

'It's Aboot Justice and Journey': Community Development Practitioners' Perspectives Reveal Insights on Practice in Scotland

Jean McEwan-Short
Community development is commonly described as contested practice, it is defined in many nuanced ways and there are challenges across the literature encouraging practitioners to engage more fully with critical thinking and transformative intent. The aim of this inquiry was to investigate community development practitioners’ perspectives on their practice in Scotland. Using an interpretivist framework, the research was designed to foreground the participants’ voices as experts on their own practice. Dyadic dialogical interviews were developed...

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